ZMYND10 Gene
protein-coding GIFtS : 54
GCID: GC03 M050378
zinc finger, MYND-type containing 10
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Aliasesfor ZMYND10 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Zinc Finger, MYND-Type Containing 10 1 2 BLU1 2 3 Protein BLu2 3 FLU2 5 Zinc Finger MYND Domain-Containing Protein 102 Zinc Finger, MYND Domain Containing 102
Export aliases for ZMYND10 gene to outside databases Previous GC identifers: GC03M050232 GC03M050337 GC03M050353
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Summariesfor ZMYND10 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Gene Wiki entry for ZMYND10
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Genomic Viewsfor ZMYND10 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000003.11 NC_018914.1 NT_022517.18 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ZMYND10 gene promoter: AP-1 GR-alpha Other transcription factors Search SABiosciences Chromatin IP Primers for ZMYND10 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ZMYND10
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 3p21.3 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.3 ZMYND10 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 3 GeneLoc Exon Structure
GeneLoc location for GC03M050378: view genomic region
(about GC identifiers )
Start:
50,378,537 bp from pter
End:
50,384,283 bp from pter
Size:
5,747 bases
Orientation:
minus strand
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Proteinsfor ZMYND10 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ZMY10_HUMAN, O75800 (See
protein sequence )Recommended Name: Zinc finger MYND domain-containing protein 10 Size : 440 amino acids; 50344 Da
Sequence caution : Sequence=AAB67311.1; Type=Erroneous gene model prediction;
2 PDB 3D structures from and Proteopedia for ZMYND10 :2D8Q (3D)
  2DAN (3D)
 
Secondary accessions : A6NK41 O14570 O75801 Q8N4R6 Q8NDN6Alternative splicing : 2 isoforms : O75800-1 O75800-2 Explore the universe of human proteins at neXtProt for ZMYND10: NX_O75800 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_O75800 ZMYND10 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_056980.2 ENSEMBL proteins: ENSP00000231749 ENSP00000353289 ENSP00000393687 ENSP00000415661 ENSP00000391545 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005737 cytoplasm
IDA --
ZMYND10 for ontologies About GeneDecksing ZMYND10 Antibody Products: Assay Products for ZMYND10:
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Protein
Domains / Familiesfor ZMYND10 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ZMYND10 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry O75800 ProtoNet protein and cluster: O75800
1 Blocks protein family : IPB002893 Zn-finger UniProtKB/Swiss-Prot: ZMY10_HUMAN, O75800 Similarity : Contains 1 MYND-type zinc finger
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Functionfor ZMYND10 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ZMYND10 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ZMYND10OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ZMYND10 (NM_015896 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZMYND10 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ZMYND10
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZMYND10
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
ZMYND10 for ontologies About GeneDecksing 4 GenomeRNAi human phenotypes for ZMYND10 :
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Pathways & Interactionsfor ZMYND10 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZMYND10 STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)4 Interacting proteins for ZMYND10 (O75800 1 , 2 , 3 ENSP00000231749 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor ZMYND10 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
ZMYND10 for compounds About GeneDecksing Browse Tocris compounds for ZMYND10 1 Novoseek chemical compound relationship for ZMYND10 gene About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
5-aza-2'deoxycytidine
68.3
2
12794757 (1), 15122337 (1)
Search CenterWatch for drugs/clinical trials and news about ZMYND10 / ZMY10
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Transcriptsfor ZMYND10 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ZMYND10 gene: NM_015896.2 Unigene Clusters for ZMYND10:
Zinc finger, MYND-type containing 10 Hs.526735 [show with all ESTs ] , Hs.627171 Unigene Representative Sequences: AK096525 , AB209621 9 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000490675 ENST00000231749 (uc003dag.1 ) ENST00000360165 (uc010hll.1 )ENST00000475688 ENST00000442887 (uc010hlm.1 ) ENST00000443080 ENST00000478269 ENST00000431869 ENST00000468182 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ZMYND10 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ZMYND10OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ZMYND10 (NM_015896 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZMYND10 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ZMYND10
Additional cDNA sequence: AB209621.1
6 DOTS entries : DT.442104 DT.120843941
DT.120843950 DT.95133573 DT.100020875 DT.120843956 24/138 AceView cDNA sequences (see all 138 ):
BI826963 AI824983 U70880 CR591482 BG222909 NM_015896 AX748138 AK058135 CA439834 BM922211 BP369597 BI828525 BM563601 CB854843 CR615130 BC022186 BC033732 BI825468 AW452864 BP370895 BX280613 BI829087 BI520071 BI824818 GeneLoc Exon Structure 5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ZMYND10 (see all 9 ) About this scheme ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b SP1 :               -   -           -         -                   SP2 :               -   -           -       -                     SP3 :               -   -       -   -   -         -                   SP4 :             -   -   -           -                           SP5 :               -   -                                    
ECgene alternative splicing isoforms for ZMYND10
