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Aliases for ZMYND11 Gene

Aliases for ZMYND11 Gene

  • Zinc Finger, MYND-Type Containing 11 2 3
  • Bone Morphogenetic Protein Receptor-Associated Molecule 1 3 4
  • Adenovirus 5 E1A-Binding Protein 3 4
  • BRAM1 3 4
  • BS69 3 4
  • Zinc Finger MYND Domain-Containing Protein 11 3
  • Zinc Finger, MYND Domain Containing 11 2
  • Protein BS69 4
  • MRD30 3

External Ids for ZMYND11 Gene

Summaries for ZMYND11 Gene

Entrez Gene Summary for ZMYND11 Gene

  • The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZMYND11 Gene

ZMYND11 (Zinc Finger, MYND-Type Containing 11) is a Protein Coding gene. Diseases associated with ZMYND11 include mental retardation, autosomal dominant 30. An important paralog of this gene is ZMYND8.

UniProtKB/Swiss-Prot for ZMYND11 Gene

  • Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at Lys-36 (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth.

Gene Wiki entry for ZMYND11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZMYND11 Gene

Genomics for ZMYND11 Gene

Genomic Location for ZMYND11 Gene

Start:
134,465 bp from pter
End:
254,637 bp from pter
Size:
120,173 bases
Orientation:
Plus strand

Genomic View for ZMYND11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZMYND11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZMYND11 Gene

Proteins for ZMYND11 Gene

  • Protein details for ZMYND11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15326-ZMY11_HUMAN
    Recommended name:
    Zinc finger MYND domain-containing protein 11
    Protein Accession:
    Q15326
    Secondary Accessions:
    • B2R6G8
    • B7Z293
    • F6UH50
    • Q2LD45
    • Q2LD46
    • Q2LD47
    • Q2LD48
    • Q5VUI1
    • Q8N4B3

    Protein attributes for ZMYND11 Gene

    Size:
    602 amino acids
    Molecular mass:
    70963 Da
    Quaternary structure:
    • Homooligomer; forms homooligomers via its C-terminus. Interacts with histone H3.3 trimethylated at Lys-36 (H3.3K36me3). Interacts (via MYND-type zinc finger) with NCOR1. Interacts (via MYND-type zinc finger) with MGA protein (via PXLXP motif). Interacts (via MYND-type zinc finger) with EZH2. Interacts with C11orf30/EMSY and E2F6. Interacts with PIAS1 and UBE2I. Interacts (via MYND-type zinc finger) with human adenovirus early E1A protein (via PXLXP motif); this interaction inhibits E1A mediated transactivation. Interacts (via MYND-type zinc finger) with Epstein-Barr virus EBNA2 protein (via PXLXP motif). Interacts with Epstein-Barr virus-derived protein LMP1; leading to negatively regulate NF-kappa-B activation by Epstein-Barr virus-derived protein LMP1.
    SequenceCaution:
    • Sequence=AAH34784.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG35465.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA60052.1; Type=Frameshift; Positions=11, 39; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZMYND11 Gene

    Alternative splice isoforms for ZMYND11 Gene

neXtProt entry for ZMYND11 Gene

Proteomics data for ZMYND11 Gene at MOPED

Post-translational modifications for ZMYND11 Gene

No data available for DME Specific Peptides for ZMYND11 Gene

Domains for ZMYND11 Gene

Gene Families for ZMYND11 Gene

HGNC:
  • ZMYND :Zinc fingers, MYND-type

Graphical View of Domain Structure for InterPro Entry

Q15326

UniProtKB/Swiss-Prot:

ZMY11_HUMAN
Domain:
  • The PWWP domain specifically recognizes and binds histone H3.3 trimethylated at Lys-36 (H3.3K36me3) and adopts a five-bladed beta-barrel fold with an extended C-terminal alpha-helix, with a conserved H3.3K36me3-binding aromatic cage formed by Phe-291 and Trp-294 of the beta1-beta2 loop and Phe-310 of the beta3-beta4 loop. Specific recognition of H3.3 histone is mediated by the encapsulation of the H3.3-specific Ser 31 residue in a composite pocket formed by the tandem bromo-PWWP domains (By similarity).:
    • Q15326
  • Contains 1 bromo domain.:
    • Q15326
  • Contains 1 PWWP domain.:
    • Q15326
Similarity:
  • Contains 1 MYND-type zinc finger.:
    • Q15326
  • Contains 1 PHD-type zinc finger.:
    • Q15326
genes like me logo Genes that share domains with ZMYND11: view

Function for ZMYND11 Gene

Molecular function for ZMYND11 Gene

UniProtKB/Swiss-Prot Function: Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at Lys-36 (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth.
UniProtKB/Swiss-Prot Induction: Down-regulated in breast cancer patients with poor prognosis.

