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Aliases for ZMYND8 Gene

Aliases for ZMYND8 Gene

  • Zinc Finger, MYND-Type Containing 8 2 3
  • Cutaneous T-Cell Lymphoma-Associated Antigen Se14-3 3 4
  • Zinc Finger MYND Domain-Containing Protein 8 3 4
  • PRKCBP1 3 4
  • RACK7 3 4
  • Protein Kinase C Binding Protein 1 2
  • CTCL-Associated Antigen Se14-3 4
  • Predicted Protein Of HQ2893 3
  • CTCL Tumor Antigen Se14-3 3
  • KIAA1125 4
  • PRO2893 3

External Ids for ZMYND8 Gene

Previous HGNC Symbols for ZMYND8 Gene

  • PRKCBP1

Previous GeneCards Identifiers for ZMYND8 Gene

  • GC20M045272
  • GC20M045837
  • GC20M042581

Summaries for ZMYND8 Gene

Entrez Gene Summary for ZMYND8 Gene

  • The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZMYND8 Gene

ZMYND8 (Zinc Finger, MYND-Type Containing 8) is a Protein Coding gene. Diseases associated with ZMYND8 include cutaneous t cell lymphoma. Among its related pathways are Integrated Breast Cancer Pathway. GO annotations related to this gene include repressing transcription factor binding and RNA polymerase II transcription corepressor activity. An important paralog of this gene is ZMYND11.

Gene Wiki entry for ZMYND8 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZMYND8 Gene

Genomics for ZMYND8 Gene

Regulatory Elements for ZMYND8 Gene

Genomic Location for ZMYND8 Gene

Chromosome:
20
Start:
47,209,214 bp from pter
End:
47,356,889 bp from pter
Size:
147,676 bases
Orientation:
Minus strand

Genomic View for ZMYND8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZMYND8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZMYND8 Gene

Proteins for ZMYND8 Gene

  • Protein details for ZMYND8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULU4-PKCB1_HUMAN
    Recommended name:
    Protein kinase C-binding protein 1
    Protein Accession:
    Q9ULU4
    Secondary Accessions:
    • B3KVL2
    • B7Z2A8
    • B7Z3E0
    • B7Z680
    • B7ZM62
    • E1P5U5
    • F5H0X3
    • H7C0U2
    • J3KPU3
    • Q13517
    • Q2HXV1
    • Q2HXV2
    • Q2HXV3
    • Q2HXV4
    • Q2HXV7
    • Q2HXV8
    • Q2HXV9
    • Q2HXW0
    • Q2HXW1
    • Q2HXW2
    • Q4JJ94
    • Q4JJ95
    • Q5TH09
    • Q5TH11
    • Q6MZM1
    • Q8WXC5
    • Q9H1F3
    • Q9H1F4
    • Q9H1F5
    • Q9H1L8
    • Q9H1L9
    • Q9H2G5
    • Q9NYN3
    • Q9UIX6

    Protein attributes for ZMYND8 Gene

    Size:
    1186 amino acids
    Molecular mass:
    131692 Da
    Quaternary structure:
    • Interacts in vitro with PRKCB1
    SequenceCaution:
    • Sequence=AAC72244.1; Type=Frameshift; Positions=816; Evidence={ECO:0000305}; Sequence=BAA86439.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZMYND8 Gene

neXtProt entry for ZMYND8 Gene

Proteomics data for ZMYND8 Gene at MOPED

Post-translational modifications for ZMYND8 Gene

  • Ubiquitination at Lys 356
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ZMYND8 Gene

Domains & Families for ZMYND8 Gene

Graphical View of Domain Structure for InterPro Entry

Q9ULU4

UniProtKB/Swiss-Prot:

PKCB1_HUMAN :
  • Contains 1 bromo domain.
  • Contains 1 MYND-type zinc finger.
Domain:
  • Contains 1 bromo domain.
  • Contains 1 PWWP domain.
Similarity:
  • Contains 1 MYND-type zinc finger.
  • Contains 1 PHD-type zinc finger.
genes like me logo Genes that share domains with ZMYND8: view

Function for ZMYND8 Gene

Gene Ontology (GO) - Molecular Function for ZMYND8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0001106 RNA polymerase II transcription corepressor activity ISS --
GO:0003682 chromatin binding IBA --
GO:0003712 transcription cofactor activity IBA --
GO:0005515 protein binding IPI 15095401
genes like me logo Genes that share ontologies with ZMYND8: view

Phenotypes for ZMYND8 Gene

genes like me logo Genes that share phenotypes with ZMYND8: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZMYND8

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ZMYND8 Gene

Localization for ZMYND8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZMYND8 Gene COMPARTMENTS Subcellular localization image for ZMYND8 gene
Compartment Confidence
nucleus 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for ZMYND8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
genes like me logo Genes that share ontologies with ZMYND8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZMYND8 Gene

Pathways & Interactions for ZMYND8 Gene

genes like me logo Genes that share pathways with ZMYND8: view

Pathways by source for ZMYND8 Gene

1 BioSystems pathway for ZMYND8 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ZMYND8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZMYND8: view

