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ZMYND11 Gene

protein-coding   GIFtS: 55
GCID: GC10P000170

Zinc Finger, MYND-Type Containing 11

(Previous names: zinc finger, MYND domain containing 11)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger, MYND-Type Containing 111 2     BRAM12
Adenovirus 5 E1A-Binding Protein2 3     Bone Morphogenetic Protein Receptor-Associated Molecule 12
BS692 3     Zinc Finger MYND Domain-Containing Protein 112
Zinc Finger, MYND Domain Containing 111     Protein BS693

External Ids:    HGNC: 169661   Entrez Gene: 107712   Ensembl: ENSG000000151717   OMIM: 6086685   UniProtKB: Q153263   

Export aliases for ZMYND11 gene to outside databases

Previous GC identifer: GC10P000144


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZMYND11 Gene:
The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The
protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits
this repression. Alternatively spliced transcript variants encoding different isoforms have been identified.
(provided by RefSeq, Jul 2008)

GeneCards Summary for ZMYND11 Gene:
ZMYND11 (zinc finger, MYND-type containing 11) is a protein-coding gene. An important paralog of this gene is ZMYND8.

UniProtKB/Swiss-Prot: ZMY11_HUMAN, Q15326
Function: Corepressor of transcription (Probable). May be involved in chromatin remodeling through association
with several remodeling factors

Gene Wiki entry for ZMYND11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_008705.17  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZMYND11 gene promoter:
         N-Myc   PPAR-gamma1   GATA-6   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   PPAR-gamma2   POU3F2   NF-kappaB1   Gfi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZMYND11 promoter sequence
   Search Chromatin IP Primers for ZMYND11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZMYND11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p14   Ensembl cytogenetic band:  10p15.3   HGNC cytogenetic band: 10p14

ZMYND11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZMYND11 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P000170:  view genomic region     (about GC identifiers)

Start:
180,405 bp from pter      End:
300,577 bp from pter
Size:
120,173 bases      Orientation:
plus strand

1 alternative location:
Chr10+,NW_003571043 124,465-147,861     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZMY11_HUMAN, Q15326 (See protein sequence)
Recommended Name: Zinc finger MYND domain-containing protein 11  
Size: 602 amino acids; 70963 Da
Subunit: Interacts (via MYND-type zinc finger) with NCOR1. Interacts (via MYND-type zinc finger) with human
adenovirus early E1A protein (via PXLXP motif); this interaction inhibits E1A mediated transactivation. Interacts
(via MYND-type zinc finger) with Epstein-Barr virus EBNA2 protein (via PXLXP motif). Interacts (via MYND-type
zinc finger) with EZH2. Interacts with E2F6
Sequence caution: Sequence=AAH34784.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAG35465.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAA60052.1;
Type=Frameshift; Positions=11, 39;
Secondary accessions: B2R6G8 B7Z293 F6UH50 Q2LD45 Q2LD46 Q2LD47 Q2LD48 Q5VUI1 Q8N4B3
Alternative splicing: 6 isoforms:  Q15326-1   Q15326-2   Q15326-3   Q15326-4   Q15326-5   Q15326-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZMYND11: NX_Q15326

Explore proteomics data for ZMYND11 at MOPED

Post-translational modifications: 

  • Ubiquitinated, leading to proteasomal degradation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZMYND11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001189393.1  NP_001189394.1  NP_001189395.1  NP_001189396.1  NP_001189397.1  NP_006615.2  NP_997644.2  

    ENSEMBL proteins: 
     ENSP00000397072   ENSP00000424205   ENSP00000371003   ENSP00000385484   ENSP00000386010  
     ENSP00000473321   ENSP00000381046   ENSP00000370996   ENSP00000452959   ENSP00000381053  
     ENSP00000381050   ENSP00000309992   ENSP00000371020   ENSP00000371017   ENSP00000438461  
     ENSP00000371015   ENSP00000439587  

