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ZNF10 Gene

protein-coding   GIFtS: 53
GCID: GC12P133709

Zinc Finger Protein 10

(Previous name: zinc finger protein 10 (KOX 1))
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 101 2
KOX12 3 5
Zinc Finger Protein 10 (KOX 1)1 2
Zinc Finger Protein KOX12 3

External Ids:    HGNC: 128791   Entrez Gene: 75562   Ensembl: ENSG000002562237   OMIM: 1945385   UniProtKB: P215063   

Export aliases for ZNF10 gene to outside databases

Previous GC identifers: GC12P131228 GC12P133310 GC12P131897 GC12P131392 GC12P132317 GC12P133708


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZNF10 Gene:
The protein encoded by this gene contains a C2H2 zinc finger, and has been shown to function as a transcriptional
repressor. The Kruppel-associated box (KRAB) domain of this protein is found to be responsible for its
transcriptional repression activity. RING finger containing protein TIF1 was reported to interact with the KRAB
domain, and may serve as a mediator for the repression activity of this protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for ZNF10 Gene:
ZNF10 (zinc finger protein 10) is a protein-coding gene. Diseases associated with ZNF10 include schizophrenia. An important paralog of this gene is ZNF436.

UniProtKB/Swiss-Prot: ZNF10_HUMAN, P21506
Function: May be involved in transcriptional regulation

Gene Wiki entry for ZNF10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_024477.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF10 gene promoter:
         CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF10 promoter sequence
   Search Chromatin IP Primers for ZNF10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.33   Ensembl cytogenetic band:  12q24.33   HGNC cytogenetic band: 12q24.33

ZNF10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF10 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P133709:  view genomic region     (about GC identifiers)

Start:
133,707,161 bp from pter      End:
133,736,051 bp from pter
Size:
28,891 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZNF10_HUMAN, P21506 (See protein sequence)
Recommended Name: Zinc finger protein 10  
Size: 573 amino acids; 66455 Da
Subunit: Interacts (via the KRAB domain) with TRIM28 (via the RBCC domain)
Secondary accessions: B2RBS1 Q8TC91

Explore the universe of human proteins at neXtProt for ZNF10: NX_P21506

Explore proteomics data for ZNF10 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056209.2  
    ENSEMBL proteins: 
     ENSP00000445997   ENSP00000438232   ENSP00000248211   ENSP00000443607   ENSP00000441339  
     ENSP00000393814   ENSP00000384893   ENSP00000437397  
    Reactome Protein details: P21506

    ZNF10 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P21506

    ProtoNet protein and cluster: P21506

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZNF10_HUMAN, P21506
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 11 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZNF10_HUMAN, P21506
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF10:
    zinc finger protein 10 (KOX1) (C2H2 type,Kruppel-like)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI--
    GO:0046872metal ion binding IEA--
         
    ZNF10 for ontologies           About GeneDecksing


    Animal Models:
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    hsa-miR-877* hsa-miR-7-1* hsa-miR-7-2* hsa-miR-545 hsa-miR-340 hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidZNF10 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZNF10_HUMAN, P21506: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--

    ZNF10 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF10 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF10
        Generic Transcription Pathway



    ZNF10 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF10
    Interactions:

        GeneGlobe Interaction Network for ZNF10

    4 Interacting proteins for ZNF10 (P215063) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIM28Q132633I2D: score=3 
    NDEL1Q9GZM83I2D: score=2 
    TRIM24O151643I2D: score=2 
    CBX3Q131853I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    ZNF10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF10

    1 Novoseek inferred chemical compound relationship for ZNF10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 55 4 10320774 (1), 9278146 (1), 8723389 (1)



    ZNF10 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF10 gene: 
    NM_015394.4  

    Unigene Cluster for ZNF10:

    Zinc finger protein 10
    Hs.573983  [show with all ESTs]
    Unigene Representative Sequence: BC024182
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000538918 ENST00000540609 ENST00000248211(uc009zzb.3 uc001ulq.3)
    ENST00000543271 ENST00000540927 ENST00000536704 ENST00000536877 ENST00000426665
    ENST00000402932 ENST00000537119
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate ZNF10:
    hsa-miR-877* hsa-miR-7-1* hsa-miR-7-2* hsa-miR-545 hsa-miR-340 hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidZNF10 3' UTR sequence
    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZNF10
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF10
      QuantiFast Probe-based Assays in human, mouse, rat ZNF10

    Additional mRNA sequence: 

    AK314784.1 AL110188.1 BC024182.2 X52332.1 

    13 DOTS entries:

    DT.310962  DT.40120522  DT.121213897  DT.121214075  DT.100744886  DT.121213981  DT.75116105  DT.75124016 
    DT.105968  DT.121214143  DT.100776858  DT.207392  DT.97780318 

    Selected AceView cDNA sequences (see all 72):

    BM711074 AA649047 AA374600 CB155180 BM666170 BQ954641 BC024182 AA668926 
    AI078585 NM_015394 AL110188 AI038094 AI382864 BM721456 AI373657 BX116826 
    AI972895 BU683824 BP377793 AI305171 BQ721103 AW611832 BP367323 BE550590 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCCTGCTG
    ZNF10 Expression
    About this image

