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ZNF101 Gene

protein-coding   GIFtS: 51
GCID: GC19P019779

Zinc Finger Protein 101

(Previous name: zinc finger protein 101 (Y2))
  Search for ZNF101
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 1011 2
Zinc Finger Protein 101 (Y2)1 2
Zinc Finger Protein HZF122 3
HZF122
Zinc Finger Protein 122

External Ids:    HGNC: 128811   Entrez Gene: 940392   Ensembl: ENSG000001818967   OMIM: 6039835   UniProtKB: Q8IZC73   

Export aliases for ZNF101 gene to outside databases

Previous GC identifers: GC19U990121 GC19P019640 GC19P019341


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZNF101 Gene:
Zinc finger proteins (ZNFs), such as ZNF101, bind nucleic acids and perform many key functions, the most important
of which is regulating transcription (summary by Bellefroid et al., 1993 (PubMed 8467795)). See ZNF91 (MIM
603971) for general information on ZNFs.(supplied by OMIM, Nov 2010)

GeneCards Summary for ZNF101 Gene:
ZNF101 (zinc finger protein 101) is a protein-coding gene. An important paralog of this gene is ZNF669.

UniProtKB/Swiss-Prot: ZN101_HUMAN, Q8IZC7
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF101 gene promoter:
         AhR   AML1a   HTF   CUTL1   Arnt   Roaz   POU2F1   POU2F1a   TGIF   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF101 promoter sequence
   Search Chromatin IP Primers for ZNF101

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF101


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.11

ZNF101 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF101 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P019779:  view genomic region     (about GC identifiers)

Start:
19,779,605 bp from pter      End:
19,794,318 bp from pter
Size:
14,714 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN101_HUMAN, Q8IZC7 (See protein sequence)
Recommended Name: Zinc finger protein 101  
Size: 436 amino acids; 50339 Da

Explore the universe of human proteins at neXtProt for ZNF101: NX_Q8IZC7

Explore proteomics data for ZNF101 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys62
  • Modification sites at PhosphoSitePlus

  • See ZNF101 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_149981.2  
    ENSEMBL proteins: 
     ENSP00000467112   ENSP00000319716   ENSP00000466697   ENSP00000468049   ENSP00000400952  
     ENSP00000466744  
    Reactome Protein details: Q8IZC7

    ZNF101 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8IZC7

    ProtoNet protein and cluster: Q8IZC7

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN101_HUMAN, Q8IZC7
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 10 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF101           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN101_HUMAN, Q8IZC7
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF101           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF101
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNF101
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZNF101

    miRNA
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    hsa-mir-1260b (MIRT052716)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN101_HUMAN, Q8IZC7: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF101           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF101 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF101           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF101
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF101
    Interactions:

        Search GeneGlobe Interaction Network for ZNF101

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for ZNF101 (Q8IZC72, 3 ENSP000003197164) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALCOCO2Q131372, 3, ENSP000002589474MINT-66786 I2D: score=4 STRING: ENSP00000258947
    MDFIQ997502, 3, ENSP000002303214MINT-68069 I2D: score=4 STRING: ENSP00000230321
    ARHGAP19Q14CB83I2D: score=1 
    TEX11Q8IYF33I2D: score=1 
    CDK4ENSP000002579044STRING: ENSP00000257904
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF101           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF101 (ZN101)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF101 gene: 
    NM_033204.2  

    Unigene Cluster for ZNF101:

    Zinc finger protein 101
    Hs.631642  [show with all ESTs]
    Unigene Representative Sequence: AK097169
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000541458 ENST00000318110 ENST00000444249 ENST00000592502 ENST00000415784(uc010ecg.2)
    ENST00000415440(uc002nni.2 uc002nnj.2) ENST00000585565 ENST00000586745

    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF101
      QuantiFast Probe-based Assays in human, mouse, rat ZNF101

    Additional mRNA sequence: 

    AK097169.1 AY149174.1 BC011502.1 BC094808.1 BC119680.1 BC119681.1 

    5 DOTS entries:

    DT.75163712  DT.95368838  DT.121492603  DT.121493179  DT.121425048 

    Selected AceView cDNA sequences (see all 38):

    BP344642 AA232904 AI434146 CB069539 BU532885 BE314293 BF794147 CB148564 
    BI837762 BM797078 BQ685360 AK097169 AL096747 BE464819 NM_033204 AK123904 
    AA380298 BI838075 BC011502 AY149174 BF974514 BX105661 W86428 AA356572 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF101    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b
    SP1:                        
    SP2:                        


    ECgene alternative splicing isoforms for ZNF101

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF101 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF101 Expression
    About this image

