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Aliases for ZMYM4 Gene

Aliases for ZMYM4 Gene

  • Zinc Finger MYM-Type Containing 4 2 3 5
  • Zinc Finger Protein 262 2 3 4
  • ZNF262 3 4
  • Zinc Finger MYM-Type Protein 4 3
  • Cell Death Inhibiting RNA 3
  • Zinc Finger, MYM-Type 4 3
  • ZNF198L3 3
  • KIAA0425 4
  • CDIR 3
  • MYM 3

External Ids for ZMYM4 Gene

Previous HGNC Symbols for ZMYM4 Gene

  • ZNF262

Previous GeneCards Identifiers for ZMYM4 Gene

  • GC01P035404
  • GC01P035507
  • GC01P035734
  • GC01P033853

Summaries for ZMYM4 Gene

GeneCards Summary for ZMYM4 Gene

ZMYM4 (Zinc Finger MYM-Type Containing 4) is a Protein Coding gene. Diseases associated with ZMYM4 include Non-Syndromic X-Linked Intellectual Disability. An important paralog of this gene is ZMYM6.

UniProtKB/Swiss-Prot for ZMYM4 Gene

  • Plays a role in the regulation of cell morphology and cytoskeletal organization.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZMYM4 Gene

Genomics for ZMYM4 Gene

Regulatory Elements for ZMYM4 Gene

Enhancers for ZMYM4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G034865 1.6 Ensembl ENCODE dbSUPER 55.9 -402.2 -402195 2.7 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 ZNF263 SFPQ ZMYM1 LOC653160 ZMYM4 RPL5P4 ENSG00000230163 TMEM35B GJB4 TFAP2E SMIM12
GH01G035800 1.4 Ensembl ENCODE dbSUPER 55.9 +531.9 531887 1.2 ZNF493 ZFP64 ZNF121 ZNF302 KLF7 SP3 MCM3 TSHZ1 REST ZNF623 ZMYM1 SFPQ ZMYM4 RPL5P4 LOC653160 ENSG00000230163 COL8A2 THRAP3 EVA1B LOC105378647
GH01G035856 1.1 dbSUPER 54 +588.7 588706 2.0 HDGF PKNOX1 ARNT AGO1 ZFP64 ZNF263 SP3 MXD4 ZHX2 REST SFPQ ZMYM1 ZMYM4 RPL5P4 LOC653160 THRAP3 COL8A2 EVA1B LOC105378647 TRAPPC3
GH01G036154 1.4 ENCODE dbSUPER 41.1 +888.0 887954 4.5 PKNOX1 ARID4B SIN3A ZNF2 ZBTB7B ZNF143 ZNF548 FOS ZNF263 SP3 SFPQ RPL5P4 ZMYM4 THRAP3 MAP7D1 COL8A2 EVA1B TRAPPC3 LOC105378647 RN7SL131P
GH01G036266 0.9 dbSUPER 55.9 +997.9 997926 0.8 ATF1 ZNF493 ZFP64 ZNF121 ZNF302 KLF7 TSHZ1 REST ZNF623 ZNF518A ZMYM4 RPL5P4 COL8A2 THRAP3 EVA1B LOC105378647 UBE2V2P4 SH3D21
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZMYM4 on UCSC Golden Path with GeneCards custom track

Promoters for ZMYM4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000004658 586 1801 HDGF PKNOX1 CREB3L1 ARNT ZFP64 SIN3A FEZF1 ZNF2 YY1 ZNF766

Genomic Location for ZMYM4 Gene

35,268,714 bp from pter
35,422,058 bp from pter
153,345 bases
Plus strand

Genomic View for ZMYM4 Gene

Genes around ZMYM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZMYM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZMYM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZMYM4 Gene

Proteins for ZMYM4 Gene

  • Protein details for ZMYM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger MYM-type protein 4
    Protein Accession:
    Secondary Accessions:
    • A0JP19
    • A0JP20
    • O43308
    • Q5T5E1
    • Q5T5E2
    • Q7L3Q4

    Protein attributes for ZMYM4 Gene

    1548 amino acids
    Molecular mass:
    172788 Da
    Quaternary structure:
    No Data Available
    • The 3-UTR region of the mRNA encoding this protein contains a motif called CDIR (for cell death inhibiting RNA) that binds HNRPD/AUF1 and HSPB1/HSP27. It is able to inhibit interferon-gamma induced apoptosis.
    • Sequence=CAI22686.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI22687.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZMYM4 Gene


neXtProt entry for ZMYM4 Gene

Post-translational modifications for ZMYM4 Gene

  • Ubiquitination at isoforms=2, 4140, posLast=11271127, isoforms=2, 3, 41341, and isoforms=2, 3, 41479
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZMYM4 Gene

Domains & Families for ZMYM4 Gene

Gene Families for ZMYM4 Gene

Protein Domains for ZMYM4 Gene

Suggested Antigen Peptide Sequences for ZMYM4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZMYM4: view

No data available for UniProtKB/Swiss-Prot for ZMYM4 Gene

Function for ZMYM4 Gene

Molecular function for ZMYM4 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of cell morphology and cytoskeletal organization.

