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Aliases for ZMYM3 Gene

Aliases for ZMYM3 Gene

  • Zinc Finger, MYM-Type 3 2 3
  • Zinc Finger Protein 261 2 3 4
  • DXS6673E 3 4 6
  • ZNF261 3 4 6
  • Zinc Finger MYM-Type Protein 3 3
  • ZNF198L2 3
  • KIAA0385 4
  • XFIM 3
  • MYM 3

External Ids for ZMYM3 Gene

Previous HGNC Symbols for ZMYM3 Gene

  • ZNF261

Previous GeneCards Identifiers for ZMYM3 Gene

  • GC0XM070243
  • GC0XM070376
  • GC0XM070459
  • GC0XM064255

Summaries for ZMYM3 Gene

Entrez Gene Summary for ZMYM3 Gene

  • This gene is located on the X chromosome and is subject to X inactivation. It is highly conserved in vertebrates and most abundantly expressed in the brain. The encoded protein is a component of histone deacetylase-containing multiprotein complexes that function through modifying chromatin structure to keep genes silent. A chromosomal translocation (X;13) involving this gene is associated with X-linked mental retardation. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2010]

GeneCards Summary for ZMYM3 Gene

ZMYM3 (Zinc Finger, MYM-Type 3) is a Protein Coding gene. An important paralog of this gene is ZMYM6.

UniProtKB/Swiss-Prot for ZMYM3 Gene

  • Plays a role in the regulation of cell morphology and cytoskeletal organization.

Gene Wiki entry for ZMYM3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZMYM3 Gene

Genomics for ZMYM3 Gene

Regulatory Elements for ZMYM3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZMYM3 Gene

71,239,624 bp from pter
71,255,197 bp from pter
15,574 bases
Minus strand

Genomic View for ZMYM3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZMYM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZMYM3 Gene

Proteins for ZMYM3 Gene

  • Protein details for ZMYM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger MYM-type protein 3
    Protein Accession:
    Secondary Accessions:
    • D3DVV3
    • O15089
    • Q96E26

    Protein attributes for ZMYM3 Gene

    1370 amino acids
    Molecular mass:
    152379 Da
    Quaternary structure:
    • May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I.
    • Sequence=BAA20839.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZMYM3 Gene


neXtProt entry for ZMYM3 Gene

Proteomics data for ZMYM3 Gene at MOPED

Post-translational modifications for ZMYM3 Gene

  • Ubiquitination at Lys577, Lys1072, Lys1078, Lys1086, Lys1100, Lys1251, Lys1298, and Lys1306
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ZMYM3 Gene

Domains for ZMYM3 Gene

Gene Families for ZMYM3 Gene

Protein Domains for ZMYM3 Gene

Suggested Antigen Peptide Sequences for ZMYM3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 9 MYM-type zinc fingers.
  • Contains 9 MYM-type zinc fingers.
genes like me logo Genes that share domains with ZMYM3: view

Function for ZMYM3 Gene

Molecular function for ZMYM3 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of cell morphology and cytoskeletal organization.

Gene Ontology (GO) - Molecular Function for ZMYM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 10486218
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ZMYM3: view

Phenotypes for ZMYM3 Gene

GenomeRNAi human phenotypes for ZMYM3:
genes like me logo Genes that share phenotypes with ZMYM3: view

Animal Model Products

miRNA for ZMYM3 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZMYM3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZMYM3 Gene

Localization for ZMYM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZMYM3 Gene

Subcellular locations from

Jensen Localization Image for ZMYM3 Gene COMPARTMENTS Subcellular localization image for ZMYM3 gene
Compartment Confidence
nucleus 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ZMYM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZMYM3: view

Pathways for ZMYM3 Gene

SuperPathways for ZMYM3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZMYM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IMP 21834987
GO:0007275 multicellular organismal development TAS 10486218
GO:0022604 regulation of cell morphogenesis IMP 21834987
genes like me logo Genes that share ontologies with ZMYM3: view

No data available for Pathways by source for ZMYM3 Gene

Transcripts for ZMYM3 Gene

Unigene Clusters for ZMYM3 Gene

Zinc finger, MYM-type 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZMYM3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZMYM3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a ·
SP1: - - -
SP2: - -
SP4: - - - - - - - - - -

