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Aliases for ZMYM6 Gene

Aliases for ZMYM6 Gene

  • Zinc Finger MYM-Type Containing 6 2 3 5
  • Zinc Finger Protein 258 2 3 4
  • Transposon-Derived Buster2 Transposase-Like Protein 3 4
  • Zinc Finger, BED-Type Containing 7 2 3
  • Buster2 3 4
  • ZNF258 3 4
  • Zinc Finger MYM-Type Protein 6 3
  • Zinc Finger, MYM-Type 6 3
  • ZNF198L4 3
  • KIAA1353 4
  • ZBED7 3
  • MYM 3

External Ids for ZMYM6 Gene

Previous HGNC Symbols for ZMYM6 Gene

  • ZNF258

Previous GeneCards Identifiers for ZMYM6 Gene

  • GC01M035111
  • GC01M035219
  • GC01M035445
  • GC01M033569
  • GC01M035450
  • GC01M035453

Summaries for ZMYM6 Gene

GeneCards Summary for ZMYM6 Gene

ZMYM6 (Zinc Finger MYM-Type Containing 6) is a Protein Coding gene. Diseases associated with ZMYM6 include Non-Syndromic X-Linked Intellectual Disability. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ENSG00000271741.

UniProtKB/Swiss-Prot for ZMYM6 Gene

  • Plays a role in the regulation of cell morphology and cytoskeletal organization.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZMYM6 Gene

Genomics for ZMYM6 Gene

Regulatory Elements for ZMYM6 Gene

Enhancers for ZMYM6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F035078 1.1 ENCODE 11.9 -47.9 -47942 2.4 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 CBX5 ZNF143 KLF13 ZMYM1 LOC653160 SFPQ ENSG00000230163 RPL5P4 ZMYM6 AGO1 TMEM35B LOC105378647 ZMYM4
GH01F034983 0.4 ENCODE 11.3 +47.0 47018 2.5 HDGF ATF1 PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF48 YY1 RPL5P4 ZMYM1 ZMYM6 SFPQ LOC653160 DLGAP3
GH01F035162 0.7 Ensembl ENCODE 11 -130.5 -130482 0.9 IRF2 SAP130 MLX DDX20 ZNF384 RAD21 YY1 ZNF316 GATA3 GATA2 ZMYM1 CLSPN ENSG00000201868 SFPQ ZMYM6 ENSG00000201542 LOC653160 TMEM35B LOC105378644
GH01F035178 0.6 ENCODE 11 -147.8 -147785 2.6 PKNOX1 ARID4B RAD21 YY1 BCLAF1 CREM MIXL1 THAP11 SMAD5 POLR2H ZMYM6 ENSG00000201542 LOC653160 TMEM35B KIAA0319L SFPQ LOC105378644
GH01F034970 0.7 Ensembl 10.7 +60.9 60920 0.3 SOX5 FOXA1 OSR2 ZNF274 MAFF ZNF316 PATZ1 MAFK EMSY ZNF558 ZMYM6 LOC653160 DLGAP3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZMYM6 on UCSC Golden Path with GeneCards custom track

Promoters for ZMYM6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000076261 668 2600 HDGF ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143

Genomic Location for ZMYM6 Gene

Chromosome:
1
Start:
34,986,165 bp from pter
End:
35,031,968 bp from pter
Size:
45,804 bases
Orientation:
Minus strand

Genomic View for ZMYM6 Gene

Genes around ZMYM6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZMYM6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZMYM6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZMYM6 Gene

Proteins for ZMYM6 Gene

  • Protein details for ZMYM6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95789-ZMYM6_HUMAN
    Recommended name:
    Zinc finger MYM-type protein 6
    Protein Accession:
    O95789
    Secondary Accessions:
    • B4DRJ6
    • Q32Q23
    • Q4G108
    • Q5SVZ9
    • Q5SW00
    • Q69YL4
    • Q96IY0
    • Q9NWF1
    • Q9P2J4

    Protein attributes for ZMYM6 Gene

    Size:
    1325 amino acids
    Molecular mass:
    148089 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH33903.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI07881.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA92591.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZMYM6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZMYM6 Gene

Post-translational modifications for ZMYM6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZMYM6 Gene

No data available for DME Specific Peptides for ZMYM6 Gene

Domains & Families for ZMYM6 Gene

Gene Families for ZMYM6 Gene

Protein Domains for ZMYM6 Gene

Suggested Antigen Peptide Sequences for ZMYM6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95789

UniProtKB/Swiss-Prot:

ZMYM6_HUMAN :
  • Contains 8 MYM-type zinc fingers.
Similarity:
  • Contains 8 MYM-type zinc fingers.
genes like me logo Genes that share domains with ZMYM6: view

Function for ZMYM6 Gene

Molecular function for ZMYM6 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of cell morphology and cytoskeletal organization.

