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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF114 Gene

protein-coding GIFtS: 46
GCID: GC19P048775

zinc finger protein 114

Search for ZNF114
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger Protein 114¹ ²
MGC17986¹
Zinc Finger Protein 114 (Y18)²

External Ids:	HGNC: 12894¹	Entrez Gene: 163071²	Ensembl: ENSG00000178150⁷	OMIM: 603996⁵	UniProtKB: Q8NC26³

Export aliases for ZNF114 gene to outside databases

Previous GC identifers: GC19U990132 GC19P053467 GC19P045156

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN114_HUMAN, Q8NC26

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF114 gene promoter:
NF-1 NF-1/L Tal-1 ITF-2 Tal-1beta GATA-1 E47
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF114 promoter sequence

Search SABiosciences Chromatin IP Primers for ZNF114

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF114

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.32

ZNF114 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF114 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P048775: view genomic region (about GC identifiers)

Start:	48,774,654 bp from pter	End:	48,790,863 bp from pter
Size:	16,210 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN114_HUMAN, Q8NC26 (See protein sequence)

Recommended Name: Zinc finger protein 114

Size: 417 amino acids; 47747 Da

Subcellular location: Nucleus (Probable)

Secondary accessions: A8K6B0 Q08AQ6

Alternative splicing: 2 isoforms: Q8NC26-1 Q8NC26-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF114: NX_Q8NC26

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8NC26

ZNF114 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_705836.1

ENSEMBL proteins:

ENSP00000318898

Reactome Protein details: Q8NC26
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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

ZNF114 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF114 for domains About GeneDecksing

4 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR001909 Krueppel-associated_box

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q8NC26

ProtoNet protein and cluster: Q8NC26

1 Blocks protein family: IPB001909 KRAB box

UniProtKB/Swiss-Prot: ZN114_HUMAN, Q8NC26

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 4 C2H2-type zinc fingers

Similarity: Contains 1 KRAB domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZN114_HUMAN, Q8NC26

Function: May be involved in transcriptional regulation

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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

ZNF114 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Generic Transcription Pathway

Generic Transcription Pathway

1.00

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Reactome Pathways for ZNF114

	Generic Transcription Pathway
	Gene Expression

ZNF114 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF114

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

ZNF114 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Search CenterWatch for drugs/clinical trials and news about ZNF114 / ZN114

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZNF114 gene:

NM_153608.1

Unigene Cluster for ZNF114:

Zinc finger protein 114

Hs.511883 [show with all ESTs]

Unigene Representative Sequence: AK075062

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000315849(uc002pil.1 uc010elv.1 uc002pim.1 uc002pin.2)

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Additional cDNA sequence:

AK075062.1 AK291575.1 BC014935.2 BC016811.1 BC034032.1 BC050996.1 BC125068.1 BC125069.1

5 DOTS entries:

DT.95283313 DT.91747116 DT.100022529 DT.91745678 DT.75185963

16 AceView cDNA sequences:

BU149961 BC034032 BC050996 BG481514 BC016811 BC014935 BG476217 AK075062

BU182389 CB115138 NM_153608 BU630935 BG121986 BE898185 AI656091 BU152948

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF114 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTCATACAA

About this image

ZNF114 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ZNF114 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF114

SOURCE GeneReport for Unigene cluster: Hs.511883

SABiosciences Custom PCR Arrays for ZNF114

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for ZNF114 (if available)
TreeFam Gene Tree for ZNF114 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF114 gene

18/343 SIMAP similar genes for ZNF114 using alignment to 5 protein entries: ZN114_HUMAN (see all proteins) (see all similar genes):

ZNF22 ZNF232 ZNF78L1 ZNF433 DKFZp761O1618 ZFP41

ZKSCAN7 ZNF167 ZSCAN31 ZNF DKFZp686M04222 ZNF200

ZNF75A ZNF833P Nbla00121 ZNF24 ZNF345 ZNF559

ZNF114 for paralogs About GeneDecksing

5/9 Pseudogenes.org Pseudogenes for ZNF114 (see all 9)
PGOHUM00000248503 PGOHUM00000234875 PGOHUM00000239137 PGOHUM00000240778 PGOHUM00000236076

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183255252^1,2		--	48772718(+)	`TGAAAC/TGGAGT`	1	--	us2k¹		0	--	--	--	--
rs28489914^1,2	C,F,	--	48772799(+)	`CAAACG/AATTCT`	1	--	us2k¹		4		NA	8
rs139491658^1,2		--	48772821(+)	`CTCCCA/GAGCAG`	1	--	us2k¹		0	--	--	--	--
rs188670400^1,2		--	48772823(+)	`CCCGAA/GCAGCT`	1	--	us2k¹		0	--	--	--	--
rs192284924^1,2		--	48772893(+)	`GTTTCA/GCCATG`	1	--	us2k¹		0	--	--	--	--
rs34074707^1,2	C,	--	48772963(+)	`ATCAC-/TTTAAG`	1	--	us2k¹		1		NA	2
rs143696301^1,2		--	48773102(+)	`CCAGTG/TCCTGC`	1	--	us2k¹		0	--	--	--	--
rs10423410^1,2	C,	--	48773179(+)	`tcagtC/Agaccc`	1	--	us2k¹		3		NA WA	122
rs57146478^1,2	C,	--	48773208(+)	`GACAAT/GGAGTC`	1	--	us2k¹		5		WA NA EA	362
rs183942754^1,2		--	48773262(+)	`GACAAC/TAAATA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZNF114 (48774654 - 48790863 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for ZNF114
3 CNVs: 47965 5106 32261

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZNF114 for disorders About MalaCards

ZNF114 for disorders About GeneDecksing

OMIM gene information: 603996 OMIM disorders: --

Export disorders for ZNF114 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF114 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF114)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. (PubMed id 8467795)¹ Bellefroid E.J.... Martial J.A. (1993)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 163071	HGNC: 12894	AceView: MGC17986	Ensembl:ENSG00000178150	euGenes: HUgn163071
ECgene: ZNF114	H-InvDB: ZNF114

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF114	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF114 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF114 gene:
Search GeneIP for patents involving ZNF114

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
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About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZNF114 gene at Home site.

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ZNF114 Gene

zinc finger protein 114

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ZNF114 Gene

zinc finger protein 114

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for ZNF114 gene

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for ZNF114 gene

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for ZNF114 gene

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for ZNF114 gene

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for ZNF114 gene

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for ZNF114 gene

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for ZNF114 gene

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for ZNF114 gene

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