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Aliases for ZMYM5 Gene

Aliases for ZMYM5 Gene

  • Zinc Finger MYM-Type Containing 5 2 3
  • Zinc Finger Protein 237 2 3 4
  • Zinc Finger Protein 198-Like 1 3 4
  • Zinc Finger, MYM-Type 5 3 5
  • ZNF198L1 3 4
  • ZNF237 3 4
  • HSPC050 3
  • MYM 3

External Ids for ZMYM5 Gene

Previous HGNC Symbols for ZMYM5 Gene

  • ZNF237

Previous GeneCards Identifiers for ZMYM5 Gene

  • GC13M019310
  • GC13M020397
  • GC13M001202

Summaries for ZMYM5 Gene

GeneCards Summary for ZMYM5 Gene

ZMYM5 (Zinc Finger MYM-Type Containing 5) is a Protein Coding gene. An important paralog of this gene is ZMYM6.

UniProtKB/Swiss-Prot for ZMYM5 Gene

  • Functions as a transcriptional regulator.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZMYM5 Gene

Genomics for ZMYM5 Gene

Regulatory Elements for ZMYM5 Gene

Promoters for ZMYM5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZMYM5 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZMYM5 Gene

Chromosome:
13
Start:
19,823,482 bp from pter
End:
19,863,636 bp from pter
Size:
40,155 bases
Orientation:
Minus strand

Genomic View for ZMYM5 Gene

Genes around ZMYM5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZMYM5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZMYM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZMYM5 Gene

Proteins for ZMYM5 Gene

  • Protein details for ZMYM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJ78-ZMYM5_HUMAN
    Recommended name:
    Zinc finger MYM-type protein 5
    Protein Accession:
    Q9UJ78
    Secondary Accessions:
    • B2R6V1
    • Q5T6E1
    • Q5T6E2
    • Q5T6E4
    • Q96IY6
    • Q9NZY5
    • Q9UBW0
    • Q9UJ77

    Protein attributes for ZMYM5 Gene

    Size:
    669 amino acids
    Molecular mass:
    74817 Da
    Quaternary structure:
    • Interacts (via N-terminal 120 amino acid region) with ETV5 (via C-terminal).
    SequenceCaution:
    • Sequence=AAF29022.1; Type=Frameshift; Positions=286, 322, 337; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZMYM5 Gene

    Alternative splice isoforms for ZMYM5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZMYM5 Gene

Proteomics data for ZMYM5 Gene at MOPED

Post-translational modifications for ZMYM5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZMYM5 Gene

No data available for DME Specific Peptides for ZMYM5 Gene

Domains & Families for ZMYM5 Gene

Gene Families for ZMYM5 Gene

Protein Domains for ZMYM5 Gene

Suggested Antigen Peptide Sequences for ZMYM5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UJ78

UniProtKB/Swiss-Prot:

ZMYM5_HUMAN :
  • Contains 4 MYM-type zinc fingers.
Similarity:
  • Contains 4 MYM-type zinc fingers.
genes like me logo Genes that share domains with ZMYM5: view

Function for ZMYM5 Gene

Molecular function for ZMYM5 Gene

UniProtKB/Swiss-Prot Function:
Functions as a transcriptional regulator.

Gene Ontology (GO) - Molecular Function for ZMYM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA 17126306
genes like me logo Genes that share ontologies with ZMYM5: view

Phenotypes for ZMYM5 Gene

genes like me logo Genes that share phenotypes with ZMYM5: view

Animal Model Products

CRISPR Products

miRNA for ZMYM5 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZMYM5 Gene

Localization for ZMYM5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZMYM5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZMYM5 Gene COMPARTMENTS Subcellular localization image for ZMYM5 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZMYM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with ZMYM5: view

Pathways & Interactions for ZMYM5 Gene

SuperPathways for ZMYM5 Gene

No Data Available

Interacting Proteins for ZMYM5 Gene

Gene Ontology (GO) - Biological Process for ZMYM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IBA --
genes like me logo Genes that share ontologies with ZMYM5: view

