ZMYND15 Gene
protein-coding GIFtS: 41
GCID: GC17P004644
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zinc finger, MYND-type containing 15
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Aliases
for ZMYND15 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger, MYND-Type Containing 151 2 | | DKFZp434N1271 | | Zinc Finger MYND Domain-Containing Protein 152 | | Zinc Finger, MYND Domain Containing 152 |
Export aliases for ZMYND15 gene to outside databasesPrevious GC identifers: GC17P004594 GC17P004850 GC17P004849 GC17P004590 GC17P004531 |
Summaries
for ZMYND15 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZMYND15:
This gene encodes a MYND-containing zinc-binding protein with a nuclear localization sequence. A similar gene in micehas been shown to act as a testis-specific transcriptional repressor by recruiting histone deacetylase enzymes toregulate spatiotemporal expression of many haploid genes. This protein may play an important role in spermatogenesis.Alternative splicing results in multiple transcript variants and protein isoforms. (provided by RefSeq, Jun 2012)
UniProtKB/Swiss-Prot: ZMY15_HUMAN, Q9H091Function: Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May regulatehaploid genes important for spermiogenesis (By similarity)
|
Genomic Views
for ZMYND15 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZMYND15 gene promoter:
PPAR-gamma1 STAT3 PPAR-gamma2 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZMYND15
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZMYND15 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13.2 Ensembl cytogenetic band: 17p13.2 HGNC cytogenetic band: 17p13.3ZMYND15 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P004644: view genomic region
(about GC identifiers)
Start:
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4,643,319 bp from pter |
End:
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4,649,411 bp from pter |
Size:
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6,093 bases |
Orientation:
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plus strand |
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Proteins
for ZMYND15 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZMY15_HUMAN, Q9H091 (See
protein sequence)Recommended Name: Zinc finger MYND domain-containing protein 15 Size: 742 amino acids; 81860 Da
Subunit: Interacts with HDAC1, HDAC3, HDAC6 and, to a lesser extent, with HDAC7 (By similarity)
Subcellular location: Nucleus (By similarity). Cytoplasm (By similarity)
Secondary accessions: B4DXY5Alternative splicing: 2 isoforms: Q9H091-1 Q9H091-2 Explore the universe of human proteins at neXtProt for ZMYND15: NX_Q9H091
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H091
ZMYND15 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001129518.1 NP_001254751.1 NP_115641.1
ENSEMBL proteins: ENSP00000391742 ENSP00000465435 ENSP00000459501 ENSP00000269289
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZMYND15 for ontologies About GeneDecksing
ZMYND15 Antibody Products:
Assay Products for ZMYND15: |
Protein
Domains /
Families
for ZMYND15 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZMYND15 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9H091ProtoNet protein and cluster: Q9H091 1 Blocks protein family: IPB002893 Zn-finger
UniProtKB/Swiss-Prot: ZMY15_HUMAN, Q9H091Similarity: Contains 1 MYND-type zinc finger |
Function
for ZMYND15 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZMY15_HUMAN, Q9H091Function: Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May regulatehaploid genes important for spermiogenesis (By similarity)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZMYND15 (see all 2)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZMYND15 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- | | GO:0042826 | histone deacetylase binding |
IEA | -- |
ZMYND15 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZMYND15:
Animal Models:
Mouse knock-out Cxcl16/Zmynd15Cxcl16/tm1Ifc for ZMYND15
5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Zmynd15):
ZMYND15 for phenotypes About GeneDecksing
|
Pathways & Interactions
for ZMYND15 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZMYND15
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/6 Interacting proteins for ZMYND15 (ENSP000003917424) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0007286 | spermatid development |
IEA | -- | | GO:0045892 | negative regulation of transcription, DNA-dependent |
IEA | -- |
ZMYND15 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZMYND15 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZMYND15
Search CenterWatch for drugs/clinical trials and news about ZMYND15 / ZMY15
|
Transcripts
for ZMYND15 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZMYND15 gene (3 alternative transcripts): NM_001136046.2 NM_001267822.1 NM_032265.2 Unigene Cluster for ZMYND15: Zinc finger, MYND-type containing 15 Hs.47223 [show with all ESTs]Unigene Representative Sequence: NM_0012678226 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000433935(uc002fyv.2 uc002fyt.2) ENST00000574829 ENST00000592813
ENST00000573751(uc002fyu.2) ENST00000571782 ENST00000269289
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZMYND15 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZMYND15 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ZMYND15 (NM_032265) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZMYND15 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZMYND15 |
Additional cDNA sequence: AK302181.1 AL136893.1 BC067296.1 BC090874.1 BC136407.1 4 DOTS entries: DT.120991873 DT.75120541 DT.100673645 DT.448143 24/42 AceView cDNA sequences (see all 42): CA311658 AL136893 BM053139 AL041800 NM_032265 BM977693 BE139547 CB306761 CK904017 BC067296 BX110841 AI217394 CA455035 CA310234 BM982473 AI798209 BM839326 BX358284 AW072453 AW135938 AI769912 CA312523 AI809982 BM997985
GeneLoc Exon Structure
|
Expression
for ZMYND15 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZMYND15 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAAGGTAAA
About this image
See ZMYND15 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZMYND15
SOURCE GeneReport for Unigene cluster: Hs.47223
SABiosciences Custom PCR Arrays for ZMYND15
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZMYND15
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZMYND15 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZMYND15 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZMYND15 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZMYND15 |
Orthologs
for ZMYND15 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ZMYND15 gene from 4/11 species (see all 11) About this table
ENSEMBL Gene Tree for ZMYND15 (if available)
TreeFam Gene Tree for ZMYND15 (if available) |
Paralogs
for ZMYND15 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ZMYND15 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZMYND15 (4643319 - 4649411 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZMYND15
1 CNV: 4985 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZMYND15 |
|
Disorders
/ Diseases
for ZMYND15 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ZMYND15 for disorders About MalaCards
ZMYND15 for disorders About GeneDecksing
OMIM gene information: 614312
OMIM disorders: --
Export disorders for ZMYND15 gene to outside databases
|
Publications
for ZMYND15 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZMYND15 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZMYND15) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
- Zmynd15 encodes a histone deacetylase-dependent transc riptional repressor essential for spermiogenesis and male fertility. (PubMed id 20675388)1 Yan W....Charo I.F. (2010)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZMYND15 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing ZMYND15 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZMYND15 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZMYND15 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZMYND15 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZMYND15 gene:
Search GeneIP for patents involving ZMYND15
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZMYND15 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZMYND15 |
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