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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZMYND10 Gene

protein-coding   GIFtS: 54
GCID: GC03M050378

zinc finger, MYND-type containing 10

 Explore 19 diseases affiliated with
ZMYND10 via our new
 Human Malady Compendium 
Biological research products
for ZMYND10
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Zinc Finger, MYND-Type Containing 101 2
BLU1 2 3
Protein BLu2 3
FLU2 5
Zinc Finger MYND Domain-Containing Protein 102
Zinc Finger, MYND Domain Containing 102

External Ids:    HGNC: 194121   Entrez Gene: 513642   Ensembl: ENSG000000048387   OMIM: 6070705   UniProtKB: O758003   

Export aliases for ZMYND10 gene to outside databases

Previous GC identifers: GC03M050232 GC03M050337 GC03M050353


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for ZMYND10


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZMYND10 gene promoter:
         AP-1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZMYND10 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZMYND10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZMYND10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.3

ZMYND10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZMYND10 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M050378:  view genomic region     (about GC identifiers)

Start:
50,378,537 bp from pter      End:
50,384,283 bp from pter
Size:
5,747 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZMY10_HUMAN, O75800 (See protein sequence)
Recommended Name: Zinc finger MYND domain-containing protein 10  
Size: 440 amino acids; 50344 Da
Sequence caution: Sequence=AAB67311.1; Type=Erroneous gene model prediction;
2 PDB 3D structures from and Proteopedia for ZMYND10:
2D8Q (3D)        2DAN (3D)    
Secondary accessions: A6NK41 O14570 O75801 Q8N4R6 Q8NDN6
Alternative splicing: 2 isoforms:  O75800-1   O75800-2   

Explore the universe of human proteins at neXtProt for ZMYND10: NX_O75800

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75800

  • ZMYND10 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_056980.2  
    ENSEMBL proteins: 
     ENSP00000231749   ENSP00000353289   ENSP00000393687   ENSP00000415661   ENSP00000391545  

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    Uscn Proteins for ZMYND10

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--


    ZMYND10 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZMYND10 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR002893 Znf_MYND
     IPR017333 UCP037948_Znf-MYND

    Graphical View of Domain Structure for InterPro Entry O75800

    ProtoNet protein and cluster: O75800

    1 Blocks protein family: IPB002893 Zn-finger

    UniProtKB/Swiss-Prot: ZMY10_HUMAN, O75800
    Similarity: Contains 1 MYND-type zinc finger


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    hsa-miR-516b hsa-miR-3151 hsa-miR-486-3p hsa-miR-877 hsa-miR-3916 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmidZMYND10 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
    GO:0008270zinc ion binding IEA--


    ZMYND10 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for ZMYND10:
     G0/1 arrest  Increased G1 DNA content  Increased HPV18 LCR reporter a  Proliferating cells 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZMYND10

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for ZMYND10 (O758001, 2, 3 ENSP000002317494) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TSC22D4Q9Y3Q81, 2, 3, ENSP000003001814EBI-747061,EBI-739485 MINT-66981 I2D: score=6 STRING: ENSP00000300181
    NR0B2ENSP000002542274STRING: ENSP00000254227
    RNF181ENSP000003069064STRING: ENSP00000306906
    SERINC1ENSP000003429624STRING: ENSP00000342962
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ZMYND10 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZMYND10
    1 Novoseek chemical compound relationship for ZMYND10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-aza-2'deoxycytidine 68.3 2 12794757 (1), 15122337 (1)

    Search CenterWatch for drugs/clinical trials and news about ZMYND10 / ZMY10 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZMYND10 gene: 
    NM_015896.2  

    Unigene Clusters for ZMYND10:

    Zinc finger, MYND-type containing 10
    Hs.526735  [show with all ESTs], Hs.627171
    Unigene Representative Sequences: AK096525, AB209621
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000490675 ENST00000231749(uc003dag.1) ENST00000360165(uc010hll.1)
    ENST00000475688 ENST00000442887(uc010hlm.1) ENST00000443080 ENST00000478269
    ENST00000431869 ENST00000468182

    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate ZMYND10:
    hsa-miR-516b hsa-miR-3151 hsa-miR-486-3p hsa-miR-877 hsa-miR-3916 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmidZMYND10 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: AB209621.1 

    6 DOTS entries:

    DT.442104  DT.120843941  DT.120843950  DT.95133573  DT.100020875  DT.120843956 

    24/138 AceView cDNA sequences (see all 138):

    BI826963 AI824983 U70880 CR591482 BG222909 NM_015896 AX748138 AK058135 
    CA439834 BM922211 BP369597 BI828525 BM563601 CB854843 CR615130 BC022186 
    BC033732 BI825468 AW452864 BP370895 BX280613 BI829087 BI520071 BI824818 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ZMYND10 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
    SP1:                                            -     -                             -                       -                                                   
    SP2:                                            -     -                             -                 -                                                         
    SP3:                                            -     -                 -     -     -                       -                                                   
    SP4:                                      -     -     -                             -                                                                           
    SP5:                                            -     -                                                                                                         


    ECgene alternative splicing isoforms for ZMYND10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZMYND10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CATTGCCATC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    ZMYND10 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ZMYND10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZMYND10