No data available for SIGNOR curated interactions for ZMYND8 Gene

Drugs & Compounds for ZMYND8 Gene

No Compound Related Data Available

Transcripts for ZMYND8 Gene

Unigene Clusters for ZMYND8 Gene

Zinc finger, MYND-type containing 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZMYND8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZMYND8 Gene

No ASD Table

Relevant External Links for ZMYND8 Gene

GeneLoc Exon Structure for
ZMYND8
ECgene alternative splicing isoforms for
ZMYND8

Expression for ZMYND8 Gene

mRNA expression in normal human tissues for ZMYND8 Gene

Protein differential expression in normal tissues from HIPED for ZMYND8 Gene

This gene is overexpressed in Adrenal (17.7), Peripheral blood mononuclear cells (16.5), and Placenta (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZMYND8 Gene



SOURCE GeneReport for Unigene cluster for ZMYND8 Gene Hs.446240

mRNA Expression by UniProt/SwissProt for ZMYND8 Gene

Q9ULU4-PKCB1_HUMAN
Tissue specificity: Expressed in all tissues examined with highest expression in brain, lung, pancreas, and placenta. Expressed in cutaneous T-cell lymphomas (CTCL)
genes like me logo Genes that share expression patterns with ZMYND8: view

Protein tissue co-expression partners for ZMYND8 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZMYND8 Gene

Orthologs for ZMYND8 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZMYND8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZMYND8 35
  • 91.34 (n)
  • 93.42 (a)
ZMYND8 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZMYND8 35
  • 90.79 (n)
  • 94.1 (a)
ZMYND8 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zmynd8 35
  • 86.87 (n)
  • 90.92 (a)
Zmynd8 16
Zmynd8 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZMYND8 35
  • 99.54 (n)
  • 99.35 (a)
ZMYND8 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zmynd8 35
  • 85.73 (n)
  • 89.89 (a)
oppossum
(Monodelphis domestica)
Mammalia ZMYND8 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZMYND8 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZMYND8 35
  • 79.29 (n)
  • 87.49 (a)
ZMYND8 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZMYND8 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16445 35
zmynd8 35
  • 74.63 (n)
  • 80.02 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18946 35
zebrafish
(Danio rerio)
Actinopterygii wufb99d12 35
zmynd8 35
  • 70.14 (n)
  • 73.09 (a)
prkcbp1l 36
  • 64 (a)
OneToMany
zmynd8 36
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1815 36
  • 15 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToOne
Species with no ortholog for ZMYND8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZMYND8 Gene

ENSEMBL:
Gene Tree for ZMYND8 (if available)
TreeFam:
Gene Tree for ZMYND8 (if available)

Paralogs for ZMYND8 Gene

Paralogs for ZMYND8 Gene

genes like me logo Genes that share paralogs with ZMYND8: view

Variants for ZMYND8 Gene

Sequence variations from dbSNP and Humsavar for ZMYND8 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs713164 -- 47,267,055(-) ggctc(A/G)gtaac intron-variant
rs761021 -- 47,265,215(-) AGCCC(C/T)GGTCT intron-variant
rs761022 -- 47,323,378(-) GTGGT(C/G)TTAGC intron-variant
rs910187 -- 47,212,407(+) AGAGC(A/G)AGGAC intron-variant
rs910188 -- 47,212,566(+) ATACA(C/T)GGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZMYND8 Gene

Variant ID Type Subtype PubMed ID
esv33497 CNV Loss 17666407
esv990338 CNV Deletion 20482838
esv2663936 CNV Deletion 23128226

Variation tolerance for ZMYND8 Gene

Residual Variation Intolerance Score: .95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.09; 84.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZMYND8 Gene

HapMap Linkage Disequilibrium report
ZMYND8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZMYND8 Gene

Disorders for ZMYND8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZMYND8 Gene - From: GeneCards

Disorder Aliases PubMed IDs
cutaneous t cell lymphoma
  • cutaneous t-cell lymphoma
- elite association

Relevant External Links for ZMYND8

Genetic Association Database (GAD)
ZMYND8
Human Genome Epidemiology (HuGE) Navigator
ZMYND8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZMYND8
genes like me logo Genes that share disorders with ZMYND8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZMYND8 Gene

Publications for ZMYND8 Gene

  1. Identification of FHOD1-binding proteins and mechanisms of FHOD1- regulated actin dynamics. (PMID: 15095401) Westendorf J.J. … Koka S. (J. Cell. Biochem. 2004) 23 67
  2. Identification of differentially expressed genes following treatment of monkey kidney cells with the mycotoxin fumonisin B(1). (PMID: 11259850) Zhang Y. … Dickman M.B. (Food Chem. Toxicol. 2001) 23 67
  3. Identification and characterization of PRKCBP1, a candidate RACK-like protein. (PMID: 11003709) Fossey S.C. … Bowden D.W. (Mamm. Genome 2000) 23 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination. (PMID: 25593309) Gong F. … Miller K.M. (Genes Dev. 2015) 67

Products for ZMYND8 Gene

Sources for ZMYND8 Gene

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