Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ZMYM6 Gene

protein-coding   GIFtS: 50
GCID: GC01M035453

Zinc Finger, MYM-Type 6

(Previous names: zinc finger protein 258, zinc finger, MYM-type containing...)
(Previous symbol: ZNF258)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Zinc Finger, MYM-Type 61 2     Buster22 3
ZNF2581 2 3 5     MYM2
Zinc Finger Protein 2581 2 3     ZNF198L42
Zinc Finger, MYM-Type Containing 61 2     Zinc Finger MYM-Type Protein 62
Transposon-Derived Buster2 Transposase-Like Protein2 3     KIAA13533

External Ids:    HGNC: 130501   Entrez Gene: 92042   Ensembl: ENSG000001638677   OMIM: 6135675   UniProtKB: O957893   

Export aliases for ZMYM6 gene to outside databases

Previous GC identifers: GC01M035111 GC01M035219 GC01M035445 GC01M033569 GC01M035450


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for ZMYM6 Gene:
ZMYM6 (zinc finger, MYM-type 6) is a protein-coding gene. Diseases associated with ZMYM6 include non-specific x-linked mental retardation, and t-cell leukemia. An important paralog of this gene is ZMYM4.

UniProtKB/Swiss-Prot: ZMYM6_HUMAN, O95789
Function: Plays a role in the regulation of cell morphology and cytoskeletal organization




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZMYM6 gene promoter:
         USF1   SREBP-1c   USF2   USF-1:USF-2   C/EBPalpha   SREBP-1b   SREBP-1a   USF-1   Msx-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZMYM6 promoter sequence
   Search Chromatin IP Primers for ZMYM6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZMYM6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.2   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p34.2

ZMYM6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZMYM6 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M035453:  view genomic region     (about GC identifiers)

Start:
35,449,523 bp from pter      End:
35,497,569 bp from pter
Size:
48,047 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ZMYM6_HUMAN, O95789 (See protein sequence)
Recommended Name: Zinc finger MYM-type protein 6  
Size: 1325 amino acids; 148089 Da
Sequence caution: Sequence=AAH33903.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAI07881.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=BAA92591.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B4DRJ6 Q32Q23 Q4G108 Q5SVZ9 Q5SW00 Q69YL4 Q96IY0 Q9NWF1 Q9P2J4
Alternative splicing: 5 isoforms:  O95789-3   O95789-2   O95789-1   O95789-4   O95789-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZMYM6: NX_O95789

Explore proteomics data for ZMYM6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZMYM6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009098.3  
    ENSEMBL proteins: 
     ENSP00000349708   ENSP00000391337   ENSP00000326695   ENSP00000362430   ENSP00000362437  

    ZMYM6 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ZMYM6
    GenScript Custom Purified and Recombinant Proteins Services for ZMYM6
    Novus Biologicals ZMYM6 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZMYM6

    ZMYM6 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ZMYM6
    Novus Biologicals ZMYM6 Antibodies
    Abcam antibodies for ZMYM6
    Cloud-Clone Corp. Antibodies for ZMYM6
    Search ThermoFisher Antibodies for ZMYM6
    LSBio Antibodies in human, mouse, rat for ZMYM6

    ZMYM6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ZMYM6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ZMYM6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ZMYM6
    Cloud-Clone Corp. CLIAs for ZMYM6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ZBED: Zinc fingers, BED-type
    ZMYM: Zinc fingers, MYM type

    4 InterPro protein domains:
     IPR025398 DUF4371
     IPR011017 TRASH_dom
     IPR010507 Znf_MYM
     IPR012337 RNaseH-like_dom

    Graphical View of Domain Structure for InterPro Entry O95789

    ProtoNet protein and cluster: O95789

    2 Blocks protein domains:
    IPB010507 MYM-type zinc finger
    IPB011017 TRASH


    UniProtKB/Swiss-Prot: ZMYM6_HUMAN, O95789
    Similarity: Contains 8 MYM-type zinc fingers


    ZMYM6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZMYM6_HUMAN, O95789
    Function: Plays a role in the regulation of cell morphology and cytoskeletal organization

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding TAS10486218
    GO:0008270zinc ion binding IEA--
         
    ZMYM6 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZMYM6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ZMYM6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZMYM6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZMYM6

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ZMYM6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZMYM6 (see all 13):
    hsa-miR-3140-3p hsa-miR-300 hsa-miR-3065-5p hsa-miR-381 hsa-miR-944 hsa-miR-570 hsa-miR-373* hsa-miR-370
    SwitchGear 3'UTR luciferase reporter plasmidZMYM6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ZMYM6
    Predesigned siRNA for gene silencing in human, mouse, rat ZMYM6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ZMYM6

    Clone
    Products:
         
    OriGene clones in human, mouse for ZMYM6 (see all 9)
    OriGene ORF clones in mouse, rat for ZMYM6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZMYM6 (NM_007167)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZMYM6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZMYM6

