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ZNF114 Gene

protein-coding   GIFtS: 46
GCID: GC19P048675

Zinc Finger Protein 114

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 1141 2
Zinc Finger Protein 114 (Y18)2

External Ids:    HGNC: 128941   Entrez Gene: 1630712   Ensembl: ENSG000001781507   OMIM: 6039965   UniProtKB: Q8NC263   

Export aliases for ZNF114 gene to outside databases

Previous GC identifers: GC19U990132 GC19P053467 GC19P048775 GC19P045156


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF114 Gene:
ZNF114 (zinc finger protein 114) is a protein-coding gene.

UniProtKB/Swiss-Prot: ZN114_HUMAN, Q8NC26
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF114 gene promoter:
         NF-1   NF-1/L   Tal-1   ITF-2   Tal-1beta   GATA-1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF114 promoter sequence
   Search Chromatin IP Primers for ZNF114

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF114


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.32

ZNF114 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF114 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P048675:  view genomic region     (about GC identifiers)

Start:
48,675,575 bp from pter      End:
48,790,865 bp from pter
Size:
115,291 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN114_HUMAN, Q8NC26 (See protein sequence)
Recommended Name: Zinc finger protein 114  
Size: 417 amino acids; 47747 Da
Secondary accessions: A8K6B0 Q08AQ6
Alternative splicing: 2 isoforms:  Q8NC26-1   Q8NC26-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF114: NX_Q8NC26

Explore proteomics data for ZNF114 at MOPED


See ZNF114 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_705836.1  
ENSEMBL proteins: 
 ENSP00000472747   ENSP00000469998   ENSP00000471727   ENSP00000469287   ENSP00000471469  
 ENSP00000471237   ENSP00000318898  
Reactome Protein details: Q8NC26

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ZNF: Zinc fingers, C2H2-type

4 InterPro protein domains:
 IPR001909 Krueppel-associated_box
 IPR015880 Znf_C2H2-like
 IPR013087 Znf_C2H2/integrase_DNA-bd
 IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q8NC26

ProtoNet protein and cluster: Q8NC26

1 Blocks protein domain: IPB001909 KRAB box

UniProtKB/Swiss-Prot: ZN114_HUMAN, Q8NC26
Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
Similarity: Contains 4 C2H2-type zinc fingers
Similarity: Contains 1 KRAB domain


Find genes that share domains with ZNF114           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ZN114_HUMAN, Q8NC26
Function: May be involved in transcriptional regulation

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003674molecular_function ND--
GO:0003676nucleic acid binding ----
GO:0003677DNA binding IEA--
GO:0046872metal ion binding IEA--
     
Find genes that share ontologies with ZNF114           About GenesLikeMe


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hsa-mir-215-5p (MIRT024291), hsa-mir-192-5p (MIRT026850)

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2 qRT-PCR Assays for microRNAs that regulate ZNF114:
hsa-miR-376a* hsa-miR-4302
SwitchGear 3'UTR luciferase reporter plasmidZNF114 3' UTR sequence
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ZN114_HUMAN, Q8NC26: Nucleus (Probable)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus4
cytosol1

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005575cellular_component ND--
GO:0005622intracellular ----
GO:0005634nucleus IEA--
GO:0070062extracellular vesicular exosome IDA19056867

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for ZNF114 About    
See pathways by source

SuperPathContained pathways About
1Gene Expression
Generic Transcription Pathway0.40
Gene Expression0.40


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Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for ZNF114
    Generic Transcription Pathway


    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF114
Interactions:

    Search GeneGlobe Interaction Network for ZNF114

Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated IEA--
GO:0008150biological_process ND--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for ZNF114 (ZN114)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ZNF114 gene: 
NM_153608.1  

Unigene Cluster for ZNF114:

Zinc finger protein 114
Hs.511883  [show with all ESTs]
Unigene Representative Sequence: AK075062
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000597695 ENST00000595607 ENST00000600687 ENST00000594024 ENST00000595408
ENST00000601320 ENST00000598898 ENST00000315849(uc002pil.1 uc010elv.1 uc002pim.1 uc002pin.2)

miRNA
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hsa-miR-376a* hsa-miR-4302
SwitchGear 3'UTR luciferase reporter plasmidZNF114 3' UTR sequence
Inhib. RNA
Products:
     
