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Aliases for ZMYND8 Gene

Aliases for ZMYND8 Gene

  • Zinc Finger MYND-Type Containing 8 2 3 5
  • Cutaneous T-Cell Lymphoma-Associated Antigen Se14-3 3 4
  • Zinc Finger MYND Domain-Containing Protein 8 3 4
  • PRKCBP1 3 4
  • RACK7 3 4
  • Protein Kinase C Binding Protein 1 2
  • Protein Kinase C-Binding Protein 1 3
  • CTCL-Associated Antigen Se14-3 4
  • Predicted Protein Of HQ2893 3
  • CTCL Tumor Antigen Se14-3 3
  • KIAA1125 4
  • PRO2893 3

External Ids for ZMYND8 Gene

Previous HGNC Symbols for ZMYND8 Gene

  • PRKCBP1

Previous GeneCards Identifiers for ZMYND8 Gene

  • GC20M045272
  • GC20M045837
  • GC20M042581

Summaries for ZMYND8 Gene

Entrez Gene Summary for ZMYND8 Gene

  • The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZMYND8 Gene

ZMYND8 (Zinc Finger MYND-Type Containing 8) is a Protein Coding gene. Diseases associated with ZMYND8 include Cutaneous T Cell Lymphoma. Among its related pathways are Integrated Breast Cancer Pathway. GO annotations related to this gene include repressing transcription factor binding and RNA polymerase II transcription corepressor activity. An important paralog of this gene is ZMYND11.

UniProtKB/Swiss-Prot for ZMYND8 Gene

  • May act as a transcriptional corepressor for KDM5D. Required for KDM5D-mediated down-regulation of diverse metastasis-associated genes; the function seems to involve the recognition of the dual histone signature H3K4me1-H3K14ac. Suppresses prostate cancer cell invasion.

Gene Wiki entry for ZMYND8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZMYND8 Gene

Genomics for ZMYND8 Gene

Regulatory Elements for ZMYND8 Gene

Enhancers for ZMYND8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G047313 2.1 FANTOM5 Ensembl ENCODE dbSUPER 13.7 +29.2 29208 28.0 CREB3L1 MLX AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ZMYND8 RPL35AP RNU6-497P EYA2 LOC100131496 ENSG00000273451
GH20G047382 1.9 VISTA Ensembl ENCODE dbSUPER 11.9 -27.0 -27040 3.8 HDGF PKNOX1 MLX CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A DMAP1 ZMYND8 NCOA3 GC20P047395 GC20M047326
GH20G047272 1.6 Ensembl ENCODE dbSUPER 11.4 +80.8 80832 7.4 HDGF FOXA2 WRNIP1 ZFP64 ARID4B SIN3A ZNF2 ZNF143 FOS DEK ZMYND8 RPL35AP RNU6-497P TP53RK ZNF663P GC20P047290 GC20M047253
GH20G047312 1.3 Ensembl ENCODE dbSUPER 12 +44.1 44097 1.2 CTCF SOX13 SAP130 ZMYM3 ARID4B ZNF384 NFXL1 RARA SLC30A9 NR2F6 ZMYND8 GC20M047308 LOC100131496
GH20G047295 1.1 ENCODE dbSUPER 11.2 +60.5 60457 2.8 ELF3 FOXA2 ARID4B RAD21 RARA ETV6 MXD4 CEBPB REST TGIF2 ZMYND8 RPL35AP RNU6-497P GC20P047290 GC20M047308
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZMYND8 on UCSC Golden Path with GeneCards custom track

Promoters for ZMYND8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000137906 1289 801 HDAC1 ELF3 TBP FOXA2 WRNIP1 ARID4B NFXL1 DNMT3B RARA ETV6

Genomic Location for ZMYND8 Gene

Chromosome:
20
Start:
47,209,214 bp from pter
End:
47,356,889 bp from pter
Size:
147,676 bases
Orientation:
Minus strand

Genomic View for ZMYND8 Gene

Genes around ZMYND8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZMYND8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZMYND8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZMYND8 Gene