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ZMYM6
    Browse ESI BIO Cell Lines and PureStem Progenitors for ZMYM6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZMYM6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ZMYM6_HUMAN, O95789: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZMYM6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZMYM6
    Interactions:

        Search GeneGlobe Interaction Network for ZMYM6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for ZMYM6 (O957893 ENSP000003497084) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KLHL13Q9P2N73, ENSP000002628204I2D: score=2 STRING: ENSP00000262820
    CDK9P507503, ENSP000003623614I2D: score=1 STRING: ENSP00000362361
    FOSP011003I2D: score=1 
    C1orf146ENSP000003594014STRING: ENSP00000359401
    CRYZENSP000003393994STRING: ENSP00000339399
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007010cytoskeleton organization IMP--
    GO:0007275multicellular organismal development TAS10486218
    GO:0022604regulation of cell morphogenesis IMP--

    ZMYM6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZMYM6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ZMYM6 gene: 
    NM_007167.3  

    Unigene Cluster for ZMYM6:

    Zinc finger, MYM-type 6
    Hs.623978
    Unigene Representative Sequence: BC043174
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000493328(uc021olg.1 uc009vur.1 uc001byh.3 uc010oht.2 uc009vup.3)
    ENST00000357182 ENST00000466345 ENST00000472971 ENST00000415531 ENST00000317538(uc001byi.2 uc001byj.2 uc001byk.2)
    ENST00000460607 ENST00000373333 ENST00000471566 ENST00000373340(uc009vuq.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ZMYM6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZMYM6 (see all 13):
    hsa-miR-3140-3p hsa-miR-300 hsa-miR-3065-5p hsa-miR-381 hsa-miR-944 hsa-miR-570 hsa-miR-373* hsa-miR-370
    SwitchGear 3'UTR luciferase reporter plasmidZMYM6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZMYM6
    Predesigned siRNA for gene silencing in human, mouse, rat ZMYM6
    Clone
    Products:
         
    OriGene clones in human, mouse for ZMYM6 (see all 9)
    OriGene ORF clones in mouse, rat for ZMYM6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZMYM6 (NM_007167)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZMYM6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZMYM6
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ZMYM6
    OriGene qSTAR qPCR primer pairs in human, mouse for ZMYM6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZMYM6
      QuantiTect SYBR Green Assays in human, mouse, rat ZMYM6
      QuantiFast Probe-based Assays in human, mouse, rat ZMYM6

    Additional mRNA sequence: BC043174.1 

    1 DOTS entry:

    DT.100687616 

    Selected AceView cDNA sequences (see all 222):

    NM_153248 BC017791 AL833263 CA436657 BG194526 BE326793 BG099266 AA582409 
    AA494557 AA358326 AI679115 BU428774 AW515692 BQ433793 AA808128 AI679691 
    AI935035 AI923852 AF055470 AW768451 AI201302 BC042172 AI432925 H65044 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZMYM6 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a ·
    SP1:                    -     -     -                                   -                                                                                       
    SP2:                                                                    -                                                                             -     -   
    SP3:                                -                                   -                                                                                       
    SP4:                    -     -                                                                                                                                 
    SP5:                                                                                                                                                            

    ExUns: 19b ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23a · 23b
    SP1:                                                
    SP2:  -                                             
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for ZMYM6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ZMYM6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACACTGAAA
    ZMYM6 Expression
    About this image


    ZMYM6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    ZMYM6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZMYM6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.623978

    UniProtKB/Swiss-Prot: ZMYM6_HUMAN, O95789
    Tissue specificity: Expressed at high levels in heart, skeletal muscle, kidney and liver

        Custom PCR Arrays for ZMYM6
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ZMYM6
    OriGene qSTAR qPCR primer pairs in human, mouse for ZMYM6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZMYM6
    QuantiTect SYBR Green Assays in human, mouse, rat ZMYM6
    QuantiFast Probe-based Assays in human, mouse, rat ZMYM6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZMYM6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for ZMYM6 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zmym61 , 5 zinc finger, MYM-type 61, 5 76.91(n)1
    68.07(a)1
      4 (61.25 cM)5
    1001771  NM_001285885.11  NP_001272814.11 
     1270773835 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    38(a)
    1 → many
    23(4300142-4333315)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    52(a)
    1 → many
    GL343558.1(321265-328034)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.5552 Transcribed sequence with weak similarity to protein more 74.88(n)    137726423 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-266o15.16
    zmym46
    (see all 3)
    zinc finger, MYM-type 4
    (see all 3)
    23(a)
    22(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    17(14572554-14621817) ENSDARG00000057681
    19(41029866-41074277) ENSDARG00000035823
    fruit fly
    (Drosophila melanogaster)
    Insecta woc6
    without children
    11(a)
    1 → many
    3R(23082315-23089758)


    ENSEMBL Gene Tree for ZMYM6 (if available)
    TreeFam Gene Tree for ZMYM6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ZMYM6 gene
    ZMYM42  ENSG000002717412  ZMYM52  ZMYM32  ZMYM22  QRICH12  
    5 SIMAP similar genes for ZMYM6 using alignment to 1 protein entry:     ZMYM6_HUMAN:
    ZMYM4    FAM200A    ZMYM1    ZBED5    ZBED8

