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ZNF100 Gene

protein-coding   GIFtS: 48
GCID: GC19M021906

Zinc Finger Protein 100

(Previous name: zinc finger protein 100 (Y1))
  Search for ZNF100
at
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Aliases
for ZNF100 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 1001 2
Zinc Finger Protein 100 (Y1)1 2

External Ids:    HGNC: 128801   Entrez Gene: 1632272   Ensembl: ENSG000001970207   OMIM: 6039825   UniProtKB: Q8IYN03   

Export aliases for ZNF100 gene to outside databases

Previous GC identifers: GC19U990120 GC19M021697 GC19M021446


Summaries
for ZNF100 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF100 Gene:
ZNF100 (zinc finger protein 100) is a protein-coding gene. An important paralog of this gene is ZNF85.

UniProtKB/Swiss-Prot: ZN100_HUMAN, Q8IYN0
Function: May be involved in transcriptional regulation




Genomic Views
for ZNF100 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ZNF100
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF100 promoter sequence
   Search Chromatin IP Primers for ZNF100

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF100


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p12   Ensembl cytogenetic band:  19p12   HGNC cytogenetic band: 19p13.1

ZNF100 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF100 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M021906:  view genomic region     (about GC identifiers)

Start:
 21,905,568 bp from pter      End:
 21,950,430 bp from pter
Size:
 44,863 bases      Orientation:
 minus strand

1 alternative location:
Chr19-,NW_003315964 85,231-128,818     

Proteins
for ZNF100 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN100_HUMAN, Q8IYN0 (See protein sequence)
Recommended Name: Zinc finger protein 100  
Size: 542 amino acids; 62745 Da
Secondary accessions: Q7M4M0

Explore the universe of human proteins at neXtProt for ZNF100: NX_Q8IYN0

Explore proteomics data for ZNF100 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys12, Lys346
  • Modification sites at PhosphoSitePlus

    • See ZNF100 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_775802.2  
    ENSEMBL proteins: 
     ENSP00000351042   ENSP00000445201   ENSP00000471371   ENSP00000471057  
    Reactome Protein details: Q8IYN0

    ZNF100 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ZNF100

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    LSBio Antibodies in human, mouse, rat for ZNF100

    ZNF100 Assay Products:

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    Cloud-Clone Corp. ELISAs for ZNF100
    Cloud-Clone Corp. CLIAs for ZNF100

    Domains /
    Families
    for ZNF100 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8IYN0

    ProtoNet protein and cluster: Q8IYN0

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN100_HUMAN, Q8IYN0
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 12 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF100 for domains           About GeneDecksing


    Function
    for ZNF100 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN100_HUMAN, Q8IYN0
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    ZNF100 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF100
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    miRNA
    Products:            		miRTarBase miRNAs that target ZNF100:
    hsa-mir-378a-3p (MIRT043863)

    Block miRNA regulation of human, mouse, rat ZNF100 using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmid: ZNF100 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZNF100

    Gene Editing
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    Clone
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    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ZNF100 
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF100


    Localization
    for ZNF100 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN100_HUMAN, Q8IYN0: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF100 for ontologies           About GeneDecksing


    Pathways & Interactions
    for ZNF100 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF100 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    		Generic Transcription Pathway0.40
    		Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF100
        Generic Transcription Pathway



    ZNF100 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF100
    Interactions:

        Search GeneGlobe Interaction Network for ZNF100

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    ZNF100 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ZNF100 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF100 (ZN100)



    Transcripts
    for ZNF100 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF100 gene: 
    NM_173531.3  

    Unigene Cluster for ZNF100:

    Zinc finger protein 100
    Hs.365142  [show with all ESTs]
    Unigene Representative Sequence: BC035579
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358296(uc002nqh.3 uc002nqi.3) ENST00000305570(uc002npb.1 uc002npc.1)
    ENST00000594401 ENST00000598026 ENST00000596452
    miRNA
    Products:             		 Block miRNA regulation of human, mouse, rat ZNF100 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ZNF100
    SwitchGear 3'UTR luciferase reporter plasmid: ZNF100 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZNF100
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZNF100
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF100
      QuantiFast Probe-based Assays in human, mouse, rat ZNF100

    Additional mRNA sequence: 

    AK126551.1 AK308798.1 BC031248.1 BC035579.1 BX640982.1 

    7 DOTS entries:

    DT.95071826  DT.101976780  DT.121421774  DT.75122213  DT.100799832  DT.121421758  DT.91873758 

    Selected AceView cDNA sequences (see all 52):

    AW515912 BM466181 AA282536 H54456 BQ436588 BM471621 BX640982 AA282641 
    AA580396 CB146744 AI818947 BX414754 BC035579 BX508716 BX426165 BC031248 
    AW974553 NM_173531 BQ421861 AI818966 CD688588 AA319414 BG285112 AW300694 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF100    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
    SP1:                          -                                 
    SP2:                          -                                 
    SP3:                          -     -     -                     
    SP4:                                                            


