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Aliases for ZMYND10 Gene

Aliases for ZMYND10 Gene

  • Zinc Finger MYND-Type Containing 10 2 3 5
  • Protein BLu 3 4
  • BLU 3 4
  • Zinc Finger MYND Domain-Containing Protein 10 3
  • CILD22 3
  • FLU 3

External Ids for ZMYND10 Gene

Previous GeneCards Identifiers for ZMYND10 Gene

  • GC03M050232
  • GC03M050337
  • GC03M050353

Summaries for ZMYND10 Gene

Entrez Gene Summary for ZMYND10 Gene

  • This gene encodes a protein containing a MYND-type zinc finger domain that likely functions in assembly of the dynein motor. Mutations in this gene can cause primary ciliary dyskinesia. This gene is also considered a tumor suppressor gene and is often mutated, deleted, or hypermethylated and silenced in cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

GeneCards Summary for ZMYND10 Gene

ZMYND10 (Zinc Finger MYND-Type Containing 10) is a Protein Coding gene. Diseases associated with ZMYND10 include Ciliary Dyskinesia, Primary, 22 and Primary Ciliary Dyskinesia22: Zmynd10-Related Primary Ciliary Dyskinesia.

UniProtKB/Swiss-Prot for ZMYND10 Gene

  • Required for motile ciliary function. Probably involved in axonemal assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins.

Gene Wiki entry for ZMYND10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZMYND10 Gene

Genomics for ZMYND10 Gene

Regulatory Elements for ZMYND10 Gene

Enhancers for ZMYND10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F050453 0.3 FANTOM5 39.3 -107.2 -107224 0.2 ZNF263 ZMYND10 C3orf18 GNAI2 HYAL3 NAT6 LOC105377082 RNA5SP131
GH03F049872 1.1 FANTOM5 Ensembl ENCODE 11.2 +473.6 473621 2.4 ELF3 PKNOX1 MLX ARID4B BMI1 DMAP1 ZNF48 ZSCAN9 RAD21 THAP11 RBM6 ZMYND10 GNAI2 HYAL3 NAT6 CAMKV ACTBP13
GH03F050342 0.2 ENCODE 0.8 +4.3 4277 0.3 ZMYND10 ZMYND10-AS1
GH03F050346 0.2 ENCODE 0.8 -0.5 -533 1.1 CTCF JUN ZNF384 RAD21 ZBTB40 PATZ1 SCRT2 ZNF143 SMC3 FOS HYAL1 CYB561D2 ZMYND10
GH03F050345 0.9 ENCODE 0.8 +1.3 1259 0.8 MAZ RFX1 ZBTB2 SMAD5 NRF1 SP2 SIN3A ZBTB8A BMI1 E2F1 ZMYND10 ZMYND10-AS1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZMYND10 on UCSC Golden Path with GeneCards custom track

Promoters for ZMYND10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001847801 1152 601 MAZ RFX1 ZBTB2 SMAD5 NRF1 SP2 SIN3A ZBTB8A BMI1 E2F1

Genomic Location for ZMYND10 Gene

Chromosome:
3
Start:
50,341,106 bp from pter
End:
50,346,852 bp from pter
Size:
5,747 bases
Orientation:
Minus strand

Genomic View for ZMYND10 Gene

Genes around ZMYND10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZMYND10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZMYND10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZMYND10 Gene

Proteins for ZMYND10 Gene

  • Protein details for ZMYND10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75800-ZMY10_HUMAN
    Recommended name:
    Zinc finger MYND domain-containing protein 10
    Protein Accession:
    O75800
    Secondary Accessions:
    • A6NK41
    • B3KU54
    • O14570
    • O75801
    • Q53FE6
    • Q8N4R6
    • Q8NDN6

    Protein attributes for ZMYND10 Gene

    Size:
    440 amino acids
    Molecular mass:
    50344 Da
    Quaternary structure:
    • Interacts with LRRC6.
    SequenceCaution:
    • Sequence=AAB67311.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZMYND10 Gene

    Alternative splice isoforms for ZMYND10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZMYND10 Gene

Post-translational modifications for ZMYND10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZMYND10 Gene

Antibody Products

  • Abcam antibodies for ZMYND10
  • Santa Cruz Biotechnology (SCBT) Antibodies for ZMYND10

