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Aliases for ZMYND15 Gene

Aliases for ZMYND15 Gene

  • Zinc Finger MYND-Type Containing 15 2 3
  • Zinc Finger, MYND-Type Containing 15 3 5
  • SPGF14 3

External Ids for ZMYND15 Gene

Previous GeneCards Identifiers for ZMYND15 Gene

  • GC17P004594
  • GC17P004850
  • GC17P004849
  • GC17P004590
  • GC17P004644
  • GC17P004531

Summaries for ZMYND15 Gene

Entrez Gene Summary for ZMYND15 Gene

  • This gene encodes a MYND-containing zinc-binding protein with a nuclear localization sequence. A similar gene in mice has been shown to act as a testis-specific transcriptional repressor by recruiting histone deacetylase enzymes to regulate spatiotemporal expression of many haploid genes. This protein may play an important role in spermatogenesis. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]

GeneCards Summary for ZMYND15 Gene

ZMYND15 (Zinc Finger MYND-Type Containing 15) is a Protein Coding gene. Diseases associated with ZMYND15 include Spermatogenic Failure 14 and Azoospermia. GO annotations related to this gene include histone deacetylase binding.

UniProtKB/Swiss-Prot for ZMYND15 Gene

  • Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May be important for spermiogenesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZMYND15 Gene

Genomics for ZMYND15 Gene

Regulatory Elements for ZMYND15 Gene

Enhancers for ZMYND15 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZMYND15 on UCSC Golden Path with GeneCards custom track

Promoters for ZMYND15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZMYND15 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZMYND15 Gene

4,740,015 bp from pter
4,746,119 bp from pter
6,105 bases
Plus strand

Genomic View for ZMYND15 Gene

Genes around ZMYND15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZMYND15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZMYND15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZMYND15 Gene

Proteins for ZMYND15 Gene

  • Protein details for ZMYND15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger MYND domain-containing protein 15
    Protein Accession:
    Secondary Accessions:
    • B4DXY5
    • I3L296

    Protein attributes for ZMYND15 Gene

    742 amino acids
    Molecular mass:
    81860 Da
    Quaternary structure:
    • Interacts with HDAC1, HDAC3, HDAC6 and, to a lesser extent, with HDAC7.

    Alternative splice isoforms for ZMYND15 Gene


neXtProt entry for ZMYND15 Gene

Proteomics data for ZMYND15 Gene at MOPED

Post-translational modifications for ZMYND15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZMYND15 Gene

No data available for DME Specific Peptides for ZMYND15 Gene

Domains & Families for ZMYND15 Gene

Gene Families for ZMYND15 Gene

Protein Domains for ZMYND15 Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains 1 MYND-type zinc finger.
  • Contains 1 MYND-type zinc finger.
genes like me logo Genes that share domains with ZMYND15: view

Function for ZMYND15 Gene

Molecular function for ZMYND15 Gene

UniProtKB/Swiss-Prot Function:
Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May be important for spermiogenesis.
genes like me logo Genes that share phenotypes with ZMYND15: view

Human Phenotype Ontology for ZMYND15 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZMYND15 Gene

Localization for ZMYND15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZMYND15 Gene

Nucleus. Cytoplasm.

Subcellular locations from

Jensen Localization Image for ZMYND15 Gene COMPARTMENTS Subcellular localization image for ZMYND15 gene
Compartment Confidence
nucleus 5
cytosol 3
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for ZMYND15 Gene

Pathways & Interactions for ZMYND15 Gene

SuperPathways for ZMYND15 Gene

No Data Available

Interacting Proteins for ZMYND15 Gene

Gene Ontology (GO) - Biological Process for ZMYND15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007286 spermatid development IEA --
GO:0045892 negative regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZMYND15: view

No data available for Pathways by source and SIGNOR curated interactions for ZMYND15 Gene

Drugs & Compounds for ZMYND15 Gene

No Compound Related Data Available

Transcripts for ZMYND15 Gene

Unigene Clusters for ZMYND15 Gene

Zinc finger, MYND-type containing 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZMYND15 Gene

No ASD Table

Relevant External Links for ZMYND15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZMYND15 Gene

mRNA expression in normal human tissues for ZMYND15 Gene

mRNA differential expression in normal tissues according to GTEx for ZMYND15 Gene

This gene is overexpressed in Testis (x13.0).

