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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF101 Gene

protein-coding   GIFtS: 50
GCID: GC19P019779

Zinc Finger Protein 101

(Previous name: zinc finger protein 101 (Y2))
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 1011 2
Zinc Finger Protein 101 (Y2)1 2
Zinc Finger Protein HZF122 3
HZF122
Zinc Finger Protein 122

External Ids:    HGNC: 128811   Entrez Gene: 940392   Ensembl: ENSG000001818967   OMIM: 6039835   UniProtKB: Q8IZC73   

Export aliases for ZNF101 gene to outside databases

Previous GC identifers: GC19U990121 GC19P019640 GC19P019341


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZNF101 Gene:
Zinc finger proteins (ZNFs), such as ZNF101, bind nucleic acids and perform many key functions, the most important
of which is regulating transcription (summary by Bellefroid et al., 1993 (PubMed 8467795)). See ZNF91 (MIM
603971) for general information on ZNFs.(supplied by OMIM, Nov 2010)

GeneCards Summary for ZNF101 Gene: 
ZNF101 (zinc finger protein 101) is a protein-coding gene. Diseases associated with ZNF101 include coronary heart disease, and among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF669.

UniProtKB/Swiss-Prot: ZN101_HUMAN, Q8IZC7
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011295.11  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF101 gene promoter:
         AhR   AML1a   HTF   CUTL1   Arnt   Roaz   POU2F1   POU2F1a   TGIF   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF101 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF101

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF101


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.11

ZNF101 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF101 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P019779:  view genomic region     (about GC identifiers)

Start:
19,779,605 bp from pter      End:
19,794,318 bp from pter
Size:
14,714 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN101_HUMAN, Q8IZC7 (See protein sequence)
Recommended Name: Zinc finger protein 101  
Size: 436 amino acids; 50339 Da
Subcellular location: Nucleus (Probable)

Explore the universe of human proteins at neXtProt for ZNF101: NX_Q8IZC7

Explore proteomics data for ZNF101 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IZC7

  • ZNF101 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF101 Protein Expression
    REFSEQ proteins: NP_149981.2  
    ENSEMBL proteins: 
     ENSP00000467112   ENSP00000319716   ENSP00000466697   ENSP00000468049   ENSP00000400952  
     ENSP00000466744  
    Reactome Protein details: Q8IZC7
    Human Recombinant Protein Products for ZNF101: 
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    Novus Biologicals ZNF101 Lysates
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF101 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF101 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8IZC7

    ProtoNet protein and cluster: Q8IZC7

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN101_HUMAN, Q8IZC7
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 10 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF101 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN101_HUMAN, Q8IZC7
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF101 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF101 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF101
        Generic Transcription Pathway
    Gene Expression



    ZNF101 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF101

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/7 Interacting proteins for ZNF101 (Q8IZC72, 3 ENSP000003197164) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALCOCO2Q131372, 3, ENSP000002589474MINT-66786 I2D: score=4 STRING: ENSP00000258947
    MDFIQ997502, 3, ENSP000002303214MINT-68069 I2D: score=4 STRING: ENSP00000230321
    ARHGAP19Q14CB83I2D: score=1 
    ARHGAP19-SLIT1Q14CB83I2D: score=1 
    TEX11Q8IYF33I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF101 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF101 (ZN101)

    Search CenterWatch for drugs/clinical trials and news about ZNF101 / ZN101

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF101 gene: 
    NM_033204.2  

    Unigene Cluster for ZNF101:

    Zinc finger protein 101
    Hs.631642  [show with all ESTs]
    Unigene Representative Sequence: AK097169
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000541458 ENST00000318110 ENST00000444249 ENST00000592502 ENST00000415784(uc010ecg.2)
    ENST00000415440(uc002nni.2 uc002nnj.2) ENST00000585565 ENST00000586745

    miRNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF101
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF101

    Additional mRNA sequence: 

    AK097169.1 AY149174.1 BC011502.1 BC094808.1 BC119680.1 BC119681.1 

    5 DOTS entries:

    DT.75163712  DT.95368838  DT.121492603  DT.121493179  DT.121425048 

    24/38 AceView cDNA sequences (see all 38):

    BP344642 AA232904 BI837762 CB148564 AI434146 BE464819 AK097169 BC011502 
    AL096747 NM_033204 AA380298 BM797078 AY149174 AK123904 BQ685360 CB069539 
    BE314293 BI838075 BF794147 BF974514 BU532885 AW847142 BE313621 W86428 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF101    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b
    SP1:                        
    SP2:                        


    ECgene alternative splicing isoforms for ZNF101

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF101 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF101 Expression
    About this image


