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Aliases for ZMYND15 Gene

Aliases for ZMYND15 Gene

  • Zinc Finger MYND-Type Containing 15 2 3 5
  • Zinc Finger MYND Domain-Containing Protein 15 3
  • SPGF14 3

External Ids for ZMYND15 Gene

Previous GeneCards Identifiers for ZMYND15 Gene

  • GC17P004594
  • GC17P004850
  • GC17P004849
  • GC17P004590
  • GC17P004644
  • GC17P004531

Summaries for ZMYND15 Gene

Entrez Gene Summary for ZMYND15 Gene

  • This gene encodes a MYND-containing zinc-binding protein with a nuclear localization sequence. A similar gene in mice has been shown to act as a testis-specific transcriptional repressor by recruiting histone deacetylase enzymes to regulate spatiotemporal expression of many haploid genes. This protein may play an important role in spermatogenesis. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]

GeneCards Summary for ZMYND15 Gene

ZMYND15 (Zinc Finger MYND-Type Containing 15) is a Protein Coding gene. Diseases associated with ZMYND15 include Spermatogenic Failure 14. GO annotations related to this gene include histone deacetylase binding.

UniProtKB/Swiss-Prot for ZMYND15 Gene

  • Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May be important for spermiogenesis.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZMYND15 Gene

Genomics for ZMYND15 Gene

Regulatory Elements for ZMYND15 Gene

Enhancers for ZMYND15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G004709 1.5 FANTOM5 ENCODE 25.3 -28.7 -28697 4.1 HDGF PKNOX1 FOXA2 MLX ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ARRB2 ZMYND15 C17orf107 CXCL16 MINK1 GC17M004721
GH17G004847 1.7 FANTOM5 Ensembl ENCODE dbSUPER 15 +109.6 109617 4.4 PKNOX1 ZBTB40 RAD21 RFX5 RARA RCOR1 FOS THAP11 CEBPB NR2F2 CHRNE ENO3 PFN1 ZMYND15 ARRB2 C17orf107 PLD2 CXCL16 RPS12P29 PELP1
GH17G004842 1.5 FANTOM5 Ensembl ENCODE dbSUPER 16.8 +104.5 104486 3.4 PKNOX1 HLF CEBPB GATA2 ZNF341 PBX2 EED ETV6 PRDM10 NFE2 CHRNE ARRB2 ZMYND15 CXCL16 C17orf107 PLD2 ENO3 PSMB6 RPS12P29 GLTPD2
GH17G004764 1.3 FANTOM5 Ensembl ENCODE 18.8 +25.9 25887 3.4 CTCF ZNF792 ZNF398 EP300 ATF2 ZSCAN5C PATZ1 ZBTB33 PRDM1 SPI1 ZMYND15 CXCL16 ARRB2 C17orf107 VMO1 ENSG00000262165 SCIMP MINK1 SPAG7 TM4SF5
GH17G004852 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.5 +113.6 113621 3.3 CTCF NFIB ZIC2 RAD21 ZFHX2 POLR2A ZNF547 EED PRDM10 EGR2 CHRNE MINK1 PLD2 ZMYND15 CXCL16 RNF167 SLC25A11 SPAG7 ENO3 PFN1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZMYND15 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZMYND15 Gene

Chromosome:
17
Start:
4,740,015 bp from pter
End:
4,746,119 bp from pter
Size:
6,105 bases
Orientation:
Plus strand

Genomic View for ZMYND15 Gene

Genes around ZMYND15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZMYND15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZMYND15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZMYND15 Gene

Proteins for ZMYND15 Gene

  • Protein details for ZMYND15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H091-ZMY15_HUMAN
    Recommended name:
    Zinc finger MYND domain-containing protein 15
    Protein Accession:
    Q9H091
    Secondary Accessions:
    • B4DXY5
    • I3L296

    Protein attributes for ZMYND15 Gene

    Size:
    742 amino acids
    Molecular mass:
    81860 Da
    Quaternary structure:
    • Interacts with HDAC1, HDAC3, HDAC6 and, to a lesser extent, with HDAC7.

    Alternative splice isoforms for ZMYND15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZMYND15 Gene

Post-translational modifications for ZMYND15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZMYND15 Gene

No data available for DME Specific Peptides for ZMYND15 Gene

Domains & Families for ZMYND15 Gene

Gene Families for ZMYND15 Gene

Protein Domains for ZMYND15 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZMYND15: view

No data available for UniProtKB/Swiss-Prot for ZMYND15 Gene

Function for ZMYND15 Gene

Molecular function for ZMYND15 Gene

UniProtKB/Swiss-Prot Function:
Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May be important for spermiogenesis.

