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Aliases for ZNF101 Gene

Aliases for ZNF101 Gene

  • Zinc Finger Protein 101 2 3 5
  • Zinc Finger Protein 101 (Y2) 2 3
  • Zinc Finger Protein HZF12 3 4
  • Zinc Finger Protein 12 3
  • HZF12 3

External Ids for ZNF101 Gene

Previous GeneCards Identifiers for ZNF101 Gene

  • GC19U990121
  • GC19P019779
  • GC19P019341

Summaries for ZNF101 Gene

Entrez Gene Summary for ZNF101 Gene

  • Zinc finger proteins (ZNFs), such as ZNF101, bind nucleic acids and perform many key functions, the most important of which is regulating transcription (summary by Bellefroid et al., 1993 [PubMed 8467795]). See ZNF91 (MIM 603971) for general information on ZNFs.[supplied by OMIM, Nov 2010]

GeneCards Summary for ZNF101 Gene

ZNF101 (Zinc Finger Protein 101) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF14.

UniProtKB/Swiss-Prot for ZNF101 Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF101 Gene

Genomics for ZNF101 Gene

Regulatory Elements for ZNF101 Gene

Enhancers for ZNF101 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F019899 1 ENCODE 11.8 +233.0 233006 3.0 ATF1 PKNOX1 SIN3A ZNF2 YY1 GTF3C2 ELK1 FOS YY2 NFYC ZNF93 ZNF506 ZNF66 ZNF90 ZNF101 ATP13A1 LOC101928960 BNIP3P24 ENSG00000267268 LOC102724360
GH19F019816 1.2 Ensembl ENCODE 11.7 +150.1 150082 2.6 ZBTB33 REST SPI1 ZNF506 ATP13A1 ZNF101 HAPLN4 ENSG00000267581 ENSG00000267481
GH19F019956 1 Ensembl ENCODE 11.3 +288.6 288611 0.7 PKNOX1 POLR2A PBX2 ATP13A1 ZNF101 ENSG00000267268 ZNF93 BNIP3P12 VN1R77P
GH19F019959 0.8 Ensembl ENCODE 11.3 +291.2 291182 0.4 CTCF ZNF654 ZNF610 REST RAD21 ATP13A1 ZNF101 ENSG00000267268 BNIP3P12 VN1R77P
GH19F019774 0.5 ENCODE 11.2 +108.0 107997 3.1 HDGF CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 KLF13 LINC00663 ENSG00000267419 ZNF506 ZNF14 ATP13A1 ZNF101 ENSG00000267693
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF101 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF101 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001418408 1047 2401 PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 CBX5 ZNF143 FOS CEBPZ

Genomic Location for ZNF101 Gene

Chromosome:
19
Start:
19,668,153 bp from pter
End:
19,683,509 bp from pter
Size:
15,357 bases
Orientation:
Plus strand

Genomic View for ZNF101 Gene

Genes around ZNF101 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF101 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF101 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF101 Gene

Proteins for ZNF101 Gene

  • Protein details for ZNF101 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZC7-ZN101_HUMAN
    Recommended name:
    Zinc finger protein 101
    Protein Accession:
    Q8IZC7
    Secondary Accessions:
    • C9JU83
    • Q0VDG9

    Protein attributes for ZNF101 Gene

    Size:
    436 amino acids
    Molecular mass:
    50339 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF101 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF101 Gene

Post-translational modifications for ZNF101 Gene

  • Ubiquitination at Lys 62
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF101 Gene

No data available for DME Specific Peptides for ZNF101 Gene

Domains & Families for ZNF101 Gene

Gene Families for ZNF101 Gene

Suggested Antigen Peptide Sequences for ZNF101 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IZC7

UniProtKB/Swiss-Prot:

ZN101_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 10 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 10 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF101: view

Function for ZNF101 Gene

Molecular function for ZNF101 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF101: view
genes like me logo Genes that share phenotypes with ZNF101: view

Animal Model Products

miRNA for ZNF101 Gene

miRTarBase miRNAs that target ZNF101

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF101 Gene

Localization for ZNF101 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF101 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF101 Gene COMPARTMENTS Subcellular localization image for ZNF101 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF101: view

