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ZMYND8 Gene

protein-coding   GIFtS: 56
GCID: GC20M045837

Zinc Finger, MYND-Type Containing 8

(Previous name: protein kinase C binding protein 1)
(Previous symbol: PRKCBP1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger, MYND-Type Containing 81 2     CTCL Tumor Antigen Se14-32
PRKCBP11 2 3 5     Predicted Protein Of HQ28932
Cutaneous T-Cell Lymphoma-Associated Antigen Se14-32 3     Protein Kinase C-Binding Protein 12
Zinc Finger MYND Domain-Containing Protein 82 3     KIAA11253
RACK72 3     Rack73
Protein Kinase C Binding Protein 11     CTCL-Associated Antigen Se14-33
PRO28932     

External Ids:    HGNC: 93971   Entrez Gene: 236132   Ensembl: ENSG000001010407   OMIM: 6157135   UniProtKB: Q9ULU43   

Export aliases for ZMYND8 gene to outside databases

Previous GC identifers: GC20M045272 GC20M042581


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZMYND8 Gene:
The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been
shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell
lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to
be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found
for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for ZMYND8 Gene:
ZMYND8 (zinc finger, MYND-type containing 8) is a protein-coding gene. GO annotations related to this gene include RNA polymerase II transcription corepressor activity and repressing transcription factor binding. An important paralog of this gene is ZMYND11.

Gene Wiki entry for ZMYND8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZMYND8 gene promoter:
         USF1   Bach2   Olf-1   E47   C/EBPalpha   CBF-B   FOXJ2 (long isoform)   USF-1   FOXJ2   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZMYND8 promoter sequence
   Search Chromatin IP Primers for ZMYND8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZMYND8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.12   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q13.12

ZMYND8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZMYND8 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M045837:  view genomic region     (about GC identifiers)

Start:
45,837,859 bp from pter      End:
45,985,567 bp from pter
Size:
147,709 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PKCB1_HUMAN, Q9ULU4 (See protein sequence)
Recommended Name: Protein kinase C-binding protein 1  
Size: 1186 amino acids; 131692 Da
Subunit: Interacts in vitro with PRKCB1
Sequence caution: Sequence=AAC72244.1; Type=Frameshift; Positions=816; Sequence=BAA86439.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened;
Secondary accessions: B7Z680 E1P5U5 Q13517 Q2HXV2 Q2HXV4 Q2HXV7 Q2HXV8 Q2HXV9 Q2HXW0 Q2HXW1
Q2HXW2 Q4JJ94 Q4JJ95 Q5TH09 Q6MZM1 Q8WXC5 Q9H1F3 Q9H1F4 Q9H1F5 Q9H1L8 Q9H1L9 Q9H2G5 Q9NYN3
Q9UIX6
Alternative splicing: 16 isoforms:  Q9ULU4-1   Q9ULU4-2   Q9ULU4-3   Q9ULU4-4   Q9ULU4-5   Q9ULU4-6   Q9ULU4-7   Q9ULU4-8   
Q9ULU4-9   Q9ULU4-10   Q9ULU4-11   Q9ULU4-12   Q9ULU4-13   Q9ULU4-14   Q9ULU4-15   Q9ULU4-16   
(No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZMYND8: NX_Q9ULU4

Explore proteomics data for ZMYND8 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys356
  • Modification sites at PhosphoSitePlus

  • See ZMYND8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (18 alternative transcripts): 
    NP_001268698.1  NP_001268700.1  NP_001268701.1  NP_001268702.1  NP_001268703.1  NP_001268704.1  NP_001268705.1  NP_001268706.1  
    NP_001268707.1  NP_001268708.1  NP_001268709.1  NP_001268710.1  NP_001268711.1  NP_001268712.1  NP_001268713.1  NP_036540.3  
    NP_898868.1  NP_898869.1  

    ENSEMBL proteins: 
     ENSP00000312237   ENSP00000354166   ENSP00000392964   ENSP00000418495   ENSP00000262975  
     ENSP00000420095   ENSP00000335537   ENSP00000418210   ENSP00000413727   ENSP00000394379  
     ENSP00000393806   ENSP00000361093   ENSP00000443086   ENSP00000439800   ENSP00000379577  
     ENSP00000348246   ENSP00000396725  