    See ZNF101 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF101

    SOURCE GeneReport for Unigene cluster: Hs.631642

    UniProtKB/Swiss-Prot: ZN101_HUMAN, Q8IZC7
    Tissue specificity: Expressed in a variety of adult and fetal tissues

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for ZNF101 (if available)
    TreeFam Gene Tree for ZNF101 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF101 gene
    ZNF6692  ZNF5642  ZNF4902  ZNF4412  ZNF625-ZNF202  ZNF8782  ENSG000002671792  ZNF142  
    ENSG000002697552  ENSG000001968262  ZNF7002  ZNF692  ZNF4402  ZNF4432  ZNF442  ZNF4392  
    ZNF8232  ENSG000001884742  ZNF4912  ZNF5552  ENSG000002688702  ZNF7092  ZNF6252  ZNF7992  
    ZNF202  ZNF7882  ZNF7912  ZNF4422  ZNF4332  ZNF572  ZNF6272  ZNF5632  
    ENSG000002573552  ZNF1362  ZNF5562  ZNF6702  ZNF7632  ZNF1242  ENSG000002687442  ZNF6992  
    ZNF8442  ZNF772  
    18/526 SIMAP similar genes for ZNF101 using alignment to 6 protein entries:     ZN101_HUMAN (see all proteins) (see all similar genes):
    DKFZp570I0164    AVGR4    FIK    MRPS17    ZNF226    ZNF738
    ZFP90    KRBOX1    ZFP57    ZNF175    AVGR5    KRBOX4
    ZNF235    MGC12518    PMS2P3    POM121C    ZNF528    ZNF527

    ZNF101 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ZNF101
    PGOHUM00000238382 PGOHUM00000244381


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/322 SNPs in ZNF101 are shown (see all 322)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs735372621,2
    C,F--19777735(+) GCTGCA/GTATTA 1 -- us2k14Minor allele frequency- G:0.18WA CSA 124
    rs1126111351,2
    C--19777757(+) GACTTT/CGTAAA 1 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs1817815481,2
    --19777807(+) TATCAA/GATAAG 1 -- us2k10--------
    rs795328931,2
    C,F--19777852(+) TGTCCC/GATGAT 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs757808431,2
    C--19778006(+) ACGGTA/GGCTCA 1 -- us2k10--------
    rs341748181,2
    C,F--19778046(+) AAGGCG/AGGCAG 1 -- us2k13Minor allele frequency- A:0.17NA 6
    rs781411131,2
    C,F--19778090(+) TAACAC/G/TGGTGA 1 -- us2k11NA 2
    rs603593571,2
    C--19778142(+) AAAAA-/A/AA  
            
    TTGGC
    1 -- us2k11NA 2
    rs129743081,2
    C,F,A--19778155(+) GGCATG/AGTGGC 1 -- us2k13Minor allele frequency- A:0.33NA 6
    rs341887321,2
    C--19778298(+) GTCTC-/AAAAAA 1 -- us2k13Minor allele frequency- A:0.17NA CSA 6

    HapMap Linkage Disequilibrium report for ZNF101 (19779605 - 19794318 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ZNF101:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2659968CNV Deletion23128226
    nsv911310CNV Loss21882294
    nsv911309CNV Loss21882294
    nsv519533CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603983    OMIM disorders: --

    2 diseases for ZNF101:    About MalaCards
    coronary heart disease    


    ZNF101 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF101

    Export disorders for ZNF101 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF101 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with ZNF101)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study identifies novel loci as sociated with circulating phospho- and sphingolipid concentrations. (PubMed id 22359512)1, 4 Demirkan A....Schmitz G. (2012)
    2. Genetic variants influencing circulating lipid levels and risk of coronary artery disease. (PubMed id 20864672)1, 4 Waterworth D.M....Sandhu M.S. (2010)
    3. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. (PubMed id 19060911)1, 4 Aulchenko Y.S....Peltonen L. (2009)
    4. A novel Kruppel-associated box identified in a panel of mammalian zinc finger proteins. (PubMed id 14727140)1, 2 Looman C.... Abrink M. (2004)
    5. Human chromosome 19 and related regions in mouse: con servative and lineage-specific evolution. (PubMed id 11441184)1, 3 Dehal P....Stubbs L. (2001)
    6. A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells. (PubMed id 22094256)1 Anders L....Sicinski P. (2011)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (2006)
    8. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 94039 HGNC: 12881 AceView: ZNF101 Ensembl:ENSG00000181896 euGenes: HUgn94039
    ECgene: ZNF101 H-InvDB: ZNF101

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF101 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF101 gene:
    Search GeneIP for patents involving ZNF101

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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