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    Cloud-Clone Corp. Proteins for ZMYND11

     
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    antibodies-online proteins for ZMYND11 (2 products) 

     
    antibodies-online peptides for ZMYND11

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZMYND: Zinc fingers, MYND-type

    Selected InterPro protein domains (see all 9):
     IPR002893 Znf_MYND
     IPR001841 Znf_RING
     IPR001965 Znf_PHD
     IPR013083 Znf_RING/FYVE/PHD
     IPR019786 Zinc_finger_PHD-type_CS

    Graphical View of Domain Structure for InterPro Entry Q15326

    ProtoNet protein and cluster: Q15326

    4 Blocks protein domains:
    IPB000313 PWWP domain
    IPB001487 Bromodomain signature
    IPB001965 Zn-finger-like
    IPB002893 Zn-finger


    UniProtKB/Swiss-Prot: ZMY11_HUMAN, Q15326
    Similarity: Contains 1 bromo domain
    Similarity: Contains 1 MYND-type zinc finger
    Similarity: Contains 1 PHD-type zinc finger
    Similarity: Contains 1 PWWP domain


    Find genes that share domains with ZMYND11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZMY11_HUMAN, Q15326
    Function: Corepressor of transcription (Probable). May be involved in chromatin remodeling through association
    with several remodeling factors

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI10734313
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with ZMYND11           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ZMYND11:
     Decreased viability of wild-ty 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZMYND11

    miRNA
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    miRTarBase miRNAs that target ZMYND11:
    hsa-mir-361-5p (MIRT020086), hsa-mir-27b-3p (MIRT046219), hsa-mir-324-5p (MIRT043022), hsa-mir-125b-5p (MIRT045941), hsa-mir-192-5p (MIRT026851), hsa-mir-222-3p (MIRT046758), hsa-mir-215-5p (MIRT024469)

    Block miRNA regulation of human, mouse, rat ZMYND11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZMYND11 (see all 124):
    hsa-miR-548j hsa-miR-520e hsa-miR-520f hsa-miR-3607-3p hsa-miR-376b hsa-miR-300 hsa-miR-4272 hsa-miR-1258
    SwitchGear 3'UTR luciferase reporter plasmidZMYND11 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZMYND11

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZMYND11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZMY11_HUMAN, Q15326: Nucleus. Chromosome. Note=Associates with chromatin and mitotic chromosomes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    extracellular1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005694chromosome IEA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm ----

    Find genes that share ontologies with ZMYND11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZMYND11
    Interactions:

        Search GeneGlobe Interaction Network for ZMYND11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ZMYND11 (Q153261, 2, 3 ENSP000003099924) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRAF5O004632, 3, ENSP000002614644MINT-7556634 I2D: score=1 STRING: ENSP00000261464
    TRAF6Q9Y4K32, 3MINT-7556646 I2D: score=5 
    SMAD2Q157962, 3MINT-61607 I2D: score=3 
    TRAF3Q131141, 2, 3, ENSP000003324684EBI-2623509,EBI-357631 MINT-7556658 MINT-7556670 I2D: score=1 STRING: ENSP00000332468
    NCOR1O753762, 3, ENSP000002687124MINT-2735454 I2D: score=3 STRING: ENSP00000268712
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS7621829
    GO:0006351transcription, DNA-templated IEA--
    GO:0007049cell cycle IEA--
    GO:0008283cell proliferation TAS7621829
    GO:0016032viral process IEA--

    Find genes that share ontologies with ZMYND11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZMYND11 (ZMY11)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZMYND11 gene (7 alternative transcripts): 
    NM_001202464.1  NM_001202465.1  NM_001202466.1  NM_001202467.1  NM_001202468.1  NM_006624.5  NM_212479.3  

    Unigene Cluster for ZMYND11:

    Zinc finger, MYND-type containing 11
    Hs.292265  [show with all ESTs]
    Unigene Representative Sequence: NM_006624
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000439456 ENST00000509513 ENST00000381591(uc009xhg.3 uc010pzy.2 uc009xhh.3)
    ENST00000403354 ENST00000402736 ENST00000602682 ENST00000397955 ENST00000381584
    ENST00000558098 ENST00000488275 ENST00000473115 ENST00000397962 ENST00000397959
    ENST00000309776(uc010pzu.2 uc010pzv.2 uc010pzw.2) ENST00000381607(uc001ifm.3)
    ENST00000381604 ENST00000545619 ENST00000381602(uc001ifk.3 uc010pzx.2 uc001ifn.3)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ZMYND11 (see all 124):
    hsa-miR-548j hsa-miR-520e hsa-miR-520f hsa-miR-3607-3p hsa-miR-376b hsa-miR-300 hsa-miR-4272 hsa-miR-1258
    SwitchGear 3'UTR luciferase reporter plasmidZMYND11 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ZMYND11
      QuantiFast Probe-based Assays in human, mouse, rat ZMYND11

    Additional mRNA sequence: 

    AK294469.1 AK294781.1 AK296427.1 AK296518.1 AK312570.1 AY732489.1 BC012586.2 BC034784.1 
    BC091489.1 DQ335452.1 DQ335453.1 DQ335454.1 DQ335455.1 X86098.1 

    14 DOTS entries:

    DT.418372  DT.100027363  DT.97843638  DT.97810742  DT.75173911  DT.70103010  DT.121288414  DT.121288380 
    DT.40310342  DT.121288416  DT.121288421  DT.92004325  DT.97843639  DT.40197315 

    Selected AceView cDNA sequences (see all 286):

    CK903826 T35200 AI718809 AA844105 CB241408 BM726388 Z44907 BU168132 
    AI859939 BU146160 NM_006624 AI276596 T35201 BC012586 AA421906 AI796319 
    AI073881 T16648 AI479336 AI096530 Z38931 AI022843 AA725310 AA911540 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZMYND11    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17
    SP1:                                                                                                                    -         
    SP2:                    -           -                                                                                             
    SP3:                                -                 -                                                                 -         
    SP4:              -     -           -                                                                                             


    ECgene alternative splicing isoforms for ZMYND11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZMYND11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGTGAGAT
    ZMYND11 Expression
    About this image


    ZMYND11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    ZMYND11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZMYND11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.292265

    UniProtKB/Swiss-Prot: ZMY11_HUMAN, Q15326
    Tissue specificity: Ubiquitous

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZMYND11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZMYND11 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zmynd111 , 5 zinc finger, MYND domain containing 111, 5 90.53(n)1
    97.67(a)1
      13 (3.72 cM)5
    665051  NM_001199141.11  NP_001186070.11 
     96848365 
    chicken
    (Gallus gallus)
    Aves ZMYND111 zinc finger, MYND-type containing 11 87.76(n)
    97.34(a)
      420455  XM_004939163.1  XP_004939220.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZMYND116
    zinc finger, MYND-type containing 11
    95(a)
    1 ↔ 1
    6(7543513-7608075)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia zmynd111 zinc finger, MYND-type containing 11 79.13(n)
    86.05(a)
      100125090  NM_001103001.1  NP_001096471.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570662092   -- 78.87(n)    57066209 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG85696
    --
    23(a)
    1 ↔ 1
    2R(8406654-8409131)
    worm
    (Caenorhabditis elegans)
    Secernentea bra-16
    bra-26
    Protein BRA-2 (bra-2) mRNA, complete cds
    32(a)
    27(a)
    1 ↔ many
    1 ↔ many
    X(13598471-13599675) WBGene00000262
    III(911261-912239) WBGene00017757


    ENSEMBL Gene Tree for ZMYND11 (if available)
    TreeFam Gene Tree for ZMYND11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZMYND11 gene
    ZMYND82  
    3 SIMAP similar genes for ZMYND11 using alignment to 12 protein entries:     ZMY11_HUMAN (see all proteins):
    PRKCBP1    ZMYND8    DKFZp564P1772

