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ZMYM2 Gene

protein-coding   GIFtS: 58
GCID: GC13P020532

Zinc Finger, MYM-Type 2

(Previous name: zinc finger protein 198)
(Previous symbol: ZNF198)
  See ZMYM2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger, MYM-Type 21 2     MYM2
ZNF1981 2 3 5     SCLL2
Zinc Finger Protein 1981 2 3     Rearranged In An Atypical Myeloproliferative Disorder2
FIM2 3 5     Zinc Finger MYM-Type Protein 22
RAMP2 3 5     Rearranged In Atypical Myeloproliferative Disorder Protein3
Fused In Myeloproliferative Disorders Protein2 3     

External Ids:    HGNC: 129891   Entrez Gene: 77502   Ensembl: ENSG000001217417   OMIM: 6022215   UniProtKB: Q9UBW73   

Export aliases for ZMYM2 gene to outside databases

Previous GC identifers: GC13P019431 GC13P001338


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZMYM2 Gene:
The protein encoded by this gene is a zinc finger protein that may act as a transcription factor. The encoded
protein may be part of a BHC histone deacetylase complex. Translocation of this gene with the fibroblast growth
factor receptor-1 gene (FGFR1) results in a fusion gene, which may be a cause of stem cell leukemia lymphoma
syndrome (SCLL). Several transcript variants encoding the same protein have been found for this gene. (provided
by RefSeq, Jul 2010)

GeneCards Summary for ZMYM2 Gene:
ZMYM2 (zinc finger, MYM-type 2) is a protein-coding gene. Diseases associated with ZMYM2 include myeloproliferative disorder, and 8p11 myeloproliferative syndrome. GO annotations related to this gene include ubiquitin conjugating enzyme binding. An important paralog of this gene is ZMYM4.

UniProtKB/Swiss-Prot: ZMYM2_HUMAN, Q9UBW7
Function: May function as a transcription factor

Gene Wiki entry for ZMYM2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NT_024524.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZMYM2 gene promoter:
         MAZR   Pax-5   RREB-1   POU3F1   C/EBPalpha   CHOP-10   POU2F1   Nkx6-1   HOXA5   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZMYM2 promoter sequence
   Search Chromatin IP Primers for ZMYM2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZMYM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q11-q12   Ensembl cytogenetic band:  13q12.11   HGNC cytogenetic band: 13q11-q12

ZMYM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZMYM2 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P020532:  view genomic region     (about GC identifiers)

Start:
20,532,810 bp from pter      End:
20,665,968 bp from pter
Size:
133,159 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZMYM2_HUMAN, Q9UBW7 (See protein sequence)
Recommended Name: Zinc finger MYM-type protein 2  
Size: 1377 amino acids; 154911 Da
Subunit: May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A,
RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I
Sequence caution: Sequence=AAB88464.1; Type=Frameshift; Positions=330, 966, 1009, 1017; Sequence=AAC23591.1;
Type=Frameshift; Positions=330; Sequence=CAA73875.1; Type=Frameshift; Positions=388, 403, 406, 409, 418;
Secondary accessions: A6NDG0 A6NI02 O43212 O43434 O60898 Q5W0Q4 Q5W0T3 Q63HP0 Q8NE39 Q9H0V5
Q9H538 Q9UEU2
Alternative splicing: 2 isoforms:  Q9UBW7-1   Q9UBW7-2   

Explore the universe of human proteins at neXtProt for ZMYM2: NX_Q9UBW7

Explore proteomics data for ZMYM2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys88, Lys1107, Lys1280, Lys1313
  • Modification sites at PhosphoSitePlus

  • See ZMYM2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001177893.1  NP_001177894.1  NP_003444.1  NP_932072.1  

    ENSEMBL proteins: 
     ENSP00000372334   ENSP00000372327   ENSP00000372324   ENSP00000372322   ENSP00000372336  
    Reactome Protein details: Q9UBW7

    ZMYM2 Human Recombinant Protein Products:

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    antibodies-online peptides for ZMYM2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZMYM: Zinc fingers, MYM type

