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Aliases for ZNF117 Gene

Aliases for ZNF117 Gene

  • Zinc Finger Protein 117 2 3 5
  • Provirus-Linked Krueppel 3 4
  • Zinc Finger Protein HPF9 3 4
  • H-Plk 3 4
  • Krueppel-Related Zinc Finger Protein 3
  • Zinc Finger Protein 117 (HPF9) 2
  • HPF9 3

External Ids for ZNF117 Gene

Previous GeneCards Identifiers for ZNF117 Gene

  • GC07U990128
  • GC07M063078
  • GC07M063835
  • GC07M063848
  • GC07M063881
  • GC07M064074
  • GC07M064434
  • GC07M060814

Summaries for ZNF117 Gene

GeneCards Summary for ZNF117 Gene

ZNF117 (Zinc Finger Protein 117) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF718.

UniProtKB/Swiss-Prot for ZNF117 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF117 Gene

Genomics for ZNF117 Gene

Regulatory Elements for ZNF117 Gene

Enhancers for ZNF117 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF117 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF117 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF117 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF117 Gene

64,971,776 bp from pter
65,006,684 bp from pter
34,909 bases
Minus strand

Genomic View for ZNF117 Gene

Genes around ZNF117 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF117 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF117 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF117 Gene

Proteins for ZNF117 Gene

  • Protein details for ZNF117 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 117
    Protein Accession:
    Secondary Accessions:
    • Q02313
    • Q7Z7Q7

    Protein attributes for ZNF117 Gene

    483 amino acids
    Molecular mass:
    56376 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAA36010.1; Type=Erroneous termination; Positions=428; Note=Translated as Arg.; Evidence={ECO:0000305}; Sequence=AAA58666.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAG41761.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

neXtProt entry for ZNF117 Gene

Proteomics data for ZNF117 Gene at MOPED

Post-translational modifications for ZNF117 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF117 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF117 Gene

Domains & Families for ZNF117 Gene

Gene Families for ZNF117 Gene

Protein Domains for ZNF117 Gene

Suggested Antigen Peptide Sequences for ZNF117 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF117: view

Function for ZNF117 Gene

Molecular function for ZNF117 Gene

GENATLAS Biochemistry:
zinc finger protein 117 (HPF9),KRAB subfamily (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF117 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with ZNF117: view
genes like me logo Genes that share phenotypes with ZNF117: view

Animal Model Products

CRISPR Products

miRNA for ZNF117 Gene

miRTarBase miRNAs that target ZNF117

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF117 Gene

Localization for ZNF117 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF117 Gene

Subcellular locations from

Jensen Localization Image for ZNF117 Gene COMPARTMENTS Subcellular localization image for ZNF117 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF117 Gene

Pathways & Interactions for ZNF117 Gene

SuperPathways for ZNF117 Gene

No Data Available

Interacting Proteins for ZNF117 Gene

Gene Ontology (GO) - Biological Process for ZNF117 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZNF117 Gene

Drugs & Compounds for ZNF117 Gene

No Compound Related Data Available

Transcripts for ZNF117 Gene

Unigene Clusters for ZNF117 Gene

Zinc finger protein 117:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF117 Gene

No ASD Table

Relevant External Links for ZNF117 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF117 Gene

mRNA expression in normal human tissues for ZNF117 Gene

Protein differential expression in normal tissues from HIPED for ZNF117 Gene

This gene is overexpressed in Stomach (68.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF117 Gene

SOURCE GeneReport for Unigene cluster for ZNF117 Gene Hs.250693

genes like me logo Genes that share expression patterns with ZNF117: view

Protein tissue co-expression partners for ZNF117 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF117 Gene

Orthologs for ZNF117 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF117 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia -- 36
  • 47 (a)
(Canis familiaris)
Mammalia -- 36
  • 34 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 37 (a)
-- 36
  • 42 (a)
(Mus musculus)
Mammalia Zfp87 36
  • 39 (a)
(Pan troglodytes)
Mammalia ZNF117 36
  • 90 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 50 (a)
-- 36
  • 31 (a)
-- 36
  • 38 (a)
-- 36
  • 35 (a)
-- 36
  • 29 (a)
-- 36
  • 30 (a)
-- 36
  • 29 (a)
-- 36
  • 26 (a)
Species with no ortholog for ZNF117:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF117 Gene

Gene Tree for ZNF117 (if available)
Gene Tree for ZNF117 (if available)

Paralogs for ZNF117 Gene

(508) SIMAP similar genes for ZNF117 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF117: view

Variants for ZNF117 Gene

Sequence variations from dbSNP and Humsavar for ZNF117 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs3807069 - 64,979,323(+) TATTA(C/T)ATTGA reference, missense
rs3807068 - 64,979,235(+) CATTC(A/G/T)TTACA reference, missense
rs1060379 -- 64,975,111(-) CTATT(A/T)AATAA utr-variant-3-prime
rs1060382 -- 64,974,500(+) TTTTG(C/T)TCCAA utr-variant-3-prime
rs1060383 -- 64,974,478(-) ATAAA(G/T)TAATG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF117 Gene

Variant ID Type Subtype PubMed ID
dgv1147e201 CNV Deletion 23290073
esv2422405 CNV Duplication 17116639
nsv464518 CNV Gain 19166990
dgv7308n71 CNV Gain 21882294
dgv7309n71 CNV Gain 21882294
dgv226e55 CNV Loss 17911159
nsv888284 CNV Gain 21882294

Variation tolerance for ZNF117 Gene

Residual Variation Intolerance Score: 81.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.23; 97.00% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF117 Gene

Disorders for ZNF117 Gene

Relevant External Links for ZNF117

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF117 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF117 Gene

Publications for ZNF117 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Localization of the human KRAB finger gene ZNF117 (HPF9) to chromosome 7q11.2. (PMID: 1427907) Bellefroid E.J. … Martial J.A. (Genomics 1992) 2 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. (PMID: 2023909) Bellefroid E.J. … Martial J.A. (Proc. Natl. Acad. Sci. U.S.A. 1991) 3
  5. Human proviral mRNAs down regulated in choriocarcinoma encode a zinc finger protein related to Kruppel. (PMID: 2115127) Kato N. … Cohen M. (Mol. Cell. Biol. 1990) 3

Products for ZNF117 Gene

Sources for ZNF117 Gene