Gene Ontology (GO) - Molecular Function for ZMYND11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003714 transcription corepressor activity ISS --
GO:0005515 protein binding IPI 10734313
GO:0008270 zinc ion binding ISS --
GO:0035064 methylated histone binding ISS --
genes like me logo Genes that share ontologies with ZMYND11: view

Phenotypes for ZMYND11 Gene

genes like me logo Genes that share phenotypes with ZMYND11: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZMYND11 Gene

Localization for ZMYND11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZMYND11 Gene

Nucleus. Chromosome. Note=Associates with chromatin and mitotic chromosomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZMYND11 Gene COMPARTMENTS Subcellular localization image for ZMYND11 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ZMYND11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 7621829
GO:0005654 nucleoplasm IDA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with ZMYND11: view

Pathways for ZMYND11 Gene

SuperPathways for ZMYND11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZMYND11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS 7621829
GO:0006351 transcription, DNA-templated IEA --
GO:0007049 cell cycle IEA --
GO:0008283 cell proliferation TAS 7621829
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with ZMYND11: view

No data available for Pathways by source for ZMYND11 Gene

Transcripts for ZMYND11 Gene

Unigene Clusters for ZMYND11 Gene

Zinc finger, MYND-type containing 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZMYND11 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17
SP1: -
SP2: - -
SP3: - - -
SP4: - - -

Relevant External Links for ZMYND11 Gene

GeneLoc Exon Structure for
ZMYND11
ECgene alternative splicing isoforms for
ZMYND11

Expression for ZMYND11 Gene

mRNA expression in normal human tissues for ZMYND11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZMYND11 Gene

SOURCE GeneReport for Unigene cluster for ZMYND11 Gene Hs.292265

mRNA Expression by UniProt/SwissProt for ZMYND11 Gene

Q15326-ZMY11_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with ZMYND11: view

No data available for mRNA differential expression in normal tissues for ZMYND11 Gene

Orthologs for ZMYND11 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZMYND11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZMYND11 35
  • 99.83 (n)
  • 100 (a)
ZMYND11 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZMYND11 35
  • 90.63 (n)
  • 99.09 (a)
ZMYND11 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZMYND11 35
  • 90.7 (n)
  • 99 (a)
ZMYND11 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zmynd11 35
  • 90.53 (n)
  • 97.67 (a)
Zmynd11 16
Zmynd11 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZMYND11 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZMYND11 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zmynd11 35
  • 89.53 (n)
  • 95.35 (a)
chicken
(Gallus gallus)
Aves ZMYND11 35
  • 87.76 (n)
  • 97.34 (a)
ZMYND11 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZMYND11 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zmynd11 35
  • 79.13 (n)
  • 86.05 (a)
zebrafish
(Danio rerio)
Actinopterygii zmynd11 35
  • 72.04 (n)
  • 74.09 (a)
zmynd11 36
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8569 36
  • 23 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea bra-1 36
  • 32 (a)
OneToMany
bra-2 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToOne
Species with no ortholog for ZMYND11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZMYND11 Gene

ENSEMBL:
Gene Tree for ZMYND11 (if available)
TreeFam:
Gene Tree for ZMYND11 (if available)

Paralogs for ZMYND11 Gene

Paralogs for ZMYND11 Gene

genes like me logo Genes that share paralogs with ZMYND11: view

Variants for ZMYND11 Gene

Sequence variations from dbSNP and Humsavar for ZMYND11 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs750596 -- 212,433(-) GATAT(A/G)TTCAC intron-variant
rs1017361 -- 249,013(+) AAGGA(A/G)GAATT reference, synonymous-codon
rs1105116 -- 194,848(+) GGATG(G/T)AATGG intron-variant
rs1126922 -- 240,966(+) TTATC(A/C/T)TTGTG missense, reference
rs1367896 -- 181,008(-) AAGCT(A/T)CATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZMYND11 Gene

Variant ID Type Subtype PubMed ID
dgv209e1 CNV Complex 17122850
nsv894694 CNV Gain 21882294
dgv117n67 CNV Gain 20364138
nsv8594 CNV Gain+Loss 18304495
dgv582n71 CNV Gain 21882294
nsv466693 CNV Gain 19166990
nsv819561 CNV Loss 19587683

Relevant External Links for ZMYND11 Gene

HapMap Linkage Disequilibrium report
ZMYND11
Human Gene Mutation Database (HGMD)
ZMYND11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZMYND11 Gene

Disorders for ZMYND11 Gene

UniProtKB/Swiss-Prot

ZMY11_HUMAN
  • Note=A chromosomal aberration involving ZMYND11 is a cause of acute poorly differentiated myeloid leukemia. Translocation (10;17)(p15;q21) with MBTD1.
  • Mental retardation, autosomal dominant 30 (MRD30) [MIM:616083]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD30 patients manifest mild intellectual disability and subtle facial dysmorphisms, including hypertelorism, ptosis, and a wide mouth. {ECO:0000269 PubMed:25217958}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ZMYND11

Genetic Association Database (GAD)
ZMYND11
genes like me logo Genes that share disorders with ZMYND11: view

Publications for ZMYND11 Gene

  1. BS69, a specific adaptor in the latent membrane protein 1-mediated c-Jun N-terminal kinase pathway. (PMID: 16382137) Wan J. … Wu Z. (Mol. Cell. Biol. 2006) 3 4 23
  2. BS69, a novel adenovirus E1A-associated protein that inhibits E1A transactivation. (PMID: 7621829) Hateboer G. … Bernards R. (EMBO J. 1995) 2 3 4
  3. The adenovirus E1A binding protein BS69 is a corepressor of transcription through recruitment of N-CoR. (PMID: 10734313) Masselink H. … Bernards R. (Oncogene 2000) 2 3 4
  4. Oligomerized TICAM-1 (TRIF) in the cytoplasm recruits nuclear BS69 to enhance NF-kappaB activation and type I IFN induction. (PMID: 19795416) Takaki H. … Seya T. (Eur. J. Immunol. 2009) 3 23
  5. BS69 negatively regulates the canonical NF-kappaB activation induced by Epstein-Barr virus-derived LMP1. (PMID: 19379743) Ikeda O. … Matsuda T. (FEBS Lett. 2009) 3 4

Products for ZMYND11 Gene

Sources for ZMYND11 Gene

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