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Aliases for ZNF107 Gene

Aliases for ZNF107 Gene

  • Zinc Finger Protein 107 2 3 5
  • Zinc Finger Protein 588 2 3 4
  • ZNF588 3 4
  • ZFD25 3 4
  • C2H2 Type Zinc-Finger Protein 3
  • Zinc Finger Protein 107 (Y8) 2
  • Zinc Finger Protein (ZFD25) 3
  • Zinc Finger Protein ZFD25 4
  • Smap-7 3
  • Y8 3

External Ids for ZNF107 Gene

Previous HGNC Symbols for ZNF107 Gene

  • ZNF588

Previous GeneCards Identifiers for ZNF107 Gene

  • GC07U990127
  • GC07P063764
  • GC07P064126
  • GC07P060507

Summaries for ZNF107 Gene

Entrez Gene Summary for ZNF107 Gene

  • This gene encodes a protein containing multiple C2H2-type zinc finger regions. Proteins containing zinc fingers may act as transcriptional regulators, but may also have other cellular functions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for ZNF107 Gene

ZNF107 (Zinc Finger Protein 107) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF718.

UniProtKB/Swiss-Prot for ZNF107 Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF107 Gene

Genomics for ZNF107 Gene

Regulatory Elements for ZNF107 Gene

Enhancers for ZNF107 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF107 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF107 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF107 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ZNF107 gene promoter:

Genomic Location for ZNF107 Gene

Chromosome:
7
Start:
64,666,083 bp from pter
End:
64,711,582 bp from pter
Size:
45,500 bases
Orientation:
Plus strand

Genomic View for ZNF107 Gene

Genes around ZNF107 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF107 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF107 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF107 Gene

Proteins for ZNF107 Gene

  • Protein details for ZNF107 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UII5-ZN107_HUMAN
    Recommended name:
    Zinc finger protein 107
    Protein Accession:
    Q9UII5

    Protein attributes for ZNF107 Gene

    Size:
    783 amino acids
    Molecular mass:
    90673 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF107 Gene

Proteomics data for ZNF107 Gene at MOPED

Post-translational modifications for ZNF107 Gene

  • Ubiquitination at Lys 133
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF107 Gene

Domains & Families for ZNF107 Gene

Gene Families for ZNF107 Gene

Protein Domains for ZNF107 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UII5

UniProtKB/Swiss-Prot:

ZN107_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 25 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 25 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF107: view

Function for ZNF107 Gene

Molecular function for ZNF107 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF107 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with ZNF107: view
genes like me logo Genes that share phenotypes with ZNF107: view

Animal Model Products

CRISPR Products

miRNA for ZNF107 Gene

miRTarBase miRNAs that target ZNF107

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF107 Gene

Localization for ZNF107 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF107 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF107 Gene COMPARTMENTS Subcellular localization image for ZNF107 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF107 Gene

Pathways & Interactions for ZNF107 Gene

SuperPathways for ZNF107 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF107 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZNF107 Gene

Drugs & Compounds for ZNF107 Gene

No Compound Related Data Available

Transcripts for ZNF107 Gene

Unigene Clusters for ZNF107 Gene

Zinc finger protein 107:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF107 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7
SP1: - - - - -
SP2:
SP3: - - - -
SP4: - -

Relevant External Links for ZNF107 Gene

GeneLoc Exon Structure for
ZNF107
ECgene alternative splicing isoforms for
ZNF107

Expression for ZNF107 Gene

mRNA expression in normal human tissues for ZNF107 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF107 Gene

This gene is overexpressed in Bone marrow stromal cell (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF107 Gene



SOURCE GeneReport for Unigene cluster for ZNF107 Gene Hs.732661

mRNA Expression by UniProt/SwissProt for ZNF107 Gene

Q9UII5-ZN107_HUMAN
Tissue specificity: Expressed in brain, heart, skeletal muscle, kidney and pancreas. Weakly expressed in aorta, liver and lung.
genes like me logo Genes that share expression patterns with ZNF107: view

Protein tissue co-expression partners for ZNF107 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ZNF107 Gene

Orthologs for ZNF107 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF107 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF107 35
  • 99.37 (n)
  • 99.41 (a)
rat
(Rattus norvegicus)
Mammalia Zfp748 35
  • 66.1 (n)
  • 55.74 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 41 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 42 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 38 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia A530054K11Rik 36
  • 41 (a)
ManyToMany
AA987161 36
  • 37 (a)
ManyToMany
Zfp457 36
  • 48 (a)
ManyToMany
Zfp458 36
  • 50 (a)
ManyToMany
Zfp738 36
  • 45 (a)
ManyToMany
Zfp748 36
  • 39 (a)
ManyToMany
Zfp759 36
  • 46 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 54 (a)
OneToMany
Species with no ortholog for ZNF107:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF107 Gene

ENSEMBL:
Gene Tree for ZNF107 (if available)
TreeFam:
Gene Tree for ZNF107 (if available)

Paralogs for ZNF107 Gene

(399) SIMAP similar genes for ZNF107 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZNF107 Gene

genes like me logo Genes that share paralogs with ZNF107: view

Variants for ZNF107 Gene

Sequence variations from dbSNP and Humsavar for ZNF107 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs6955471 -- 64,672,898(+) TTACA(C/T)TCCCA intron-variant
rs12667134 -- 64,670,402(+) cttta(C/G)gaggg intron-variant
rs12667158 -- 64,670,502(+) attaa(C/G)aagaa intron-variant
rs12667199 -- 64,670,691(+) taatc(A/G)cagct intron-variant
rs12667645 -- 64,670,835(+) gttct(A/G)tgagt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF107 Gene

Variant ID Type Subtype PubMed ID
dgv1147e201 CNV Deletion 23290073
esv2422405 CNV Duplication 17116639
nsv464518 CNV Gain 19166990
dgv7307n71 CNV Gain 21882294
dgv7308n71 CNV Gain 21882294
nsv888278 CNV Gain 21882294
esv23182 CNV Gain 19812545
nsv888279 CNV Loss 21882294
esv2734578 CNV Deletion 23290073
esv2734579 CNV Deletion 23290073
nsv888280 CNV Loss 21882294

Variation tolerance for ZNF107 Gene

Residual Variation Intolerance Score: 49.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.61; 56.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF107 Gene

HapMap Linkage Disequilibrium report
ZNF107

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF107 Gene

Disorders for ZNF107 Gene

Relevant External Links for ZNF107

Genetic Association Database (GAD)
ZNF107
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF107

No disorders were found for ZNF107 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF107 Gene

Publications for ZNF107 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. (PMID: 8467795) Bellefroid E.J. … Martial J.A. (EMBO J. 1993) 2 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Functional proteomics mapping of a human signaling pathway. (PMID: 15231748) Colland F. … Gauthier J.M. (Genome Res. 2004) 3
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3

Products for ZNF107 Gene

Sources for ZNF107 Gene

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