ZMYND12 Gene
protein-coding GIFtS: 40
GCID: GC01M042896
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|
zinc finger, MYND-type containing 12
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Aliases
for ZMYND12 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger, MYND-Type Containing 121 2 | | DKFZp434N24351 | | Zinc Finger MYND Domain-Containing Protein 122 | | Zinc Finger, MYND Domain Containing 122 |
Export aliases for ZMYND12 gene to outside databasesPrevious GC identifers: GC01M042359 GC01M042309 GC01M042565 GC01M042668 GC01M041016 |
Summaries
for ZMYND12 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ZMYND12 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZMYND12 gene promoter:
Elk-1 RFX1 SREBP-1c CUTL1 SREBP-1b YY1 HEN1 SREBP-1a Pax-4a En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZMYND12
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZMYND12 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p34.2 Ensembl cytogenetic band: 1p34.2 HGNC cytogenetic band: 1p34.1ZMYND12 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M042896: view genomic region
(about GC identifiers)
Start:
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42,896,000 bp from pter |
End:
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42,921,938 bp from pter |
Size:
|
25,939 bases |
Orientation:
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minus strand |
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Proteins
for ZMYND12 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZMY12_HUMAN, Q9H0C1 (See
protein sequence)Recommended Name: Zinc finger MYND domain-containing protein 12 Size: 365 amino acids; 41818 Da
Secondary accessions: Q5VUS6 Q8TC87 Q96M51Explore the universe of human proteins at neXtProt for ZMYND12: NX_Q9H0C1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H0C1
ZMYND12 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001139664.1 NP_115633.3
ENSEMBL proteins: ENSP00000361646 ENSP00000398340
Human Recombinant Protein Products for ZMYND12:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IDA | -- |
ZMYND12 for ontologies About GeneDecksing
ZMYND12 Antibody Products:
Assay Products for ZMYND12: |
Protein
Domains /
Families
for ZMYND12 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZMYND12 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H0C1ProtoNet protein and cluster: Q9H0C1 1 Blocks protein family: IPB002893 Zn-finger
UniProtKB/Swiss-Prot: ZMY12_HUMAN, Q9H0C1Similarity: Contains 1 MYND-type zinc fingerSimilarity: Contains 2 TPR repeats |
Function
for ZMYND12 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
ZMYND12 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZMYND12 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZMYND12 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for ZMYND12 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZMYND12 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZMYND12 |
|
Pathways & Interactions
for ZMYND12 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZMYND12
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for ZMYND12 (ENSP000003616464) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for ZMYND12 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZMYND12
Search CenterWatch for drugs/clinical trials and news about ZMYND12 / ZMY12
|
Transcripts
for ZMYND12 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZMYND12 gene (2 alternative transcripts): NM_001146192.1 NM_032257.4 Unigene Cluster for ZMYND12: Zinc finger, MYND-type containing 12 Hs.294009 [show with all ESTs]Unigene Representative Sequence: NM_0322574 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372565(uc001chj.3 uc010ojt.2) ENST00000475426 ENST00000461083
ENST00000433602
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZMYND12 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZMYND12 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ZMYND12 (NM_032257) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZMYND12 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZMYND12 |
Additional cDNA sequence: AK057384.1 AK301839.1 AL136858.1 BC024186.2 4 DOTS entries: DT.309714 DT.97806178 DT.92418932 DT.95374028 24/60 AceView cDNA sequences (see all 60): AW473200 AI474319 AI350648 AA644135 BM988201 AI025700 AI024816 AA644419 BU785749 AL040261 BQ271103 AL042693 BF434102 BC024186 BG121027 BG721793 BI602269 BM543918 AW662748 AI682240 AA906838 AW235944 AI800230 AI027500
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for ZMYND12 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 |
|---|
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| SP1: | | | | | | | - | | | | | | | | | | | | - | | | | | | - | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZMYND12
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Expression
for ZMYND12 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZMYND12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGGCCCTCA
About this image
See ZMYND12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZMYND12
SOURCE GeneReport for Unigene cluster: Hs.294009
SABiosciences Custom PCR Arrays for ZMYND12
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZMYND12
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZMYND12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZMYND12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZMYND12 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZMYND12 |
Orthologs
for ZMYND12 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZMYND12 gene from 4/16 species (see all 16) About this table
ENSEMBL Gene Tree for ZMYND12 (if available)
TreeFam Gene Tree for ZMYND12 (if available) |
Paralogs
for ZMYND12 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ZMYND12 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZMYND12 (42896000 - 42921938 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZMYND12: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZMYND12 |
|
Disorders
/ Diseases
for ZMYND12 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZMYND12 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZMYND12 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZMYND12) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)1 Simpson J.C.... Wiemann S. (2000)
|
External Searches for ZMYND12 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZMYND12 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZMYND12 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZMYND12 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZMYND12 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZMYND12 gene:
Search GeneIP for patents involving ZMYND12
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZMYND12 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZMYND12 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZMYND12 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZMYND12 | | | OriGene Protein Over-expression Lysate for ZMYND12 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZMYND12 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZMYND12 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZMYND12 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ZMYND12 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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 | | | ZMYND12 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZMYND12 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZMYND12 |
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