    Find genes that share paralogs with ZMYND11           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZMYND11 (see all 2302)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs70898891,2
    C,F,A,H--117210(+) ACACAG/TTTTTG 4 -- us2k114Minor allele frequency- T:0.23NS EA NA WA CSA 791
    rs771782871,2
    C,F--117225(+) CTGCCC/TCGCAG 4 -- us2k13Minor allele frequency- T:0.15WA NA EA 358
    rs750268681,2
    C,F--117275(+) TGTGAC/TGTTTA 4 -- us2k12Minor allele frequency- T:0.10WA EA 238
    rs1920689631,2
    --117323(+) AGTTAC/TAGTTA 4 -- us2k10--------
    rs1381545561,2
    --117497(+) AGAGCA/GGTGCT 4 -- us2k10--------
    rs1436037611,2
    --117568(+) CAGCTC/TTGAGA 4 -- us2k10--------
    rs1458991661,2
    --117643(+) AAAATC/GTGTCT 4 -- us2k10--------
    rs1482239401,2
    --117760(+) ACCCAC/TACACA 4 -- us2k10--------
    rs1411895521,2
    --118055(+) TTTTAC/TGTGGG 4 -- us2k10--------
    rs1507203011,2
    C--118204(+) TCTGCA/GTATAA 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZMYND11 (180405 - 300577 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ZMYND11:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv819561CNV Loss19587683
    dgv117n67CNV Gain20364138
    nsv466693CNV Gain19166990
    dgv582n71CNV Gain21882294
    nsv894694CNV Gain21882294
    nsv8594CNV Gain+Loss18304495
    dgv209e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): ZMYND11
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZMYND11
    DNA2.0 Custom Variant and Variant Library Synthesis for ZMYND11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608668    OMIM disorders: --


    Find genes that share disorders with ZMYND11           About GenesLikeMe

    Genetic Association Database (GAD): ZMYND11

    Export disorders for ZMYND11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZMYND11 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with ZMYND11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The adenovirus E1A binding protein BS69 is a corepressor of transcription through recruitment of N-CoR. (PubMed id 10734313)1, 2, 3 Masselink H. and Bernards R. (Oncogene 2000)
    2. BS69, a novel adenovirus E1A-associated protein that inhibits E1A transactivation. (PubMed id 7621829)1, 2, 3 Hateboer G.... Bernards R. (EMBO J. 1995)
    3. New insights into BS69 functions. (PubMed id 16565076)1, 2 Velasco G.... Ansieau S. (J. Biol. Chem. 2006)
    4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    5. The conserved Mynd domain of BS69 binds cellular and oncoviral proteins through a common PXLXP motif. (PubMed id 11733528)1, 2 Ansieau S. and Leutz A. (J. Biol. Chem. 2002)
    6. Oligomerized TICAM-1 (TRIF) in the cytoplasm recruits nuclear BS69 to enhance NF-kappaB activation and type I IFN induction. (PubMed id 19795416)1, 9 Takaki H....Seya T. (Eur. J. Immunol. 2009)
    7. BS69, a specific adaptor in the latent membrane protein 1-mediated c-Jun N-terminal kinase pathway. (PubMed id 16382137)1, 9 Wan J....Wu Z. (Mol. Cell. Biol. 2006)
    8. ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression. (PubMed id 24590075)1 Wen H....Shi X. (Nature 2014)
    9. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    10. Viral immune modulators perturb the human molecular network by common and unique strategies. (PubMed id 22810585)1 Pichlmair A....Superti-Furga G. (Nature 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10771 HGNC: 16966 AceView: ZMYND11 Ensembl:ENSG00000015171 euGenes: HUgn10771
    ECgene: ZMYND11 H-InvDB: ZMYND11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ZMYND11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZMYND11 gene:
    Search GeneIP for patents involving ZMYND11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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