    3 InterPro protein domains:
     IPR011017 TRASH_dom
     IPR021893 DUF3504
     IPR010507 Znf_MYM

    Graphical View of Domain Structure for InterPro Entry Q9UBW7

    ProtoNet protein and cluster: Q9UBW7

    2 Blocks protein domains:
    IPB010507 MYM-type zinc finger
    IPB011017 TRASH


    UniProtKB/Swiss-Prot: ZMYM2_HUMAN, Q9UBW7
    Similarity: Contains 9 MYM-type zinc fingers


    Find genes that share domains with ZMYM2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZMYM2_HUMAN, Q9UBW7
    Function: May function as a transcription factor

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding NAS9576949
    GO:0031624ubiquitin conjugating enzyme binding IPI12776193
         
    Find genes that share ontologies with ZMYM2           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZMYM2

    miRNA
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    miRTarBase miRNAs that target ZMYM2:
    hsa-mir-23b-3p (MIRT046293), hsa-mir-21-5p (MIRT030845), hsa-let-7b-5p (MIRT052144), hsa-mir-1229-3p (MIRT036270), hsa-mir-19b-3p (MIRT031158)

    Block miRNA regulation of human, mouse, rat ZMYM2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZMYM2 (see all 144):
    hsa-miR-361-5p hsa-miR-520f hsa-miR-106a hsa-miR-605 hsa-miR-3653 hsa-miR-138-2* hsa-miR-298 hsa-miR-376a*
    SwitchGear 3'UTR luciferase reporter plasmidZMYM2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 4): ZMYM2 (NM_197968)
    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZMYM2_HUMAN, Q9UBW7: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0016605PML body IDA17027752

    Find genes that share ontologies with ZMYM2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZMYM2 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by FGFR1 mutants
    Signaling by FGFR1 mutants0.67
    Signaling by FGFR1 fusion mutants0.00
    Signaling by FGFR mutants0.67
    2Signaling by FGFR
    Signaling by FGFR in disease0.91
    3Disease
    Disease


    Find genes that share SuperPaths with ZMYM2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZMYM2
        Signaling by FGFR1 fusion mutants


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZMYM2
    Interactions:

        GeneGlobe Interaction Network for ZMYM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ZMYM2 (Q9UBW72, 3 ENSP000003723224) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFPQP232462, 3, ENSP000003497484MINT-62330 MINT-62323 MINT-62320 MINT-62322 I2D: score=3 STRING: ENSP00000349748
    PTBP1P265992, 3, ENSP000003494284MINT-62327 MINT-62326 I2D: score=2 STRING: ENSP00000349428
    UBTFP174802, 3, ENSP000003026404MINT-62331 I2D: score=3 STRING: ENSP00000302640
    HNRNPA2B1P226262, 3, ENSP000003466944MINT-62319 I2D: score=2 STRING: ENSP00000346694
    SNIP1Q8TAD82, 3MINT-62152 I2D: score=3 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0008150biological_process ND--

    Find genes that share ontologies with ZMYM2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZMYM2

    2 Novoseek inferred chemical compound relationships for ZMYM2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 50.7 10 9499416 (2), 11550283 (1), 9576949 (1), 18787627 (1) (see all 7)
    zinc 37.5 8 18806873 (3), 9576949 (1), 9949182 (1), 18787627 (1)



    Find genes that share compounds with ZMYM2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZMYM2 gene (4 alternative transcripts): 
    NM_001190964.2  NM_001190965.2  NM_003453.4  NM_197968.3  

    Unigene Cluster for ZMYM2:

    Zinc finger, MYM-type 2
    Hs.507433  [show with all ESTs]
    Unigene Representative Sequence: NM_003453
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382881(uc001umq.3 uc009zzn.1) ENST00000382874 ENST00000382871
    ENST00000468677 ENST00000382870 ENST00000494061 ENST00000490152 ENST00000490422
    ENST00000382869(uc001ums.3 uc001umt.3 uc010tco.1 uc001umv.3 uc001umw.3)
    ENST00000382883
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ZMYM2 (see all 144):
    hsa-miR-361-5p hsa-miR-520f hsa-miR-106a hsa-miR-605 hsa-miR-3653 hsa-miR-138-2* hsa-miR-298 hsa-miR-376a*
    SwitchGear 3'UTR luciferase reporter plasmidZMYM2 3' UTR sequence
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZMYM2
      QuantiTect SYBR Green Assays in human, mouse, rat ZMYM2
      QuantiFast Probe-based Assays in human, mouse, rat ZMYM2

