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ZNF107 Gene

protein-coding   GIFtS: 42
GCID: GC07P064126

Zinc Finger Protein 107

(Previous names: zinc finger protein 588, zinc finger protein 107 (Y8))
(Previous symbol: ZNF588)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 1071 2     Y82
Zinc Finger Protein 5881 2 3     C2H2 Type Zinc-Finger Protein2
ZNF5881 2 3     smap-72
ZFD252 3     Zinc Finger Protein (ZFD25)2
Zinc Finger Protein 107 (Y8)1     Zinc Finger Protein ZFD253

External Ids:    HGNC: 128871   Entrez Gene: 514272   Ensembl: ENSG000001962477   OMIM: 6039895   UniProtKB: Q9UII53   

Export aliases for ZNF107 gene to outside databases

Previous GC identifers: GC07U990127 GC07P063764 GC07P060507


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZNF107 Gene:
This gene encodes a protein containing multiple C2H2-type zinc finger regions. Proteins containing zinc fingers
may act as transcriptional regulators, but may also have other cellular functions. Alternative splicing results
in multiple transcript variants. (provided by RefSeq, Aug 2013)

GeneCards Summary for ZNF107 Gene:
ZNF107 (zinc finger protein 107) is a protein-coding gene. An important paralog of this gene is ZNF616.

UniProtKB/Swiss-Prot: ZN107_HUMAN, Q9UII5
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF107 gene promoter:
         p53   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZNF107 promoter sequence
   Search Chromatin IP Primers for ZNF107

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF107


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.2   Ensembl cytogenetic band:  7q11.21   HGNC cytogenetic band: 7q11.2

ZNF107 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF107 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P064126:  view genomic region     (about GC identifiers)

Start:
64,126,511 bp from pter      End:
64,171,404 bp from pter
Size:
44,894 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 63,464,105-63,508,998     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN107_HUMAN, Q9UII5 (See protein sequence)
Recommended Name: Zinc finger protein 107  
Size: 783 amino acids; 90673 Da

Explore the universe of human proteins at neXtProt for ZNF107: NX_Q9UII5

Explore proteomics data for ZNF107 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys133
  • Modification sites at PhosphoSitePlus

  • See ZNF107 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001013768.1  NP_001269288.1  NP_001269289.1  NP_057304.1  

    ENSEMBL proteins: 
     ENSP00000353234   ENSP00000343443   ENSP00000378789   ENSP00000400037  

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    Search eBioscience for ELISAs for ZNF107 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9UII5

    ProtoNet protein and cluster: Q9UII5

    UniProtKB/Swiss-Prot: ZN107_HUMAN, Q9UII5
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 25 C2H2-type zinc fingers


    Find genes that share domains with ZNF107           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN107_HUMAN, Q9UII5
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF107           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF107
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    miRNA
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    miRTarBase miRNAs that target ZNF107:
    hsa-mir-340-5p (MIRT019600)

    Block miRNA regulation of human, mouse, rat ZNF107 using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidZNF107 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZNF107

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN107_HUMAN, Q9UII5: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF107           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF107
    Interactions:

        Search GeneGlobe Interaction Network for ZNF107

    2 Interacting proteins for ZNF107 (Q9UII52, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIPK3Q9H4222, 3MINT-61749 I2D: score=3 
    SMAD7O151052, 3MINT-61813 I2D: score=3 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0008150biological_process ND--

    Find genes that share ontologies with ZNF107           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF107 (ZN107)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF107 gene (4 alternative transcripts): 
    NM_001013746.2  NM_001282359.1  NM_001282360.1  NM_016220.4  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360117 ENST00000344930(uc003tte.3) ENST00000395391 ENST00000423627(uc003ttd.3)

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidZNF107 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZNF107
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF107
    Clone
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    OriGene clones in human, mouse for ZNF107 (see all 9)
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    GenScript: all cDNA clones in your preferred vector (see all 2): ZNF107 (NM_016220)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF107
    Primer
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    OriGene qPCR primer pairs and template standards for ZNF107
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZNF107
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF107
      QuantiFast Probe-based Assays in human, mouse, rat ZNF107

    Selected AceView cDNA sequences (see all 66):

    AI884422 AA827146 BU193507 AB014735 BC017809 AA747556 NM_016220 CF136291 
    AW072084 AI394116 BQ228688 AA599639 BF511657 BG503639 AL601710 AI760251 
    AA278839 BG107212 CD644724 BX119229 BX091975 AW003458 BU570291 CF137958 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF107    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7
    SP1:        -     -     -     -     -               
    SP2:                                                
    SP3:        -     -     -     -                     
    SP4:        -     -                                 


