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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZMYND19 Gene

protein-coding   GIFtS: 47
GCID: GC09M140476

Zinc Finger, MYND-Type Containing 19

  Search for ZMYND19
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger, MYND-Type Containing 191 2     RP11-48C7.42
MIZIP2 3 5     Melanin-Concentrating Hormone Receptor 1 Interacting Zinc-Finger Protein2
Melanin-Concentrating Hormone Receptor 1-Interacting Zinc Finger Protein2 3     Zinc Finger MYND Domain-Containing Protein 192
MCH-R1-Interacting Zinc Finger Protein2 3     Zinc Finger, MYND Domain Containing 192

External Ids:    HGNC: 211461   Entrez Gene: 1162252   Ensembl: ENSG000001657247   OMIM: 6114245   UniProtKB: Q96E353   

Export aliases for ZMYND19 gene to outside databases

Previous GC identifers: GC09M133778 GC09M135695 GC09M137752 GC09M139596 GC09M109938


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZMYND19 Gene:
ZMYND19 is a MYND zinc finger domain-containing protein that binds to the C terminus of melanin-concentrating
hormone receptor-1 (MCHR1; MIM 601751) (Bachner et al., 2002 (PubMed 12208518)), and to the N termini of
alpha-tubulin (TUBA1; MIM 191110), and beta-tubulin (TUBB; MIM 191130) (Francke et al., 2005 (PubMed
16039987)).(supplied by OMIM, Mar 2008)

GeneCards Summary for ZMYND19 Gene: 
ZMYND19 (zinc finger, MYND-type containing 19) is a protein-coding gene. GO annotations related to this gene include zinc ion binding.

UniProtKB/Swiss-Prot: ZMY19_HUMAN, Q96E35
Function: May be involved as a regulatory molecule in GPR24/MCH-R1 signaling




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_024000.16  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZMYND19 gene promoter:
         Tal-1   Pbx1a   Tal-1beta   HNF-4alpha1   E47   MEF-2A   COMP1   aMEF-2   Zic3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ZMYND19

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZMYND19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34.3

ZMYND19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZMYND19 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M140476:  view genomic region     (about GC identifiers)

Start:
140,476,531 bp from pter      End:
140,484,942 bp from pter
Size:
8,412 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZMY19_HUMAN, Q96E35 (See protein sequence)
Recommended Name: Zinc finger MYND domain-containing protein 19  
Size: 227 amino acids; 26433 Da
Subunit: Interacts with GPR24/MCH-R1
Subcellular location: Cytoplasm. Cell membrane; Peripheral membrane protein
Secondary accessions: Q5T366

Explore the universe of human proteins at neXtProt for ZMYND19: NX_Q96E35

Explore proteomics data for ZMYND19 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96E35

  • ZMYND19 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZMYND19 Protein Expression
    REFSEQ proteins: NP_612471.1  
    ENSEMBL proteins: 
     ENSP00000298585  

    Human Recombinant Protein Products for ZMYND19: 
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    Cloud-Clone Corp. Proteins for ZMYND19 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005794Golgi apparatus IDA--
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0043231intracellular membrane-bounded organelle IDA--

    ZMYND19 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZMYND: Zinc fingers, MYND-type

    1 InterPro protein domain:
     IPR002893 Znf_MYND

    Graphical View of Domain Structure for InterPro Entry Q96E35

    ProtoNet protein and cluster: Q96E35

    1 Blocks protein domain: IPB002893 Zn-finger

    UniProtKB/Swiss-Prot: ZMY19_HUMAN, Q96E35
    Similarity: Contains 1 MYND-type zinc finger


    ZMYND19 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZMY19_HUMAN, Q96E35
    Function: May be involved as a regulatory molecule in GPR24/MCH-R1 signaling

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZMYND19 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZMYND19:
     Decreased homologous recombina 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZMYND19

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/10 Interacting proteins for ZMYND19 (Q96E352, 3 ENSP000002985854) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNNT1P138052, 3, ENSP000002919014MINT-67556 I2D: score=4 STRING: ENSP00000291901
    HACL1Q9UJ832, 3, ENSP000003238114MINT-66872 I2D: score=4 STRING: ENSP00000323811
    KCTD13Q8WZ192, 3, ENSP000003112024MINT-67349 I2D: score=4 STRING: ENSP00000311202
    MCHR1Q997053, ENSP000002490164I2D: score=1 STRING: ENSP00000249016
    LZTS2Q9BRK43I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZMYND19 (ZMY19)

    Search CenterWatch for drugs/clinical trials and news about ZMYND19 / ZMY19

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZMYND19 gene: 
    NM_138462.2  

    Unigene Cluster for ZMYND19:

    Zinc finger, MYND-type containing 19
    Hs.128096  [show with all ESTs]
    Unigene Representative Sequence: AK302968
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000298585(uc004cno.1) ENST00000471957
    miRNA
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    hsa-miR-548am hsa-miR-520d-5p hsa-miR-622 hsa-miR-3120-3p hsa-miR-548e hsa-miR-138-2* hsa-miR-548a-3p hsa-miR-548g
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    Inhib. RNA
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    Additional mRNA sequence: 