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Expression for ZMYND10 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ZMYND10 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CATTGCCATC
About this image ZMYND10 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category Posterior foregut-like cells (A scalable, suspensi... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See ZMYND10 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ZMYND10 SOURCE GeneReport for Unigene clusters: Hs.526735 Hs.627171 SABiosciences Custom PCR Arrays for ZMYND10 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ZMYND10Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat ZMYND10 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ZMYND10 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ZMYND10 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZMYND10
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Orthologsfor ZMYND10 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for ZMYND10 gene from 5/21 species (see all 21 ) About this table
ENSEMBL Gene Tree for ZMYND10 (if available)TreeFam Gene Tree for ZMYND10 (if available)
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Paralogsfor ZMYND10 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor ZMYND10 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 3 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for ZMYND10 (50378537 - 50384283 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 3 variations for ZMYND10 3 CNVs : 30176 4335 4336
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ZMYND10
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Disorders
/ Diseasesfor ZMYND10 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
ZMYND10 for disorders About GeneDecksing
OMIM gene information: 607070
OMIM disorders : --19 diseases for ZMYND10 : About MalaCards choroid plexus papilloma hydranencephaly nasopharynx carcinoma hemorrhagic disease papilloma gallbladder carcinoma ependymoma choroiditis nasopharyngitis lung adenoma carcinoma influenza pancreatic cancer lung cancer pancreatitis adenoma cervicitis neuroblastoma malaria 1 disease from the University of Copenhagen DISEASES database for ZMYND10 :Influenza 7 Novoseek disease relationships for ZMYND10 gene About this table
Export disorders for ZMYND10 gene to outside databases
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Publicationsfor ZMYND10 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ZMYND10 gene, integrated from 9 sources (see all 31 ): (articles sorted by number of sources associating them with ZMYND10) Utopia : connect your pdf to the dynamic world of online information
The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997) 1 , 2 Muzny D.M....Gibbs R.A. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Epigenetic inactivation of the candidate 3p21.3 suppressor gene BLU in human cancers. (PubMed id 12629521) 1 , 3 Agathanggelou A....Latif F. (2003) The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. (PubMed id 11085536) 1 , 2 Lerman M.I. and Minna J.D. (2000) The candidate tumor suppressor gene BLU, located at the commonly deleted region 3p21.3, is an E2F-regulated, stress-responsive gene and inactivated by both epigenetic and genetic mechanisms in nasopharyngeal carcinoma. (PubMed id 15122337) 1 , 9 Qiu G.H....Tao Q. (2004) Alterations of BLU, a candidate tumor suppressor gene on chromosome 3p21.3, in human nasopharyngeal carcinoma. (PubMed id 12794757) 1 , 9 Liu X.Q....Zeng Y.X. (2003) Hypermethylation of RASSF1A and BLU tumor suppressor genes in non-small cell lung cancer: implications for tobacco smoking during adolescence. (PubMed id 15540210) 1 , 9 Marsit C.J....Kelsey K.T. (2005) RASSF1A, BLU, NORE1A, PTEN and MGMT expression and promoter methylation in gliomas and glioma cell lines and evidence of deregulated expression of de novo DNMTs. (PubMed id 18616639) 1 , 9 Lorente A....Castresana J.S. (2009) Tumor suppressor BLU enhances pro-apoptotic activity o f sMEK1 through physical interaction. (PubMed id 22349239) 1 Dong S.M....Rho S.B. (2012) Tumor suppressor gene BLU is frequently downregulated by promoter hypermethylation in myelodysplastic syndrome. (PubMed id 22246278) 1 Yang Y....Li X. (2012)
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External Searches for ZMYND10 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ZMYND10 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing ZMYND10 gene
(According to HUGE )
About This Section --
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Specialized Databases showing ZMYND10 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for ZMYND10 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for ZMYND10 gene: Search GeneIP for patents involving ZMYND10 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ZMYND10 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for ZMYND10 OriGene shRNA RFP for ZMYND10 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for ZMYND10 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ZMYND10 OriGene Protein Over-expression Lysate for ZMYND10 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ZMYND10 OriGene 3'-UTR Clone for ZMYND10 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ZMYND10 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ZMYND10 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for ZMYND10 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ZMYND10 OriGene Custom Protein Services for ZMYND10 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZMYND10 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ZMYND10 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ZMYND10 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat ZMYND10 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ZMYND10 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ZMYND10
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ZMYND10 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZMYND10
ThermoFisher Antibodies for ZMYND10
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ZMYND10
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