Proteins for ZMYND8 Gene

  • Protein details for ZMYND8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULU4-PKCB1_HUMAN
    Recommended name:
    Protein kinase C-binding protein 1
    Protein Accession:
    Q9ULU4
    Secondary Accessions:
    • B3KVL2
    • B7Z2A8
    • B7Z3E0
    • B7Z680
    • B7ZM62
    • E1P5U5
    • F5H0X3
    • H7C0U2
    • J3KPU3
    • Q13517
    • Q2HXV1
    • Q2HXV2
    • Q2HXV3
    • Q2HXV4
    • Q2HXV7
    • Q2HXV8
    • Q2HXV9
    • Q2HXW0
    • Q2HXW1
    • Q2HXW2
    • Q4JJ94
    • Q4JJ95
    • Q5TH09
    • Q5TH11
    • Q6MZM1
    • Q8WXC5
    • Q9H1F3
    • Q9H1F4
    • Q9H1F5
    • Q9H1L8
    • Q9H1L9
    • Q9H2G5
    • Q9NYN3
    • Q9UIX6

    Protein attributes for ZMYND8 Gene

    Size:
    1186 amino acids
    Molecular mass:
    131692 Da
    Quaternary structure:
    • Interacts in vitro with PRKCB1 (PubMed:11003709). Interacts with KDM5D and KDM1A. Interacts with histone H3 (via N-terminus) that is both methylated at Lys-4 (H3K4me1) and acetylated at Lys-14 (H3K14ac), and with histone H3 (via N-terminus) unmodified at Lys-4 (H3K4me0) and acetylated at Lys-14 (H3K14ac).
    SequenceCaution:
    • Sequence=AAC72244.1; Type=Frameshift; Positions=816; Evidence={ECO:0000305}; Sequence=BAA86439.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZMYND8 Gene

neXtProt entry for ZMYND8 Gene

Post-translational modifications for ZMYND8 Gene

  • Ubiquitination at posLast=356356
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZMYND8 Gene

Domains & Families for ZMYND8 Gene

No data available for UniProtKB/Swiss-Prot for ZMYND8 Gene

Function for ZMYND8 Gene

Molecular function for ZMYND8 Gene

UniProtKB/Swiss-Prot Function:
May act as a transcriptional corepressor for KDM5D. Required for KDM5D-mediated down-regulation of diverse metastasis-associated genes; the function seems to involve the recognition of the dual histone signature H3K4me1-H3K14ac. Suppresses prostate cancer cell invasion.

Gene Ontology (GO) - Molecular Function for ZMYND8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0001106 RNA polymerase II transcription corepressor activity ISS --
GO:0003682 chromatin binding IBA --
GO:0003712 transcription cofactor activity IBA --
GO:0005515 protein binding IPI 15095401
genes like me logo Genes that share ontologies with ZMYND8: view
genes like me logo Genes that share phenotypes with ZMYND8: view

Animal Models for ZMYND8 Gene

MGI Knock Outs for ZMYND8:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZMYND8 Gene

Localization for ZMYND8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZMYND8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZMYND8 gene
Compartment Confidence
nucleus 5
golgi apparatus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for ZMYND8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,ISS --
GO:0005737 cytoplasm IEA --
GO:0043197 dendritic spine IEA --
GO:0043198 dendritic shaft IEA --
genes like me logo Genes that share ontologies with ZMYND8: view

Pathways & Interactions for ZMYND8 Gene

genes like me logo Genes that share pathways with ZMYND8: view

Pathways by source for ZMYND8 Gene

1 BioSystems pathway for ZMYND8 Gene

Gene Ontology (GO) - Biological Process for ZMYND8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0030336 negative regulation of cell migration IMP 27477906
GO:0051491 positive regulation of filopodium assembly IEA --
GO:0060999 positive regulation of dendritic spine development IEA --
genes like me logo Genes that share ontologies with ZMYND8: view

No data available for SIGNOR curated interactions for ZMYND8 Gene

Drugs & Compounds for ZMYND8 Gene

No Compound Related Data Available

Transcripts for ZMYND8 Gene

Unigene Clusters for ZMYND8 Gene

Zinc finger, MYND-type containing 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZMYND8 Gene

No ASD Table

Relevant External Links for ZMYND8 Gene

GeneLoc Exon Structure for
ZMYND8
ECgene alternative splicing isoforms for
ZMYND8

Expression for ZMYND8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZMYND8 Gene

Protein differential expression in normal tissues from HIPED for ZMYND8 Gene

This gene is overexpressed in Adrenal (17.7), Peripheral blood mononuclear cells (16.5), and Placenta (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZMYND8 Gene



Protein tissue co-expression partners for ZMYND8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZMYND8 Gene:

ZMYND8

SOURCE GeneReport for Unigene cluster for ZMYND8 Gene:

Hs.446240

mRNA Expression by UniProt/SwissProt for ZMYND8 Gene:

Q9ULU4-PKCB1_HUMAN
Tissue specificity: Expressed in all tissues examined with highest expression in brain, lung, pancreas, and placenta. Expressed in cutaneous T-cell lymphomas (CTCL).