    AJ298882.2 AK302968.1 BC012948.1 

    4 DOTS entries:

    DT.303654  DT.95323083  DT.92008323  DT.100740106 

    24/51 AceView cDNA sequences (see all 51):

    BQ081877 AW674828 AI689230 AL565563 NM_138462 BF982885 AA340797 BC012948 
    BQ636461 BM354167 F10762 AA971179 BF341831 AW673964 BP343859 CD558046 
    BE394519 BF056889 BU147462 AA306768 AI468638 BX374142 AL534550 AI866259 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZMYND19 expression in normal human tissues (normalized intensities)      ZMYND19 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACAGTTTTT
    ZMYND19 Expression
    About this image


    ZMYND19 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/34 selected tissues (see all 34) fully expand
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Epithelium
             cervix, uterine ; squamous epithelial cells   

    See ZMYND19 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZMYND19

    SOURCE GeneReport for Unigene cluster: Hs.128096

    UniProtKB/Swiss-Prot: ZMY19_HUMAN, Q96E35
    Tissue specificity: Expressed in brain, testis, placenta, heart, liver, skeletal muscle, kidney and stomach

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZMYND19 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zmynd191 , 5 zinc finger, MYND domain containing 191, 5 90.16(n)1
    100(a)1
      2 (16.86 cM)5
    671871  NM_026021.31  NP_080297.11 
     249497925 
    chicken
    (Gallus gallus)
    Aves ZMYND191 zinc finger, MYND-type containing 19 83.99(n)
    94.71(a)
      395088  NM_204443.1  NP_989774.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZMYND196
    Uncharacterized protein
    85(a)
    1 ↔ 1
    GL344004.1(5587-11180)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.127772 Xenopus laevis mRNA for melanin-concentrating hormone more 78.04(n)    AJ488145.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zmynd192 zinc finger, MYND domain containing 19 75.08(n)   325735  BC045296.1 


    ENSEMBL Gene Tree for ZMYND19 (if available)
    TreeFam Gene Tree for ZMYND19 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZMYND19 gene

    ZMYND19 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZMYND19
    PGOHUM00000248238


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/248 SNPs in ZMYND19 are shown (see all 248)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1158430031,2
    C,F--140476115(+) ACGGAC/TGGAGA 1 -- int11Minor allele frequency- T:0.06WA 118
    rs1426689721,2
    C--140476306(+) ACAGCA/GGGCAG 1 -- int10--------
    rs736691301,2
    C--140476574(+) CTCCCG/ATGCAG 1 -- ut312Minor allele frequency- A:0.04WA 120
    rs1124376331,2
    C,F--140476980(+) ATGTGT/CGGCTC 1 -- ut311Minor allele frequency- C:0.06WA 118
    rs749641611,2
    C,F--140477032(+) GACGCA/C/TTCCTC 3 K R M mis13CSA NA EU 5872
    rs2012651141,2
    --140477048(+) ACAGTA/GCTTCT 2 H Y mis10--------
    rs1469020821,2
    C--140477055(+) TTCTTA/GTGGGC 2 H syn10--------
    rs2007964931,2
    C--140477091(+) GAGCCG/ACAGTA 2 /C syn11Minor allele frequency- A:0.00EU 1241
    rs1388977151,2
    C--140477160(+) CTGTGA/GCTTCA 1 -- int10--------
    rs1895851371,2
    --140477163(+) TGGCTA/TCACCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for ZMYND19 (140476531 - 140484942 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ZMYND19:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831762CNV Loss17160897
    nsv894502CNV Loss21882294
    dgv8462n71CNV Loss21882294
    nsv831763CNV Loss17160897
    dgv8412n71CNV Loss21882294
    nsv894387CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZMYND19 for disorders           About MalaCards
    OMIM gene information: 611424    OMIM disorders: --


    ZMYND19 for disorders           About GeneDecksing


    Export disorders for ZMYND19 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZMYND19 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZMYND19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MIZIP, a highly conserved, vertebrate specific melanin-concentrating hormone receptor 1 interacting zinc-finger protein. (PubMed id 12208518)1, 2, 9 Baechner D.... Richter D. (2002)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. MYND domain specific interaction of the melanin-concentrating hormone receptor 1 interacting zinc-finger protein with alpha- and beta-tubulin. (PubMed id 16039987)1, 9 Francke F....Bachner D. (2005)
    4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    5. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    6. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    7. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Immunohistochemical distribution of MIZIP and its co-expression with the Melanin-concentrating hormone receptor 1 in the adult rodent brain. (PubMed id 15950311)9 Francke F....Bachner D. (2005)
    10. Periplakin interferes with G protein activation by the melanin-concentrating hormone receptor-1 by binding to the proximal segment of the receptor C-terminal tail. (PubMed id 15590649)9 Murdoch H....Milligan G. (2005)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 116225 HGNC: 21146 AceView: ZMYND19 Ensembl:ENSG00000165724 euGenes: HUgn116225
    ECgene: ZMYND19 H-InvDB: ZMYND19

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZMYND19 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZMYND19 gene:
    Search GeneIP for patents involving ZMYND19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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