ZNF10 Gene
protein-coding GIFtS: 51
GCID: GC12P133709
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zinc finger protein 10(Previous name: zinc finger protein 10 (KOX 1) )
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Aliases
for ZNF10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 101 2 | | KOX11 2 3 5 | | Zinc Finger Protein 10 (KOX 1)1 2 | | Zinc Finger Protein KOX12 3 |
Export aliases for ZNF10 gene to outside databasesPrevious GC identifers: GC12P131228 GC12P133310 GC12P131897 GC12P131392 GC12P132317 GC12P133708 |
Summaries
for ZNF10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZNF10:
The protein encoded by this gene contains a C2H2 zinc finger, and has been shown to function as a transcriptionalrepressor. The Kruppel-associated box (KRAB) domain of this protein is found to be responsible for its transcriptionalrepression activity. RING finger containing protein TIF1 was reported to interact with the KRAB domain, and may serveas a mediator for the repression activity of this protein. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: ZNF10_HUMAN, P21506Function: May be involved in transcriptional regulation
Gene Wiki entry for ZNF10
|
Genomic Views
for ZNF10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_024477.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF10 gene promoter:
CREB deltaCREB
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF10
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF10 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24.33 Ensembl cytogenetic band: 12q24.33 HGNC cytogenetic band: 12q24.33ZNF10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P133709: view genomic region
(about GC identifiers)
Start:
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133,707,161 bp from pter |
End:
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133,736,051 bp from pter |
Size:
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28,891 bases |
Orientation:
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plus strand |
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Proteins
for ZNF10 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZNF10_HUMAN, P21506 (See
protein sequence)Recommended Name: Zinc finger protein 10 Size: 573 amino acids; 66455 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: B2RBS1 Q8TC91Explore the universe of human proteins at neXtProt for ZNF10: NX_P21506
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P21506
ZNF10 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_056209.2
ENSEMBL proteins: ENSP00000445997 ENSP00000438232 ENSP00000248211 ENSP00000443607 ENSP00000441339 ENSP00000393814 ENSP00000384893 ENSP00000437397 Reactome Protein details: P21506
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF10 for ontologies About GeneDecksing
ZNF10 Antibody Products:
Assay Products for ZNF10: |
Protein
Domains /
Families
for ZNF10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF10 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P21506ProtoNet protein and cluster: P21506 2 Blocks protein families: IPB001909 KRAB box IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZNF10_HUMAN, P21506Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 11 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZNF10_HUMAN, P21506Function: May be involved in transcriptional regulation Genatlas biochemistry entry for ZNF10:zinc finger protein 10 (KOX1) (C2H2 type,Kruppel-like)
Clone
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF10 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF10 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF10
ZNF10 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZNF10
4 Interacting proteins for ZNF10 (P215063) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF10 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ZNF10 for compounds About GeneDecksing
 Browse Tocris compounds for ZNF10
1 Novoseek chemical compound relationship for ZNF10 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| zinc |
55 |
4 |
10320774 (1), 9278146 (1), 8723389 (1) |
Search CenterWatch for drugs/clinical trials and news about ZNF10
|
Transcripts
for ZNF10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF10 gene: NM_015394.4 Unigene Cluster for ZNF10: Zinc finger protein 10 Hs.744089 [show with all ESTs]Unigene Representative Sequence: BC02418210 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000538918 ENST00000540609 ENST00000248211(uc009zzb.3 uc001ulq.3)
ENST00000543271 ENST00000540927 ENST00000536704 ENST00000536877 ENST00000426665
ENST00000402932 ENST00000537119
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF10
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF10
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF10 (NM_015394) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF10 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF10 |
Additional cDNA sequence: AK314784.1 AL110188.1 BC024182.2 X52332.1 10 DOTS entries: DT.310962 DT.40120522 DT.121213897 DT.121214075 DT.100744886 DT.121213981 DT.75116105 DT.121214143 DT.75124016 DT.100776858 24/72 AceView cDNA sequences (see all 72): NM_015394 AI972895 AI078585 AI038094 AI382864 BQ721103 AL110188 BQ954641 AA668926 BC024182 BM721456 AI373657 BM666170 BX116826 CB155180 BM711074 AA649047 BP377793 AI305171 BU683824 AA374600 BX112405 AI364664 W72653
GeneLoc Exon Structure
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Expression
for ZNF10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTCCTGCTG
About this image
Genevestigator expression for ZNF10
SOURCE GeneReport for Unigene cluster: Hs.744089
SABiosciences Custom PCR Arrays for ZNF10
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF10
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF10 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF10 |
Orthologs
for ZNF10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZNF10 (if available)
TreeFam Gene Tree for ZNF10 (if available) |
Paralogs
for ZNF10 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF10 gene
- ZNF1802 ZNF3292 ZNF5442 ZNF6062
18/543 SIMAP similar genes for ZNF10 using alignment to 7 protein entries: ZNF10_HUMAN (see all proteins)
(see all similar genes):PLEKHH2 DKFZp434G1621 ZNF596 POM121C ZNF705A ZNF577
ZNF84 ZNF66 ZNF268 ZNF506 DKFZp686M04222 ZNF24
ZNF738 ZNF78L1 ZNF81 ZNF420 ZNF248 ZNF519
ZNF10 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZNF10
PGOHUM00000259737
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Genomic Variants
for ZNF10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF10 (133707161 - 133736051 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 13 variations for ZNF10
13 CNVs: 66385 86695 29933 66384 76244 76240 37673 30627 76243 53396 3002 29934 66386 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for ZNF10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF10 for disorders About GeneDecksing
OMIM gene information: 194538
OMIM disorders: --
2  diseases for ZNF10: About MalaCardsschizophrenia immunodeficiency
Export disorders for ZNF10 gene to outside databases
|
Publications
for ZNF10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF10 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with ZNF10) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PubMed id 7865130)1, 3 Abrink M.... Hellman L. (1995)
- Chromosomal localization of 9 KOX zinc finger genes: physical linkages suggest clustering of KOX genes on chromosomes 12, 16, and 19 . (PubMed id 8262519)1, 3 Rousseau-Merck M.F....Berger R. (1993)
- Multiple genes encoding zinc finger domains are expressed in human T cells. (PubMed id 2288909)1, 2 Thiesen H.-J. (1990)
- Silencing of RNA polymerases II and III-dependent transcription by the KRAB protein domain of KOX1, a Kruppel-type zinc finger factor. (PubMed id 9278146)1, 9 Moosmann P....Schaffner W. (1997)
- Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domain. (PubMed id 10748030)1, 9 Peng H....Rauscher F.J. (2000)
- ZNF274 recruits the histone methyltransferase SETDB1 to the 3' ends of ZNF genes. (PubMed id 21170338)1 Frietze S.... Farnham P.J. (2010)
- The NIZP1 KRAB and C2HR domains cross-talk for transc riptional regulation. (PubMed id 20176155)1 Losson R. and Nielsen A.L. (2010)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The structurally disordered KRAB repression domain is incorporated into a protease resistant core upon binding to KAP-1-RBCC domain. (PubMed id 17512541)1 Peng H....Rauscher F.J. (2007)
|
External Searches for ZNF10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for ZNF10 gene:
Search GeneIP for patents involving ZNF10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF10 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF10 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF10 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF10 |
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| | | | Search Tocris compounds for ZNF10 |
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 | | | ZNF10 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF10 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNF10 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF10 |
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