Evidence on tissue expression from TISSUES for ZMYND8 Gene

  • Nervous system(4.9)
  • Eye(4.3)
  • Liver(4.3)
  • Intestine(2.9)
  • Lung(2.9)
  • Skin(2.3)
genes like me logo Genes that share expression patterns with ZMYND8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZMYND8 Gene

Orthologs for ZMYND8 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZMYND8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZMYND8 34 35
  • 99.54 (n)
cow
(Bos Taurus)
Mammalia ZMYND8 34 35
  • 91.34 (n)
dog
(Canis familiaris)
Mammalia ZMYND8 34 35
  • 90.79 (n)
mouse
(Mus musculus)
Mammalia Zmynd8 34 16 35
  • 86.87 (n)
rat
(Rattus norvegicus)
Mammalia Zmynd8 34
  • 85.73 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZMYND8 35
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZMYND8 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZMYND8 34 35
  • 79.29 (n)
lizard
(Anolis carolinensis)
Reptilia ZMYND8 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zmynd8 34
  • 74.63 (n)
Str.16445 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.18946 34
zebrafish
(Danio rerio)
Actinopterygii zmynd8 34 35
  • 70.14 (n)
prkcbp1l 35
  • 64 (a)
OneToMany
wufb99d12 34
fruit fly
(Drosophila melanogaster)
Insecta CG1815 35
  • 15 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 37 (a)
OneToOne
Species where no ortholog for ZMYND8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZMYND8 Gene

ENSEMBL:
Gene Tree for ZMYND8 (if available)
TreeFam:
Gene Tree for ZMYND8 (if available)

Paralogs for ZMYND8 Gene

Paralogs for ZMYND8 Gene

genes like me logo Genes that share paralogs with ZMYND8: view

Variants for ZMYND8 Gene

Sequence variations from dbSNP and Humsavar for ZMYND8 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000010017 -- 47,237,962(+) TGAGG(C/T)TGGCT intron-variant
rs1000038465 -- 47,329,016(+) AGGGA(-/AT)TCAGC intron-variant
rs1000042682 -- 47,288,831(+) GCGTG(C/G)TCTCT intron-variant
rs1000063894 -- 47,228,988(+) TAGAT(A/G)GCTTA intron-variant
rs1000076138 -- 47,285,127(+) AACCT(A/G)CCCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZMYND8 Gene

Variant ID Type Subtype PubMed ID
esv2663936 CNV deletion 23128226
esv33497 CNV loss 17666407
esv3567997 CNV loss 25503493
esv3567999 CNV loss 25503493
esv3645968 CNV loss 21293372
esv990338 CNV deletion 20482838
nsv1061899 CNV loss 25217958
nsv1066814 CNV gain 25217958
nsv1066907 CNV gain 25217958
nsv1125728 CNV tandem duplication 24896259

Variation tolerance for ZMYND8 Gene

Residual Variation Intolerance Score: 0.946% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.09; 84.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZMYND8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZMYND8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZMYND8 Gene

Disorders for ZMYND8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZMYND8 Gene - From: GeneCards

Disorder Aliases PubMed IDs
cutaneous t cell lymphoma
  • cutaneous t-cell lymphoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZMYND8

Genetic Association Database (GAD)
ZMYND8
Human Genome Epidemiology (HuGE) Navigator
ZMYND8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZMYND8
genes like me logo Genes that share disorders with ZMYND8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZMYND8 Gene

Publications for ZMYND8 Gene

  1. Identification and characterization of PRKCBP1, a candidate RACK-like protein. (PMID: 11003709) Fossey S.C. … Bowden D.W. (Mamm. Genome 2000) 3 4 22 64
  2. ZMYND8 reads the dual histone mark H3K4me1-H3K14ac to antagonize the expression of metastasis-linked genes. (PMID: 27477906) Li N. … Lee M.G. (Mol. Cell 2016) 3 4 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for ZMYND8 Gene

Sources for ZMYND8 Gene

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