    ECgene alternative splicing isoforms for ZNF107

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF107 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTAGGTTT
    ZNF107 Expression
    About this image

    ZNF107 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF107 Protein Expression

    UniProtKB/Swiss-Prot: ZN107_HUMAN, Q9UII5
    Tissue specificity: Expressed in brain, heart, skeletal muscle, kidney and pancreas. Weakly expressed in aorta,
    liver and lung

        Custom PCR Arrays for ZNF107
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF107

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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      --

    ENSEMBL Gene Tree for ZNF107 (if available)
    TreeFam Gene Tree for ZNF107 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF107 gene
    ZNF6162  ZNF4732  ZNF1602  ZNF4932  ZNF5462  ZNF992  ZNF8362  ZNF7212  
    ZNF5942  ZFP622  ZNF8412  ZNF432  ZNF780B2  ZNF1972  ZNF585A2  ZNF8082  
    ZNF3472  ZNF8452  ZNF585B2  ZNF6582  ZNF6292  ZNF6242  ZNF2682  ZNF8142  
    Selected SIMAP similar genes for ZNF107 using alignment to 3 protein entries:     ZN107_HUMAN (see all proteins) (see all similar genes):
    smap-7    ZNF232    ZFS-1    ZNF85    ZNF117    ZNF43
    DKFZp762K012    ZNF273    ZNF420    ZNF429    ZNF675    ZNF676
    ZSCAN21    ZNF138    ZNF430    ZNF492    ZNF680    ZNF702P

    Find genes that share paralogs with ZNF107           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ZNF107
    PGOHUM00000234558


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF107 (see all 965)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs18389011,2
    C,F,A,H--64124512(-) tgagcG/Acctgt 2 -- us2k16Minor allele frequency- A:0.32NA WA EA 364
    rs1859251441,2
    --64124513(+) CAGGCA/GCTCAC 2 -- us2k10--------
    rs15969291,2
    C,F,A,H--64124530(-) attaaC/Gtgggc 2 -- us2k1 tfbs311Minor allele frequency- G:0.23MN NS EA NA WA 612
    rs1501897821,2
    C--64124586(+) GGTCT-/CCCATC 2 -- us2k10--------
    rs733618541,2
    C,F--64124680(+) GTTTGG/AGGTGT 2 -- us2k12Minor allele frequency- A:0.12WA EA 238
    rs1379022951,2
    C--64124742(+) ATGTCA/GTAGGG 2 -- us2k10--------
    rs1424489041,2
    --64124856(+) GTTTGA/GTACAG 2 -- us2k10--------
    rs1161747591,2
    C,F--64125296(+) AATTGT/CTTTTC 2 -- us2k11Minor allele frequency- C:0.03WA 118
    rs782932501,2
    F--64125385(+) CCTCTG/CCTCTT 2 -- us2k11Minor allele frequency- C:0.04NA 120
    rs1895664091,2
    --64125397(+) TTATGG/TCCACG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF107 (64126511 - 64171404 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZNF107 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734578CNV Deletion23290073
    dgv1147e201CNV Deletion23290073
    esv2734579CNV Deletion23290073
    esv2422405CNV Duplication17116639
    nsv888280CNV Loss21882294
    nsv888279CNV Loss21882294
    dgv7308n71CNV Gain21882294
    dgv7307n71CNV Gain21882294
    nsv888278CNV Gain21882294
    nsv464518CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF107
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603989    OMIM disorders: --


    Find genes that share disorders with ZNF107           About GenesLikeMe

    Genetic Association Database (GAD): ZNF107

    Export disorders for ZNF107 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF107 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF107)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Cloning and characterization of a novel gene encoding a zinc finger protein with 25 fingers. (PubMed id 10673043)1, 2 Li X.-A.... Yutani C. (Biochim. Biophys. Acta 1999)
    3. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. (PubMed id 8467795)1, 3 Bellefroid E.J.... Martial J.A. (EMBO J. 1993)
    4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    6. A universal strategy for proteomic studies of SUMO and other ubiquitin-like modifiers. (PubMed id 15576338)1 Rosas-Acosta G....Wilson V.G. (amp 2005)
    7. Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)1 Colland F....Gauthier J.M. (Genome Res. 2004)
    8. The DNA sequence of human chromosome 7. (PubMed id 12853948)1 Hillier L.W.... Wilson R.K. (Nature 2003)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51427 HGNC: 12887 AceView: ZFD25 Ensembl:ENSG00000196247 euGenes: HUgn51427
    ECgene: ZNF107 H-InvDB: ZNF107

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF107 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF107 gene:
    Search GeneIP for patents involving ZNF107

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     Block miRNA regulation of human, mouse, rat ZNF107 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ZNF107
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