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Aliases for ZMYND15 Gene

Aliases for ZMYND15 Gene

  • Zinc Finger, MYND-Type Containing 15 2 3
  • Zinc Finger MYND Domain-Containing Protein 15 3
  • SPGF14 3

External Ids for ZMYND15 Gene

Previous GeneCards Identifiers for ZMYND15 Gene

  • GC17P004594
  • GC17P004850
  • GC17P004849
  • GC17P004590
  • GC17P004644
  • GC17P004531

Summaries for ZMYND15 Gene

Entrez Gene Summary for ZMYND15 Gene

  • This gene encodes a MYND-containing zinc-binding protein with a nuclear localization sequence. A similar gene in mice has been shown to act as a testis-specific transcriptional repressor by recruiting histone deacetylase enzymes to regulate spatiotemporal expression of many haploid genes. This protein may play an important role in spermatogenesis. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]

GeneCards Summary for ZMYND15 Gene

ZMYND15 (Zinc Finger, MYND-Type Containing 15) is a Protein Coding gene. Diseases associated with ZMYND15 include spermatogenic failure 14. GO annotations related to this gene include histone deacetylase binding.

UniProtKB/Swiss-Prot for ZMYND15 Gene

  • Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May be important for spermiogenesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZMYND15 Gene

Genomics for ZMYND15 Gene

Regulatory Elements for ZMYND15 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZMYND15 Gene

Start:
4,740,015 bp from pter
End:
4,746,119 bp from pter
Size:
6,105 bases
Orientation:
Plus strand

Genomic View for ZMYND15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZMYND15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZMYND15 Gene

Proteins for ZMYND15 Gene

  • Protein details for ZMYND15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H091-ZMY15_HUMAN
    Recommended name:
    Zinc finger MYND domain-containing protein 15
    Protein Accession:
    Q9H091
    Secondary Accessions:
    • B4DXY5
    • I3L296

    Protein attributes for ZMYND15 Gene

    Size:
    742 amino acids
    Molecular mass:
    81860 Da
    Quaternary structure:
    • Interacts with HDAC1, HDAC3, HDAC6 and, to a lesser extent, with HDAC7.

    Alternative splice isoforms for ZMYND15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZMYND15 Gene

Proteomics data for ZMYND15 Gene at MOPED

Post-translational modifications for ZMYND15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZMYND15 Gene

No data available for DME Specific Peptides for ZMYND15 Gene

Domains for ZMYND15 Gene

Gene Families for ZMYND15 Gene

HGNC:
  • ZMYND :Zinc fingers, MYND-type

Protein Domains for ZMYND15 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9H091

UniProtKB/Swiss-Prot:

ZMY15_HUMAN :
  • Q9H091
Similarity:
  • Contains 1 MYND-type zinc finger.
genes like me logo Genes that share domains with ZMYND15: view

Function for ZMYND15 Gene

Molecular function for ZMYND15 Gene

UniProtKB/Swiss-Prot Function: Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May be important for spermiogenesis.

Gene Ontology (GO) - Molecular Function for ZMYND15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042826 histone deacetylase binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZMYND15: view
genes like me logo Genes that share phenotypes with ZMYND15: view

Animal Models for ZMYND15 Gene

MGI Knock Outs for ZMYND15:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ZMYND15 Gene

Localization for ZMYND15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZMYND15 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZMYND15 Gene COMPARTMENTS Subcellular localization image for ZMYND15 gene
Compartment Confidence
nucleus 3
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ZMYND15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ZMYND15: view

Pathways for ZMYND15 Gene

SuperPathways for ZMYND15 Gene

No Data Available

Interacting Proteins for ZMYND15 Gene

Gene Ontology (GO) - Biological Process for ZMYND15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0007286 spermatid development IEA --
GO:0045892 negative regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZMYND15: view

No data available for Pathways by source for ZMYND15 Gene

Transcripts for ZMYND15 Gene

Unigene Clusters for ZMYND15 Gene

Zinc finger, MYND-type containing 15:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZMYND15

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZMYND15

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZMYND15 Gene

No ASD Table

Relevant External Links for ZMYND15 Gene

GeneLoc Exon Structure for
ZMYND15
ECgene alternative splicing isoforms for
ZMYND15

Expression for ZMYND15 Gene

mRNA expression in normal human tissues for ZMYND15 Gene

mRNA differential expression in normal tissues according to GTEx for ZMYND15 Gene

This gene is overexpressed in Testis (13.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ZMYND15 Gene

SOURCE GeneReport for Unigene cluster for ZMYND15 Gene Hs.47223

genes like me logo Genes that share expressions with ZMYND15: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZMYND15 Gene

Orthologs for ZMYND15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZMYND15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZMYND15 35
  • 98.7 (n)
  • 97.98 (a)
ZMYND15 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZMYND15 35
  • 87.93 (n)
  • 88.36 (a)
ZMYND15 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZMYND15 35
  • 86.36 (n)
  • 87.13 (a)
ZMYND15 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zmynd15 35
  • 83.9 (n)
  • 84.49 (a)
Zmynd15 16
Zmynd15 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZMYND15 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zmynd15 35
  • 83.83 (n)
  • 84.96 (a)
lizard
(Anolis carolinensis)
Reptilia ZMYND15 36
  • 44 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G70150 35
  • 39.29 (n)
  • 30.26 (a)
rice
(Oryza sativa)
Liliopsida Os07g0481000 35
  • 40.16 (n)
  • 32.05 (a)
Species with no ortholog for ZMYND15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZMYND15 Gene

ENSEMBL:
Gene Tree for ZMYND15 (if available)
TreeFam:
Gene Tree for ZMYND15 (if available)

Paralogs for ZMYND15 Gene

No data available for Paralogs for ZMYND15 Gene

Variants for ZMYND15 Gene

Sequence variations from dbSNP and Humsavar for ZMYND15 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2271165 -- 4,746,083(+) AAACA(C/T)GAAAA utr-variant-3-prime
rs3809848 -- 4,742,112(-) ATTTG(C/T)CTATT intron-variant
rs3826517 -- 4,742,029(-) CACAC(A/G)TGGCA synonymous-codon, reference
rs4790224 -- 4,742,769(+) GTGTG(A/G)CCTTA intron-variant
rs4790697 -- 4,742,317(+) CCACC(C/T)GCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZMYND15 Gene

Variant ID Type Subtype PubMed ID
nsv833346 CNV Loss 17160897
nsv1952 CNV Insertion 18451855

Relevant External Links for ZMYND15 Gene

HapMap Linkage Disequilibrium report
ZMYND15
Human Gene Mutation Database (HGMD)
ZMYND15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZMYND15 Gene

Disorders for ZMYND15 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ZMYND15 Gene including...

Search for ZMYND15 Gene in MalaCards »

UniProtKB/Swiss-Prot

ZMY15_HUMAN
  • Spermatogenic failure 14 (SPGF14) [MIM:615842]: A disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility. {ECO:0000269 PubMed:24431330}. Note=The disease is caused by mutations affecting the gene represented in this entry.
genes like me logo Genes that share disorders with ZMYND15: view

Publications for ZMYND15 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  2. Truncating mutations in TAF4B and ZMYND15 causing recessive azoospermia. (PMID: 24431330) Ayhan O. … Tolun A. (J. Med. Genet. 2014) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4

Products for ZMYND15 Gene

Sources for ZMYND15 Gene

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