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ZNF106 Gene

protein-coding   GIFtS: 42
GCID: GC15M042707

Zinc Finger Protein 106

(Previous name: zinc finger protein 106 homolog (mouse))
(Previous symbol: ZFP106)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 1061 2     SH3BP32 3
ZFP1061 2 3     ZNF4742 3
SH3-Domain Binding Protein 31 2     Zinc Finger Protein 106 Homolog (Mouse)1
Zinc Finger Protein 4742 3     Zfp-1063

External Ids:    HGNC: 128861   Entrez Gene: 643972   Ensembl: ENSG000001039947   OMIM: 6039885   UniProtKB: Q9H2Y73   

Export aliases for ZNF106 gene to outside databases

Previous GC identifer: GC19U990126


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF106 Gene:
ZNF106 (zinc finger protein 106) is a protein-coding gene. Diseases associated with ZNF106 include congenital dyserythropoietic anemia type i, and congenital dyserythropoietic anemia. GO annotations related to this gene include opioid peptide activity and SH3 domain binding. An important paralog of this gene is FBXW7.

Gene Wiki entry for ZNF106 (ZFP106) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for ZNF106
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF106 promoter sequence
   Search Chromatin IP Primers for ZNF106

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF106


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15.1   Ensembl cytogenetic band:  15q15.1   HGNC cytogenetic band: 15q15.1

ZNF106 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF106 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M042707:  view genomic region     (about GC identifiers)

Start:
42,705,021 bp from pter      End:
42,783,321 bp from pter
Size:
78,301 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN106_HUMAN, Q9H2Y7 (See protein sequence)
Recommended Name: Zinc finger protein 106  
Size: 1883 amino acids; 208883 Da
Subunit: Interacts with KNOP1 (By similarity)
Sequence caution: Sequence=AAH58023.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAH70244.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=BAB14976.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAD91134.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q6NSD9 Q6PEK1 Q86T43 Q86T45 Q86T50 Q86T58 Q86TA9 Q96M37 Q9H7B8

Explore the universe of human proteins at neXtProt for ZNF106: NX_Q9H2Y7

Explore proteomics data for ZNF106 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys243, Lys356, Lys539, Lys775
  • Modification sites at PhosphoSitePlus

  • See ZNF106 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001271235.1  NP_001271236.1  NP_071918.1  

    ENSEMBL proteins: 
     ENSP00000263805   ENSP00000455674   ENSP00000456604   ENSP00000456191   ENSP00000457637  
     ENSP00000475881   ENSP00000455049   ENSP00000456845   ENSP00000454882  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    Selected InterPro protein domains (see all 6):
     IPR015880 Znf_C2H2-like
     IPR018391 PQQ_beta_propeller_repeat
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9H2Y7

    ProtoNet protein and cluster: Q9H2Y7

    UniProtKB/Swiss-Prot: ZN106_HUMAN, Q9H2Y7
    Similarity: Contains 2 C2H2-type zinc fingers
    Similarity: Contains 6 WD repeats


    ZNF106 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001515opioid peptide activity IEA--
    GO:0005515protein binding ----
    GO:0017124SH3 domain binding IEA--
    GO:0044822poly(A) RNA binding IDA--
    GO:0046872metal ion binding IEA--
         
    ZNF106 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF106:
     Decreased viability with pacli 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Zfp106):
     behavior/neurological  other  vision/eye 

    ZNF106 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF106
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    miRNA
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    miRTarBase miRNAs that target ZNF106:
    hsa-mir-345-5p (MIRT042733), hsa-let-7b-5p (MIRT052188), hsa-mir-28-5p (MIRT050005), hsa-mir-1237-3p (MIRT036247)

    Block miRNA regulation of human, mouse, rat ZNF106 using miScript Target Protectors
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN106_HUMAN, Q9H2Y7: Nucleus, nucleolus (By similarity)

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IEA--
    GO:0005829cytosol IEA--
    GO:0016020membrane IEA--

    ZNF106 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF106
    Interactions:

        Search GeneGlobe Interaction Network for ZNF106

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ZNF106 (Q9H2Y72, 3 ENSP000002638054) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKILP127572, 3MINT-61683 I2D: score=3 
    APCP250543, ENSP000002574304I2D: score=3 STRING: ENSP00000257430
    UBE2IP632793, ENSP000003248974I2D: score=3 STRING: ENSP00000324897
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008286insulin receptor signaling pathway IEA--

    ZNF106 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF106 (ZN106)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF106 gene (3 alternative transcripts): 
    NM_001284306.1  NM_001284307.1  NM_022473.2  

    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263805(uc001zpu.3 uc001zpw.3 uc001zpv.3 uc001zpx.3 uc010udh.1 uc001zpy.1)
    ENST00000565380 ENST00000565500 ENST00000569648 ENST00000565611 ENST00000568906
    ENST00000565660 ENST00000570078 ENST00000567772 ENST00000565948 ENST00000564754
    ENST00000567041
    miRNA
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    Selected AceView cDNA sequences (see all 475):

