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Aliases for ZMYM4 Gene

Aliases for ZMYM4 Gene

  • Zinc Finger MYM-Type Containing 4 2 3
  • Zinc Finger Protein 262 2 3 4
  • Zinc Finger, MYM-Type 4 3 5
  • ZNF262 3 4
  • Cell Death Inhibiting RNA 3
  • ZNF198L3 3
  • KIAA0425 4
  • CDIR 3
  • MYM 3

External Ids for ZMYM4 Gene

Previous HGNC Symbols for ZMYM4 Gene

  • ZNF262

Previous GeneCards Identifiers for ZMYM4 Gene

  • GC01P035404
  • GC01P035507
  • GC01P035734
  • GC01P033853

Summaries for ZMYM4 Gene

GeneCards Summary for ZMYM4 Gene

ZMYM4 (Zinc Finger MYM-Type Containing 4) is a Protein Coding gene. Diseases associated with ZMYM4 include non-syndromic x-linked intellectual disability. An important paralog of this gene is ZMYM6.

UniProtKB/Swiss-Prot for ZMYM4 Gene

  • Plays a role in the regulation of cell morphology and cytoskeletal organization.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZMYM4 Gene

Genomics for ZMYM4 Gene

Regulatory Elements for ZMYM4 Gene

Promoters for ZMYM4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZMYM4 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZMYM4 Gene

Chromosome:
1
Start:
35,268,714 bp from pter
End:
35,422,058 bp from pter
Size:
153,345 bases
Orientation:
Plus strand

Genomic View for ZMYM4 Gene

Genes around ZMYM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZMYM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZMYM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZMYM4 Gene

Proteins for ZMYM4 Gene

  • Protein details for ZMYM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VZL5-ZMYM4_HUMAN
    Recommended name:
    Zinc finger MYM-type protein 4
    Protein Accession:
    Q5VZL5
    Secondary Accessions:
    • A0JP19
    • A0JP20
    • O43308
    • Q5T5E1
    • Q5T5E2
    • Q7L3Q4

    Protein attributes for ZMYM4 Gene

    Size:
    1548 amino acids
    Molecular mass:
    172788 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The 3-UTR region of the mRNA encoding this protein contains a motif called CDIR (for cell death inhibiting RNA) that binds HNRPD/AUF1 and HSPB1/HSP27. It is able to inhibit interferon-gamma induced apoptosis.
    SequenceCaution:
    • Sequence=CAI22686.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI22687.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZMYM4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZMYM4 Gene

Proteomics data for ZMYM4 Gene at MOPED

Post-translational modifications for ZMYM4 Gene

  • Ubiquitination at Lys 140, Lys 1127, Lys 1341, and Lys 1479
  • Modification sites at PhosphoSitePlus

Other Protein References for ZMYM4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZMYM4 Gene

Domains & Families for ZMYM4 Gene

Gene Families for ZMYM4 Gene

Protein Domains for ZMYM4 Gene

Suggested Antigen Peptide Sequences for ZMYM4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5VZL5

UniProtKB/Swiss-Prot:

ZMYM4_HUMAN :
  • Contains 9 MYM-type zinc fingers.
Similarity:
  • Contains 9 MYM-type zinc fingers.
genes like me logo Genes that share domains with ZMYM4: view

Function for ZMYM4 Gene

Molecular function for ZMYM4 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of cell morphology and cytoskeletal organization.

Gene Ontology (GO) - Molecular Function for ZMYM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
genes like me logo Genes that share ontologies with ZMYM4: view
genes like me logo Genes that share phenotypes with ZMYM4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ZMYM4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZMYM4 Gene

Localization for ZMYM4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZMYM4 Gene COMPARTMENTS Subcellular localization image for ZMYM4 gene
Compartment Confidence
cytosol 3
nucleus 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ZMYM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with ZMYM4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZMYM4 Gene

Pathways & Interactions for ZMYM4 Gene

SuperPathways for ZMYM4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZMYM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development TAS 10486218
genes like me logo Genes that share ontologies with ZMYM4: view

No data available for Pathways by source and SIGNOR curated interactions for ZMYM4 Gene

Drugs & Compounds for ZMYM4 Gene

No Compound Related Data Available

Transcripts for ZMYM4 Gene

Unigene Clusters for ZMYM4 Gene

Zinc finger, MYM-type 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZMYM4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: -
SP2:
SP3:
SP4:
SP5: -
SP6:

