ZMYND19 Gene
protein-coding GIFtS: 45
GCID: GC09M140476
|
|
zinc finger, MYND-type containing 19
| |
Aliases
for ZMYND19 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger, MYND-Type Containing 191 2 | | RP11-48C7.42 | | MIZIP1 2 3 5 | | Melanin-Concentrating Hormone Receptor 1 Interacting Zinc-Finger Protein2 | | Melanin-Concentrating Hormone Receptor 1-Interacting Zinc Finger Protein2 3 | | Zinc Finger MYND Domain-Containing Protein 192 | | MCH-R1-Interacting Zinc Finger Protein2 3 | | Zinc Finger, MYND Domain Containing 192 |
Export aliases for ZMYND19 gene to outside databasesPrevious GC identifers: GC09M133778 GC09M135695 GC09M137752 GC09M139596 GC09M109938 |
Summaries
for ZMYND19 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZMYND19:
ZMYND19 is a MYND zinc finger domain-containing protein that binds to the C terminus of melanin-concentrating hormonereceptor-1 (MCHR1; MIM 601751) (Bachner et al., 2002 (PubMed 12208518)), and to the N termini of alpha-tubulin (TUBA1;MIM 191110), and beta-tubulin (TUBB; MIM 191130) (Francke et al., 2005 (PubMed 16039987)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: ZMY19_HUMAN, Q96E35Function: May be involved as a regulatory molecule in GPR24/MCH-R1 signaling
|
Genomic Views
for ZMYND19 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_024000.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZMYND19 gene promoter:
Tal-1 Pbx1a Tal-1beta HNF-4alpha1 E47 MEF-2A COMP1 aMEF-2 Zic3
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZMYND19
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZMYND19 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.3 Ensembl cytogenetic band: 9q34.3 HGNC cytogenetic band: 9q34.3ZMYND19 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M140476: view genomic region
(about GC identifiers)
Start:
|
140,476,531 bp from pter |
End:
|
140,484,942 bp from pter |
Size:
|
8,412 bases |
Orientation:
|
minus strand |
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Proteins
for ZMYND19 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZMY19_HUMAN, Q96E35 (See
protein sequence)Recommended Name: Zinc finger MYND domain-containing protein 19 Size: 227 amino acids; 26433 Da
Subunit: Interacts with GPR24/MCH-R1
Subcellular location: Cytoplasm. Cell membrane; Peripheral membrane protein
Secondary accessions: Q5T366Explore the universe of human proteins at neXtProt for ZMYND19: NX_Q96E35
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96E35
ZMYND19 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_612471.1
ENSEMBL proteins: ENSP00000298585
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
ZMYND19 for ontologies About GeneDecksing
ZMYND19 Antibody Products:
Assay Products for ZMYND19: |
Protein
Domains /
Families
for ZMYND19 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZMYND19 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96E35ProtoNet protein and cluster: Q96E35 1 Blocks protein family: IPB002893 Zn-finger
UniProtKB/Swiss-Prot: ZMY19_HUMAN, Q96E35Similarity: Contains 1 MYND-type zinc finger |
Function
for ZMYND19 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZMY19_HUMAN, Q96E35Function: May be involved as a regulatory molecule in GPR24/MCH-R1 signaling
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZMYND19 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZMYND19
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZMYND19 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
ZMYND19 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZMYND19:
|
Pathways & Interactions
for ZMYND19 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZMYND19
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/10 Interacting proteins for ZMYND19 (Q96E352, 3 ENSP000002985854) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
|
Drugs & Compounds
for ZMYND19 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZMYND19
Search CenterWatch for drugs/clinical trials and news about ZMYND19 / ZMY19
|
Transcripts
for ZMYND19 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZMYND19 gene: NM_138462.2 Unigene Cluster for ZMYND19: Zinc finger, MYND-type containing 19 Hs.128096 [show with all ESTs]Unigene Representative Sequence: AK3029682 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000298585(uc004cno.1) ENST00000471957
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZMYND19 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZMYND19