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GenScript: all cDNA clones in your preferred vector: ZNF114 (NM_153608)
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  QuantiFast Probe-based Assays in human, mouse, rat ZNF114

Additional mRNA sequence: 

AK075062.1 AK291575.1 BC014935.2 BC016811.1 BC034032.1 BC050996.1 BC125068.1 BC125069.1 

5 DOTS entries:

DT.95283313  DT.91747116  DT.100022529  DT.91745678  DT.75185963 

16 AceView cDNA sequences:

BC034032 BU149961 NM_153608 BU182389 BC014935 BC016811 BC050996 BG476217 
BU630935 AK075062 CB115138 BG481514 BG121986 BE898185 AI656091 BU152948 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZNF114 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GTTCATACAA
ZNF114 Expression
About this image

ZNF114 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ZNF114 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.511883
    Custom PCR Arrays for ZNF114
Primer
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of mammals.

Orthologs for ZNF114 gene from Selected species (see all 3)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia ZNF1141 zinc finger protein 114 72.06(n)
54.9(a)
  100684128  XM_005616359.1  XP_005616416.1 


ENSEMBL Gene Tree for ZNF114 (if available)
TreeFam Gene Tree for ZNF114 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ZNF114 gene
Selected SIMAP similar genes for ZNF114 using alignment to 5 protein entries:     ZN114_HUMAN (see all proteins) (see all similar genes):
TUBA1C    NDUFS3    HINFP    PFKFB3    ZNF556    PUS1
ZNF669    AARSD1    DPP9    MRPL45    NLN    UBXN4
AGBL3    LOC101928664    TMX3    TNNT1    PTPLAD1    CALCOCO2

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Selected Pseudogenes.org Pseudogenes for ZNF114 (see all 9)
PGOHUM00000248503 PGOHUM00000234875 PGOHUM00000239137 PGOHUM00000240778 PGOHUM00000236076


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ZNF114 (see all 491)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs104166711,2
C--45154256(+) acccgG/Tgaggc 1 -- us2k10--------
rs350201421,2
C--48790984(+) TCTAC-/AAAAAA 1 -- ds50011Minor allele frequency- A:0.50CSA 2
rs1832552521,2
--48949330(+) TGAAAC/TGGAGT 1 -- us2k10--------
rs284899141,2
C,F--48949411(+) CAAACG/AATTCT 1 -- us2k14Minor allele frequency- A:0.50NA 8
rs1394916581,2
--48949433(+) CTCCCA/GAGCAG 1 -- us2k10--------
rs1886704001,2
--48949435(+) CCCGAA/GCAGCT 1 -- us2k10--------
rs1922849241,2
--48949505(+) GTTTCA/GCCATG 1 -- us2k10--------
rs340747071,2
C--48949575(+) ATCAC-/TTTAAG 1 -- us2k11Minor allele frequency- T:0.00NA 2
rs1436963011,2
--48949713(+) CCAGTG/TCCTGC 1 -- us2k10--------
rs104234101,2
C,F--48949790(+) tcagtC/Agaccc 1 -- us2k13Minor allele frequency- A:0.07NA WA 122

HapMap Linkage Disequilibrium report for ZNF114 (48675575 - 48790865 bp)

Structural Variations
     Database of Genomic Variants (DGV) 7 variations for ZNF114:    About this table    
Variant IDTypeSubtypePubMed ID
esv2672581CNV Deletion23128226
esv2657727CNV Deletion23128226
esv269836CNV Insertion20981092
nsv833854CNV Loss17160897
esv34181CNV Loss18971310
nsv9739CNV Gain+Loss18304495
nsv469623CNV Complex16826518

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 603996    OMIM disorders: --


Find genes that share disorders with ZNF114           About GenesLikeMe


Export disorders for ZNF114 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ZNF114 gene integrated from 10 sources:
(articles sorted by number of sources associating them with ZNF114)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  5. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. (PubMed id 8467795)1 Bellefroid E.J.... Martial J.A. (EMBO J. 1993)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 163071 HGNC: 12894 AceView: MGC17986 Ensembl:ENSG00000178150 euGenes: HUgn163071
ECgene: ZNF114 H-InvDB: ZNF114

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ZNF114 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ZNF114 gene:
Search GeneIP for patents involving ZNF114

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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