Gene Ontology (GO) - Molecular Function for ZMYM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding TAS 10486218
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZMYM6: view
genes like me logo Genes that share phenotypes with ZMYM6: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZMYM6 Gene

Localization for ZMYM6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZMYM6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZMYM6 Gene COMPARTMENTS Subcellular localization image for ZMYM6 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZMYM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with ZMYM6: view

Pathways & Interactions for ZMYM6 Gene

SuperPathways for ZMYM6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZMYM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0007010 cytoskeleton organization IMP 21834987
GO:0007275 multicellular organism development TAS 10486218
GO:0022604 regulation of cell morphogenesis IMP 21834987
genes like me logo Genes that share ontologies with ZMYM6: view

No data available for Pathways by source and SIGNOR curated interactions for ZMYM6 Gene

Transcripts for ZMYM6 Gene

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZMYM6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a ·
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - -
SP5:
SP6: - - -
SP7: - -
SP8: - - - - -
SP9:
SP10:
SP11:
SP12:

ExUns: 19b ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23a · 23b
SP1:
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11: - - - - -
SP12:

Relevant External Links for ZMYM6 Gene

GeneLoc Exon Structure for
ZMYM6
ECgene alternative splicing isoforms for
ZMYM6

Expression for ZMYM6 Gene

mRNA expression in normal human tissues for ZMYM6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZMYM6 Gene

This gene is overexpressed in Monocytes (41.7), Tlymphocyte (16.0), and Heart (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZMYM6 Gene



Protein tissue co-expression partners for ZMYM6 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZMYM6 Gene:

ZMYM6

SOURCE GeneReport for Unigene cluster for ZMYM6 Gene:

Hs.623978

mRNA Expression by UniProt/SwissProt for ZMYM6 Gene:

O95789-ZMYM6_HUMAN
Tissue specificity: Expressed at high levels in heart, skeletal muscle, kidney and liver.
genes like me logo Genes that share expression patterns with ZMYM6: view

Primer Products

No data available for mRNA differential expression in normal tissues for ZMYM6 Gene

Orthologs for ZMYM6 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZMYM6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZMYM6 34 35
  • 99.82 (n)
dog
(Canis familiaris)
Mammalia ZMYM6 34 35
  • 90.16 (n)
cow
(Bos Taurus)
Mammalia ZMYM6 34
  • 90.09 (n)
rat
(Rattus norvegicus)
Mammalia Zmym6 34
  • 76.93 (n)
mouse
(Mus musculus)
Mammalia Zmym6 34 16 35
  • 76.91 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 45 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 38 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 38 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 52 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.555 34
zebrafish
(Danio rerio)
Actinopterygii si:ch211-266o15.1 35
  • 23 (a)
ManyToMany
zmym4 35
  • 22 (a)
ManyToMany
si:ch211-173p18.3 35
  • 21 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta woc 35
  • 11 (a)
OneToMany
Species where no ortholog for ZMYM6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZMYM6 Gene

ENSEMBL:
Gene Tree for ZMYM6 (if available)
TreeFam:
Gene Tree for ZMYM6 (if available)

Paralogs for ZMYM6 Gene

Paralogs for ZMYM6 Gene

(5) SIMAP similar genes for ZMYM6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZMYM6: view

Variants for ZMYM6 Gene

Sequence variations from dbSNP and Humsavar for ZMYM6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10081980 -- 35,033,479(+) GTATC(A/T)CACTG upstream-variant-2KB
rs10157517 -- 35,005,289(+) AAAAA(A/G)TTAAG intron-variant
rs10158256 -- 35,003,981(+) TGATC(C/T)TTGCT reference, missense
rs10158284 -- 35,005,276(+) TACTG(A/T)TTAAA intron-variant
rs10158530 -- 35,007,688(+) CTCTC(A/C)TGGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZMYM6 Gene

Variant ID Type Subtype PubMed ID
nsv1133836 CNV deletion 24896259
nsv508138 CNV deletion 20534489
nsv511093 OTHER complex 20534489

Variation tolerance for ZMYM6 Gene

Residual Variation Intolerance Score: 39.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.19; 69.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZMYM6 Gene

Human Gene Mutation Database (HGMD)
ZMYM6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZMYM6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZMYM6 Gene

Disorders for ZMYM6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZMYM6 Gene - From: DISEASES

Disorder Aliases PubMed IDs
non-syndromic x-linked intellectual disability
  • mrx
- elite association - COSMIC cancer census association via MalaCards
Search ZMYM6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ZMYM6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZMYM6
genes like me logo Genes that share disorders with ZMYM6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZMYM6 Gene

Publications for ZMYM6 Gene

  1. Cloning and mapping of members of the MYM family. (PMID: 10486218) Smedley D. … Shipley J. (Genomics 1999) 2 3 4 64
  2. ZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions. (PMID: 23533661) Hayward A. … Jern P. (PLoS ONE 2013) 2 3 64
  3. Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. (PMID: 21834987) Bai S.W. … Ridley A.J. (BMC Biol. 2011) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for ZMYM6 Gene

Sources for ZMYM6 Gene

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