    ZNF101 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF101 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631642

    UniProtKB/Swiss-Prot: ZN101_HUMAN, Q8IZC7
    Tissue specificity: Expressed in a variety of adult and fetal tissues

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF101

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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      --

    ENSEMBL Gene Tree for ZNF101 (if available)
    TreeFam Gene Tree for ZNF101 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF101 gene
    ZNF6692  ZNF5642  ZNF4902  ZNF4412  ZNF625-ZNF202  ZNF8782  ENSG000002671792  ZNF142  
    ENSG000002697552  ENSG000001968262  ZNF7002  ZNF692  ZNF4402  ZNF4432  ZNF670-ZNF6952  ZNF442  
    ZNF4392  ZNF8232  ENSG000001884742  ZNF4912  ZNF5552  ENSG000002688702  ZNF7092  ZNF6252  
    ZNF7992  ZNF202  ZNF7882  ZNF7912  ZNF4422  ZNF4332  ZNF572  ZNF6272  
    ZNF5632  ENSG000002573552  ZNF1362  ZNF5562  ZNF7632  ENSG000002687442  ZNF8442  ZNF772  
    Selected SIMAP similar genes for ZNF101 using alignment to 6 protein entries:     ZN101_HUMAN (see all proteins) (see all similar genes):
    DKFZp570I0164    LOC101928664    ZNF625-ZNF20    AVGR4    FIK    MRPS17
    ZNF226    ZNF738    ZFP90    ZNF177    KRBOX1    ZFP57
    ZNF175    AVGR5    KRBOX4    ZNF235    MGC12518    PMS2P3

    Find genes that share paralogs with ZNF101           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for ZNF101
    PGOHUM00000238382 PGOHUM00000244381


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF101 (see all 322)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs735372621,2
    C,F--19777735(+) GCTGCA/GTATTA 1 -- us2k14Minor allele frequency- G:0.18WA CSA 124
    rs1126111351,2
    C--19777757(+) GACTTT/CGTAAA 1 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs1817815481,2
    --19777807(+) TATCAA/GATAAG 1 -- us2k10--------
    rs795328931,2
    C,F--19777852(+) TGTCCC/GATGAT 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs757808431,2
    C--19778006(+) ACGGTA/GGCTCA 1 -- us2k10--------
    rs341748181,2
    C,F--19778046(+) AAGGCG/AGGCAG 1 -- us2k13Minor allele frequency- A:0.17NA 6
    rs781411131,2
    C,F--19778090(+) TAACAC/G/TGGTGA 1 -- us2k11NA 2
    rs603593571,2
    C--19778142(+) AAAAA-/A/AA  
            
    TTGGC
    1 -- us2k11NA 2
    rs129743081,2
    C,F,A--19778155(+) GGCATG/AGTGGC 1 -- us2k13Minor allele frequency- A:0.33NA 6
    rs341887321,2
    C--19778298(+) GTCTC-/AAAAAA 1 -- us2k13Minor allele frequency- A:0.17NA CSA 6

    HapMap Linkage Disequilibrium report for ZNF101 (19779605 - 19794318 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ZNF101:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2659968CNV Deletion23128226
    nsv911310CNV Loss21882294
    nsv911309CNV Loss21882294
    nsv519533CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603983    OMIM disorders: --


    Find genes that share disorders with ZNF101           About GenesLikeMe

    Genetic Association Database (GAD): ZNF101

    Export disorders for ZNF101 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF101 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with ZNF101)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. (PubMed id 22359512)1, 4 Demirkan A....Schmitz G. (PLoS Genet. 2012)
    2. Genetic variants influencing circulating lipid levels and risk of coronary artery disease. (PubMed id 20864672)1, 4 Waterworth D.M....Sandhu M.S. (Arterioscler. Thromb. Vasc. Biol. 2010)
    3. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. (PubMed id 19060911)1, 4 Aulchenko Y.S....Peltonen L. (Nat. Genet. 2009)
    4. A novel Kruppel-associated box identified in a panel of mammalian zinc finger proteins. (PubMed id 14727140)1, 2 Looman C.... Abrink M. (Mamm. Genome 2004)
    5. Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution. (PubMed id 11441184)1, 3 Dehal P....Stubbs L. (Science 2001)
    6. A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells. (PubMed id 22094256)1 Anders L....Sicinski P. (Cancer Cell 2011)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (Cell 2006)
    8. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 94039 HGNC: 12881 AceView: ZNF101 Ensembl:ENSG00000181896 euGenes: HUgn94039
    ECgene: ZNF101 H-InvDB: ZNF101

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF101 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF101 gene:
    Search GeneIP for patents involving ZNF101

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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