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ZNF117 Gene

protein-coding   GIFtS: 48
GCID: GC07M064434

Zinc Finger Protein 117

(Previous name: zinc finger protein 117 (HPF9))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 1171 2     H-plk2
Provirus-Linked Krueppel2 3     HPF92
Zinc Finger Protein HPF92 3     Krueppel-Related Zinc Finger Protein2
Zinc Finger Protein 117 (HPF9)1     h-PLK3

External Ids:    HGNC: 128971   Entrez Gene: 513512   Ensembl: ENSG000001529267   OMIM: 1946245   UniProtKB: Q039243   

Export aliases for ZNF117 gene to outside databases

Previous GC identifers: GC07U990128 GC07M063078 GC07M063835 GC07M063848 GC07M063881 GC07M064074 GC07M060814


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF117 Gene:
ZNF117 (zinc finger protein 117) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF85.

UniProtKB/Swiss-Prot: ZN117_HUMAN, Q03924
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF117 gene promoter:
         TBP   HOXA9   HOXA9B   p53   LUN-1   Meis-1b   POU2F1   POU2F1a   TFIID   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): ZNF117 promoter sequence
   Search Chromatin IP Primers for ZNF117

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF117


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.21   Ensembl cytogenetic band:  7q11.21   HGNC cytogenetic band: 7q11.2

ZNF117 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF117 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M064434:  view genomic region     (about GC identifiers)

Start:
64,432,154 bp from pter      End:
64,467,062 bp from pter
Size:
34,909 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 63,772,424-63,789,008     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN117_HUMAN, Q03924 (See protein sequence)
Recommended Name: Zinc finger protein 117  
Size: 483 amino acids; 56376 Da
Developmental stage: Expressed early during embryonic development
Sequence caution: Sequence=AAA36010.1; Type=Erroneous termination; Positions=428; Note=Translated as Arg;
Sequence=AAA58666.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAG41761.1;
Type=Miscellaneous discrepancy; Note=Aberrant splicing;
Secondary accessions: Q02313 Q7Z7Q7

Explore the universe of human proteins at neXtProt for ZNF117: NX_Q03924

Explore proteomics data for ZNF117 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF117 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056936.2  
    ENSEMBL proteins: 
     ENSP00000282869  

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    antibodies-online antibodies for ZNF117 (16 products) 

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    antibodies-online kits for ZNF117 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q03924

    ProtoNet protein and cluster: Q03924

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN117_HUMAN, Q03924
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 13 C2H2-type zinc fingers


    Find genes that share domains with ZNF117           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN117_HUMAN, Q03924
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF117:
    zinc finger protein 117 (HPF9),KRAB subfamily (C2H2 type,Kruppel-like)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity NAS2023909
    GO:0008270zinc ion binding NAS2505992
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with ZNF117           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ZNF117:
     Increased G2M DNA content  Increased HPV18 LCR reporter a 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZNF117

    miRNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF117


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN117_HUMAN, Q03924: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF117           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF117
    Interactions:

        Search GeneGlobe Interaction Network for ZNF117

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----

    Find genes that share ontologies with ZNF117           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF117 (ZN117)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF117 gene: 
    NM_015852.3  

    Unigene Cluster for ZNF117:

    Zinc finger protein 117
    Hs.250693  [show with all ESTs]
    Unigene Representative Sequence: NM_015852
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000282869(uc003ttr.2) ENST00000487644
    miRNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF117
      QuantiFast Probe-based Assays in human, mouse, rat ZNF117

    Additional mRNA sequence: 

    AF075025.1 BC063605.1 BX647584.1 M55422.1 M61867.1 

    6 DOTS entries:

    DT.208744  DT.92419120  DT.100742918  DT.101977642  DT.121053250  DT.92401121 

    Selected AceView cDNA sequences (see all 161):

    CA388658 AI479940 AA747865 BX459099 CR615024 BX952541 T28288 AI813929 
    R79708 N56821 CR608597 BX413290 AI224119 BU568736 BM922542 AI049550 
    AW170423 AI681000 R77087 BX107844 AI571044 BX647584 AA908361 M55422 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF117 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTCTCTGCC
    ZNF117 Expression
    About this image


    ZNF117 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Adipose (Muscoskeletal System)
             White adipocyte-like cells
    ZNF117 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF117 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.250693
        Custom PCR Arrays for ZNF117
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF117

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF117 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 8)
    Uncharacterized protein
    (see all 8)
    50(a)
    38(a)
    (see all 8)
    many ↔ many
    many ↔ many
    (see all 8)
    AAWZ02037240(11818-13836)
    GL343434.1(292314-296903)
            Species with no ortholog for ZNF117