Protein differential expression in normal tissues from HIPED for ZMYND15 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (60.0) and Liver (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZMYND15 Gene

SOURCE GeneReport for Unigene cluster for ZMYND15 Gene Hs.47223

genes like me logo Genes that share expression patterns with ZMYND15: view

Protein tissue co-expression partners for ZMYND15 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZMYND15 Gene

Orthologs for ZMYND15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZMYND15 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZMYND15 35
  • 87.93 (n)
  • 88.36 (a)
ZMYND15 36
  • 88 (a)
(Canis familiaris)
Mammalia ZMYND15 35
  • 86.36 (n)
  • 87.13 (a)
ZMYND15 36
  • 87 (a)
(Mus musculus)
Mammalia Zmynd15 35
  • 83.9 (n)
  • 84.49 (a)
Zmynd15 16
Zmynd15 36
  • 85 (a)
(Pan troglodytes)
Mammalia ZMYND15 35
  • 98.7 (n)
  • 97.98 (a)
ZMYND15 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Zmynd15 35
  • 83.83 (n)
  • 84.96 (a)
(Monodelphis domestica)
Mammalia ZMYND15 36
  • 75 (a)
(Anolis carolinensis)
Reptilia ZMYND15 36
  • 44 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G70150 35
  • 39.29 (n)
  • 30.26 (a)
(Oryza sativa)
Liliopsida Os07g0481000 35
  • 40.16 (n)
  • 32.05 (a)
Species with no ortholog for ZMYND15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZMYND15 Gene

Gene Tree for ZMYND15 (if available)
Gene Tree for ZMYND15 (if available)

Paralogs for ZMYND15 Gene

No data available for Paralogs for ZMYND15 Gene

Variants for ZMYND15 Gene

Sequence variations from dbSNP and Humsavar for ZMYND15 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs35005394 - 4,743,360(-) AGCCA(C/T)GAGTG reference, missense
rs2271165 -- 4,746,083(+) AAACA(C/T)GAAAA utr-variant-3-prime
rs4790697 -- 4,742,317(+) CCACC(C/T)GCTGT intron-variant
rs4790698 -- 4,742,699(+) GAGAG(A/C)GTGCA intron-variant
rs3809848 -- 4,742,112(-) ATTTG(C/T)CTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZMYND15 Gene

Variant ID Type Subtype PubMed ID
nsv833346 CNV Loss 17160897
nsv1952 CNV Insertion 18451855

Variation tolerance for ZMYND15 Gene

Residual Variation Intolerance Score: 31.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.66; 56.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZMYND15 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZMYND15 Gene

Disorders for ZMYND15 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZMYND15 Gene - From: OMIM, ClinVar, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
spermatogenic failure 14
  • spgf14
  • spermatogenic failure
- elite association - COSMIC cancer census association via MalaCards


  • Spermatogenic failure 14 (SPGF14) [MIM:615842]: A disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility. {ECO:0000269 PubMed:24431330}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ZMYND15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ZMYND15: view

No data available for Genatlas for ZMYND15 Gene

Publications for ZMYND15 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 67
  2. Truncating mutations in TAF4B and ZMYND15 causing recessive azoospermia. (PMID: 24431330) Ayhan O. … Tolun A. (J. Med. Genet. 2014) 3
  3. Zmynd15 encodes a histone deacetylase-dependent transcriptional repressor essential for spermiogenesis and male fertility. (PMID: 20675388) Yan W. … Charo I.F. (J. Biol. Chem. 2010) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZMYND15 Gene

Sources for ZMYND15 Gene