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Aliases for ZMYND10 Gene

Aliases for ZMYND10 Gene

  • Zinc Finger, MYND-Type Containing 10 2 3
  • BLU 3 4 6
  • Protein BLu 3 4
  • Zinc Finger MYND Domain-Containing Protein 10 3
  • Zinc Finger, MYND Domain Containing 10 3
  • CILD22 3
  • FLU 3

External Ids for ZMYND10 Gene

Previous GeneCards Identifiers for ZMYND10 Gene

  • GC03M050232
  • GC03M050337
  • GC03M050353

Summaries for ZMYND10 Gene

GeneCards Summary for ZMYND10 Gene

ZMYND10 (Zinc Finger, MYND-Type Containing 10) is a Protein Coding gene. Diseases associated with ZMYND10 include ciliary dyskinesia, primary, 22 and nasopharynx carcinoma.

UniProtKB/Swiss-Prot for ZMYND10 Gene

  • Required for motile ciliary function. Probably involved in axonemal assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins.

Gene Wiki entry for ZMYND10 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZMYND10 Gene

Genomics for ZMYND10 Gene

Regulatory Elements for ZMYND10 Gene

Transcription factor binding sites by QIAGEN in the ZMYND10 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZMYND10 Gene

Start:
50,341,106 bp from pter
End:
50,346,852 bp from pter
Size:
5,747 bases
Orientation:
Minus strand

Genomic View for ZMYND10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZMYND10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZMYND10 Gene

Proteins for ZMYND10 Gene

  • Protein details for ZMYND10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75800-ZMY10_HUMAN
    Recommended name:
    Zinc finger MYND domain-containing protein 10
    Protein Accession:
    O75800
    Secondary Accessions:
    • A6NK41
    • B3KU54
    • O14570
    • O75801
    • Q53FE6
    • Q8N4R6
    • Q8NDN6

    Protein attributes for ZMYND10 Gene

    Size:
    440 amino acids
    Molecular mass:
    50344 Da
    Quaternary structure:
    • Interacts with LRRC6.
    SequenceCaution:
    • Sequence=AAB67311.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZMYND10 Gene

    Alternative splice isoforms for ZMYND10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZMYND10 Gene

Proteomics data for ZMYND10 Gene at MOPED

Post-translational modifications for ZMYND10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZMYND10 Gene

Antibody Products

No data available for DME Specific Peptides for ZMYND10 Gene

Domains for ZMYND10 Gene

Gene Families for ZMYND10 Gene

HGNC:
  • ZMYND :Zinc fingers, MYND-type

Protein Domains for ZMYND10 Gene

Suggested Antigen Peptide Sequences for ZMYND10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75800

UniProtKB/Swiss-Prot:

ZMY10_HUMAN :
  • O75800
Family:
  • Belongs to the ZMYND10 family.
Similarity:
  • Contains 1 MYND-type zinc finger.
genes like me logo Genes that share domains with ZMYND10: view

Function for ZMYND10 Gene

Molecular function for ZMYND10 Gene

UniProtKB/Swiss-Prot Function: Required for motile ciliary function. Probably involved in axonemal assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins.

Gene Ontology (GO) - Molecular Function for ZMYND10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZMYND10: view

Phenotypes for ZMYND10 Gene

genes like me logo Genes that share phenotypes with ZMYND10: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZMYND10 Gene

Localization for ZMYND10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZMYND10 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Localizes to sites proximal to the axoneme. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZMYND10 Gene COMPARTMENTS Subcellular localization image for ZMYND10 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ZMYND10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0034451 centriolar satellite ISS --
genes like me logo Genes that share ontologies with ZMYND10: view

Pathways for ZMYND10 Gene

SuperPathways for ZMYND10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZMYND10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0036158 outer dynein arm assembly IMP 23891469
GO:0036159 inner dynein arm assembly IMP 23891469
GO:0044458 motile cilium assembly IMP 23891469
genes like me logo Genes that share ontologies with ZMYND10: view

No data available for Pathways by source for ZMYND10 Gene

Compounds for ZMYND10 Gene

(1) Novoseek inferred chemical compound relationships for ZMYND10 Gene

Compound -log(P) Hits PubMed IDs
5-aza-2deoxycytidine 68.3 2
genes like me logo Genes that share compounds with ZMYND10: view

Transcripts for ZMYND10 Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZMYND10

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZMYND10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZMYND10 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
SP1: - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - -
SP5: - -
SP6:
SP7: -
SP8:
SP9:

Relevant External Links for ZMYND10 Gene

GeneLoc Exon Structure for
ZMYND10
ECgene alternative splicing isoforms for
ZMYND10