ExUns: 20b · 20c ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25
SP1: - -
SP5: -

Relevant External Links for ZMYM3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZMYM3 Gene

mRNA expression in normal human tissues for ZMYM3 Gene

Protein differential expression in normal tissues for ZMYM3 Gene

This gene is overexpressed in Platelet (19.5), Fetal ovary (10.1), Blymphocyte (9.8), and Fetal Brain (7.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZMYM3 Gene

SOURCE GeneReport for Unigene cluster for ZMYM3 Gene Hs.522684

mRNA Expression by UniProt/SwissProt for ZMYM3 Gene

Tissue specificity: Most abundant in brain, moderate in muscle and heart, low in other tissues except placenta
genes like me logo Genes that share expressions with ZMYM3: view

Expression partners for ZMYM3 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZMYM3 Gene

Orthologs for ZMYM3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZMYM3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZMYM3 35
  • 94.7 (n)
  • 97.88 (a)
ZMYM3 36
  • 98 (a)
(Canis familiaris)
Mammalia ZMYM3 35
  • 94.77 (n)
  • 98.18 (a)
ZMYM3 36
  • 98 (a)
(Mus musculus)
Mammalia Zmym3 35
  • 92.51 (n)
  • 95.54 (a)
Zmym3 16
Zmym3 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Zmym3 35
  • 92.37 (n)
  • 95.83 (a)
(Monodelphis domestica)
Mammalia ZMYM3 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 35 (a)
(Pan troglodytes)
Mammalia ZMYM3 36
  • 97 (a)
(Gallus gallus)
Aves ZMYM3 35
  • 73.64 (n)
  • 78.7 (a)
ZMYM3 36
  • 75 (a)
(Anolis carolinensis)
Reptilia ZMYM3 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19029 35
zmym3 35
  • 69.09 (n)
  • 74.64 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.11236 35
fruit fly
(Drosophila melanogaster)
Insecta woc 36
  • 22 (a)
Species with no ortholog for ZMYM3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZMYM3 Gene

Gene Tree for ZMYM3 (if available)
Gene Tree for ZMYM3 (if available)

Paralogs for ZMYM3 Gene

Paralogs for ZMYM3 Gene

(2) SIMAP similar genes for ZMYM3 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ZMYM3: view

Variants for ZMYM3 Gene

Sequence variations from dbSNP and Humsavar for ZMYM3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs749789 -- 71,248,904(+) ATCCA(C/T)GGGGA intron-variant, downstream-variant-500B
rs1803001 -- 71,239,903(-) TTCTC(C/T)CTTCC utr-variant-3-prime
rs1803002 -- 71,239,735(-) GCCTG(A/G)CCTGT utr-variant-3-prime
rs1803003 -- 71,239,688(-) GAGAA(A/G)CTGTT utr-variant-3-prime
rs1803004 -- 71,239,764(-) TGTTT(A/T)AATTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZMYM3 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354
esv33082 CNV Loss 17666407
nsv508781 CNV Insertion 20534489

Relevant External Links for ZMYM3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZMYM3 Gene

Disorders for ZMYM3 Gene


  • Note=A chromosomal aberration involving ZMYM3 may be a cause of X-linked mental retardation in Xq13.1. Translocation t(X;13)(q13.1;?).

No disorders were found for ZMYM3 Gene.

No data available for MalaCards , OMIM , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ZMYM3 Gene

Publications for ZMYM3 Gene

  1. Cloning and characterization of DXS6673E, a candidate gene for X- linked mental retardation in Xq13.1. (PMID: 8817323) van der Maarel S.M. … Ropers H.-H. (Hum. Mol. Genet. 1996) 3 4 23
  2. A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. (PMID: 12493763) Hakimi M.-A. … Shiekhattar R. (J. Biol. Chem. 2003) 3 4
  3. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 3 4
  4. Cloning and mapping of members of the MYM family. (PMID: 10486218) Smedley D. … Shipley J. (Genomics 1999) 2 3
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for ZMYM3 Gene

Sources for ZMYM3 Gene

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