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ZNF112 Gene

protein-coding   GIFtS: 41
GCID: GC19M044832

Zinc Finger Protein 112

(Previous names: zinc finger protein 112 homolog (mouse), zinc finger protein...)
(Previous symbols: ZFP112, ZNF228)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 1121 2     zfp-1122
Zinc Finger Protein 2281 2 3     Zinc Finger Protein 112 (Y14)2
ZFP1121 2 3     Zinc Finger Protein 112 Homolog2
ZNF2281 2 3     Zfp-1123
Zinc Finger Protein 112 Homolog (Mouse)1     

External Ids:    HGNC: 128921   Entrez Gene: 77712   Ensembl: ENSG000000623707   OMIM: 6039945   UniProtKB: Q9UJU33   

Export aliases for ZNF112 gene to outside databases

Previous GC identifers: GC19U990130 GC00U934196


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZNF112 Gene:
DISCONTINUED: This record has been withdrawn by HGNC

GeneCards Summary for ZNF112 Gene:
ZNF112 (zinc finger protein 112) is a protein-coding gene. An important paralog of this gene is ZNF229.

UniProtKB/Swiss-Prot: ZN112_HUMAN, Q9UJU3
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ZNF112
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF112 promoter sequence
   Search Chromatin IP Primers for ZNF112

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF112


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.31   HGNC cytogenetic band: 19q13.2

ZNF112 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF112 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M044832:  view genomic region     (about GC identifiers)

Start:
44,830,706 bp from pter      End:
44,871,377 bp from pter
Size:
40,672 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN112_HUMAN, Q9UJU3 (See protein sequence)
Recommended Name: Zinc finger protein 112  
Size: 913 amino acids; 105842 Da
Secondary accessions: A4FU53 Q9HCA7
Alternative splicing: 2 isoforms:  Q9UJU3-1   Q9UJU3-2   

Explore the universe of human proteins at neXtProt for ZNF112: NX_Q9UJU3

Explore proteomics data for ZNF112 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF112 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001076804.1  NP_037512.3  

    ENSEMBL proteins: 
     ENSP00000346305   ENSP00000337081   ENSP00000466797   ENSP00000467064   ENSP00000464862  
     ENSP00000467994   ENSP00000441990  
    Reactome Protein details: Q9UJU3

    ZNF112 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online peptides for ZNF112

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    antibodies-online antibodies for ZNF112 (8 products) 

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    Search eBioscience for ELISAs for ZNF112 
    antibodies-online kits for ZNF112 (3 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9UJU3

    ProtoNet protein and cluster: Q9UJU3

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN112_HUMAN, Q9UJU3
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 17 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF112           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN112_HUMAN, Q9UJU3
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF112           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF112:
     Synthetic lethal with c-Myc af 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZNF112

    miRNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN112_HUMAN, Q9UJU3: Nucleus (Probable)

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF112           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF112 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF112           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF112
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF112
    Interactions:

        Search GeneGlobe Interaction Network for ZNF112

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ZNF112 (ENSP000003370814) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HAP1ENSP000003340024STRING: ENSP00000334002
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF112           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF112 (ZN112)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF112 gene (2 alternative transcripts): 
    NM_001083335.1  NM_013380.3  

    Unigene Cluster for ZNF112:

    Zinc finger protein 112 homolog (mouse)
    Hs.48589  [show with all ESTs]
    Unigene Representative Sequence: NM_001083335
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354340(uc002ozc.4 uc010xwz.2) ENST00000337401(uc010ejj.3 uc010xwy.2)
    ENST00000587909 ENST00000590687 ENST00000592151 ENST00000588057 ENST00000536500

    miRNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF112
      QuantiFast Probe-based Assays in human, mouse, rat ZNF112

    Additional mRNA sequence: 

    AF198358.1 AK023099.1 AK026230.1 AK130371.1 AK302594.1 AK302966.1 AL122078.1 BC101753.1 
    BC117223.1 

    6 DOTS entries:

    DT.91734150  DT.95363306  DT.100768316  DT.101955189  DT.40203954  DT.92424718 

    Selected AceView cDNA sequences (see all 54):

    AK026230 AK130371 BM697287 AU118814 AA913353 AA995242 AA449338 AA301436 
    AW591882 AA724335 AL122078 BX089522 AW078557 BE278868 CK004639 AW236100 
    BM790306 BM667932 AA600876 AI366198 AK023099 W15410 AF198358 AA455379 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF112    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
    SP1:                                                            
    SP2:                                                            
    SP3:                    -                                       
    SP4:                    -     -                                 