    ZMYND8 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ZMYND8

     
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    Search eBioscience for ELISAs for ZMYND8 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZMYND: Zinc fingers, MYND-type
    PHF: Zinc fingers, PHD-type

    Selected InterPro protein domains (see all 9):
     IPR002893 Znf_MYND
     IPR021931 DUF3544
     IPR001965 Znf_PHD
     IPR013083 Znf_RING/FYVE/PHD
     IPR019786 Zinc_finger_PHD-type_CS

    Graphical View of Domain Structure for InterPro Entry Q9ULU4

    ProtoNet protein and cluster: Q9ULU4

    4 Blocks protein domains:
    IPB000313 PWWP domain
    IPB001487 Bromodomain signature
    IPB001965 Zn-finger-like
    IPB002893 Zn-finger


    UniProtKB/Swiss-Prot: PKCB1_HUMAN, Q9ULU4
    Similarity: Contains 1 bromo domain
    Similarity: Contains 1 MYND-type zinc finger
    Similarity: Contains 1 PHD-type zinc finger
    Similarity: Contains 1 PWWP domain


    Find genes that share domains with ZMYND8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001106RNA polymerase II transcription corepressor activity ISS--
    GO:0005515protein binding IPI15095401
    GO:0008270zinc ion binding IEA--
    GO:0016301kinase activity ----
    GO:0070491repressing transcription factor binding ISS--
         
    Find genes that share ontologies with ZMYND8           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ZMYND8:
     Gemcitabine induced cell-death  Increased cell death HMECs cel 

         1 MGI phenotypic allele for Zmynd8 (no phenotypes)

    Find genes that share phenotypes with ZMYND8           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZMYND8
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZMYND8
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    miRNA
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    miRTarBase miRNAs that target ZMYND8:
    hsa-mir-421 (MIRT039404), hsa-mir-18a-5p (MIRT050675), hsa-mir-548d-5p (MIRT037778), hsa-mir-92a-3p (MIRT049407)

    Block miRNA regulation of human, mouse, rat ZMYND8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZMYND8 (see all 22):
    hsa-miR-30c hsa-miR-323-3p hsa-miR-142-3p hsa-miR-3607-3p hsa-let-7a-2* hsa-miR-30d hsa-miR-30a hsa-miR-204
    SwitchGear 3'UTR luciferase reporter plasmidZMYND8 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ZMYND8
    Predesigned siRNA for gene silencing in human, mouse, rat ZMYND8

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for ZMYND8 (see all 17)
    OriGene ORF clones in mouse, rat for ZMYND8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ZMYND8 (NM_183048)
    Sino Biological Human cDNA Clone for ZMYND8
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZMYND8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZMYND8

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZMYND8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1
    golgi apparatus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--

    Find genes that share ontologies with ZMYND8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZMYND8 About    
    See pathways by source

    SuperPathContained pathways About
    1Integrated Breast Cancer Pathway
    Integrated Breast Cancer Pathway


    1 BioSystems Pathway for ZMYND8
        Integrated Breast Cancer Pathway



        Pathway & Disease-focused RT2 Profiler PCR Array including ZMYND8: 
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ZMYND8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for ZMYND8 (Q9ULU41, 2, 3 ENSP000004182104) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    REREQ9P2R62, 3, ENSP000003386294MINT-2871418 I2D: score=3 STRING: ENSP00000338629
    CSNK1EP496742, 3, ENSP000003529294MINT-8252835 I2D: score=2 STRING: ENSP00000352929
    ZFYVE9O954052, 3MINT-62049 I2D: score=3 
    ATN1P542592, 3, ENSP000003490764MINT-2871399 I2D: score=3 STRING: ENSP00000349076
    USP7Q930092, 3, ENSP000003435354MINT-2871437 I2D: score=3 STRING: ENSP00000343535
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--