    ECgene alternative splicing isoforms for ZNF100

    Expression
    for ZNF100 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF100 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAGACCCCT
    ZNF100 Expression
    About this image

    ZNF100 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    ZNF100 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.365142
        Custom PCR Arrays for ZNF100
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF100

    Orthologs
    for ZNF100 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF100 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 8)    		 Uncharacterized protein
    (see all 8)    		 48(a)
    39(a)
    (see all 8)    		 many ↔ many
    many ↔ many
    (see all 8)    		 AAWZ02037240(11818-13836)
    GL343434.1(292314-296903)
            Species with no ortholog for ZNF100

    ENSEMBL Gene Tree for ZNF100 (if available)
    TreeFam Gene Tree for ZNF100 (if available)

    Paralogs
    for ZNF100 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF100 gene
    ZNF852  ZNF4862  ZNF1952  ZNF922  ZNF7322  ZNF6752  ZNF1382  ZNF5062  
    ZNF662  ZNF2732  ZNF6952  ZNF6262  ZNF6802  ZNF4792  ZNF2532  ZNF932  
    ZNF6822  ZNF4922  ZNF6762  ZNF6812  ZNF1412  ZNF7362  ZNF6792  ZNF2572  
    ZNF2542  ZNF7372  ZNF724P2  ZNF982  ZNF7162  ZNF7142  ZNF4292  ZNF5192  
    ZNF4302  ZNF7302  ZNF1172  ZNF7082  ZNF4312  ZNF902  ZNF7262  ZNF7282  
    Selected SIMAP similar genes for ZNF100 using alignment to 4 protein entries:     ZN100_HUMAN (see all proteins) (see all similar genes):
    DKFZp686M04222    MGC12518    ZNF724P    ZNF273    ZNF98    ZNF257
    ZNF818P    ZNF506    ZNF90    ZNF730    ZNF430    ZNF429
    ERBB2    ZFS-6    ZNF43    ZNF492    ZNF675    ZNF738

    ZNF100 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNF100
    PGOHUM00000234606


    Genomic Variants
    for ZNF100 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF100 (see all 1048)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1435746971,2
    		C--21449069(+) ATGAA-/TTATC 
                TTATG     		1 -- ut310--------
    rs37952471,2
    		C,F,H--21906428(+) CCACAT/CGAAGA 1 -- int115Minor allele frequency- C:0.19EA NA NS CSA WA 2374
    rs1490235021,2
    		--21906466(+) TTTTCA/CATCTC 1 -- int10--------
    rs1114682211,2
    		F--21906612(+) TAGTAG/CTTACC 1 -- int12Minor allele frequency- C:0.50CSA 4
    rs345047421,2
    		C,F,H--21906655(+) ATGTCA/GACTAT 1 -- int14Minor allele frequency- G:0.01NS NA 232
    rs796810711,2
    		C,F--21906685(+) AACTAA/CAGGGC 1 -- int13Minor allele frequency- C:0.08NA 124
    rs1866284191,2
    		--21906747(+) GTAACC/TTAATA 1 -- int10--------
    rs1915220081,2
    		--21906787(+) TTGTAG/TGCACT 1 -- int10--------
    rs1840877451,2
    		--21906836(+) TCACAA/TAATGA 1 -- int10--------
    rs1888241151,2
    		--21906880(+) AAAGAC/TACAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZNF100 (21905568 - 21950430 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZNF100 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718343CNV Deletion23290073
    esv2675419CNV Deletion23128226
    dgv552e201CNV Deletion23290073
    esv2718335CNV Deletion23290073
    nsv833783CNV Loss17160897
    esv2578515CNV Loss19546169
    nsv833784CNV Loss17160897
    nsv911422CNV Loss21882294
    dgv3808n71CNV Gain21882294
    dgv3809n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF100
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    Disorders / Diseases
    for ZNF100 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus    		 OMIM gene information: 603982    OMIM disorders: --


    ZNF100 for disorders           About GeneDecksing


    Export disorders for ZNF100 gene to outside databases

    Publications
    for ZNF100 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF100 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF100)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    3. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    6. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)
    7. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. (PubMed id 8467795)1 Bellefroid E.J.... Martial J.A. (EMBO J. 1993)
    8. High-resolution localization of 69 potential human zinc finger protein genes: a number are clustered. (PubMed id 1740334)2 Hoovers J.M.N.... Little P.F.R. (Genomics 1992)

    External Searches for ZNF100 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
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    Genome Databases showing ZNF100 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 163227 HGNC: 12880 AceView: ZNF100 Ensembl:ENSG00000197020 euGenes: HUgn163227
    ECgene: ZNF100 H-InvDB: ZNF100

    Other Databases showing ZNF100 gene

    (According to HUGE)
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    Specialized Databases showing ZNF100 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF100 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ZNF100 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    TryGeneCards Plus    		Patent Information for ZNF100 gene:
    Search GeneIP for patents involving ZNF100

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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