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Aliases for ZMYM4 Gene

Aliases for ZMYM4 Gene

  • Zinc Finger, MYM-Type 4 2 3
  • Zinc Finger Protein 262 2 3 4
  • ZNF262 3 4
  • Zinc Finger MYM-Type Protein 4 3
  • Cell Death Inhibiting RNA 3
  • ZNF198L3 3
  • KIAA0425 4
  • CDIR 3
  • MYM 3

External Ids for ZMYM4 Gene

Previous Symbols for ZMYM4 Gene

  • ZNF262

Summaries for ZMYM4 Gene

GeneCards Summary for ZMYM4 Gene

ZMYM4 (Zinc Finger, MYM-Type 4) is a Protein Coding gene. An important paralog of this gene is ZMYM6.

UniProtKB/Swiss-Prot for ZMYM4 Gene

  • Plays a role in the regulation of cell morphology and cytoskeletal organization.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZMYM4 Gene

Genomics for ZMYM4 Gene

Genomic Location for ZMYM4 Gene

Start:
35,268,850 bp from pter
End:
35,422,058 bp from pter
Size:
153,209 bases
Orientation:
Plus strand

Genomic View for ZMYM4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZMYM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZMYM4 Gene

Regulatory Elements for ZMYM4 Gene

Proteins for ZMYM4 Gene

  • Protein details for ZMYM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VZL5-ZMYM4_HUMAN
    Recommended name:
    Zinc finger MYM-type protein 4
    Protein Accession:
    Q5VZL5
    Secondary Accessions:
    • A0JP19
    • A0JP20
    • O43308
    • Q5T5E1
    • Q5T5E2
    • Q7L3Q4

    Protein attributes for ZMYM4 Gene

    Size:
    1548 amino acids
    Molecular mass:
    172788 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The 3-UTR region of the mRNA encoding this protein contains a motif called CDIR (for cell death inhibiting RNA) that binds HNRPD/AUF1 and HSPB1/HSP27. It is able to inhibit interferon-gamma induced apoptosis
    SequenceCaution:
    • Sequence=CAI22686.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI22687.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZMYM4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZMYM4 Gene

Proteomics data for ZMYM4 Gene at MOPED

Post-translational modifications for ZMYM4 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys140, Lys1127, Lys1341, and Lys1479

Other Protein References for ZMYM4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZMYM4 Gene

Domains for ZMYM4 Gene

Gene Families for ZMYM4 Gene

HGNC:
  • ZMYM :Zinc fingers, MYM type

Protein Domains for ZMYM4 Gene

UniProtKB/Swiss-Prot:

ZMYM4_HUMAN
Similarity:
  • Contains 9 MYM-type zinc fingers.:
    • Q5VZL5
genes like me logo Genes that share domains with ZMYM4: view

Function for ZMYM4 Gene

Molecular function for ZMYM4 Gene

UniProtKB/Swiss-Prot Function: Plays a role in the regulation of cell morphology and cytoskeletal organization.

Gene Ontology (GO) - Molecular Function for ZMYM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 10486218
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ZMYM4: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZMYM4 Gene

Localization for ZMYM4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZMYM4 Gene COMPARTMENTS Subcellular localization image for ZMYM4 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ZMYM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ZMYM4: view

Pathways for ZMYM4 Gene

SuperPathways for ZMYM4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZMYM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IMP 21834987
GO:0007275 multicellular organismal development TAS 10486218
GO:0022604 regulation of cell morphogenesis IMP 21834987
genes like me logo Genes that share ontologies with ZMYM4: view

No data available for Pathways by source for ZMYM4 Gene

Transcripts for ZMYM4 Gene

Unigene Clusters for ZMYM4 Gene

Zinc finger, MYM-type 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZMYM4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: -
SP2:
SP3:
SP4:
SP5: -
SP6:

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30a · 30b ^ 31
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for ZMYM4 Gene

GeneLoc Exon Structure for
ZMYM4
ECgene alternative splicing isoforms for
ZMYM4

Expression for ZMYM4 Gene

mRNA expression in normal human tissues for ZMYM4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZMYM4 Gene