No data available for DME Specific Peptides for ZMYND10 Gene

Domains & Families for ZMYND10 Gene

Gene Families for ZMYND10 Gene

Protein Domains for ZMYND10 Gene

Suggested Antigen Peptide Sequences for ZMYND10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75800

UniProtKB/Swiss-Prot:

ZMY10_HUMAN :
  • Belongs to the ZMYND10 family.
  • Contains 1 MYND-type zinc finger.
Family:
  • Belongs to the ZMYND10 family.
Similarity:
  • Contains 1 MYND-type zinc finger.
genes like me logo Genes that share domains with ZMYND10: view

Function for ZMYND10 Gene

Molecular function for ZMYND10 Gene

UniProtKB/Swiss-Prot Function:
Required for motile ciliary function. Probably involved in axonemal assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins.

Gene Ontology (GO) - Molecular Function for ZMYND10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZMYND10: view
genes like me logo Genes that share phenotypes with ZMYND10: view

Human Phenotype Ontology for ZMYND10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZMYND10 Gene

Localization for ZMYND10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZMYND10 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Localizes to sites proximal to the axoneme. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZMYND10 Gene COMPARTMENTS Subcellular localization image for ZMYND10 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2
plasma membrane 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ZMYND10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA --
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
GO:0034451 centriolar satellite ISS --
genes like me logo Genes that share ontologies with ZMYND10: view

Pathways & Interactions for ZMYND10 Gene

SuperPathways for ZMYND10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZMYND10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0036158 outer dynein arm assembly IMP 23891469
GO:0036159 inner dynein arm assembly IMP 23891469
GO:0044458 motile cilium assembly IMP 23891469
genes like me logo Genes that share ontologies with ZMYND10: view

No data available for Pathways by source and SIGNOR curated interactions for ZMYND10 Gene

Drugs & Compounds for ZMYND10 Gene

(1) Additional Compounds for ZMYND10 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZMYND10: view

Transcripts for ZMYND10 Gene

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZMYND10 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
SP1: - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - -
SP5: - -
SP6:
SP7: -
SP8:
SP9:

Relevant External Links for ZMYND10 Gene

GeneLoc Exon Structure for
ZMYND10
ECgene alternative splicing isoforms for
ZMYND10

Expression for ZMYND10 Gene

mRNA expression in normal human tissues for ZMYND10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZMYND10 Gene

This gene is overexpressed in Testis (x33.3).

Protein differential expression in normal tissues from HIPED for ZMYND10 Gene

This gene is overexpressed in Ovary (24.5), Testis (24.4), and Fetal Brain (20.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZMYND10 Gene



Protein tissue co-expression partners for ZMYND10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZMYND10 Gene:

ZMYND10

SOURCE GeneReport for Unigene cluster for ZMYND10 Gene:

Hs.526735
genes like me logo Genes that share expression patterns with ZMYND10: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ZMYND10 Gene

Orthologs for ZMYND10 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZMYND10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZMYND10 34 35
  • 99.77 (n)
cow
(Bos Taurus)
Mammalia ZMYND10 34 35
  • 91.09 (n)
dog
(Canis familiaris)
Mammalia ZMYND10 34 35
  • 88.91 (n)
mouse
(Mus musculus)
Mammalia Zmynd10 34 16 35
  • 85.68 (n)
rat
(Rattus norvegicus)
Mammalia Zmynd10 34
  • 85.61 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZMYND10 35
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZMYND10 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZMYND10 35
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZMYND10 35
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zmynd10 34
  • 62.88 (n)
zebrafish
(Danio rerio)
Actinopterygii zmynd10 34 35
  • 58.1 (n)
zgc63660 34
fruit fly
(Drosophila melanogaster)
Insecta CG11253 34 35
  • 47.94 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011078 34
  • 47.19 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5292 34
Species where no ortholog for ZMYND10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZMYND10 Gene

ENSEMBL:
Gene Tree for ZMYND10 (if available)
TreeFam:
Gene Tree for ZMYND10 (if available)