Gene Ontology (GO) - Molecular Function for ZMYM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003677 DNA binding TAS 10486218
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZMYM4: view
genes like me logo Genes that share phenotypes with ZMYM4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZMYM4 Gene

Localization for ZMYM4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZMYM4 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ZMYM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with ZMYM4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZMYM4 Gene

Pathways & Interactions for ZMYM4 Gene

SuperPathways for ZMYM4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZMYM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0007010 cytoskeleton organization IMP 21834987
GO:0007275 multicellular organism development TAS 10486218
GO:0022604 regulation of cell morphogenesis IMP 21834987
genes like me logo Genes that share ontologies with ZMYM4: view

No data available for Pathways by source and SIGNOR curated interactions for ZMYM4 Gene

Drugs & Compounds for ZMYM4 Gene

No Compound Related Data Available

Transcripts for ZMYM4 Gene

Unigene Clusters for ZMYM4 Gene

Zinc finger, MYM-type 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZMYM4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: -
SP5: -

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30a · 30b ^ 31
SP1: - -

Relevant External Links for ZMYM4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZMYM4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZMYM4 Gene

Protein differential expression in normal tissues from HIPED for ZMYM4 Gene

This gene is overexpressed in Cerebrospinal fluid (60.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZMYM4 Gene

Protein tissue co-expression partners for ZMYM4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZMYM4 Gene:


SOURCE GeneReport for Unigene cluster for ZMYM4 Gene:


mRNA Expression by UniProt/SwissProt for ZMYM4 Gene:

Tissue specificity: Expressed at higher level in heart, skeletal muscle, kidney and liver.

Evidence on tissue expression from TISSUES for ZMYM4 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with ZMYM4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZMYM4 Gene

Orthologs for ZMYM4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZMYM4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZMYM4 34 35
  • 99.83 (n)
(Bos Taurus)
Mammalia ZMYM4 34 35
  • 95.24 (n)
(Canis familiaris)
Mammalia ZMYM4 34 35
  • 95.08 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 93 (a)
(Mus musculus)
Mammalia Zmym4 34 16 35
  • 91.76 (n)
(Rattus norvegicus)
Mammalia Zmym4 34
  • 90.99 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 26 (a)
(Gallus gallus)
Aves -- 35
  • 84 (a)
ZMYM4 34
  • 80.2 (n)
(Anolis carolinensis)
Reptilia -- 35
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zmym4 34
  • 70.73 (n)
(Danio rerio)
Actinopterygii zmym4 34 35
  • 56.08 (n)
si:ch211-266o15.1 35
  • 41 (a)
si:ch211-173p18.3 35
  • 39 (a)
fruit fly
(Drosophila melanogaster)
Insecta woc 35
  • 23 (a)
Species where no ortholog for ZMYM4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZMYM4 Gene

Gene Tree for ZMYM4 (if available)
Gene Tree for ZMYM4 (if available)

Paralogs for ZMYM4 Gene

Paralogs for ZMYM4 Gene

(4) SIMAP similar genes for ZMYM4 Gene using alignment to 2 proteins: Pseudogenes for ZMYM4 Gene

genes like me logo Genes that share paralogs with ZMYM4: view

Variants for ZMYM4 Gene

Sequence variations from dbSNP and Humsavar for ZMYM4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs191217255 A colorectal cancer sample 35,415,633(+) TGAGA(C/T)GGACC nc-transcript-variant, reference, missense
rs1000000642 -- 35,269,374(+) GAGGT(A/G)TCAGA intron-variant
rs1000003586 -- 35,417,252(+) AAAAA(-/AAAG)AAAGA intron-variant
rs1000030174 -- 35,388,550(+) TTCTC(C/T)TCTGT intron-variant
rs1000032644 -- 35,282,589(+) CTCAC(C/T)TTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZMYM4 Gene

Variant ID Type Subtype PubMed ID
esv32554 CNV loss 17666407
esv3585718 CNV loss 21293372
esv3585719 CNV loss 21293372
esv8737 CNV gain 19470904
nsv1012556 CNV gain 25217958
nsv1133838 CNV deletion 24896259
nsv508149 CNV deletion 20534489
nsv818134 CNV loss 17921354
nsv822287 CNV gain 20364138
nsv822298 CNV loss 20364138
nsv945878 CNV duplication 23825009
nsv945879 CNV duplication 23825009

Variation tolerance for ZMYM4 Gene

Residual Variation Intolerance Score: 6.87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.45; 43.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZMYM4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZMYM4 Gene

Disorders for ZMYM4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZMYM4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
non-syndromic x-linked intellectual disability
  • non-specific x-linked mental retardation
- elite association - COSMIC cancer census association via MalaCards
Search ZMYM4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ZMYM4

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ZMYM4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZMYM4 Gene

Publications for ZMYM4 Gene

  1. Assignment of ZNF262 to human chromosome band 1p34-->p32 by in situ hybridization. (PMID: 10449923) Sohal J. … Cross N.C.P. (Cytogenet. Cell Genet. 1999) 2 3 4 64
  2. Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. (PMID: 21834987) Bai S.W. … Ridley A.J. (BMC Biol. 2011) 3 4 64
  3. Cell death inhibiting RNA (CDIR) derived from a 3'-untranslated region binds AUF1 and heat shock protein 27. (PMID: 12356764) Shchors K. … Deiss L.P. (J. Biol. Chem. 2002) 3 4 64
  4. Cloning and mapping of members of the MYM family. (PMID: 10486218) Smedley D. … Shipley J. (Genomics 1999) 3 4 64
  5. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 3 4 64

Products for ZMYM4 Gene

Sources for ZMYM4 Gene

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