    Find genes that share ontologies with ZMYND8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZMYND8 (PKCB1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZMYND8 gene (18 alternative transcripts): 
    NM_001281769.1  NM_001281771.2  NM_001281772.2  NM_001281773.2  NM_001281774.2  NM_001281775.2  NM_001281776.2  NM_001281777.2  
    NM_001281778.2  NM_001281779.2  NM_001281780.2  NM_001281781.2  NM_001281782.2  NM_001281783.2  NM_001281784.2  NM_012408.5  
    NM_183047.3  NM_183048.3  

    Unigene Clusters for ZMYND8:

    Zinc finger, MYND-type containing 8
    Hs.446240  [show with all ESTs], Hs.658553  [show with all ESTs]
    Unigene Representative Sequences: NM_183047, AF144233
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311275(uc002xsu.1 uc002xsv.1 uc002xsw.1 uc002xsx.1 uc002xta.1 uc010zxy.1 uc002xtb.1 uc002xss.2 uc002xtc.1 uc002xte.1 uc010zya.1 uc002xtf.1)
    ENST00000360911(uc002xsr.1 uc010ghq.1 uc010ghr.1 uc002xst.1 uc002xsy.1 uc002xsz.1 uc010zxz.1 uc002xtd.1)
    ENST00000458360 ENST00000467200 ENST00000262975(uc002xth.3) ENST00000471951
    ENST00000352431 ENST00000461685 ENST00000468376(uc002xtg.3 uc010ghs.2)
    ENST00000435836 ENST00000446894 ENST00000441977 ENST00000372023 ENST00000540497
    ENST00000536340 ENST00000396281 ENST00000355972 ENST00000446994
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ZMYND8 (see all 22):
    hsa-miR-30c hsa-miR-323-3p hsa-miR-142-3p hsa-miR-3607-3p hsa-let-7a-2* hsa-miR-30d hsa-miR-30a hsa-miR-204
    SwitchGear 3'UTR luciferase reporter plasmidZMYND8 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZMYND8
    Clone
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    OriGene ORF clones in mouse, rat for ZMYND8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ZMYND8 (NM_183048)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZMYND8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZMYND8
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ZMYND8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZMYND8
      QuantiTect SYBR Green Assays in human, mouse, rat ZMYND8
      QuantiFast Probe-based Assays in human, mouse, rat ZMYND8

    Additional mRNA sequence: AF144233.1 

    Selected DOTS entries (see all 42):

    DT.95118374  DT.91791034  DT.91747769  DT.120796799  DT.449137  DT.101984841  DT.100031543  DT.100789643 
    DT.100789639  DT.92003694  DT.100789644  DT.311950  DT.120796814  DT.87077800  DT.100789645  DT.75101056 
    DT.102836771  DT.91664452  DT.120796912  DT.40116061  DT.95118344  DT.91663821  DT.311581  DT.91653007 

    Selected AceView cDNA sequences (see all 415):

    CN479054 CA419817 BQ644015 BF058242 BF063306 T31750 BQ010417 AA258274 
    AA405960 CA440231 AI378555 AI372878 BG944994 BI087291 Z44423 AI335671 
    BP341519 AA918361 BG119595 BP364660 CB142339 CR606493 AI214209 AW001635 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZMYND8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAACTGGAA
    ZMYND8 Expression
    About this image

    ZMYND8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZMYND8 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.446240 Hs.658553

    UniProtKB/Swiss-Prot: PKCB1_HUMAN, Q9ULU4
    Tissue specificity: Expressed in all tissues examined with highest expression in brain, lung, pancreas, and
    placenta. Expressed in cutaneous T-cell lymphomas (CTCL)

