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Aliases for ZNF114 Gene

Aliases for ZNF114 Gene

  • Zinc Finger Protein 114 2 3 5

External Ids for ZNF114 Gene

Previous GeneCards Identifiers for ZNF114 Gene

  • GC19U990132
  • GC19P053467
  • GC19P048775
  • GC19P045156
  • GC19P048675

Summaries for ZNF114 Gene

GeneCards Summary for ZNF114 Gene

ZNF114 (Zinc Finger Protein 114) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF558.

UniProtKB/Swiss-Prot for ZNF114 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF114 Gene

Genomics for ZNF114 Gene

Regulatory Elements for ZNF114 Gene

Enhancers for ZNF114 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF114 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF114 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF114 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF114 Gene

48,172,318 bp from pter
48,287,608 bp from pter
115,291 bases
Plus strand

Genomic View for ZNF114 Gene

Genes around ZNF114 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF114 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF114 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF114 Gene

Proteins for ZNF114 Gene

  • Protein details for ZNF114 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 114
    Protein Accession:
    Secondary Accessions:
    • A8K6B0
    • Q08AQ6

    Protein attributes for ZNF114 Gene

    417 amino acids
    Molecular mass:
    47747 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF114 Gene


neXtProt entry for ZNF114 Gene

Proteomics data for ZNF114 Gene at MOPED

Post-translational modifications for ZNF114 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF114 Gene

Domains & Families for ZNF114 Gene

Gene Families for ZNF114 Gene

Protein Domains for ZNF114 Gene

Suggested Antigen Peptide Sequences for ZNF114 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 4 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF114: view

Function for ZNF114 Gene

Molecular function for ZNF114 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF114 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with ZNF114: view

Phenotypes for ZNF114 Gene

genes like me logo Genes that share phenotypes with ZNF114: view

Animal Model Products

CRISPR Products

miRNA for ZNF114 Gene

miRTarBase miRNAs that target ZNF114

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF114 Gene

Localization for ZNF114 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF114 Gene

Subcellular locations from

Jensen Localization Image for ZNF114 Gene COMPARTMENTS Subcellular localization image for ZNF114 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF114 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ZNF114: view

Pathways & Interactions for ZNF114 Gene

SuperPathways for ZNF114 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF114: view

Pathways by source for ZNF114 Gene

2 Reactome pathways for ZNF114 Gene

Gene Ontology (GO) - Biological Process for ZNF114 Gene


No data available for SIGNOR curated interactions for ZNF114 Gene

Drugs & Compounds for ZNF114 Gene

No Compound Related Data Available

Transcripts for ZNF114 Gene

Unigene Clusters for ZNF114 Gene

Zinc finger protein 114:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF114 Gene

No ASD Table

Relevant External Links for ZNF114 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF114 Gene

mRNA expression in normal human tissues for ZNF114 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF114 Gene

This gene is overexpressed in Thyroid (x6.9).

SOURCE GeneReport for Unigene cluster for ZNF114 Gene Hs.511883

genes like me logo Genes that share expression patterns with ZNF114: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF114 Gene

Orthologs for ZNF114 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF114 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF114 35
  • 69.02 (n)
  • 52.44 (a)
ZNF114 36
  • 52 (a)
(Canis familiaris)
Mammalia ZNF114 35
  • 72.06 (n)
  • 54.9 (a)
ZNF114 36
  • 50 (a)
(Pan troglodytes)
Mammalia ZNF114 35
  • 98.63 (n)
  • 98.07 (a)
ZNF114 36
  • 98 (a)
Species with no ortholog for ZNF114:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF114 Gene

Gene Tree for ZNF114 (if available)
Gene Tree for ZNF114 (if available)

Paralogs for ZNF114 Gene

Paralogs for ZNF114 Gene

(465) SIMAP similar genes for ZNF114 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF114: view

Variants for ZNF114 Gene

Sequence variations from dbSNP and Humsavar for ZNF114 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs35802964 - 48,285,919(+) AACCA(A/C)ACAGG reference, missense
rs16981956 - 48,286,244(+) CACTG(C/T)GCATC reference, missense
rs7258305 -- 48,285,564(+) ggagg(A/G)aggaa intron-variant
rs7258605 -- 48,285,562(+) AAGGA(A/G)GAAGG intron-variant
rs12983046 -- 48,278,753(+) cctgg(A/C)cagca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF114 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
esv34181 CNV Loss 18971310
nsv469623 CNV Complex 16826518
nsv833854 CNV Loss 17160897
esv2657727 CNV Deletion 23128226
esv2672581 CNV Deletion 23128226
esv269836 CNV Insertion 20981092

Variation tolerance for ZNF114 Gene

Residual Variation Intolerance Score: 52.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.99; 20.30% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF114 Gene

Disorders for ZNF114 Gene

Relevant External Links for ZNF114

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF114 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF114 Gene

Publications for ZNF114 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. (PMID: 8467795) Bellefroid E.J. … Martial J.A. (EMBO J. 1993) 3

Products for ZNF114 Gene

Sources for ZNF114 Gene