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Aliases for ZNF107 Gene

Aliases for ZNF107 Gene

  • Zinc Finger Protein 107 2 3 5
  • Zinc Finger Protein 588 2 3 4
  • ZNF588 3 4
  • ZFD25 3 4
  • C2H2 Type Zinc-Finger Protein 3
  • Zinc Finger Protein 107 (Y8) 2
  • Zinc Finger Protein (ZFD25) 3
  • Zinc Finger Protein ZFD25 4
  • Smap-7 3
  • Y8 3

External Ids for ZNF107 Gene

Previous HGNC Symbols for ZNF107 Gene

  • ZNF588

Previous GeneCards Identifiers for ZNF107 Gene

  • GC07U990127
  • GC07P063764
  • GC07P064126
  • GC07P060507

Summaries for ZNF107 Gene

Entrez Gene Summary for ZNF107 Gene

  • This gene encodes a protein containing multiple C2H2-type zinc finger regions. Proteins containing zinc fingers may act as transcriptional regulators, but may also have other cellular functions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for ZNF107 Gene

ZNF107 (Zinc Finger Protein 107) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF729.

UniProtKB/Swiss-Prot for ZNF107 Gene

  • May be involved in transcriptional regulation.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF107 Gene

Genomics for ZNF107 Gene

Regulatory Elements for ZNF107 Gene

Enhancers for ZNF107 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G064664 1.1 ENCODE 48 +0.4 372 3.2 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 FOS ZNF263 ZNF107 CCT6P3 ZNF736 LOC441239 ERV3-1 SEPHS1P1 ZNF138 MIR6839
GH07G064685 0.8 ENCODE 37.5 +21.8 21816 5.3 ELF3 SOX13 CTCF FOXA2 CEBPG ZNF644 ZSCAN9 E2F1 CTBP1 CBX5 ZNF107 SEPHS1P1 BNIP3P11 GC07P064707
GH07G064562 1 ENCODE 14.3 -103.1 -103119 1.7 PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 ETS1 ELK1 ZNF107 CCT6P3 ZNF736 ZNF117 LOC644387 ZNF680 BNIP3P42
GH07G065373 1.1 ENCODE 12.2 +708.2 708173 2.1 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 FOS ZNF263 SP3 GTF2IP14 ZNF107 ERV3-1 ZNF92 ENSG00000238124
GH07G064463 0.9 Ensembl ENCODE 11.9 -202.3 -202272 1.2 CBX3 NFYA ELF4 ELF1 NFYB FOS ZBTB33 MGA RBFOX2 ZNF107 ZNF680P1 VN1R40P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF107 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF107 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000212819 317 1601 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 CBX5 ZNF143 ZNF207 FOS

Transcription factor binding sites by QIAGEN in the ZNF107 gene promoter:

Genomic Location for ZNF107 Gene

Chromosome:
7
Start:
64,666,083 bp from pter
End:
64,711,582 bp from pter
Size:
45,500 bases
Orientation:
Plus strand

Genomic View for ZNF107 Gene

Genes around ZNF107 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF107 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF107 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF107 Gene

Proteins for ZNF107 Gene

  • Protein details for ZNF107 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UII5-ZN107_HUMAN
    Recommended name:
    Zinc finger protein 107
    Protein Accession:
    Q9UII5

    Protein attributes for ZNF107 Gene

    Size:
    783 amino acids
    Molecular mass:
    90673 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF107 Gene

Post-translational modifications for ZNF107 Gene

  • Ubiquitination at isoforms=133
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF107 Gene

Domains & Families for ZNF107 Gene

Gene Families for ZNF107 Gene

Protein Domains for ZNF107 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UII5

UniProtKB/Swiss-Prot:

ZN107_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF107: view

Function for ZNF107 Gene

Molecular function for ZNF107 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF107 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF107: view
genes like me logo Genes that share phenotypes with ZNF107: view

Animal Model Products

CRISPR Products

miRNA for ZNF107 Gene

miRTarBase miRNAs that target ZNF107

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF107 Gene

Localization for ZNF107 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF107 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF107 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF107 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF107: view

Pathways & Interactions for ZNF107 Gene

SuperPathways for ZNF107 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF107 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZNF107: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF107 Gene

