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Aliases for ZNF112 Gene

Aliases for ZNF112 Gene

  • Zinc Finger Protein 112 2 3 5
  • Zinc Finger Protein 228 2 3 4
  • ZNF228 3 4
  • ZFP112 3 4
  • Zinc Finger Protein 112 Homolog (Mouse) 2
  • Zinc Finger Protein 112 Homolog 3
  • Zinc Finger Protein 112 (Y14) 3
  • Zfp-112 4

External Ids for ZNF112 Gene

Previous HGNC Symbols for ZNF112 Gene

  • ZFP112
  • ZNF228

Previous GeneCards Identifiers for ZNF112 Gene

  • GC19U990130
  • GC00U934196
  • GC19M044832

Summaries for ZNF112 Gene

GeneCards Summary for ZNF112 Gene

ZNF112 (Zinc Finger Protein 112) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF227.

UniProtKB/Swiss-Prot for ZNF112 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF112 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF112 Gene

Genomics for ZNF112 Gene

Regulatory Elements for ZNF112 Gene

Enhancers for ZNF112 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H043673 1.9 FANTOM5 Ensembl ENCODE dbSUPER 44.1 +692.4 692367 3 PKNOX1 ATF1 ZNF133 SIN3A YBX1 ZNF2 ZBTB7B ZNF121 ZNF143 FOS ZNF45 ZNF225 ZNF283 ZNF180 ZNF234 PLAUR ZNF226 ZNF112 ZNF224 ZNF223
GH19H044206 1.1 ENCODE 68.8 +159.6 159635 1.4 PKNOX1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF766 ZNF302 ZNF416 ZNF207 ZNF45 ZNF180 ZNF225 ZNF224 ZNF284 ZNF234 ZNF226 ZNF227 ZNF223 ZNF283
GH19H044111 1.5 FANTOM5 ENCODE 49.8 +254.2 254218 2.6 FOXA2 PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF302 ZNF416 ZNF45 ZNF180 ZNF225 ZNF224 ZNF227 ZNF155 ZNF234 XRCC1 ZNF283 ZNF576
GH19H043901 1.1 ENCODE 60.4 +465.4 465365 1.2 SIN3A ARID4B ZNF2 YY1 ZNF766 ZNF302 ZNF416 ZNF143 ZNF548 SP3 ZNF45 ZNF180 ZNF225 ZNF224 ZNF234 ZNF284 ZNF227 ZNF235 ZNF226 XRCC1
GH19H044844 1.8 FANTOM5 ENCODE dbSUPER 32.1 -480.8 -480798 7.3 YBX1 DMAP1 YY1 ZNF416 ZNF143 SP3 MCM3 ZNF610 GLIS1 RCOR2 ZNF180 ZNF45 CLASRP ZNF224 ZNF225 ZNF234 ZNF284 FBXO46 ENSG00000269148 LOC100505715
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF112 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF112 Gene

Genomic Locations for ZNF112 Gene
40,665 bases
Minus strand

Genomic View for ZNF112 Gene

Genes around ZNF112 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF112 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF112 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF112 Gene

Proteins for ZNF112 Gene

  • Protein details for ZNF112 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 112
    Protein Accession:
    Secondary Accessions:
    • A4FU53
    • Q9HCA7

    Protein attributes for ZNF112 Gene

    913 amino acids
    Molecular mass:
    105842 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF112 Gene


neXtProt entry for ZNF112 Gene

Post-translational modifications for ZNF112 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF112 Gene

Domains & Families for ZNF112 Gene

Gene Families for ZNF112 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF112 Gene

Suggested Antigen Peptide Sequences for ZNF112 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF112: view

Function for ZNF112 Gene

Molecular function for ZNF112 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF112 Gene

Gene Ontology (GO) - Molecular Function for ZNF112 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF112: view
genes like me logo Genes that share phenotypes with ZNF112: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF112 Gene

Localization for ZNF112 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF112 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF112 gene
Compartment Confidence
nucleus 5
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF112 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF112: view

Pathways & Interactions for ZNF112 Gene

SuperPathways for ZNF112 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF112: view

Pathways by source for ZNF112 Gene

2 Reactome pathways for ZNF112 Gene

Interacting Proteins for ZNF112 Gene

Gene Ontology (GO) - Biological Process for ZNF112 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA,IEA --
genes like me logo Genes that share ontologies with ZNF112: view

No data available for SIGNOR curated interactions for ZNF112 Gene

Drugs & Compounds for ZNF112 Gene

No Compound Related Data Available

Transcripts for ZNF112 Gene

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF112 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
SP3: -
SP4: - -

Relevant External Links for ZNF112 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF112 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF112 Gene

Protein differential expression in normal tissues from HIPED for ZNF112 Gene

This gene is overexpressed in Testis (46.6) and CD8 Tcells (22.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF112 Gene

Protein tissue co-expression partners for ZNF112 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF112 Gene:


Evidence on tissue expression from TISSUES for ZNF112 Gene

  • Liver(4)
  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with ZNF112: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF112 Gene

Orthologs for ZNF112 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF112 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZFP112 33
  • 98.97 (n)
ZNF112 34
  • 97 (a)
(Canis familiaris)
Mammalia ZFP112 33
  • 89.43 (n)
(Bos Taurus)
Mammalia ZFP112 33
  • 85.63 (n)
ZNF112 34
  • 80 (a)
(Mus musculus)
Mammalia Zfp112 33 16 34
  • 75.17 (n)
(Rattus norvegicus)
Mammalia Zfp112 33
  • 73.87 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 47 (a)
(Gallus gallus)
Aves -- 34
  • 47 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 52 (a)
(Danio rerio)
Actinopterygii si:ch73-367f21.5 34
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5245 34
  • 35 (a)
(Caenorhabditis elegans)
Secernentea tag-146 34
  • 23 (a)
C27A12.2 34
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9363 34
  • 27 (a)
Species where no ortholog for ZNF112 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZNF112 Gene

Gene Tree for ZNF112 (if available)
Gene Tree for ZNF112 (if available)

Paralogs for ZNF112 Gene

(547) SIMAP similar genes for ZNF112 Gene using alignment to 6 proteins: Pseudogenes for ZNF112 Gene

genes like me logo Genes that share paralogs with ZNF112: view

Variants for ZNF112 Gene

Sequence variations from dbSNP and Humsavar for ZNF112 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs386352382 Uncertain significance 44,328,788(-) TTCAG(A/G)TAGTC reference, missense
rs1000081258 -- 44,348,178(+) GATTT(G/T)CTCTG intron-variant
rs1000194691 -- 44,342,843(+) AGAAA(A/T)GGGGG intron-variant
rs1000239896 -- 44,335,097(+) GCAGA(A/G)ATGCC intron-variant
rs1000386427 -- 44,328,795(+) TGAAG(A/G)TCCTG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ZNF112 Gene

Variant ID Type Subtype PubMed ID
nsv960851 CNV duplication 23825009
nsv579856 CNV gain 21841781
nsv579855 CNV loss 21841781
nsv515911 CNV loss 19592680
nsv1123261 CNV deletion 24896259
esv2718619 CNV deletion 23290073
esv1016841 CNV insertion 17803354

Variation tolerance for ZNF112 Gene

Residual Variation Intolerance Score: 69.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.83; 83.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF112 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF112 Gene

Disorders for ZNF112 Gene

Relevant External Links for ZNF112

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF112 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF112 Gene

Publications for ZNF112 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 60
  2. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PMID: 12743021) Shannon M … Stubbs L (Genome research 2003) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60

Products for ZNF112 Gene

Sources for ZNF112 Gene

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