    Additional mRNA sequence: 

    AF012126.1 AF035374.1 AF060181.1 AJ224901.1 AK226118.1 AK289741.1 AK302917.1 AK310505.1 
    BC036372.1 BX647944.1 BX648905.1 Y13472.1 

    Selected DOTS entries (see all 29):

    DT.100736070  DT.97802656  DT.456352  DT.92437651  DT.75124863  DT.109402  DT.95288110  DT.99981451 
    DT.445966  DT.109401  DT.95288106  DT.75100191  DT.407362  DT.433282  DT.75125302  DT.86993005 
    DT.92437649  DT.95288111  DT.120780943  DT.120780960  DT.120780965  DT.120780977  DT.91922218  DT.92437643 

    Selected AceView cDNA sequences (see all 255):

    BQ940018 AA135812 AW204488 BX647944 AA281848 AW299813 AA250925 AW026945 
    AA329832 AA599563 AA452383 BX112568 NM_197968 AA283078 AI273047 BU742054 
    BI713118 BX111992 AA361348 AA553492 AU130521 AA115047 AA336998 BM661612 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZMYM2 (see all 14)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g ^ 10a ·
    SP1:                                                              -     -     -     -                 -                                                         
    SP2:                                                              -     -     -     -                 -     -                                                   
    SP3:                                                              -     -     -     -                 -                                                         
    SP4:              -     -     -     -     -     -     -     -     -     -     -     -                 -                                                         
    SP5:                                                                          -     -                 -                                                         

    ExUns: 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for ZMYM2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZMYM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATAATTTTT
    ZMYM2 Expression
    About this image

    ZMYM2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZMYM2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.507433
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZMYM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZMYM2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zmym21 , 5 zinc finger, MYM-type 21, 5 92.68(n)1
    96.15(a)1
      14 (28.99 cM)5
    760071  NM_029498.31  NP_083774.21 
     568877955 
    chicken
    (Gallus gallus)
    Aves ZMYM21 zinc finger, MYM-type 2 82.83(n)
    85.56(a)
      418954  XM_004938813.1  XP_004938870.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    84(a)
    1 → many
    3(187129734-187237374)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.311662 Xenopus laevis transcribed sequence with weak similarity to protein pirT09483 (H.sapiens) T09483 Cys-rich protein RAMP - human less 76.55(n)    BU916847.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AI496701.12   -- 76.13(n)    AI496701.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta woc6
    without children
    20(a)
    1 → many
    3R(23082315-23089758)


    ENSEMBL Gene Tree for ZMYM2 (if available)
    TreeFam Gene Tree for ZMYM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZMYM2 gene
    ZMYM42  ENSG000002717412  ZMYM52  ZMYM32  ZMYM62  QRICH12  
    2 SIMAP similar genes for ZMYM2 using alignment to 2 protein entries:     ZMYM2_HUMAN (see all proteins):
    ZMYM3    ZMYM4

    Find genes that share paralogs with ZMYM2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZMYM2 (see all 2781)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1818627061,2
    C--1338507(+) CGCCAC/GCGGCG 4 -- int10--------
    rs1995758401,2
    --1341853(+) ATGGG-/ATATATA 4 -- int10--------
    rs95782391,2
    A--1344444(+) aataaA/Taaaaa 4 -- int1 trp30--------
    rs58020351,2
    C--1350599(+) gtgtg-/TATATA
    /TGTGTATA
    tatat
    8 -- int1 cds10--------
    rs286640951,2
    F--1350605(+) TGTGTG/ATATAT 4 -- int12Minor allele frequency- A:0.33NA 6
    rs2000200411,2
    C--1370979(+) TTTTTC/TTNNNN 4 -- int10--------
    rs711989511,2
    C--1399593(+) TCTTCT/-TTTTT 4 -- int11Minor allele frequency- -:0.50NA 2
    rs2000541981,2
    C--1428166(+) GACTTG/TTTTTT 4 -- int10--------
    rs95520481,2
    C,F,A,H--1484991(+) TGATGG/ATAGTT 4 -- us2k111Minor allele frequency- A:0.40NA WA CSA EA 374
    rs2017695911,2
    --1485204(+) ATTTA-/TTTTTT 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZMYM2 (20532810 - 20665968 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for ZMYM2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1929634CNV Deletion18987734
    esv2560456CNV Deletion19546169
    esv2674061CNV Deletion23128226
    esv268973CNV Insertion20981092
    esv24803CNV Loss19812545
    nsv455828CNV Loss19166990
    nsv523961CNV Loss19592680
    nsv899868CNV Gain21882294
    nsv832557CNV Gain17160897