Pathways & Interactions for ZNF101 Gene

SuperPathways for ZNF101 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF101: view

Pathways by source for ZNF101 Gene

2 Reactome pathways for ZNF101 Gene

Gene Ontology (GO) - Biological Process for ZNF101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF101: view

No data available for SIGNOR curated interactions for ZNF101 Gene

Transcripts for ZNF101 Gene

Unigene Clusters for ZNF101 Gene

Zinc finger protein 101:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF101 Gene

ExUns: 1 ^ 2 ^ 3a · 3b
SP1:
SP2:

Relevant External Links for ZNF101 Gene

GeneLoc Exon Structure for
ZNF101
ECgene alternative splicing isoforms for
ZNF101

Expression for ZNF101 Gene

mRNA expression in normal human tissues for ZNF101 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF101 Gene

This gene is overexpressed in Whole Blood (x5.0).

Protein differential expression in normal tissues from HIPED for ZNF101 Gene

This gene is overexpressed in Breast (41.3) and Plasma (20.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF101 Gene



Protein tissue co-expression partners for ZNF101 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF101 Gene:

ZNF101

SOURCE GeneReport for Unigene cluster for ZNF101 Gene:

Hs.631642

mRNA Expression by UniProt/SwissProt for ZNF101 Gene:

Q8IZC7-ZN101_HUMAN
Tissue specificity: Expressed in a variety of adult and fetal tissues.
genes like me logo Genes that share expression patterns with ZNF101: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ZNF101 Gene

Orthologs for ZNF101 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF101 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF101 34 35
  • 99.31 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 50 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Zfp961 35
  • 36 (a)
ManyToMany
Species where no ortholog for ZNF101 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF101 Gene

ENSEMBL:
Gene Tree for ZNF101 (if available)
TreeFam:
Gene Tree for ZNF101 (if available)

Paralogs for ZNF101 Gene

(528) SIMAP similar genes for ZNF101 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for ZNF101 Gene

genes like me logo Genes that share paralogs with ZNF101: view

Variants for ZNF101 Gene

Sequence variations from dbSNP and Humsavar for ZNF101 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10401926 -- 19,681,241(+) ACCTC(A/G)GATAT utr-variant-3-prime
rs10407741 -- 19,678,274(+) GCTCA(C/T)GCCTA intron-variant
rs10410182 -- 19,673,342(+) ccttc(G/T)gggtt intron-variant
rs111279829 -- 19,681,987(+) GCACA(A/G)TCTCG utr-variant-3-prime
rs111655184 -- 19,672,233(+) GCCCA(C/G)GCTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF101 Gene

Variant ID Type Subtype PubMed ID
esv2659968 CNV deletion 23128226
esv3643854 CNV loss 21293372
nsv1160593 CNV deletion 26073780
nsv519533 CNV gain 19592680
nsv963019 CNV duplication 23825009

Variation tolerance for ZNF101 Gene

Residual Variation Intolerance Score: 78.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF101 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF101

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF101 Gene

Disorders for ZNF101 Gene

Relevant External Links for ZNF101

Genetic Association Database (GAD)
ZNF101
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF101

No disorders were found for ZNF101 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF101 Gene

Publications for ZNF101 Gene

  1. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. (PMID: 22359512) Demirkan A. … Schmitz G. (PLoS Genet. 2012) 3 46 64
  2. Genetic variants influencing circulating lipid levels and risk of coronary artery disease. (PMID: 20864672) Waterworth D.M. … Sandhu M.S. (Arterioscler. Thromb. Vasc. Biol. 2010) 3 46 64
  3. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. (PMID: 19060911) Aulchenko Y.S. … Peltonen L. (Nat. Genet. 2009) 3 46 64
  4. A novel Kruppel-associated box identified in a panel of mammalian zinc finger proteins. (PMID: 14727140) Looman C. … Abrink M. (Mamm. Genome 2004) 3 4 64
  5. Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution. (PMID: 11441184) Dehal P. … Stubbs L. (Science 2001) 2 3 64

Products for ZNF101 Gene

Sources for ZNF101 Gene

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