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ZNF100 Gene

protein-coding GIFtS: 48
GCID: GC19M021906

Zinc Finger Protein 100

(Previous name: zinc finger protein 100 (Y1))

Search for ZNF100
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Zinc Finger Protein 100¹ ²
Zinc Finger Protein 100 (Y1)¹ ²

External Ids:	HGNC: 12880¹	Entrez Gene: 163227²	Ensembl: ENSG00000197020⁷	OMIM: 603982⁵	UniProtKB: Q8IYN0³

Export aliases for ZNF100 gene to outside databases

Previous GC identifers: GC19U990120 GC19M021697 GC19M021446

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF100 Gene:

ZNF100 (zinc finger protein 100) is a protein-coding gene. An important paralog of this gene is ZNF85.

UniProtKB/Swiss-Prot: ZN100_HUMAN, Q8IYN0

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000019.10 NT_011295.12 NC_018930.2

Regulatory elements:

Search for regulatory transcription factor binding sites for ZNF100
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF100 promoter sequence

Search Chromatin IP Primers for ZNF100

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF100

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p12 Ensembl cytogenetic band: 19p12 HGNC cytogenetic band: 19p13.1

ZNF100 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF100 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M021906: view genomic region (about GC identifiers)

Start:	21,905,568 bp from pter	End:	21,950,430 bp from pter
Size:	44,863 bases	Orientation:	minus strand

1 alternative location:

Chr19-,NW_003315964 85,231-128,818

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN100_HUMAN, Q8IYN0 (See protein sequence)

Recommended Name: Zinc finger protein 100

Size: 542 amino acids; 62745 Da

Secondary accessions: Q7M4M0

Explore the universe of human proteins at neXtProt for ZNF100: NX_Q8IYN0

Explore proteomics data for ZNF100 at MOPED

Post-translational modifications:

Ubiquitination² at Lys12, Lys346

Modification sites at PhosphoSitePlus

See ZNF100 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_775802.2

ENSEMBL proteins:

ENSP00000351042 ENSP00000445201 ENSP00000471371 ENSP00000471057

Reactome Protein details: Q8IYN0

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

ZNF: Zinc fingers, C2H2-type

4 InterPro protein domains:

IPR001909 Krueppel-associated_box

IPR015880 Znf_C2H2-like

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q8IYN0

ProtoNet protein and cluster: Q8IYN0

2 Blocks protein domains:

IPB001909 KRAB box

IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: ZN100_HUMAN, Q8IYN0

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 12 C2H2-type zinc fingers

Similarity: Contains 1 KRAB domain

ZNF100 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: ZN100_HUMAN, Q8IYN0

Function: May be involved in transcriptional regulation

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	IEA	--
GO:0046872	metal ion binding	IEA	--

ZNF100 for ontologies About GeneDecksing

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

ZN100_HUMAN, Q8IYN0: Nucleus (Probable)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	4
cytosol	2

About this image

Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IEA	--

ZNF100 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for ZNF100 About

See pathways by source

SuperPath

Contained pathways About

Gene Expression

Generic Transcription Pathway

0.40

Gene Expression

0.40

Pathways by source See SuperPaths
Show all pathways

1 Reactome Pathway for ZNF100

Generic Transcription Pathway

ZNF100 for pathways About GeneDecksing

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Interactions:

Search GeneGlobe Interaction Network for ZNF100

Gene Ontology (GO): 2 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-templated	IEA	--
GO:0006355	regulation of transcription, DNA-templated	IEA	--

ZNF100 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for ZNF100 gene:

NM_173531.3

Unigene Cluster for ZNF100:

Zinc finger protein 100

Hs.365142 [show with all ESTs]

Unigene Representative Sequence: BC035579

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000358296(uc002nqh.3 uc002nqi.3) ENST00000305570(uc002npb.1 uc002npc.1)

ENST00000594401 ENST00000598026 ENST00000596452

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Additional mRNA sequence:

AK126551.1 AK308798.1 BC031248.1 BC035579.1 BX640982.1

7 DOTS entries:

DT.95071826 DT.101976780 DT.121421774 DT.75122213 DT.100799832 DT.121421758 DT.91873758

Selected AceView cDNA sequences (see all 52):

AW515912 BM466181 AA282536 H54456 BQ436588 BM471621 BX640982 AA282641

AA580396 CB146744 AI818947 BX414754 BC035579 BX508716 BX426165 BC031248

AW974553 NM_173531 BQ421861 AI818966 CD688588 AA319414 BG285112 AW300694

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF100 About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6a	·	6b	·	6c
SP1:									-
SP2:									-
SP3:									-		-		-
SP4:

ECgene alternative splicing isoforms for ZNF100

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZNF100 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ATAGACCCCT