    ZNF10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.573983
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF10 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF101 zinc finger protein 10 88.87(n)
    87.76(a)
      100856748  XM_005636043.1  XP_005636100.1 
    chicken
    (Gallus gallus)
    Aves --
    ZNF3026
    (see all 8)
    Uncharacterized protein
    Gallus gallus zinc finger protein 302 (ZNF302), mR...
    (see all 8)
    44(a)
    41(a)
    (see all 8)
    many ↔ many
    many ↔ many
    (see all 8)
    JH375242.1(146619-147632)
    18(30334-33130)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    27(a)
    many ↔ many
    2(189201393-189219330)


    ENSEMBL Gene Tree for ZNF10 (if available)
    TreeFam Gene Tree for ZNF10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF10 gene
    ZNF4362  ZNF1802  ZNF3222  ZNF712  ZNF5722  ZFP22  ZKSCAN72  ZNF6782  
    ZNF7742  ZFP372  ZSCAN22  ZNF8522  ZNF3292  ZNF5442  ZFP32  ZNF6062  
    ZNF5022  ZNF8352  
    Selected SIMAP similar genes for ZNF10 using alignment to 7 protein entries:     ZNF10_HUMAN (see all proteins) (see all similar genes):
    PLEKHH2    DKFZp434G1621    POM121C    ZNF350    ZNF596    ZNF83
    ZNF577    ZNF84    ZNF268    ZNF669    ZNF616    ZNF248
    ZNF738    ZNF705A    ZNF614    ZNF506    DKFZp686M04222    ZNF24

    ZNF10 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNF10
    PGOHUM00000259737


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF10 (see all 555)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1997980711,2
    --133709104(+) GTCTC-/AAAAAA 1 -- int10--------
    rs1438544701,2
    C--133709175(+) GACTC-/TTTTACT 1 -- int10--------
    rs1899508531,2
    --133709182(+) TTACTC/TTCATC 1 -- int10--------
    rs1826676661,2
    --133709189(+) CATCAG/TCAGTA 1 -- int10--------
    rs1383649581,2
    --133709366(+) TTGCTA/GACTGA 1 -- int10--------
    rs1495890111,2
    --133709402(+) TATTAC/TGAAGA 1 -- int10--------
    rs1873156171,2
    --133709442(+) GTTTAC/TAGTGA 1 -- int10--------
    rs731624691,2
    C,F--133709455(+) ACTTAT/CAAACC 1 -- int13Minor allele frequency- C:0.16WA NA EA 358
    rs2011689631,2
    C--133709497(-) ATTAGC/GTACAG 1 -- int10--------
    rs113255911,2
    C--133709556(+) TTTTT-/AAATTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for ZNF10 (133707161 - 133736051 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZNF10 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv899835CNV Loss21882294
    nsv470337CNV Loss18288195
    nsv455818CNV Loss19166990
    nsv518970CNV Gain19592680
    dgv220n27CNV Gain19166990
    nsv899836CNV Gain21882294
    nsv9050CNV Gain18304495
    esv27162CNV Gain+Loss19812545
    essv8522CNV CNV17122850
    nsv442301CNV CNV18776908

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 194538    OMIM disorders: --

    1 disease for ZNF10:    
    About MalaCards
    schizophrenia


    ZNF10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF10

    Export disorders for ZNF10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF10 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with ZNF10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PubMed id 7865130)1, 3 Abrink M.... Hellman L. (DNA Cell Biol. 1995)
    3. Chromosomal localization of 9 KOX zinc finger genes: physical linkages suggest clustering of KOX genes on chromosomes 12, 16, and 19. (PubMed id 8262519)1, 3 Rousseau-Merck M.F....Berger R. (Hum. Genet. 1993)
    4. Multiple genes encoding zinc finger domains are expressed in human T cells. (PubMed id 2288909)1, 2 Thiesen H.-J. (New Biol. 1990)
    5. Silencing of RNA polymerases II and III-dependent transcription by the KRAB protein domain of KOX1, a KrA1ppel-type zinc finger factor. (PubMed id 9278146)1, 9 Moosmann P....Schaffner W. (Biol. Chem. 1997)
    6. Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domain. (PubMed id 10748030)1, 9 Peng H....Rauscher F.J. (J. Biol. Chem. 2000)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1. (PubMed id 23665872)2 Wang W....Huang Z. (Cell. Mol. Life Sci. 2013)
    9. ZNF274 recruits the histone methyltransferase SETDB1 to the 3' ends of ZNF genes. (PubMed id 21170338)1 Frietze S.... Farnham P.J. (PLoS ONE 2010)
    10. The NIZP1 KRAB and C2HR domains cross-talk for transcriptional regulation. (PubMed id 20176155)1 Losson R. and Nielsen A.L. (Biochim. Biophys. Acta 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7556 HGNC: 12879 AceView: ZNF10 Ensembl:ENSG00000256223 euGenes: HUgn7556
    ECgene: ZNF10 H-InvDB: ZNF10

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ZNF10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF10 gene:
    Search GeneIP for patents involving ZNF10

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