    Human Gene Mutation Database (HGMD): ZMYM2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZMYM2
    DNA2.0 Custom Variant and Variant Library Synthesis for ZMYM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602221    OMIM disorders: --

    UniProtKB/Swiss-Prot: ZMYM2_HUMAN, Q9UBW7
  • Note=A chromosomal aberration involving ZMYM2 may be a cause of stem cell leukemia lymphoma syndrome
    (SCLL). Translocation t(8;13)(p11;q12) with FGFR1. SCLL usually presents as lymphoblastic lymphoma in association
    with a myeloproliferative disorder, often accompanied by pronounced peripheral eosinophilia and/or prominent
    eosinophilic infiltrates in the affected bone marrow

  • 2 diseases for ZMYM2:    
    About MalaCards
    myeloproliferative disorder    8p11 myeloproliferative syndrome

    1 disease from the University of Copenhagen DISEASES database for ZMYM2:
    Acute leukemia

    Find genes that share disorders with ZMYM2           About GenesLikeMe

    7 Novoseek inferred disease relationships for ZMYM2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloproliferative disorders 84.8 7 15975576 (2), 9576949 (2), 12776193 (1), 17471537 (1) (see all 5)
    lymphoma 43.5 2 9425908 (1), 10887137 (1)
    acute leukemia 43.1 1 10887137 (1)
    hyperplasia 34.8 1 15050920 (1)
    lymphoma non-hodgkins 31.7 1 15050920 (1)
    mental retardation 26 2 9499416 (1), 9576949 (1)
    leukemia 17.3 1 9425908 (1)

    Genetic Association Database (GAD): ZMYM2
    Human Genome Epidemiology (HuGE) Navigator: ZMYM2 (1 document)

    Export disorders for ZMYM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZMYM2 gene, integrated from 10 sources (see all 72):
    (articles sorted by number of sources associating them with ZMYM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The t(8;13)(p11;q11-12) rearrangement associated with an atypical myeloproliferative disorder fuses the fibroblast growth factor receptor 1 gene to a novel gene RAMP. (PubMed id 9499416)1, 2, 3, 9 Smedley D.... Shipley J. (Hum. Mol. Genet. 1998)
    2. FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome. (PubMed id 9425908)1, 2, 3, 9 Xiao S.... Fletcher J.A. (Nat. Genet. 1998)
    3. The genomic structure of ZNF198 and location of breakpoints in the t(8;13) myeloproliferative syndrome. (PubMed id 9889006)1, 2, 9 Kulkarni S.... Cross N.C.P. (Genomics 1999)
    4. Consistent fusion of ZNF198 to the fibroblast growth factor receptor- 1 in the t(8;13)(p11;q12) myeloproliferative syndrome. (PubMed id 9716603)1, 2, 9 Reiter A.... Cross N.C.P. (Blood 1998)
    5. Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13)(p12;q12). (PubMed id 9576949)1, 2, 9 Popovici C.... Pebusque M.-J. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    6. The t(8;13) atypical myeloproliferative disorder: further analysis of the ZNF198 gene and lack of evidence for multiple genes disrupted on chromosome 13. (PubMed id 9694738)1, 2, 9 Still I.H. and Cowell J.K. (Blood 1998)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. (PubMed id 12493763)1, 2 Hakimi M.-A.... Shiekhattar R. (J. Biol. Chem. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7750 HGNC: 12989 AceView: ZNF198 Ensembl:ENSG00000121741 euGenes: HUgn7750
    ECgene: ZMYM2 H-InvDB: ZMYM2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZMYM2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ZMYM2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZMYM2 gene:
    Search GeneIP for patents involving ZMYM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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