Expression for ZMYND10 Gene

mRNA expression in normal human tissues for ZMYND10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZMYND10 Gene

This gene is overexpressed in Testis (33.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZMYND10 Gene

SOURCE GeneReport for Unigene cluster for ZMYND10 Gene Hs.526735

genes like me logo Genes that share expressions with ZMYND10: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ZMYND10 Gene

Orthologs for ZMYND10 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZMYND10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZMYND10 35
  • 99.77 (n)
  • 99.77 (a)
ZMYND10 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZMYND10 35
  • 91.09 (n)
  • 91.98 (a)
ZMYND10 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZMYND10 35
  • 88.91 (n)
  • 90.89 (a)
ZMYND10 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zmynd10 35
  • 85.68 (n)
  • 88.64 (a)
Zmynd10 16
Zmynd10 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZMYND10 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZMYND10 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zmynd10 35
  • 85.61 (n)
  • 88.86 (a)
chicken
(Gallus gallus)
Aves ZMYND10 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZMYND10 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zmynd10 35
  • 62.88 (n)
  • 59.86 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc63660 35
zmynd10 35
  • 58.1 (n)
  • 56.31 (a)
zmynd10 36
  • 54 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011078 35
  • 47.19 (n)
  • 33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11253 35
  • 47.94 (n)
  • 33.81 (a)
CG11253 36
  • 31 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5292 35
Species with no ortholog for ZMYND10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZMYND10 Gene

ENSEMBL:
Gene Tree for ZMYND10 (if available)
TreeFam:
Gene Tree for ZMYND10 (if available)

Paralogs for ZMYND10 Gene

No data available for Paralogs for ZMYND10 Gene

Variants for ZMYND10 Gene

Sequence variations from dbSNP and Humsavar for ZMYND10 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs2301639 -- 50,343,230(-) CCCAG(C/T)GTGAA intron-variant
rs4688724 -- 50,346,712(-) AAAAA(C/G)CTCTT upstream-variant-2KB
rs7432096 -- 50,345,024(+) ACAGG(G/T)GTACC intron-variant
rs9825506 -- 50,343,864(+) GGTAG(A/G)GTAAA intron-variant
rs10563378 -- 50,344,618(+) CCGGC(-/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZMYND10 Gene

Variant ID Type Subtype PubMed ID
nsv523662 CNV Loss 19592680
nsv876769 CNV Loss 21882294
nsv470561 CNV Loss 18288195
nsv876770 CNV Loss 21882294
nsv834692 CNV Loss 17160897
nsv460531 CNV Loss 19166990
dgv5131n71 CNV Loss 21882294
dgv5132n71 CNV Loss 21882294
nsv834693 CNV Loss 17160897

Relevant External Links for ZMYND10 Gene

HapMap Linkage Disequilibrium report
ZMYND10
Human Gene Mutation Database (HGMD)
ZMYND10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZMYND10 Gene

Disorders for ZMYND10 Gene

(1) OMIM Diseases for ZMYND10 Gene (607070)

UniProtKB/Swiss-Prot

ZMY10_HUMAN
  • Ciliary dyskinesia, primary, 22 (CILD22) [MIM:615444]: A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. Patients may exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. {ECO:0000269 PubMed:23891469, ECO:0000269 PubMed:23891471, ECO:0000269 PubMed:25186273}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for ZMYND10 Gene

(7) Novoseek inferred disease relationships for ZMYND10 Gene

Disease -log(P) Hits PubMed IDs
nasopharyngeal carcinoma 47.9 2
primary tumor 40.1 4
tumors 36.7 24
cancer lung 29.8 3
carcinoma squamous cell 18.7 1
genes like me logo Genes that share disorders with ZMYND10: view

Publications for ZMYND10 Gene

  1. ZMYND10 is mutated in primary ciliary dyskinesia and interacts with LRRC6. (PMID: 23891469) Zariwala M.A. … Hildebrandt F. (Am. J. Hum. Genet. 2013) 2 3 4
  2. Mutations in ZMYND10, a gene essential for proper axonemal assembly of inner and outer dynein arms in humans and flies, cause primary ciliary dyskinesia. (PMID: 23891471) Moore D.J. … Mitchison H.M. (Am. J. Hum. Genet. 2013) 3 4
  3. Epigenetic inactivation of the candidate 3p21.3 suppressor gene BLU in human cancers. (PMID: 12629521) Agathanggelou A. … Latif F. (Oncogene 2003) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ZMYND10 Gene

Sources for ZMYND10 Gene

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