    ENSEMBL Gene Tree for ZNF117 (if available)
    TreeFam Gene Tree for ZNF117 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF117 gene
    ZNF852  ZNF4862  ZNF1952  ZNF922  ZNF1002  ZNF7322  ZNF6752  ZNF1382  
    ZNF5062  ZNF662  ZNF2732  ZNF6952  ZNF6262  ZNF6802  ZNF4792  ZNF2532  
    ZNF932  ZNF6822  ZNF4922  ZNF6762  ZNF6812  ZNF1412  ZNF7362  ZNF6792  
    ZNF2572  ZNF2542  ZNF7372  ZNF724P2  ZNF982  ZNF7162  ZNF7142  ZNF4292  
    ZNF5192  ZNF4302  ZNF7302  ZNF7082  ZNF4312  ZNF902  ZNF7262  ZNF7282  
    Selected SIMAP similar genes for ZNF117 using alignment to 1 protein entry:     ZN117_HUMAN(see all similar genes):
    ZNF818P    ZNF78L1    DKFZp762K012    ZFS-1    kr-znf3    ZNF85
    ZNF138    ZNF107    ZNF492    ZNF724P    ZNF98    smap-7
    DKFZp686M04222    ZFS-6    ZNF429    ZNF675    ZNF728    HZF30

    Find genes that share paralogs with ZNF117           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF117 (see all 388)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs592072541,2
    C--60824538(+) TAAAA-/CAGTTTA 1 -- int11Minor allele frequency- CA:0.00NA 2
    rs1181910891,2
    C,F--64434354(+) AAGCAC/TTGTCA 1 -- ds50011Minor allele frequency- T:0.03NA 120
    rs19708791,2
    C,F,A--64434470(+) TCAATC/TATAAC 1 -- ds50019Minor allele frequency- T:0.16NA WA CSA EA 368
    rs783321191,2
    F--64434616(+) TTTATA/TAAAAT 1 -- ds50011Minor allele frequency- T:0.04WA 118
    rs1849348231,2
    C--64434680(+) AAAAAC/TGGTAA 1 -- ds50010--------
    rs1880961451,2
    --64434682(+) AAATGA/GTAAGA 1 -- ds50010--------
    rs614962621,2
    C,F--64434791(+) GAATTC/TAATAC 1 -- ds50012Minor allele frequency- T:0.21WA 120
    rs1432991331,2
    C--64434829(+) ATTTTC/TGAAGT 1 -- ds50010--------
    rs10603831,2
    C,F,A,H--64434856(-) ATAAAG/TTAATG 1 -- ut3110Minor allele frequency- T:0.34MN NA WA CSA EA 554
    rs1466868251,2
    --64434861(+) CTTTAC/TTAAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZNF117 (64432154 - 64467062 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ZNF117:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1147e201CNV Deletion23290073
    esv2422405CNV Duplication17116639
    dgv226e55CNV Loss17911159
    nsv464518CNV Gain19166990
    dgv7308n71CNV Gain21882294
    dgv7309n71CNV Gain21882294
    nsv888284CNV Gain21882294

    Human Gene Mutation Database (HGMD): ZNF117
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF117
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF117

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 194624    OMIM disorders: --


    Find genes that share disorders with ZNF117           About GenesLikeMe

    Genetic Association Database (GAD): ZNF117
    Human Genome Epidemiology (HuGE) Navigator: ZNF117 (1 document)

    Export disorders for ZNF117 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF117 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF117)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Localization of the human KRAB finger gene ZNF117 (HPF9) to chromosome 7q11.2. (PubMed id 1427907)1, 3 Bellefroid E.J....Martial J.A. (Genomics 1992)
    3. The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. (PubMed id 2023909)1, 2 Bellefroid E.J....Martial J.A. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    4. Human proviral mRNAs down regulated in choriocarcinoma encode a zinc finger protein related to Kruppel. (PubMed id 2115127)1, 2 Kato N.... Cohen M. (Mol. Cell. Biol. 1990)
    5. The human genome contains hundreds of genes coding for finger proteins of the Kruppel type. (PubMed id 2505992)1, 2 Bellefroid E.J....Martial J.A. (DNA 1989)
    6. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    7. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (Nature 2003)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51351 HGNC: 12897 AceView: H-plk Ensembl:ENSG00000152926 euGenes: HUgn51351
    ECgene: ZNF117 H-InvDB: ZNF117

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF117 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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