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Aliases for ZNF12 Gene

Aliases for ZNF12 Gene

  • Zinc Finger Protein 12 2 3
  • Zinc Finger Protein 325 2 3 4
  • Gonadotropin-Inducible Ovary Transcription Repressor 3 3 4
  • Zinc Finger Protein KOX3 3 4
  • ZNF325 3 4
  • GIOT-3 3 4
  • KOX3 3 4
  • Gonadotropin Inducible Transcription Repressor 3 3
  • Zinc Finger Protein 11 3
  • HZF11 3
  • GIOT3 4

External Ids for ZNF12 Gene

Previous HGNC Symbols for ZNF12 Gene

  • ZNF325

Previous GeneCards Identifiers for ZNF12 Gene

  • GC07U990124
  • GC07M006474
  • GC19M009266
  • GC07M006503
  • GC07M006696
  • GC07M006599
  • GC07M006728

Summaries for ZNF12 Gene

Entrez Gene Summary for ZNF12 Gene

  • This gene is a member of the krueppel C2H2-type zinc-finger protein family and encodes a protein with eight C2H2-type zinc fingers and a KRAB domain. This nuclear protein is involved in developmental control of gene expression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF12 Gene

ZNF12 (Zinc Finger Protein 12) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF630.

UniProtKB/Swiss-Prot for ZNF12 Gene

  • Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF12 Gene

Genomics for ZNF12 Gene

Regulatory Elements for ZNF12 Gene

Genomic Location for ZNF12 Gene

6,688,433 bp from pter
6,706,935 bp from pter
18,503 bases
Minus strand

Genomic View for ZNF12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF12 Gene

Proteins for ZNF12 Gene

  • Protein details for ZNF12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 12
    Protein Accession:
    Secondary Accessions:
    • A8MYC4
    • A8WFQ8
    • B2RNQ7
    • B4DF45
    • Q6N016
    • Q8NHZ0
    • Q9H9P0
    • Q9ULZ6

    Protein attributes for ZNF12 Gene

    697 amino acids
    Molecular mass:
    81202 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB14183.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG57306.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF12 Gene


neXtProt entry for ZNF12 Gene

Proteomics data for ZNF12 Gene at MOPED

Post-translational modifications for ZNF12 Gene

  • Ubiquitination at Lys337
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF12 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ZNF12 Gene

Domains for ZNF12 Gene

Gene Families for ZNF12 Gene

  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF12 Gene

Suggested Antigen Peptide Sequences for ZNF12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P17014
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 15 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF12: view

Function for ZNF12 Gene

Molecular function for ZNF12 Gene

GENATLAS Biochemistry:
zinc finger protein 12 (KOX3) (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity.

Gene Ontology (GO) - Molecular Function for ZNF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF12: view

Phenotypes for ZNF12 Gene

genes like me logo Genes that share phenotypes with ZNF12: view

Animal Model Products

CRISPR Products

miRNA for ZNF12 Gene

miRTarBase miRNAs that target ZNF12

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF12

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF12 Gene

Localization for ZNF12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF12 Gene

Subcellular locations from

Jensen Localization Image for ZNF12 Gene COMPARTMENTS Subcellular localization image for ZNF12 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 16806083
GO:0005654 nucleoplasm IDA --
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with ZNF12: view

Pathways for ZNF12 Gene

SuperPathways for ZNF12 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF12: view

Pathways by source for ZNF12 Gene

2 Reactome pathways for ZNF12 Gene

Gene Ontology (GO) - Biological Process for ZNF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0045892 negative regulation of transcription, DNA-templated IDA 16806083
genes like me logo Genes that share ontologies with ZNF12: view

Transcripts for ZNF12 Gene

mRNA/cDNA for ZNF12 Gene

(13) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF12 Gene

Zinc finger protein 12:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF12

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF12 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5

Relevant External Links for ZNF12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF12 Gene

mRNA expression in normal human tissues for ZNF12 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF12 Gene

SOURCE GeneReport for Unigene cluster for ZNF12 Gene Hs.431471

mRNA Expression by UniProt/SwissProt for ZNF12 Gene

Tissue specificity: Widely expressed in various adult tissues and embryonic developmental stages (isoform 3).
genes like me logo Genes that share expressions with ZNF12: view

Expression partners for ZNF12 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for ZNF12 Gene

Orthologs for ZNF12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF12 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia ZNF12 35
  • 89.42 (n)
  • 91.34 (a)
ZNF12 36
  • 91 (a)
(Mus musculus)
Mammalia Zfp12 35
  • 77.37 (n)
  • 81.5 (a)
Zfp12 16
Zfp12 36
  • 81 (a)
(Pan troglodytes)
Mammalia ZNF12 35
  • 99.47 (n)
  • 99.86 (a)
ZNF12 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Zfp12 35
  • 78.76 (n)
  • 81.57 (a)
(Bos Taurus)
Mammalia ZNF12 36
  • 89 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 39 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 35 (a)
(Gallus gallus)
Aves -- 36
  • 32 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 48 (a)
(Danio rerio)
Actinopterygii CR361547.1 36
  • 40 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
-- 36
  • 41 (a)
-- 36
  • 39 (a)
-- 36
  • 39 (a)
Species with no ortholog for ZNF12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF12 Gene

Gene Tree for ZNF12 (if available)
Gene Tree for ZNF12 (if available)

Paralogs for ZNF12 Gene

Selected SIMAP similar genes for ZNF12 Gene using alignment to 2 proteins: Pseudogenes for ZNF12 Gene

genes like me logo Genes that share paralogs with ZNF12: view

Variants for ZNF12 Gene

Sequence variations from dbSNP and Humsavar for ZNF12 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs3801033 -- 6,694,472(+) TATTC(C/T)GTTGC intron-variant
rs3801034 -- 6,694,510(+) GGAGG(G/T)TCCTA intron-variant
rs3801035 -- 6,695,903(+) AGGGA(C/T)AATAG intron-variant
rs3801036 -- 6,696,098(+) GCTAG(C/T)GATGA intron-variant
rs3801037 -- 6,696,099(+) CTAGC(A/G)ATGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF12 Gene

Variant ID Type Subtype PubMed ID
nsv436904 CNV Insertion 17901297
nsv7392 OTHER Inversion 18451855
esv1914954 OTHER Inversion 16254605
esv2752174 CNV Gain 17911159
nsv887439 CNV Loss 21882294
esv2560724 CNV Deletion 19546169
esv2733934 CNV Deletion 23290073
esv4389 CNV Deletion 18987735
esv2669093 CNV Deletion 23128226
esv7643 CNV Loss 19470904
dgv1120e201 CNV Deletion 23290073
dgv7151n71 CNV Loss 21882294
nsv8038 CNV Gain 18304495
nsv887441 CNV Gain 21882294
esv32852 CNV Loss 17666407

Relevant External Links for ZNF12 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF12 Gene

Disorders for ZNF12 Gene

Relevant External Links for ZNF12

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for ZNF12 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ZNF12 Gene

Publications for ZNF12 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. ZNF325, a novel human zinc finger protein with a RBaK-like RB-binding domain, inhibits AP-1- and SRE-mediated transcriptional activity. (PMID: 16806083) Zhao Y. … Li Y. (Biochem. Biophys. Res. Commun. 2006) 3 4
  3. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen H.-J. (New Biol. 1990) 3 4
  4. Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PMID: 7865130) Abrink M. … Hellman L. (DNA Cell Biol. 1995) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZNF12 Gene

Sources for ZNF12 Gene

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