    AK091929 AW467800 CR607013 Z19367 N44690 AI338734 AI636341 AA247455 
    BU171917 AI270678 Z30049 BM461915 AA424407 AI954635 BQ721362 AI658947 
    Z28813 AI141433 AA424494 AI078752 NM_022473 AL040520 BG577249 BM453278 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZNF106 (see all 14)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a ·
    SP1:                                                                                                                                                  -         
    SP2:                                                                                                                                                  -         
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                  -         
    SP5:                                                                                                                                                            

    ExUns: 18b ^ 19 ^ 20a · 20b ^ 21a · 21b · 21c ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25
    SP1:        -     -                                                               
    SP2:        -     -                                                               
    SP3:        -     -                                                               
    SP4:        -     -     -                                                         
    SP5:                                                                              


    ECgene alternative splicing isoforms for ZNF106

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF106 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF106 Expression
    About this image

    ZNF106 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF106 Protein Expression
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZNF106 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp1061 , 5 zinc finger protein 1061, 5 82.67(n)1
    78.28(a)1
      2 (60.37 cM)5
    204021  NM_011743.21  NP_035873.21 
     1205068205 
    chicken
    (Gallus gallus)
    Aves ZFP1061 zinc finger protein 106 homolog (mouse) 66.87(n)
    62.68(a)
      423234  XM_421158.3  XP_421158.3 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF1066
    zinc finger protein 106
    56(a)
    1 ↔ 1
    1(39873335-39922241)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.97772 Xenopus laevis transcribed sequence with moderate similarity more 77.78(n)    CA988525.1 
    zebrafish
    (Danio rerio)
    Actinopterygii znf106a6
    zinc finger protein 106a
    40(a)
    1 ↔ 1
    17(45515242-45545989) ENSDARG00000016651
    fruit fly
    (Drosophila melanogaster)
    Insecta CG143226
    --
    18(a)
    1 → many
    3R(13473401-13495048)


    ENSEMBL Gene Tree for ZNF106 (if available)
    TreeFam Gene Tree for ZNF106 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF106 gene
    FBXW72  TRAF72  BTRC2  FBXW22  FBXW112  WDR862  
    2 SIMAP similar genes for ZNF106 using alignment to 8 protein entries:     ZN106_HUMAN (see all proteins):
    ZFP106    POC1B

    ZNF106 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNF106
    PGOHUM00000262444


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF106 (see all 1073)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs283645511,2
    C,F--42705028(+) AATTAG/CTAAAA 1 -- ut31 ese35Minor allele frequency- C:0.01NS 188
    rs283645521,2
    C,F,H--42705191(+) ATTAAA/GAAAAT 1 -- ut3115Minor allele frequency- G:0.04NS NA 1774
    rs1158396261,2
    F--42705300(+) AATTTA/GTTTGG 1 -- ut311Minor allele frequency- G:0.01WA 118
    rs283645531,2
    C,F,H--42705342(+) AAATGT/CAGTCA 1 -- ut31 ese319Minor allele frequency- C:0.05NS NA WA 2218
    rs283645541,2
    C,F,H--42705371(+) CCATAT/CACTTG 1 -- ut3117Minor allele frequency- C:0.05NS NA WA 1878
    rs125946331,2
    C,F,H--42705464(+) AACCTA/CGTCTA 1 -- ut31 ese317Minor allele frequency- C:0.14NS NA EA WA CSA 897
    rs80312361,2
    C,F--42705596(+) GCCTTC/TGTAAT 1 -- ut317Minor allele frequency- T:0.10NS CSA WA 288
    rs80315411,2
    C,F,H--42705597(+) CCTTCG/ATAATT 1 -- ut3111Minor allele frequency- A:0.04NS NA WA 930
    rs283645551,2
    C,F,H--42705713(+) ATATAC/TTTCAA 1 -- ut3111Minor allele frequency- T:0.01NS NA 848
    rs283645561,2
    C,F,H--42705857(+) AACCTG/ATGTTA 1 -- ut31 ese312Minor allele frequency- A:0.05NS NA WA 1076

    HapMap Linkage Disequilibrium report for ZNF106 (42705021 - 42783321 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ZNF106: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF106
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF106

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603988    OMIM disorders: --

    2 diseases for ZNF106:    
    About MalaCards
    congenital dyserythropoietic anemia type i    congenital dyserythropoietic anemia


    ZNF106 for disorders           About GeneDecksing


    Export disorders for ZNF106 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF106 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with ZNF106)
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    1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Dual promoter structure of ZFP106: regulation by myogenin and nuclear respiratory factor-1. (PubMed id 15656981)1, 9 Grasberger H....Bell G.I. (Gene 2005)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    6. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    7. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. Comparative proteomic analysis identifies a role for SUMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (Sci Signal 2011)
    10. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64397 HGNC: 12886 AceView: SH3BP3 Ensembl:ENSG00000103994 euGenes: HUgn64397
    ECgene: ZNF106 H-InvDB: ZNF106

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF106 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF106 gene:
    Search GeneIP for patents involving ZNF106

    GeneCards and IP:
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