Drugs & Compounds for ZNF107 Gene

No Compound Related Data Available

Transcripts for ZNF107 Gene

Unigene Clusters for ZNF107 Gene

Zinc finger protein 107:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF107 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7
SP1: - - - - -
SP2:
SP3: - - - -
SP4: - -

Relevant External Links for ZNF107 Gene

GeneLoc Exon Structure for
ZNF107
ECgene alternative splicing isoforms for
ZNF107

Expression for ZNF107 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF107 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF107 Gene

This gene is overexpressed in Bone marrow stromal cell (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF107 Gene



Protein tissue co-expression partners for ZNF107 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF107 Gene:

ZNF107

SOURCE GeneReport for Unigene cluster for ZNF107 Gene:

Hs.732661

mRNA Expression by UniProt/SwissProt for ZNF107 Gene:

Q9UII5-ZN107_HUMAN
Tissue specificity: Expressed in brain, heart, skeletal muscle, kidney and pancreas. Weakly expressed in aorta, liver and lung.

Evidence on tissue expression from TISSUES for ZNF107 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with ZNF107: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF107 Gene

Orthologs for ZNF107 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF107 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF107 34
  • 99.37 (n)
rat
(Rattus norvegicus)
Mammalia Zfp748 34
  • 66.1 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 54 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zfp458 35
  • 50 (a)
ManyToMany
Zfp457 35
  • 48 (a)
ManyToMany
Zfp759 35
  • 46 (a)
ManyToMany
Zfp738 35
  • 45 (a)
ManyToMany
A530054K11Rik 35
  • 41 (a)
ManyToMany
Zfp748 35
  • 39 (a)
ManyToMany
AA987161 35
  • 37 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 42 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 41 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 38 (a)
ManyToMany
Species where no ortholog for ZNF107 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF107 Gene

ENSEMBL:
Gene Tree for ZNF107 (if available)
TreeFam:
Gene Tree for ZNF107 (if available)

Paralogs for ZNF107 Gene

(399) SIMAP similar genes for ZNF107 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF107: view

Variants for ZNF107 Gene

Sequence variations from dbSNP and Humsavar for ZNF107 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000051627 -- 64,665,365(+) CCTTT(A/G/T)TTTTT intron-variant, upstream-variant-2KB
rs1000055405 -- 64,686,110(+) TAGAC(C/T)TCCTA intron-variant, nc-transcript-variant
rs1000068088 -- 64,668,305(+) TCCCC(C/G)CTCCC intron-variant
rs1000068303 -- 64,700,130(+) TGTTA(A/G)GCTTA intron-variant
rs1000068714 -- 64,708,543(+) AGAAA(A/C)CCTAC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZNF107 Gene

Variant ID Type Subtype PubMed ID
dgv1099e201 CNV deletion 23290073
dgv437e215 CNV deletion 23714750
esv23182 CNV gain 19812545
esv2422405 CNV duplication 17116639
esv2764000 CNV gain+loss 21179565
esv3571879 CNV loss 25503493
nsv1018445 CNV gain 25217958
nsv1027615 CNV gain 25217958
nsv464518 CNV gain 19166990
nsv607312 CNV gain 21841781
nsv970856 CNV duplication 23825009

Variation tolerance for ZNF107 Gene

Residual Variation Intolerance Score: 49.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.61; 56.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF107 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF107

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF107 Gene

Disorders for ZNF107 Gene

Relevant External Links for ZNF107

Genetic Association Database (GAD)
ZNF107
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF107

No disorders were found for ZNF107 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF107 Gene

Publications for ZNF107 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Cloning and characterization of a novel gene encoding a zinc finger protein with 25 fingers. (PMID: 10673043) Li X.-A. … Yutani C. (Biochim. Biophys. Acta 1999) 3 4 64
  3. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. (PMID: 8467795) Bellefroid E.J. … Martial J.A. (EMBO J. 1993) 2 3 64
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  5. Functional proteomics mapping of a human signaling pathway. (PMID: 15231748) Colland F. … Gauthier J.M. (Genome Res. 2004) 3 64

Products for ZNF107 Gene

Sources for ZNF107 Gene

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