Paralogs for ZMYND10 Gene

No data available for Paralogs for ZMYND10 Gene

Variants for ZMYND10 Gene

Sequence variations from dbSNP and Humsavar for ZMYND10 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs138815960 Ciliary dyskinesia, primary, 22 (CILD22) [MIM:615444], Pathogenic 50,345,533(+) CCCGC(A/C)CCAGC reference, missense, utr-variant-5-prime
rs182064110 Non-small cell lung cancer cell lines 50,341,601(+) GGCAT(A/C/G/T)GTGAG upstream-variant-2KB, reference, missense
rs200913791 Ciliary dyskinesia, primary, 22 (CILD22) [MIM:615444], Pathogenic 50,342,473(+) TGTAC(A/G)GGGCG upstream-variant-2KB, reference, missense
rs587621539 Ciliary dyskinesia, primary, 22 (CILD22) [MIM:615444] 50,345,495(+) TTCGG(A/G)GCCCA reference, missense, utr-variant-5-prime
rs753061612 Ciliary dyskinesia, primary, 22 (CILD22) [MIM:615444] 50,341,685(+) GCCTG(C/T)AGGTC upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZMYND10 Gene

Variant ID Type Subtype PubMed ID
dgv8317n54 CNV loss 21841781
esv3584502 CNV gain 24956385
nsv460531 CNV loss 19166990
nsv470561 CNV loss 18288195
nsv476603 CNV novel sequence insertion 20440878
nsv523662 CNV loss 19592680
nsv590255 CNV loss 21841781
nsv590258 CNV loss 21841781
nsv834692 CNV loss 17160897
nsv834693 CNV loss 17160897
nsv954855 CNV deletion 24416366

Variation tolerance for ZMYND10 Gene

Residual Variation Intolerance Score: 81.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.30; 41.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZMYND10 Gene

Human Gene Mutation Database (HGMD)
ZMYND10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZMYND10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZMYND10 Gene

Disorders for ZMYND10 Gene

MalaCards: The human disease database

(9) MalaCards diseases for ZMYND10 Gene - From: OMIM, ClinVar, GeneTests, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ciliary dyskinesia, primary, 22
  • primary ciliary dyskinesia 22
primary ciliary dyskinesia22: zmynd10-related primary ciliary dyskinesia
  • ciliary dyskinesia, primary, 22
bronchiectasis
  • kartagener syndrome
kartagener syndrome
  • kartagener's syndrome
ciliary dyskinesia, primary, 1, with or without situs inversus
  • primary ciliary dyskinesia 1
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

ZMY10_HUMAN
  • Ciliary dyskinesia, primary, 22 (CILD22) [MIM:615444]: A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. Patients may exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. {ECO:0000269 PubMed:23891469, ECO:0000269 PubMed:23891471, ECO:0000269 PubMed:25186273}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ZMYND10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZMYND10
genes like me logo Genes that share disorders with ZMYND10: view

No data available for Genatlas for ZMYND10 Gene

Publications for ZMYND10 Gene

  1. ZMYND10 is mutated in primary ciliary dyskinesia and interacts with LRRC6. (PMID: 23891469) Zariwala M.A. … Hildebrandt F. (Am. J. Hum. Genet. 2013) 2 3 4 64
  2. Ciliary beat pattern and frequency in genetic variants of primary ciliary dyskinesia. (PMID: 25186273) Raidt J. … Werner C. (Eur. Respir. J. 2014) 3 4 64
  3. Mutations in ZMYND10, a gene essential for proper axonemal assembly of inner and outer dynein arms in humans and flies, cause primary ciliary dyskinesia. (PMID: 23891471) Moore D.J. … Mitchison H.M. (Am. J. Hum. Genet. 2013) 3 4 64
  4. RASSF1A, BLU, NORE1A, PTEN and MGMT expression and promoter methylation in gliomas and glioma cell lines and evidence of deregulated expression of de novo DNMTs. (PMID: 18616639) Lorente A. … Castresana J.S. (Brain Pathol. 2009) 3 22 64
  5. Hypermethylation of two consecutive tumor suppressor genes, BLU and RASSF1A, located at 3p21.3 in cervical neoplasias. (PMID: 17097722) Lai H.C. … Chu T.Y. (Gynecol. Oncol. 2007) 3 22 64

Products for ZMYND10 Gene

Sources for ZMYND10 Gene

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