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Aliases for ZNF117 Gene

Aliases for ZNF117 Gene

  • Zinc Finger Protein 117 2 3
  • Provirus-Linked Krueppel 3 4
  • Zinc Finger Protein HPF9 3 4
  • H-Plk 3 4
  • Krueppel-Related Zinc Finger Protein 3
  • Zinc Finger Protein 117 (HPF9) 2
  • HPF9 3

External Ids for ZNF117 Gene

Summaries for ZNF117 Gene

GeneCards Summary for ZNF117 Gene

ZNF117 (Zinc Finger Protein 117) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF253.

UniProtKB/Swiss-Prot for ZNF117 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF117 Gene

Genomics for ZNF117 Gene

Genomic Location for ZNF117 Gene

64,971,776 bp from pter
65,006,684 bp from pter
34,909 bases
Minus strand

Genomic View for ZNF117 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF117 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF117 Gene

Regulatory Elements for ZNF117 Gene

Proteins for ZNF117 Gene

  • Protein details for ZNF117 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 117
    Protein Accession:
    Secondary Accessions:
    • Q02313
    • Q7Z7Q7

    Protein attributes for ZNF117 Gene

    483 amino acids
    Molecular mass:
    56376 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAA36010.1; Type=Erroneous termination; Positions=428; Note=Translated as Arg.; Evidence={ECO:0000305}; Sequence=AAA58666.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAG41761.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

neXtProt entry for ZNF117 Gene

Proteomics data for ZNF117 Gene at MOPED

Post-translational modifications for ZNF117 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF117 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF117 Gene

Domains for ZNF117 Gene

Gene Families for ZNF117 Gene

  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF117 Gene


  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q03924
  • Contains 13 C2H2-type zinc fingers.:
    • Q03924
genes like me logo Genes that share domains with ZNF117: view

Function for ZNF117 Gene

Molecular function for ZNF117 Gene

GENATLAS Biochemistry: zinc finger protein 117 (HPF9),KRAB subfamily (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF117 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 2023909
GO:0008270 zinc ion binding NAS 2505992
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with ZNF117: view

Phenotypes for ZNF117 Gene

GenomeRNAi human phenotypes for ZNF117:
genes like me logo Genes that share phenotypes with ZNF117: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF117 Gene

Localization for ZNF117 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF117 Gene

Subcellular locations from

Jensen Localization Image for ZNF117 Gene COMPARTMENTS Subcellular localization image for ZNF117 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF117 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF117: view

Pathways for ZNF117 Gene

SuperPathways for ZNF117 Gene

No Data Available

Interacting Proteins for ZNF117 Gene

Gene Ontology (GO) - Biological Process for ZNF117 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF117: view

No data available for Pathways by source for ZNF117 Gene

Transcripts for ZNF117 Gene

mRNA/cDNA for ZNF117 Gene

Unigene Clusters for ZNF117 Gene

Zinc finger protein 117:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF117 Gene

No ASD Table

Relevant External Links for ZNF117 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF117 Gene

mRNA expression in normal human tissues for ZNF117 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF117 Gene

SOURCE GeneReport for Unigene cluster for ZNF117 Gene Hs.250693

genes like me logo Genes that share expressions with ZNF117: view

Orthologs for ZNF117 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF117 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF117 37
  • 90 (a)
(Bos Taurus)
Mammalia -- 37
  • 47 (a)
(Canis familiaris)
Mammalia -- 37
  • 34 (a)
(Mus musculus)
Mammalia Zfp87 37
  • 39 (a)
(Monodelphis domestica)
Mammalia -- 37
  • 37 (a)
-- 37
  • 42 (a)
(Anolis carolinensis)
Reptilia -- 37
  • 50 (a)
-- 37
  • 31 (a)
-- 37
  • 38 (a)
-- 37
  • 35 (a)
-- 37
  • 29 (a)
-- 37
  • 30 (a)
-- 37
  • 29 (a)
-- 37
  • 26 (a)
Species with no ortholog for ZNF117:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF117 Gene

Gene Tree for ZNF117 (if available)
Gene Tree for ZNF117 (if available)

Paralogs for ZNF117 Gene

Selected SIMAP similar genes for ZNF117 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF117: view

Variants for ZNF117 Gene

Sequence variations from dbSNP and Humsavar for ZNF117 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1060379 -- 64,975,111(-) CTATT(A/T)AATAA utr-variant-3-prime
rs1060382 -- 64,974,500(+) TTTTG(C/T)TCCAA utr-variant-3-prime
rs1060383 -- 64,974,478(-) ATAAA(G/T)TAATG utr-variant-3-prime
rs1404453 -- 64,978,289(+) AGATC(A/G)GTTAA reference, stop-gained
rs1524821 -- 64,979,662(+) GGTTC(G/T)AATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF117 Gene

Variant ID Type Subtype PubMed ID
dgv1147e201 CNV Deletion 23290073
esv2422405 CNV Duplication 17116639
nsv464518 CNV Gain 19166990
dgv7308n71 CNV Gain 21882294
dgv7309n71 CNV Gain 21882294
dgv226e55 CNV Loss 17911159
nsv888284 CNV Gain 21882294

Relevant External Links for ZNF117 Gene

HapMap Linkage Disequilibrium report

Disorders for ZNF117 Gene

Relevant External Links for ZNF117

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ZNF117: view

No data available for UniProtKB/Swiss-Prot for ZNF117 Gene

Publications for ZNF117 Gene

  1. Localization of the human KRAB finger gene ZNF117 (HPF9) to chromosome 7q11.2. (PMID: 1427907) Bellefroid E.J. … Martial J.A. (Genomics 1992) 2 3
  2. The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. (PMID: 2023909) Bellefroid E.J. … Martial J.A. (Proc. Natl. Acad. Sci. U.S.A. 1991) 3 4
  3. Human proviral mRNAs down regulated in choriocarcinoma encode a zinc finger protein related to Kruppel. (PMID: 2115127) Kato N. … Cohen M. (Mol. Cell. Biol. 1990) 3 4
  4. The human genome contains hundreds of genes coding for finger proteins of the Kruppel type. (PMID: 2505992) Bellefroid E.J. … Martial J.A. (DNA 1989) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for ZNF117 Gene

Sources for ZNF117 Gene

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