    SOURCE GeneReport for Unigene clusters: Hs.526735 Hs.627171
        SABiosciences Custom PCR Arrays for ZMYND10
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZMYND10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZMYND10 gene from 5/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zmynd101 , 5 zinc finger, MYND domain containing 101, 5 85.68(n)1
    88.64(a)1
      9 (58.12 cM)5
    1146021  NM_053253.31  NP_444483.21 
     1075473105 
    chicken
    (Gallus gallus)
    Aves ZMYND106
    Uncharacterized protein
    63(a)
    1 ↔ 1
    12(1383269-1390962)
    lizard
    (Anolis carolinensis)
    Reptilia ZMYND106
    --
    61(a)
    1 ↔ 1
    2(150061317-150087731)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc636602 hypothetical protein MGC63660 73.99(n)   393368  BC054130.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG112531 CG11253 48.33(n)
    33.81(a)
      39481  NM_140368.2  NP_648625.1 


    ENSEMBL Gene Tree for ZMYND10 (if available)
    TreeFam Gene Tree for ZMYND10 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/73 NCBI SNPs in ZMYND10 are shown (see all 73    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2010582301,2
    C,--50380438(+) AGGTGC/TTGAGA 2 N S mis10--------
    rs2005555921,2
    --50380501(+) GGCCCA/GGTCTT 1 -- int10--------
    rs1118361571,2
    C--50380548(+) GCTCAG/CCTGTC 1 -- spd11Minor allele frequency- C:0.00CSA 1
    rs1495983571,2
    F--50380553(+) CCTGTC/TCACAC 2 N D mis11Minor allele frequency- T:0.00NA 4548
    rs1997297651,2
    C,--50380574(+) GTAGCA/GTAGTA 2 R C mis10--------
    rs1442955511,2
    F--50380584(+) ACTGAG/CAGGGC 2 /L syn11Minor allele frequency- C:0.00NA 4548
    rs23016391,2
    C,F,H,--50380661(-) CCCAGC/TGTGAA 1 -- int115Minor allele frequency- T:0.07EA NS NA 3714
    rs2017323551,2
    --50380730(+) AACCTC/GAACCC 1 -- int10--------
    rs1412613841,2
    F--50380763(+) GGGATC/TCCTCC 2 E G mis11Minor allele frequency- T:0.00NA 4518
    rs1380717871,2
    C,F,--50380768(+) CCCTCC/TCCCTC 2 G syn11Minor allele frequency- T:0.00NA 4486

    HapMap Linkage Disequilibrium report for ZMYND10 (50378537 - 50384283 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for ZMYND10
         3 CNVs: 30176 4335 4336

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZMYND10
    DNA2.0 Custom Variant and Variant Library Synthesis for ZMYND10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZMYND10 for disorders           About GeneDecksing

    OMIM gene information: 607070    OMIM disorders: --

    19 diseases for ZMYND10:    About MalaCards
    choroid plexus papilloma    hydranencephaly    nasopharynx carcinoma    hemorrhagic disease
    papilloma    gallbladder carcinoma    ependymoma    choroiditis
    nasopharyngitis    lung adenoma    carcinoma    influenza
    pancreatic cancer    lung cancer    pancreatitis    adenoma
    cervicitis    neuroblastoma    malaria

    1 disease from the University of Copenhagen DISEASES database for ZMYND10:
    Influenza

    7 Novoseek disease relationships for ZMYND10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nasopharyngeal carcinoma 47.9 2 12794757 (1), 15122337 (1)
    primary tumor 40.1 7 12794757 (3), 17570703 (1)
    tumors 36.7 28 15122337 (6), 14743209 (4), 12794757 (3), 15540210 (3) (see all 9)
    cancer lung 29.8 3 12794757 (1), 15540210 (1), 15704097 (1)
    carcinoma squamous cell 18.7 1 17097722 (1)
    adenocarcinoma 16.3 1 17097722 (1)
    cancer 5.31 4 15122337 (1), 18616639 (1)


    Export disorders for ZMYND10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZMYND10 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with ZMYND10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)1, 2 Muzny D.M....Gibbs R.A. (2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Epigenetic inactivation of the candidate 3p21.3 suppressor gene BLU in human cancers. (PubMed id 12629521)1, 3 Agathanggelou A....Latif F. (2003)
    4. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. (PubMed id 11085536)1, 2 Lerman M.I. and Minna J.D. (2000)
    5. The candidate tumor suppressor gene BLU, located at the commonly deleted region 3p21.3, is an E2F-regulated, stress-responsive gene and inactivated by both epigenetic and genetic mechanisms in nasopharyngeal carcinoma. (PubMed id 15122337)1, 9 Qiu G.H....Tao Q. (2004)
    6. Alterations of BLU, a candidate tumor suppressor gene on chromosome 3p21.3, in human nasopharyngeal carcinoma. (PubMed id 12794757)1, 9 Liu X.Q....Zeng Y.X. (2003)
    7. Hypermethylation of RASSF1A and BLU tumor suppressor genes in non-small cell lung cancer: implications for tobacco smoking during adolescence. (PubMed id 15540210)1, 9 Marsit C.J....Kelsey K.T. (2005)
    8. RASSF1A, BLU, NORE1A, PTEN and MGMT expression and promoter methylation in gliomas and glioma cell lines and evidence of deregulated expression of de novo DNMTs. (PubMed id 18616639)1, 9 Lorente A....Castresana J.S. (2009)
    9. Tumor suppressor BLU enhances pro-apoptotic activity o f sMEK1 through physical interaction. (PubMed id 22349239)1 Dong S.M....Rho S.B. (2012)
    10. Tumor suppressor gene BLU is frequently downregulated by promoter hypermethylation in myelodysplastic syndrome. (PubMed id 22246278)1 Yang Y....Li X. (2012)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51364 HGNC: 19412 AceView: ZMYND10 Ensembl:ENSG00000004838 euGenes: HUgn51364
    ECgene: ZMYND10 H-InvDB: ZMYND10

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