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Aliases for ZNF12 Gene

Aliases for ZNF12 Gene

  • Zinc Finger Protein 12 2 3 5
  • Zinc Finger Protein 325 2 3 4
  • Gonadotropin-Inducible Ovary Transcription Repressor 3 3 4
  • Zinc Finger Protein KOX3 3 4
  • ZNF325 3 4
  • GIOT-3 3 4
  • KOX3 3 4
  • Gonadotropin Inducible Transcription Repressor 3 3
  • Zinc Finger Protein 11 3
  • HZF11 3
  • GIOT3 4

External Ids for ZNF12 Gene

Previous HGNC Symbols for ZNF12 Gene

  • ZNF325

Previous GeneCards Identifiers for ZNF12 Gene

  • GC07U990124
  • GC07M006474
  • GC19M009266
  • GC07M006503
  • GC07M006696
  • GC07M006599
  • GC07M006728
  • GC07M006693

Summaries for ZNF12 Gene

Entrez Gene Summary for ZNF12 Gene

  • This gene is a member of the krueppel C2H2-type zinc-finger protein family and encodes a protein with eight C2H2-type zinc fingers and a KRAB domain. This nuclear protein is involved in developmental control of gene expression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF12 Gene

ZNF12 (Zinc Finger Protein 12) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF248.

UniProtKB/Swiss-Prot for ZNF12 Gene

  • Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF12 Gene

Genomics for ZNF12 Gene

Regulatory Elements for ZNF12 Gene

Enhancers for ZNF12 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF12 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF12 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF12 Gene

6,688,433 bp from pter
6,706,969 bp from pter
18,537 bases
Minus strand

Genomic View for ZNF12 Gene

Genes around ZNF12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF12 Gene

Proteins for ZNF12 Gene

  • Protein details for ZNF12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 12
    Protein Accession:
    Secondary Accessions:
    • A8MYC4
    • A8WFQ8
    • B2RNQ7
    • B4DF45
    • Q6N016
    • Q8NHZ0
    • Q9H9P0
    • Q9ULZ6

    Protein attributes for ZNF12 Gene

    697 amino acids
    Molecular mass:
    81202 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB14183.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG57306.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF12 Gene


neXtProt entry for ZNF12 Gene

Proteomics data for ZNF12 Gene at MOPED

Post-translational modifications for ZNF12 Gene

  • Ubiquitination at Lys 337
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF12 Gene

Antibody Products

  • Abcam antibodies for ZNF12

No data available for DME Specific Peptides for ZNF12 Gene

Domains & Families for ZNF12 Gene

Gene Families for ZNF12 Gene

Protein Domains for ZNF12 Gene

Suggested Antigen Peptide Sequences for ZNF12 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 15 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 15 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF12: view

Function for ZNF12 Gene

Molecular function for ZNF12 Gene

GENATLAS Biochemistry:
zinc finger protein 12 (KOX3) (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity.
genes like me logo Genes that share phenotypes with ZNF12: view

Animal Model Products

CRISPR Products

miRNA for ZNF12 Gene

miRTarBase miRNAs that target ZNF12

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF12 Gene

Localization for ZNF12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF12 Gene

Subcellular locations from

Jensen Localization Image for ZNF12 Gene COMPARTMENTS Subcellular localization image for ZNF12 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16806083
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZNF12: view

Pathways & Interactions for ZNF12 Gene

SuperPathways for ZNF12 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF12: view

Pathways by source for ZNF12 Gene

2 Reactome pathways for ZNF12 Gene

Gene Ontology (GO) - Biological Process for ZNF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045892 negative regulation of transcription, DNA-templated IDA 16806083
genes like me logo Genes that share ontologies with ZNF12: view

No data available for SIGNOR curated interactions for ZNF12 Gene

Drugs & Compounds for ZNF12 Gene

No Compound Related Data Available

Transcripts for ZNF12 Gene

mRNA/cDNA for ZNF12 Gene

(2) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF12 Gene

Zinc finger protein 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF12 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5