Gene Ontology (GO) - Molecular Function for ZMYND15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042826 histone deacetylase binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZMYND15: view
genes like me logo Genes that share phenotypes with ZMYND15: view

Human Phenotype Ontology for ZMYND15 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZMYND15 Gene

Localization for ZMYND15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZMYND15 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZMYND15 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ZMYND15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ZMYND15: view

Pathways & Interactions for ZMYND15 Gene

SuperPathways for ZMYND15 Gene

No Data Available

Interacting Proteins for ZMYND15 Gene

Gene Ontology (GO) - Biological Process for ZMYND15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007283 spermatogenesis IEA --
GO:0007286 spermatid development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with ZMYND15: view

No data available for Pathways by source and SIGNOR curated interactions for ZMYND15 Gene

Drugs & Compounds for ZMYND15 Gene

No Compound Related Data Available

Transcripts for ZMYND15 Gene

Unigene Clusters for ZMYND15 Gene

Zinc finger, MYND-type containing 15:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZMYND15 Gene

No ASD Table

Relevant External Links for ZMYND15 Gene

GeneLoc Exon Structure for
ZMYND15
ECgene alternative splicing isoforms for
ZMYND15

Expression for ZMYND15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZMYND15 Gene

mRNA differential expression in normal tissues according to GTEx for ZMYND15 Gene

This gene is overexpressed in Testis (x13.0).

Protein differential expression in normal tissues from HIPED for ZMYND15 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (60.0) and Liver (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZMYND15 Gene



Protein tissue co-expression partners for ZMYND15 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZMYND15 Gene:

ZMYND15

SOURCE GeneReport for Unigene cluster for ZMYND15 Gene:

Hs.47223

Phenotype-based relationships between genes and organs from Gene ORGANizer for ZMYND15 Gene

Germ Layers:
  • mesoderm
Systems:
  • reproductive
Organs:
Pelvis:
  • ovary
  • testicle
genes like me logo Genes that share expression patterns with ZMYND15: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Evidence on tissue expression from TISSUES for ZMYND15 Gene

Orthologs for ZMYND15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZMYND15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZMYND15 34 35
  • 98.7 (n)
cow
(Bos Taurus)
Mammalia ZMYND15 34 35
  • 87.93 (n)
dog
(Canis familiaris)
Mammalia ZMYND15 34 35
  • 86.36 (n)
mouse
(Mus musculus)
Mammalia Zmynd15 34 16 35
  • 83.9 (n)
rat
(Rattus norvegicus)
Mammalia Zmynd15 34
  • 83.83 (n)
oppossum
(Monodelphis domestica)
Mammalia ZMYND15 35
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZMYND15 35
  • 44 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G70150 34
  • 39.29 (n)
rice
(Oryza sativa)
Liliopsida Os07g0481000 34
  • 40.16 (n)
Species where no ortholog for ZMYND15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZMYND15 Gene

ENSEMBL:
Gene Tree for ZMYND15 (if available)
TreeFam:
Gene Tree for ZMYND15 (if available)

Paralogs for ZMYND15 Gene

No data available for Paralogs for ZMYND15 Gene

Variants for ZMYND15 Gene

Sequence variations from dbSNP and Humsavar for ZMYND15 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs587777432 Pathogenic 4,744,214(+) AAACA(-/AACA)GTCAC reference, frameshift-variant
rs1000693154 -- 4,739,775(+) TGCCG(A/C/G)ACCGG upstream-variant-2KB, utr-variant-5-prime
rs1000946404 -- 4,745,422(+) CTCTT(-/A)CTCTC intron-variant
rs1001300550 -- 4,745,089(+) GTCTC(C/T)GTCCT intron-variant
rs1002086062 -- 4,740,818(+) CTGGG(A/G)GACAA upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ZMYND15 Gene

Variant ID Type Subtype PubMed ID
nsv1952 CNV insertion 18451855
nsv574273 CNV gain 21841781
nsv833346 CNV loss 17160897

Variation tolerance for ZMYND15 Gene

Residual Variation Intolerance Score: 31.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.66; 56.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZMYND15 Gene

Human Gene Mutation Database (HGMD)
ZMYND15
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZMYND15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZMYND15 Gene

Disorders for ZMYND15 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZMYND15 Gene - From: OMIM, ClinVar, and GeneCards

Disorder Aliases PubMed IDs
spermatogenic failure 14
  • spgf14
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

ZMY15_HUMAN
  • Spermatogenic failure 14 (SPGF14) [MIM:615842]: A disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility. {ECO:0000269 PubMed:24431330}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ZMYND15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZMYND15
genes like me logo Genes that share disorders with ZMYND15: view

No data available for Genatlas for ZMYND15 Gene

Publications for ZMYND15 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 64
  2. Truncating mutations in TAF4B and ZMYND15 causing recessive azoospermia. (PMID: 24431330) Ayhan O. … Tolun A. (J. Med. Genet. 2014) 3 4 64
  3. Zmynd15 encodes a histone deacetylase-dependent transcriptional repressor essential for spermiogenesis and male fertility. (PMID: 20675388) Yan W. … Charo I.F. (J. Biol. Chem. 2010) 3 64
  4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64

Products for ZMYND15 Gene

Sources for ZMYND15 Gene

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