    ECgene alternative splicing isoforms for ZNF112

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF112 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF112 Expression
    About this image

    ZNF112 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF112 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.48589
        Custom PCR Arrays for ZNF112
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZNF112 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp1121 , 5 zinc finger protein 1121, 5 75.17(n)1
    65.63(a)1
      7 (10.27 cM)5
    577451  NM_021307.21  NP_067282.21 
     241123145 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    47(a)
    many ↔ many
    16(478531-480245)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    52(a)
    many ↔ many
    GL344586.1(10423-11868)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch73-367f21.56
    si:ch73-367f21.5
    41(a)
    many ↔ many
    19(7540671-7546226) ENSDARG00000089503
    fruit fly
    (Drosophila melanogaster)
    Insecta CG52456
    --
    35(a)
    many ↔ many
    3R(8255307-8256960)
    worm
    (Caenorhabditis elegans)
    Secernentea tag-1466
    C27A12.26
    Protein C27A12.2 (C27A12.2) mRNA, complete cds
    23(a)
    19(a)
    many ↔ many
    many ↔ many
    I(6038406-6041265) WBGene00006492
    I(6041670-6046176) WBGene00016154


    ENSEMBL Gene Tree for ZNF112 (if available)
    TreeFam Gene Tree for ZNF112 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF112 gene
    ZNF2292  ZNF2232  ZNF2302  ZNF1552  ZNF2272  ZNF2242  ZNF2342  ZNF2252  
    ZNF2262  ZNF2142  ZNF2222  ZNF2842  ENSG000002671732  ZNF452  ZNF2352  ZNF2212  
    ZNF2852  ENSG000002670222  ZNF2332  
    Selected SIMAP similar genes for ZNF112 using alignment to 6 protein entries:     ZN112_HUMAN (see all proteins) (see all similar genes):
    DKFZp434J0650    ZFP112    ZNF818P    kr-znf3    ZNF56    ZNF78L1
    ZNF233    ZNF235    ZNF844    DKFZp313M0722    LOC101928664    ZNF230
    ZNF323    ZNF826P    ZNF223    ZNF    ZNF225    DKFZp686M04222

    Find genes that share paralogs with ZNF112           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for ZNF112
    PGOHUM00000234719 PGOHUM00000240959 PGOHUM00000238091


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF112 (see all 798)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1487719331,2
    --44830336(+) AGATCA/GGTATG 2 -- ds50010--------
    rs1424362911,2
    --44830337(+) GATCGG/TTATGC 2 -- ds50010--------
    rs792212301,2
    C,F--44830395(+) ATATAT/CAGAAC 2 -- ds50012Minor allele frequency- C:0.04CSA WA 120
    rs1513305141,2
    C--44830401(+) AGAACA/GACAAG 2 -- ds50010--------
    rs45147901,2
    C--44830471(+) TAAATA/GGCAAC 2 -- ds50010--------
    rs782174241,2
    C,F--44830480(+) ACCCTA/TTCCTG 2 -- ds50012Minor allele frequency- T:0.07WA NA 238
    rs1831171631,2
    --44830591(+) AAAATA/CTTTCA 2 -- ds50010--------
    rs801740381,2
    C,F--44830700(+) AAAACC/TCCAAG 2 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1883264801,2
    --44830739(+) TATTTG/TTCATC 2 -- ut310--------
    rs1928240321,2
    C--44830858(+) TTAACC/TAGAAA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for ZNF112 (44830706 - 44871377 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ZNF112: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF112
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF112

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603994    OMIM disorders: --


    Find genes that share disorders with ZNF112           About GenesLikeMe


    Export disorders for ZNF112 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF112 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF112)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    2. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PubMed id 12743021)1, 2 Shannon M.... Stubbs L. (Genome Res. 2003)
    3. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. (PubMed id 8467795)1 Bellefroid E.J.... Martial J.A. (EMBO J. 1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7771 HGNC: 12892 AceView: ZNF228 Ensembl:ENSG00000062370 euGenes: HUgn7771
    ECgene: ZNF112 H-InvDB: ZNF112

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF112 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF112 gene:
    Search GeneIP for patents involving ZNF112

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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