No data available for Pathways by source and SIGNOR curated interactions for ZMYM5 Gene

Drugs & Compounds for ZMYM5 Gene

No Compound Related Data Available

Transcripts for ZMYM5 Gene

Unigene Clusters for ZMYM5 Gene

Zinc finger, MYM-type 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZMYM5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9
SP1: -
SP2: - -
SP3:
SP4: -
SP5: -
SP6:
SP7: - -

Relevant External Links for ZMYM5 Gene

GeneLoc Exon Structure for
ZMYM5
ECgene alternative splicing isoforms for
ZMYM5

Expression for ZMYM5 Gene

mRNA expression in normal human tissues for ZMYM5 Gene

Protein differential expression in normal tissues from HIPED for ZMYM5 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZMYM5 Gene



SOURCE GeneReport for Unigene cluster for ZMYM5 Gene Hs.530988

genes like me logo Genes that share expression patterns with ZMYM5: view

Protein tissue co-expression partners for ZMYM5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZMYM5 Gene

Orthologs for ZMYM5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZMYM5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZMYM5 35
  • 85.58 (n)
  • 78.29 (a)
ZMYM5 36
  • 41 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZMYM5 35
  • 87.8 (n)
  • 80.12 (a)
mouse
(Mus musculus)
Mammalia Zmym5 35
  • 79.86 (n)
  • 68.91 (a)
Zmym5 16
Zmym5 36
  • 36 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZMYM5 35
  • 99.55 (n)
  • 98.95 (a)
ZMYM5 36
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1306353 35
  • 79.98 (n)
  • 68.18 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 18 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 17 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii zmym2 36
  • 11 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta woc 36
  • 4 (a)
OneToMany
Species with no ortholog for ZMYM5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZMYM5 Gene

ENSEMBL:
Gene Tree for ZMYM5 (if available)
TreeFam:
Gene Tree for ZMYM5 (if available)

Paralogs for ZMYM5 Gene

Paralogs for ZMYM5 Gene

genes like me logo Genes that share paralogs with ZMYM5: view

Variants for ZMYM5 Gene

Sequence variations from dbSNP and Humsavar for ZMYM5 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs9579718 - 19,851,808(+) TTCTA(C/T)GTCCT reference, missense
rs9579717 - 19,851,771(+) TAAAA(A/C/T)AGGAA reference, missense
rs41292167 - 19,838,881(+) GGCTG(A/C/T)AGGCT intron-variant, reference, missense
rs711831 -- 19,864,743(-) CGCCC(C/G)GCGAT upstream-variant-2KB
rs2014460 -- 19,864,028(-) CAGGC(A/G)GCCCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZMYM5 Gene

Variant ID Type Subtype PubMed ID
nsv516945 CNV Gain+Loss 19592680
nsv899857 CNV Gain 21882294
nsv455826 CNV Loss 19166990
dgv1551n71 CNV Loss 21882294
nsv899860 CNV Loss 21882294
nsv899865 CNV Gain 21882294
dgv1553n71 CNV Loss 21882294

Variation tolerance for ZMYM5 Gene

Residual Variation Intolerance Score: 86.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.48; 77.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZMYM5 Gene

HapMap Linkage Disequilibrium report
ZMYM5
Human Gene Mutation Database (HGMD)
ZMYM5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZMYM5 Gene

Disorders for ZMYM5 Gene

Relevant External Links for ZMYM5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZMYM5

No disorders were found for ZMYM5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZMYM5 Gene

Publications for ZMYM5 Gene

  1. Cloning of ZNF237, a novel member of the MYM gene family that maps to human chromosome 13q11-->q12. (PMID: 10894931) Sohal J. … Cross N.C. (Cytogenet. Cell Genet. 2000) 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for ZMYM5 Gene

Sources for ZMYM5 Gene

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