    ZMYM6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ZMYM6 (see all 920)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs168371471,2,,4
    C,F,H--35452986(+) CTTTTC/TTTCTT 2 K E mis1 trp317Minor allele frequency- T:0.08NA NS EA WA EU 3091
    rs1488748631,2
    C--35453058(+) TGAACA/GCAAGT 2 R C mis10--------
    rs1864804441,2
    C--35453087(+) AGTCAC/TTGAAC 2 N S mis10--------
    rs803510941,2
    F--35453328(+) AAATAT/CATCTG 2 /I /V mis11Minor allele frequency- C:0.03EA 120
    rs1912865451,2
    --35453615(+) ATGGAA/GACAAC 2 S F mis10--------
    rs617448531,2
    C--35453651(+) GAATAA/CAACAA 2 C F mis11Minor allele frequency- C:0.01NS 74
    rs1824274931,2
    --35453683(+) ATGGCA/GACTTC 2 V syn10--------
    rs617431861,2
    C--35453771(+) TCCAAT/GTCAGA 2 /N /T mis11Minor allele frequency- G:0.01NS 74
    rs1411388401,2
    C--35453877(+) ATCACA/GACAAT 2 R C mis10--------
    rs1445812111,2
    C--35453878(+) TCACGA/GCAATC 2 C syn10--------

    HapMap Linkage Disequilibrium report for ZMYM6 (35449523 - 35497569 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ZMYM6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508138CNV Loss20534489
    dgv213n71CNV Loss21882294
    nsv870757CNV Gain21882294
    nsv511093CNV Complex20534489

    Human Gene Mutation Database (HGMD): ZMYM6
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZMYM6
    DNA2.0 Custom Variant and Variant Library Synthesis for ZMYM6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 613567    OMIM disorders: --

    8 diseases for ZMYM6:    
    About MalaCards
    non-specific x-linked mental retardation    t-cell leukemia    mental retardation    tonsillitis
    leukemia    thyroiditis    cerebritis    endotheliitis

    2 diseases from the University of Copenhagen DISEASES database for ZMYM6:
    non-specific X-linked mental retardation     Stem cell leukemia

    ZMYM6 for disorders           About GeneDecksing


    Export disorders for ZMYM6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ZMYM6 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with ZMYM6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and mapping of members of the MYM family. (PubMed id 10486218)1, 2, 3 Smedley D.... Shipley J. (Genomics 1999)
    2. ZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions. (PubMed id 23533661)1, 3 Hayward A.... Jern P. (PLoS ONE 2013)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. (PubMed id 21834987)2 Bai S.W.... Ridley A.J. (BMC Biol. 2011)
    8. System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (Sci Signal 2009)
    9. Defining the human deubiquitinating enzyme interaction landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (Cell 2009)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9204 HGNC: 13050 AceView: ZNF258 Ensembl:ENSG00000163867 euGenes: HUgn9204
    ECgene: ZMYM6 H-InvDB: ZMYM6

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1353

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ZMYM6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ZMYM6 gene:
    Search GeneIP for patents involving ZMYM6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ZMYM6  
     OriGene qPCR primer pairs and template standards for ZMYM6   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ZMYM6  
     OriGene qSTAR qPCR primer pairs in human, mouse for ZMYM6   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ZMYM6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ZMYM6   OriGene Custom Protein Services for ZMYM6  

     
     
     Block miRNA regulation of human, mouse, rat ZMYM6 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ZMYM6
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZMYM6 Predesigned siRNA for gene silencing in human, mouse, rat ZMYM6
     QuantiFast Probe-based Assays in human, mouse, rat ZMYM6 QuantiTect SYBR Green Assays in human, mouse, rat ZMYM6
     Custom PCR Arrays for ZMYM6 Search Chromatin IP Primers for ZMYM6
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZMYM6  Search GeneGlobe Interaction Network for ZMYM6
     Regulatory tfbs in ZMYM6 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ZMYM6 GenScript cDNA clones with any tag delivered in your preferred vector for ZMYM6
     GenScript Custom Assay Services for ZMYM6 GenScript Custom overexpressing Cell Line Services for ZMYM6
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ZMYM6
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ZMYM6 antibodies
     ZMYM6 proteins
     Antibodies for ZMYM6
     See all of Abcam's Antibodies, Kits and Proteins for ZMYM6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ZMYM6
     Antibodies for ZMYM6
     ELISAs for ZMYM6
     CLIAs for ZMYM6



     Browse ESI BIO Cell Lines and PureStem Progenitors for ZMYM6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZMYM6
     SwitchGear 3'UTR luciferase reporter plasmids for ZMYM6
     SwitchGear Promoter luciferase reporter plasmids for ZMYM6
     Search ThermoFisher Antibodies for ZMYM6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZMYM6
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZMYM6
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ZMYM6
     LSBio Antibodies in human, mouse, rat for ZMYM6
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ZMYM6 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4