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Aliases for ZNF12 Gene

Aliases for ZNF12 Gene

  • Zinc Finger Protein 12 2 3 5
  • Zinc Finger Protein 325 2 3 4
  • Gonadotropin-Inducible Ovary Transcription Repressor 3 3 4
  • Zinc Finger Protein KOX3 3 4
  • ZNF325 3 4
  • GIOT-3 3 4
  • KOX3 3 4
  • Gonadotropin Inducible Transcription Repressor 3 3
  • Zinc Finger Protein 11 3
  • HZF11 3
  • GIOT3 4

External Ids for ZNF12 Gene

Previous HGNC Symbols for ZNF12 Gene

  • ZNF325

Previous GeneCards Identifiers for ZNF12 Gene

  • GC07U990124
  • GC07M006474
  • GC19M009266
  • GC07M006503
  • GC07M006696
  • GC07M006599
  • GC07M006728
  • GC07M006693
  • GC07M006694

Summaries for ZNF12 Gene

Entrez Gene Summary for ZNF12 Gene

  • This gene is a member of the krueppel C2H2-type zinc-finger protein family and encodes a protein with eight C2H2-type zinc fingers and a KRAB domain. This nuclear protein is involved in developmental control of gene expression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF12 Gene

ZNF12 (Zinc Finger Protein 12) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is RBAK.

UniProtKB/Swiss-Prot for ZNF12 Gene

  • Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF12 Gene

Genomics for ZNF12 Gene

Regulatory Elements for ZNF12 Gene

Enhancers for ZNF12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ZNF12 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF12 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF12 Gene

Chromosome:
7
Start:
6,688,433 bp from pter
End:
6,706,969 bp from pter
Size:
18,537 bases
Orientation:
Minus strand

Genomic View for ZNF12 Gene

Genes around ZNF12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF12 Gene

Proteins for ZNF12 Gene

  • Protein details for ZNF12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17014-ZNF12_HUMAN
    Recommended name:
    Zinc finger protein 12
    Protein Accession:
    P17014
    Secondary Accessions:
    • A8MYC4
    • A8WFQ8
    • B2RNQ7
    • B4DF45
    • Q6N016
    • Q8NHZ0
    • Q9H9P0
    • Q9ULZ6

    Protein attributes for ZNF12 Gene

    Size:
    697 amino acids
    Molecular mass:
    81202 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14183.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG57306.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF12 Gene

Post-translational modifications for ZNF12 Gene

  • Ubiquitination at Lys 337
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF12 Gene

No data available for DME Specific Peptides for ZNF12 Gene

Domains & Families for ZNF12 Gene

Gene Families for ZNF12 Gene

Protein Domains for ZNF12 Gene

Suggested Antigen Peptide Sequences for ZNF12 Gene

Graphical View of Domain Structure for InterPro Entry

P17014

UniProtKB/Swiss-Prot:

ZNF12_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 15 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 15 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF12: view

Function for ZNF12 Gene

Molecular function for ZNF12 Gene

GENATLAS Biochemistry:
zinc finger protein 12 (KOX3) (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity.

Gene Ontology (GO) - Molecular Function for ZNF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF12: view
genes like me logo Genes that share phenotypes with ZNF12: view

Animal Model Products

CRISPR Products

miRNA for ZNF12 Gene

miRTarBase miRNAs that target ZNF12

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF12 Gene

Localization for ZNF12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF12 Gene COMPARTMENTS Subcellular localization image for ZNF12 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16806083
GO:0005654 nucleoplasm IDA --
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with ZNF12: view

Pathways & Interactions for ZNF12 Gene

SuperPathways for ZNF12 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF12: view

Pathways by source for ZNF12 Gene

2 Reactome pathways for ZNF12 Gene

Gene Ontology (GO) - Biological Process for ZNF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 16806083
genes like me logo Genes that share ontologies with ZNF12: view

No data available for SIGNOR curated interactions for ZNF12 Gene

Drugs & Compounds for ZNF12 Gene

No Compound Related Data Available

Transcripts for ZNF12 Gene

mRNA/cDNA for ZNF12 Gene

(2) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF12 Gene

Zinc finger protein 12:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF12 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1:
SP2:

Relevant External Links for ZNF12 Gene

GeneLoc Exon Structure for
ZNF12
ECgene alternative splicing isoforms for
ZNF12

Expression for ZNF12 Gene

mRNA expression in normal human tissues for ZNF12 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF12 Gene



Protein tissue co-expression partners for ZNF12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF12 Gene:

ZNF12

SOURCE GeneReport for Unigene cluster for ZNF12 Gene:

Hs.431471

mRNA Expression by UniProt/SwissProt for ZNF12 Gene:

P17014-ZNF12_HUMAN
Tissue specificity: Widely expressed in various adult tissues and embryonic developmental stages (isoform 3).
genes like me logo Genes that share expression patterns with ZNF12: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for ZNF12 Gene

Orthologs for ZNF12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF12 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ZNF12 34
  • 89.42 (n)
  • 91.34 (a)
ZNF12 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp12 34
  • 77.37 (n)
  • 81.5 (a)
Zfp12 16
Zfp12 35
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF12 34
  • 99.47 (n)
  • 99.86 (a)
ZNF12 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp12 34
  • 78.76 (n)
  • 81.57 (a)
cow
(Bos Taurus)
Mammalia ZNF12 35
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 39 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 35 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 32 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 48 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CR361547.1 35
  • 40 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 31 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
-- 35
  • 39 (a)
ManyToMany
-- 35
  • 39 (a)
ManyToMany
Species where no ortholog for ZNF12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF12 Gene

ENSEMBL:
Gene Tree for ZNF12 (if available)
TreeFam:
Gene Tree for ZNF12 (if available)

Paralogs for ZNF12 Gene

(483) SIMAP similar genes for ZNF12 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ZNF12 Gene

genes like me logo Genes that share paralogs with ZNF12: view

Variants for ZNF12 Gene

Sequence variations from dbSNP and Humsavar for ZNF12 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs7790915 -- 6,702,743(+) GAGAT(G/T)TGTCT intron-variant
rs7791251 -- 6,702,951(+) TTCGT(C/G)TCCCA intron-variant
rs7798471 -- 6,705,326(+) ACATC(C/T)TGTGG intron-variant
rs7810581 -- 6,702,848(+) tcaaa(A/C)tccac intron-variant
rs7811633 -- 6,690,178(+) ACCTA(A/T)CAAAT nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF12 Gene

Variant ID Type Subtype PubMed ID
dgv1073e201 CNV deletion 23290073
esv1914954 OTHER inversion 16254605
esv2560724 CNV deletion 19546169
esv2669093 CNV deletion 23128226
esv2733934 CNV deletion 23290073
esv2752174 CNV gain 17911159
esv32852 CNV loss 17666407
esv3612042 CNV gain 21293372
esv4389 CNV loss 18987735
esv7643 CNV loss 19470904
nsv1015646 CNV loss 25217958
nsv1126774 CNV deletion 24896259
nsv436904 CNV insertion 17901297
nsv7392 OTHER inversion 18451855
nsv8038 CNV gain 18304495

Variation tolerance for ZNF12 Gene

Residual Variation Intolerance Score: 12.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.38; 54.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF12 Gene

Disorders for ZNF12 Gene

Relevant External Links for ZNF12

Genetic Association Database (GAD)
ZNF12
Human Genome Epidemiology (HuGE) Navigator
ZNF12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF12

No disorders were found for ZNF12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF12 Gene

Publications for ZNF12 Gene

  1. ZNF325, a novel human zinc finger protein with a RBaK-like RB-binding domain, inhibits AP-1- and SRE-mediated transcriptional activity. (PMID: 16806083) Zhao Y. … Li Y. (Biochem. Biophys. Res. Commun. 2006) 3 4 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen H.-J. (New Biol. 1990) 3 4 65
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 65
  5. System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. (PMID: 25755297) Xiao Z. … Vertegaal A.C. (Mol. Cell. Proteomics 2015) 4 65

Products for ZNF12 Gene

Sources for ZNF12 Gene

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