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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZMYM6NB Gene

protein-coding   GIFtS: 34
GCID: GC01M035451

ZMYM6 Neighbor

  Search for ZMYM6NB
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ZMYM6 Neighbor1 2
ZMYM6 Neighbor Protein2 3
Uncharacterized Protein ZMYM6NB2

External Ids:    HGNC: 400211   Entrez Gene: 1005061442   Ensembl: ENSG000002437497   UniProtKB: Q8NCS43   

Export aliases for ZMYM6NB gene to outside databases

Previous GC identifer: GC01M035449


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZMYM6NB Gene: 
ZMYM6NB (ZMYM6 neighbor) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_032977.9  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ZMYM6NB
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ZMYM6NB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZMYM6NB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.3   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p34.3

ZMYM6NB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZMYM6NB gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M035451:  view genomic region     (about GC identifiers)

Start:
35,447,127 bp from pter      End:
35,450,954 bp from pter
Size:
3,828 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZMYNB_HUMAN, Q8NCS4 (See protein sequence)
Recommended Name: Uncharacterized protein ZMYM6NB precursor  
Size: 154 amino acids; 16885 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Explore the universe of human proteins at neXtProt for ZMYM6NB: NX_Q8NCS4

Explore proteomics data for ZMYM6NB at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NCS4

  • ZMYM6NB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZMYM6NB Protein Expression
    REFSEQ proteins: NP_001182085.1  
    ENSEMBL proteins: 
     ENSP00000362435  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    ZMYM6NB for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q8NCS4

    1 Blocks protein domain: IPB011637 DoxX

    UniProtKB/Swiss-Prot: ZMYNB_HUMAN, Q8NCS4
    Similarity: Belongs to the DoxX family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZMYM6NB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/10 Interacting proteins for ZMYM6NB (ENSP000003624354) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CPSF3LENSP000004134934STRING: ENSP00000413493
    ENSG00000173503ENSP000003729914STRING: ENSP00000372991
    ENSG00000206308ENSP000003727464STRING: ENSP00000372746
    ENSG00000227317ENSP000004031544STRING: ENSP00000403154
    ENSG00000231377ENSP000003939584STRING: ENSP00000393958
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZMYM6NB (ZMYNB)

    Search CenterWatch for drugs/clinical trials and news about ZMYM6NB / ZMYNB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for ZMYM6NB gene: 
    NM_001195156.1  

    Unigene Cluster for ZMYM6NB:

    ZMYM6 neighbor
    Hs.533986  [show with all ESTs]
    Unigene Representative Sequence: BC021230
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000373337(uc001bye.3)
    miRNA
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    Additional mRNA sequence: 

    AK129824.1 BC021230.2 BC029439.1 NR_037869.1 

    7 DOTS entries:

    DT.213947  DT.95170301  DT.100647716  DT.97838601  DT.100042004  DT.95367125  DT.95367124 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZMYM6NB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCATATGAAA
    ZMYM6NB Expression
    About this image


    See ZMYM6NB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZMYM6NB

    SOURCE GeneReport for Unigene cluster: Hs.533986
        SABiosciences Custom PCR Arrays for ZMYM6NB
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZMYM6NB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZMYM6NB gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gm129421 , 5 predicted gene 129421, 5 77.62(n)1
    70.63(a)1
      4 (61.29 cM)5
    1000399681  NM_001099319.11  NP_001092789.11 
     1271236915 
    chicken
    (Gallus gallus)
    Aves LOC1008579841 uncharacterized LOC100857984 62.72(n)
    56.3(a)
      100857984  XM_003642569.1  XP_003642617.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZMYM6NB6
    Uncharacterized protein
    57(a)
    1 ↔ 1
    GL343558.1(368624-373353)


    ENSEMBL Gene Tree for ZMYM6NB (if available)
    TreeFam Gene Tree for ZMYM6NB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/78 SNPs in ZMYM6NB are shown (see all 78)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1423118481,2
    --35446701(+) CTCCAC/TGTAGG 1 -- ds50010--------
    rs112638721,2
    C,F,A,H--35446830(+) GGAGTG/AGGAGG 1 -- ds500118Minor allele frequency- A:0.16NS EA NA WA 2346
    rs1446071691,2
    --35446871(+) CAGAAC/GCAAGT 1 -- ds50010--------
    rs1828187831,2
    C--35446941(+) ATGCAC/TGTGTT 1 -- ds50010--------
    rs1384293311,2
    --35446986(+) TAAGTA/GTGCAA 1 -- ds50010--------
    rs1873853151,2
    --35447014(+) GCTTAC/TGAGAG 1 -- ds50010--------
    rs2005867661,2
    --35447200(+) TTTCA-/TTTAAA 1 -- ut310--------
    rs73621,2
    C,F,H--35447202(+) TCATTT/AAAAAA 1 -- ut318Minor allele frequency- A:0.30MN NA WA EA 552
    rs752784171,2
    --35447203(+) CATTTA/TAAAAA 1 -- ut310--------
    rs740641041,2
    C,F--35447209(+) AAAAAT/AATATA 1 -- ut312Minor allele frequency- A:0.50WA 4

    HapMap Linkage Disequilibrium report for ZMYM6NB (35447127 - 35450954 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZMYM6NB:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv213n71CNV Loss21882294
    nsv870757CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZMYM6NB gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZMYM6NB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of VKORC1 interaction partners by spli t-ubiquitin system and coimmunoprecipitation. (PubMed id 21103663)1 Schaafhausen A....MA1ller C.R. (2011)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    5. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 100506144 HGNC: 40021 Ensembl:ENSG00000243749 euGenes: HUgn100506144 ECgene: ZMYM6NB
    H-InvDB: ZMYM6NB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZMYM6NB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZMYM6NB gene:
    Search GeneIP for patents involving ZMYM6NB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     Browse SwitchGear 3'UTR luciferase reporter plasmids for ZMYM6NB
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     inGenious Targeting Laboratory - Custom generated mouse model solutions for ZMYM6NB
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZMYM6NB
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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