Relevant External Links for ZNF12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF12 Gene

mRNA expression in normal human tissues for ZNF12 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF12 Gene

SOURCE GeneReport for Unigene cluster for ZNF12 Gene Hs.431471

mRNA Expression by UniProt/SwissProt for ZNF12 Gene

Tissue specificity: Widely expressed in various adult tissues and embryonic developmental stages (isoform 3).
genes like me logo Genes that share expression patterns with ZNF12: view

Protein tissue co-expression partners for ZNF12 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for ZNF12 Gene

Orthologs for ZNF12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF12 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia ZNF12 35
  • 89.42 (n)
  • 91.34 (a)
ZNF12 36
  • 91 (a)
(Mus musculus)
Mammalia Zfp12 35
  • 77.37 (n)
  • 81.5 (a)
Zfp12 16
Zfp12 36
  • 81 (a)
(Pan troglodytes)
Mammalia ZNF12 35
  • 99.47 (n)
  • 99.86 (a)
ZNF12 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Zfp12 35
  • 78.76 (n)
  • 81.57 (a)
(Bos Taurus)
Mammalia ZNF12 36
  • 89 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 39 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 35 (a)
(Gallus gallus)
Aves -- 36
  • 32 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 48 (a)
(Danio rerio)
Actinopterygii CR361547.1 36
  • 40 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
-- 36
  • 41 (a)
-- 36
  • 39 (a)
-- 36
  • 39 (a)
Species with no ortholog for ZNF12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF12 Gene

Gene Tree for ZNF12 (if available)
Gene Tree for ZNF12 (if available)

Paralogs for ZNF12 Gene

(483) SIMAP similar genes for ZNF12 Gene using alignment to 2 proteins: Pseudogenes for ZNF12 Gene

genes like me logo Genes that share paralogs with ZNF12: view

Variants for ZNF12 Gene

Sequence variations from dbSNP and Humsavar for ZNF12 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs6952107 -- 6,706,848(+) TTCGG(C/T)GCCCA nc-transcript-variant, utr-variant-5-prime
rs6964620 -- 6,697,492(+) TCTCT(A/G)TCATA intron-variant
rs12673800 -- 6,701,776(+) TGACT(C/T)GAGGC intron-variant
rs12702534 -- 6,694,314(+) AAACG(A/G)TATCA intron-variant
rs13221984 -- 6,704,775(+) aAGAA(A/G)GGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF12 Gene

Variant ID Type Subtype PubMed ID
nsv436904 CNV Insertion 17901297
nsv7392 OTHER Inversion 18451855
esv1914954 OTHER Inversion 16254605
esv2752174 CNV Gain 17911159
nsv887439 CNV Loss 21882294
esv2560724 CNV Deletion 19546169
esv2733934 CNV Deletion 23290073
esv4389 CNV Deletion 18987735
esv2669093 CNV Deletion 23128226
esv7643 CNV Loss 19470904
dgv1120e201 CNV Deletion 23290073
dgv7151n71 CNV Loss 21882294
nsv8038 CNV Gain 18304495
nsv887441 CNV Gain 21882294
esv32852 CNV Loss 17666407

Variation tolerance for ZNF12 Gene

Residual Variation Intolerance Score: 12.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.38; 54.03% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF12 Gene

Disorders for ZNF12 Gene

Relevant External Links for ZNF12

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF12 Gene

Publications for ZNF12 Gene

  1. ZNF325, a novel human zinc finger protein with a RBaK-like RB-binding domain, inhibits AP-1- and SRE-mediated transcriptional activity. (PMID: 16806083) Zhao Y. … Li Y. (Biochem. Biophys. Res. Commun. 2006) 3 4 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. Identification of host proteins required for HIV infection through a functional genomic screen. (PMID: 18187620) Brass A.L. … Elledge S.J. (Science 2008) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZNF12 Gene

Sources for ZNF12 Gene