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ZMYND12 Gene

protein-coding   GIFtS: 42
GCID: GC01M042896

Zinc Finger, MYND-Type Containing 12

  Search for ZMYND12
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger, MYND-Type Containing 121 2
Zinc Finger MYND Domain-Containing Protein 122
Zinc Finger, MYND Domain Containing 122

External Ids:    HGNC: 211921   Entrez Gene: 842172   Ensembl: ENSG000000661857   UniProtKB: Q9H0C13   

Export aliases for ZMYND12 gene to outside databases

Previous GC identifers: GC01M042359 GC01M042309 GC01M042565 GC01M042668 GC01M041016


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZMYND12 Gene:
ZMYND12 (zinc finger, MYND-type containing 12) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZMYND12 gene promoter:
         Elk-1   RFX1   SREBP-1c   CUTL1   SREBP-1b   YY1   HEN1   SREBP-1a   Pax-4a   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZMYND12 promoter sequence
   Search Chromatin IP Primers for ZMYND12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZMYND12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.2   Ensembl cytogenetic band:  1p34.2   HGNC cytogenetic band: 1p34.1

ZMYND12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZMYND12 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M042896:  view genomic region     (about GC identifiers)

Start:
42,896,000 bp from pter      End:
42,921,938 bp from pter
Size:
25,939 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZMY12_HUMAN, Q9H0C1 (See protein sequence)
Recommended Name: Zinc finger MYND domain-containing protein 12  
Size: 365 amino acids; 41818 Da
Secondary accessions: Q5VUS6 Q8TC87 Q96M51

Explore the universe of human proteins at neXtProt for ZMYND12: NX_Q9H0C1

Explore proteomics data for ZMYND12 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZMYND12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001139664.1  NP_115633.3  

    ENSEMBL proteins: 
     ENSP00000361646   ENSP00000398340  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZMYND: Zinc fingers, MYND-type

    3 InterPro protein domains:
     IPR002893 Znf_MYND
     IPR011990 TPR-like_helical
     IPR013105 TPR_2

    Graphical View of Domain Structure for InterPro Entry Q9H0C1

    ProtoNet protein and cluster: Q9H0C1

    1 Blocks protein domain: IPB002893 Zn-finger

    UniProtKB/Swiss-Prot: ZMY12_HUMAN, Q9H0C1
    Similarity: Contains 1 MYND-type zinc finger
    Similarity: Contains 2 TPR repeats


    Find genes that share domains with ZMYND12           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZMYND12           About GenesLikeMe


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidZMYND12 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--

    Find genes that share ontologies with ZMYND12           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZMYND12
    Interactions:

        Search GeneGlobe Interaction Network for ZMYND12

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for ZMYND12 (ENSP000003616464) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000237582ENSP000003916814STRING: ENSP00000391681
    FOXJ3ENSP000003546204STRING: ENSP00000354620
    GUCA2BENSP000003616624STRING: ENSP00000361662
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZMYND12 (ZMY12)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZMYND12 gene (2 alternative transcripts): 
    NM_001146192.1  NM_032257.4  

    Unigene Cluster for ZMYND12:

    Zinc finger, MYND-type containing 12
    Hs.294009  [show with all ESTs]
    Unigene Representative Sequence: NM_032257
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372565(uc001chj.3 uc010ojt.2) ENST00000475426 ENST00000461083
    ENST00000433602
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate ZMYND12:
    hsa-miR-520d-5p hsa-miR-1245 hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmidZMYND12 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat ZMYND12

    Additional mRNA sequence: 

    AK057384.1 AK301839.1 AL136858.1 BC024186.2 

    4 DOTS entries:

    DT.309714  DT.97806178  DT.92418932  DT.95374028 

    Selected AceView cDNA sequences (see all 60):

    AA644135 AW473200 AI350648 BM988201 AI474319 AA448554 AA644419 BQ271103 
    BI559736 AI798225 AI024816 AI025700 AI245326 BI602269 BU785749 AL042693 
    AI745121 AW662748 BG717618 BG721793 BU785445 BC024186 BI559715 BI827964 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZMYND12    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9
    SP1:                    -                                   -                 -         
    SP2:                    -                                                               
    SP3:                                                                                    
    SP4:                                                                                    


    ECgene alternative splicing isoforms for ZMYND12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZMYND12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGGCCCTCA
    ZMYND12 Expression
    About this image

    ZMYND12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZMYND12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.294009
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZMYND12 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zmynd121 , 5 zinc finger, MYND domain containing 121, 5 83.89(n)1
    83.06(a)1
      4 (55.38 cM)5
    3329341  NM_001014900.21  NP_001014900.21 
     1194228145 
    chicken
    (Gallus gallus)
    Aves ZMYND121 zinc finger, MYND-type containing 12 60.54(n)
    52.65(a)
      419510  XM_417661.4  XP_417661.4 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.33322 Transcribed sequences 71.73(n)    CF221010.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zymnd121 zinc finger, MYND-type containing 12 51.5(n)
    41.62(a)
      492338  NM_001007304.1  NP_001007305.1 


    ENSEMBL Gene Tree for ZMYND12 (if available)
    TreeFam Gene Tree for ZMYND12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZMYND12 (see all 545)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1862849171,2
    --42895604(+) TTCAGA/GATGCC 2 -- int10--------
    rs1915539031,2
    --42895618(+) CCCCTA/GGACTG 2 -- int10--------
    rs1154568951,2
    C--42895706(+) CCATAC/TTGAAG 2 -- int10--------
    rs1834167341,2
    --42895950(+) TCTACC/TTCAGA 2 -- int10--------
    rs1879013591,2
    --42896285(+) GCAATA/CCCAGG 2 -- ut310--------
    rs1439316311,2
    C,F--42896432(+) CAGTTG/TAAATG 4 * S stg11Minor allele frequency- T:0.00NA 4550
    rs413010521,2
    C,F--42896441(+) TGAGAC/ATTAAT 4 /S /I mis14Minor allele frequency- A:0.02NA EU 5996
    rs1500812591,2
    C--42896459(+) GAATGA/GTGCTT 4 T I mis10--------
    rs74151781,2
    C,H--42896460(+) AATGGT/GGCTTT 4 /T /P mis17Minor allele frequency- G:0.00NS EA NA 584
    rs740684311,2
    C,F--42896540(+) ATAGAA/GTTGCA 2 -- int13Minor allele frequency- G:0.06WA CSA 122

    HapMap Linkage Disequilibrium report for ZMYND12 (42896000 - 42921938 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZMYND12:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv870704CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZMYND12
    DNA2.0 Custom Variant and Variant Library Synthesis for ZMYND12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZMYND12 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZMYND12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)1 Simpson J.C.... Wiemann S. (EMBO Rep. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84217 HGNC: 21192 AceView: ZMYND12 Ensembl:ENSG00000066185 euGenes: HUgn84217
    ECgene: ZMYND12 H-InvDB: ZMYND12

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZMYND12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZMYND12 gene:
    Search GeneIP for patents involving ZMYND12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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