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30a · 30b ^ 31
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for ZMYM4 Gene

GeneLoc Exon Structure for
ZMYM4
ECgene alternative splicing isoforms for
ZMYM4

Expression for ZMYM4 Gene

mRNA expression in normal human tissues for ZMYM4 Gene

Protein differential expression in normal tissues from HIPED for ZMYM4 Gene

This gene is overexpressed in Cerebrospinal fluid (60.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZMYM4 Gene



SOURCE GeneReport for Unigene cluster for ZMYM4 Gene Hs.269211

mRNA Expression by UniProt/SwissProt for ZMYM4 Gene

Q5VZL5-ZMYM4_HUMAN
Tissue specificity: Expressed at higher level in heart, skeletal muscle, kidney and liver.
genes like me logo Genes that share expression patterns with ZMYM4: view

Protein tissue co-expression partners for ZMYM4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZMYM4 Gene

Orthologs for ZMYM4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZMYM4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZMYM4 35
  • 95.24 (n)
  • 97.35 (a)
ZMYM4 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZMYM4 35
  • 95.08 (n)
  • 97.51 (a)
ZMYM4 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zmym4 35
  • 91.76 (n)
  • 94.5 (a)
Zmym4 16
Zmym4 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZMYM4 35
  • 99.83 (n)
  • 99.81 (a)
ZMYM4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zmym4 35
  • 90.99 (n)
  • 94.31 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 26 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 93 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ZMYM4 35
  • 80.2 (n)
  • 84.01 (a)
-- 36
  • 84 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 82 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia zmym4 35
  • 70.73 (n)
  • 74.98 (a)
zebrafish
(Danio rerio)
Actinopterygii zmym4 35
  • 56.08 (n)
  • 51.19 (a)
si:ch211-173p18.3 36
  • 39 (a)
ManyToMany
si:ch211-266o15.1 36
  • 41 (a)
ManyToMany
zmym4 36
  • 39 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta woc 36
  • 23 (a)
OneToMany
Species with no ortholog for ZMYM4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZMYM4 Gene

ENSEMBL:
Gene Tree for ZMYM4 (if available)
TreeFam:
Gene Tree for ZMYM4 (if available)

Paralogs for ZMYM4 Gene

Paralogs for ZMYM4 Gene

(4) SIMAP similar genes for ZMYM4 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ZMYM4 Gene

genes like me logo Genes that share paralogs with ZMYM4: view

Variants for ZMYM4 Gene

Sequence variations from dbSNP and Humsavar for ZMYM4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs34924462 - 35,381,431(-) TACAA(C/T)AGCAT nc-transcript-variant, reference, missense
VAR_035672 A colorectal cancer sample
rs478042 -- 35,284,212(+) acctc(A/G)tgatc intron-variant, upstream-variant-2KB
rs488019 -- 35,347,936(-) CACTG(C/T)AATAA intron-variant
rs478071 -- 35,284,222(+) ccacc(C/T)gcctc intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZMYM4 Gene

Variant ID Type Subtype PubMed ID
nsv870757 CNV Gain 21882294
nsv508149 CNV Loss 20534489
nsv818134 CNV Loss 17921354
nsv870976 CNV Loss 21882294
nsv822287 CNV Gain 20364138
esv8737 CNV Gain 19470904
nsv822298 CNV Loss 20364138
esv32554 CNV Loss 17666407

Variation tolerance for ZMYM4 Gene

Residual Variation Intolerance Score: 6.87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.45; 43.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZMYM4 Gene

HapMap Linkage Disequilibrium report
ZMYM4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZMYM4 Gene

Disorders for ZMYM4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZMYM4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
non-syndromic x-linked intellectual disability
  • mrx
- elite association - COSMIC cancer census association via MalaCards
Search ZMYM4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ZMYM4

Genetic Association Database (GAD)
ZMYM4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZMYM4
genes like me logo Genes that share disorders with ZMYM4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZMYM4 Gene

Publications for ZMYM4 Gene

  1. Assignment of ZNF262 to human chromosome band 1p34-->p32 by in situ hybridization. (PMID: 10449923) Sohal J. … Cross N.C.P. (Cytogenet. Cell Genet. 1999) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for ZMYM4 Gene

Sources for ZMYM4 Gene

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