About this image

ZNF100 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

ZNF100 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.365142

Custom PCR Arrays for ZNF100

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for ZNF100 gene from Selected species (see all 6) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 8)	Uncharacterized protein (see all 8)	48(a) 39(a) (see all 8)	many ↔ many many ↔ many (see all 8)	AAWZ02037240(11818-13836) GL343434.1(292314-296903)

Species with no ortholog for ZNF100

ENSEMBL Gene Tree for ZNF100 (if available)
TreeFam Gene Tree for ZNF100 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for ZNF100 gene

ZNF85² ZNF486² ZNF195² ZNF92² ZNF732² ZNF675² ZNF138² ZNF506²

ZNF66² ZNF273² ZNF695² ZNF626² ZNF680² ZNF479² ZNF253² ZNF93²

ZNF682² ZNF492² ZNF676² ZNF681² ZNF141² ZNF736² ZNF679² ZNF257²

ZNF254² ZNF737² ZNF724P² ZNF98² ZNF716² ZNF714² ZNF429² ZNF519²

ZNF430² ZNF730² ZNF117² ZNF708² ZNF431² ZNF90² ZNF726² ZNF728²

Selected SIMAP similar genes for ZNF100 using alignment to 4 protein entries: ZN100_HUMAN (see all proteins) (see all similar genes):

DKFZp686M04222 MGC12518 ZNF724P ZNF273 ZNF98 ZNF257

ZNF818P ZNF506 ZNF90 ZNF730 ZNF430 ZNF429

ERBB2 ZFS-6 ZNF43 ZNF492 ZNF675 ZNF738

ZNF100 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for ZNF100
PGOHUM00000234606

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs143574697^1,2	C	--	21449069(+)	`ATGAA-/TTATC TTATG`	1	--	ut3¹		0	--	--	--	--
rs3795247^1,2	C,F,H	--	21906428(+)	`CCACAT/CGAAGA`	1	--	int¹		15		EA NA NS CSA WA	2374
rs149023502^1,2		--	21906466(+)	`TTTTCA/CATCTC`	1	--	int¹		0	--	--	--	--
rs111468221^1,2	F	--	21906612(+)	`TAGTAG/CTTACC`	1	--	int¹		2		CSA	4
rs34504742^1,2	C,F,H	--	21906655(+)	`ATGTCA/GACTAT`	1	--	int¹		4		NS NA	232
rs79681071^1,2	C,F	--	21906685(+)	`AACTAA/CAGGGC`	1	--	int¹		3		NA	124
rs186628419^1,2		--	21906747(+)	`GTAACC/TTAATA`	1	--	int¹		0	--	--	--	--
rs191522008^1,2		--	21906787(+)	`TTGTAG/TGCACT`	1	--	int¹		0	--	--	--	--
rs184087745^1,2		--	21906836(+)	`TCACAA/TAATGA`	1	--	int¹		0	--	--	--	--
rs188824115^1,2		--	21906880(+)	`AAAGAC/TACAAA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZNF100 (21905568 - 21950430 bp)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for ZNF100 (see all 13): About this table

Variant ID	Type	Subtype	PubMed ID
esv2718343	CNV	Deletion	23290073
esv2675419	CNV	Deletion	23128226
dgv552e201	CNV	Deletion	23290073
esv2718335	CNV	Deletion	23290073
nsv833783	CNV	Loss	17160897
esv2578515	CNV	Loss	19546169
nsv833784	CNV	Loss	17160897
nsv911422	CNV	Loss	21882294
dgv3808n71	CNV	Gain	21882294
dgv3809n71	CNV	Gain	21882294

Site Specific Mutation Identification with PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 603982 OMIM disorders: --

ZNF100 for disorders About GeneDecksing

Export disorders for ZNF100 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ZNF100 gene integrated from 10 sources:
(articles sorted by number of sources associating them with ZNF100)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (amp 2012)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (Genome Res. 2006)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)² Grimwood J.... Lucas S.M. (Nature 2004)
Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)¹ Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)
Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. (PubMed id 8467795)¹ Bellefroid E.J.... Martial J.A. (EMBO J. 1993)
High-resolution localization of 69 potential human zinc finger protein genes: a number are clustered. (PubMed id 1740334)² Hoovers J.M.N.... Little P.F.R. (Genomics 1992)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 163227	HGNC: 12880	AceView: ZNF100	Ensembl:ENSG00000197020	euGenes: HUgn163227
ECgene: ZNF100	H-InvDB: ZNF100

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ZNF100	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF100 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ZNF100 gene:
Search GeneIP for patents involving ZNF100

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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Hot genes Disease genes ZNF100 gene at Home site.

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ZNF100 Gene

Zinc Finger Protein 100

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ZNF100 Gene

Zinc Finger Protein 100

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