SOURCE GeneReport for Unigene cluster for ZMYM4 Gene Hs.269211

mRNA Expression by UniProt/SwissProt for ZMYM4 Gene

Q5VZL5-ZMYM4_HUMAN
Tissue specificity: Expressed at higher level in heart, skeletal muscle, kidney and liver.
genes like me logo Genes that share expressions with ZMYM4: view

Orthologs for ZMYM4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZMYM4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZMYM4 36
  • 99.83 (n)
  • 99.81 (a)
ZMYM4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZMYM4 36
  • 95.24 (n)
  • 97.35 (a)
ZMYM4 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZMYM4 36
  • 95.08 (n)
  • 97.51 (a)
ZMYM4 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zmym4 36
  • 91.76 (n)
  • 94.5 (a)
Zmym4 16
Zmym4 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 26 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 93 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Zmym4 36
  • 90.99 (n)
  • 94.31 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 84 (a)
OneToMany
ZMYM4 36
  • 80.2 (n)
  • 84.01 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 82 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia zmym4 36
  • 70.73 (n)
  • 74.98 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-173p18.3 37
  • 39 (a)
ManyToMany
si:ch211-266o15.1 37
  • 41 (a)
ManyToMany
zmym4 36
  • 56.08 (n)
  • 51.19 (a)
zmym4 37
  • 39 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta woc 37
  • 23 (a)
OneToMany
Species with no ortholog for ZMYM4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZMYM4 Gene

ENSEMBL:
Gene Tree for ZMYM4 (if available)
TreeFam:
Gene Tree for ZMYM4 (if available)

Paralogs for ZMYM4 Gene

Paralogs for ZMYM4 Gene

Selected SIMAP similar genes for ZMYM4 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ZMYM4 Gene

genes like me logo Genes that share paralogs with ZMYM4: view

Variants for ZMYM4 Gene

Sequence variations from dbSNP and Humsavar for ZMYM4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs471839 -- 35,274,196(-) TTTCT(A/T)AAAGC intron-variant
rs478042 -- 35,284,212(+) acctc(A/G)tgatc intron-variant
rs478071 -- 35,284,222(+) ccacc(C/T)gcctc intron-variant
rs480577 -- 35,293,932(+) agatc(A/G)agacc intron-variant
rs483266 -- 35,348,486(+) CCTGC(A/C)ACTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZMYM4 Gene

Variant ID Type Subtype PubMed ID
nsv870757 CNV Gain 21882294
nsv508149 CNV Loss 20534489
nsv818134 CNV Loss 17921354
nsv870976 CNV Loss 21882294
nsv822287 CNV Gain 20364138
esv8737 CNV Gain 19470904
nsv822298 CNV Loss 20364138
esv32554 CNV Loss 17666407

Relevant External Links for ZMYM4 Gene

HapMap Linkage Disequilibrium report
ZMYM4

Disorders for ZMYM4 Gene

(1) University of Copenhagen DISEASES for ZMYM4 Gene

Relevant External Links for ZMYM4

Genetic Association Database (GAD)
ZMYM4
genes like me logo Genes that share disorders with ZMYM4: view

No data available for UniProtKB/Swiss-Prot for ZMYM4 Gene

Publications for ZMYM4 Gene

  1. Assignment of ZNF262 to human chromosome band 1p34-->p32 by in situ hybridization. (PMID: 10449923) Sohal J. … Cross N.C.P. (Cytogenet. Cell Genet. 1999) 2 3 4
  2. Cloning and mapping of members of the MYM family. (PMID: 10486218) Smedley D. … Shipley J. (Genomics 1999) 3 4
  3. Cell death inhibiting RNA (CDIR) derived from a 3'-untranslated region binds AUF1 and heat shock protein 27. (PMID: 12356764) Shchors K. … Deiss L.P. (J. Biol. Chem. 2002) 3 4
  4. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 3 4
  5. Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. (PMID: 21834987) Bai S.W. … Ridley A.J. (BMC Biol. 2011) 3 4

Products for ZMYM4 Gene

Sources for ZMYM4 Gene

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