        Pathway & Disease-focused RT2 Profiler PCR Array including ZMYND8: 
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ZMYND8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZMYND8
    QuantiTect SYBR Green Assays in human, mouse, rat ZMYND8
    QuantiFast Probe-based Assays in human, mouse, rat ZMYND8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZMYND8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZMYND8 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zmynd81 , 5 zinc finger, MYND-type containing 81, 5 86.87(n)1
    90.92(a)1
      2 (85.98 cM)5
    2288801  NM_027230.51  NP_081506.31 
     1657841555 
    chicken
    (Gallus gallus)
    Aves ZMYND81 zinc finger, MYND-type containing 8 79.29(n)
    87.49(a)
      419207  XM_004947067.1  XP_004947124.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZMYND86
    zinc finger, MYND-type containing 8
    81(a)
    1 ↔ 1
    4(145055248-145107144)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.189462 Xenopus laevis transcribed sequences 81.86(n)    CA973379.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb99d122 wufb99d12 76.07(n)   323479  BC058064.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG18156
    --
    15(a)
    1 ↔ 1
    3R(27495187-27503693)


    ENSEMBL Gene Tree for ZMYND8 (if available)
    TreeFam Gene Tree for ZMYND8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZMYND8 gene
    ZMYND112  
    5 SIMAP similar genes for ZMYND8 using alignment to 13 protein entries:     PKCB1_HUMAN (see all proteins):
    DKFZp564P1772    PRKCBP1    AIRE    ZMYND11    CBFA2T1

    Find genes that share paralogs with ZMYND8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZMYND8 (see all 3180)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs45553991,2
    C,F,A,H--45837896(+) GTAAAG/AAAATC 3 -- ds50019Minor allele frequency- A:0.26NS EA NA 664
    rs1176960791,2
    F--45837922(+) GGTGGG/AGGAAG 3 -- ds50011Minor allele frequency- A:0.03EA 120
    rs113509731,2
    C--45838101(+) GGCTA-/TTTTTT 3 -- ds5001 trp32Minor allele frequency- T:0.25NA CSA 4
    rs1171018141,2
    C,F--45838134(+) AAATGT/CTCTTT 3 -- ds50011Minor allele frequency- C:0.02EA 120
    rs1449639471,2
    C--45838161(+) TAATA-/CTCTCTT 3 -- ds50010--------
    rs105525901,2
    C--45838166(+) CTCTC-/TTATTTC 3 -- ds50010--------
    rs1425992501,2
    --45838176(+) TCTTCG/TCTAAT 3 -- ds50010--------
    rs1886577561,2
    --45838380(+) CGTAGA/TGTACG 3 -- ds50010--------
    rs1910828431,2
    --45838381(+) GTAGTA/GTACGG 3 -- ut310--------
    rs1825232121,2
    --45838445(+) AAAAAC/TGTGAA 3 -- ut310--------

    HapMap Linkage Disequilibrium report for ZMYND8 (45837859 - 45985567 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ZMYND8:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2663936CNV Deletion23128226
    esv990338CNV Deletion20482838
    esv33497CNV Loss17666407

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZMYND8
    DNA2.0 Custom Variant and Variant Library Synthesis for ZMYND8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615713    OMIM disorders: --


    Find genes that share disorders with ZMYND8           About GenesLikeMe

    Genetic Association Database (GAD): ZMYND8
    Human Genome Epidemiology (HuGE) Navigator: ZMYND8 (4 documents)

    Export disorders for ZMYND8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZMYND8 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with ZMYND8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of PRKCBP1, a candidate RACK-like protein. (PubMed id 11003709)1, 2, 9 Fossey S.C....Bowden D.W. (Mamm. Genome 2000)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    7. Serological detection of cutaneous T-cell lymphoma-associated antigens. (PubMed id 11149944)1, 2 Eichmueller S....Schadendorf D. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    8. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2 Hirosawa M.... Ohara O. (DNA Res. 1999)
    9. Identification of FHOD1-binding proteins and mechanisms of FHOD1- regulated actin dynamics. (PubMed id 15095401)1, 9 Westendorf J.J. and Koka S. (J. Cell. Biochem. 2004)
    10. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23613 HGNC: 9397 AceView: PRKCBP1 Ensembl:ENSG00000101040 euGenes: HUgn23613
    ECgene: ZMYND8 H-InvDB: ZMYND8

    (According to HUGE)
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    HUGE: KIAA1125

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZMYND8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZMYND8 gene:
    Search GeneIP for patents involving ZMYND8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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