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZMYND19 (NM_138462) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZMYND19 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZMYND19 |
Additional cDNA sequence: AJ298882.2 AK302968.1 BC012948.1 4 DOTS entries: DT.303654 DT.95323083 DT.92008323 DT.100740106 24/51 AceView cDNA sequences (see all 51): AA340797 BQ081877 AL565563 BC012948 AI689230 F10762 BF982885 BQ636461 AW674828 BM354167 NM_138462 AI468638 BP343859 AA971179 AA306768 CD558046 AX766496 BF341831 AJ298882 BX374142 BF056889 F13160 BM548066 BE394519
GeneLoc Exon Structure
|
Expression
for ZMYND19 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZMYND19 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACAGTTTTT
About this image
See ZMYND19 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZMYND19
SOURCE GeneReport for Unigene cluster: Hs.128096
UniProtKB/Swiss-Prot: ZMY19_HUMAN, Q96E35Tissue specificity: Expressed in brain, testis, placenta, heart, liver, skeletal muscle, kidney and stomach
SABiosciences Custom PCR Arrays for ZMYND19
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZMYND19
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZMYND19 |
Orthologs
for ZMYND19 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZMYND19 gene from 5/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Zmynd191 , 5 |
zinc finger, MYND domain containing 191, 5 |
90.16(n)1
100(a)1 |
|
2 (16.86 cM)5
671871 NM_026021.31 NP_080297.11
249497925 |
chicken
(Gallus gallus) |
Aves |
ZMYND191 |
zinc finger, MYND-type containing 19 |
83.99(n)
94.71(a) |
|
395088 NM_204443.1 NP_989774.1 |
lizard
(Anolis carolinensis) |
Reptilia |
ZMYND196 |
-- |
95(a) |
1 ↔ 1 |
GL344004.1(6809-11180) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.127772 |
Xenopus laevis mRNA for melanin-concentrating hormone more |
78.04(n) |
|
AJ488145.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zmynd192 |
zinc finger, MYND domain containing 19 |
75.08(n) |
|
325735 BC045296.1 |
ENSEMBL Gene Tree for ZMYND19 (if available)
TreeFam Gene Tree for ZMYND19 (if available) |
Paralogs
for ZMYND19 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZMYND19 gene
ZMYND19 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZMYND19
PGOHUM00000248238
|
Genomic Variants
for ZMYND19 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZMYND19 (140476531 - 140484942 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZMYND19: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZMYND19 |
|
Disorders
/ Diseases
for ZMYND19 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ZMYND19 for disorders About MalaCards
ZMYND19 for disorders About GeneDecksing
OMIM gene information: 611424
OMIM disorders: --
Export disorders for ZMYND19 gene to outside databases
|
Publications
for ZMYND19 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZMYND19 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZMYND19) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- MIZIP, a highly conserved, vertebrate specific melanin-concentrating hormone receptor 1 interacting zinc-finger protein. (PubMed id 12208518)1, 2, 9 Baechner D.... Richter D. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- MYND domain specific interaction of the melanin-concentrating hormone receptor 1 interacting zinc-finger protein with alpha- and beta-tubulin. (PubMed id 16039987)1, 9 Francke F....Bachner D. (2005)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Immunohistochemical distribution of MIZIP and its co-expression with the Melanin-concentrating hormone receptor 1 in the adult rodent brain. (PubMed id 15950311)9 Francke F....Bachner D. (2005)
- Periplakin interferes with G protein activation by the melanin-concentrating hormone receptor-1 by binding to the proximal segment of the receptor C-terminal tail. (PubMed id 15590649)9 Murdoch H....Milligan G. (2005)
|
External Searches for ZMYND19 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZMYND19 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZMYND19 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZMYND19 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZMYND19 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZMYND19 gene:
Search GeneIP for patents involving ZMYND19
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZMYND19 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZMYND19 |
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