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Aliases for ZMYM2 Gene

Aliases for ZMYM2 Gene

  • Zinc Finger MYM-Type Containing 2 2 3
  • Zinc Finger Protein 198 2 3 4
  • Fused In Myeloproliferative Disorders Protein 3 4
  • Zinc Finger, MYM-Type 2 3 5
  • ZNF198 3 4
  • RAMP 3 4
  • FIM 3 4
  • Rearranged In Atypical Myeloproliferative Disorder Protein 4
  • Rearranged In An Atypical Myeloproliferative Disorder 3
  • SCLL 3
  • MYM 3

External Ids for ZMYM2 Gene

Previous HGNC Symbols for ZMYM2 Gene

  • ZNF198

Previous GeneCards Identifiers for ZMYM2 Gene

  • GC13P019431
  • GC13P020532
  • GC13P001338

Summaries for ZMYM2 Gene

Entrez Gene Summary for ZMYM2 Gene

  • The protein encoded by this gene is a zinc finger protein that may act as a transcription factor. The encoded protein may be part of a BHC histone deacetylase complex. Translocation of this gene with the fibroblast growth factor receptor-1 gene (FGFR1) results in a fusion gene, which may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for ZMYM2 Gene

ZMYM2 (Zinc Finger MYM-Type Containing 2) is a Protein Coding gene. Diseases associated with ZMYM2 include lymphoblastic lymphoma and 8p11 myeloproliferative syndrome. Among its related pathways are Infectious disease and Downstream signaling events of B Cell Receptor (BCR). GO annotations related to this gene include ubiquitin conjugating enzyme binding. An important paralog of this gene is ZMYM6.

UniProtKB/Swiss-Prot for ZMYM2 Gene

  • May function as a transcription factor.

Gene Wiki entry for ZMYM2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZMYM2 Gene

Genomics for ZMYM2 Gene

Regulatory Elements for ZMYM2 Gene

Enhancers for ZMYM2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZMYM2 on UCSC Golden Path with GeneCards custom track

Promoters for ZMYM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZMYM2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZMYM2 Gene

Chromosome:
13
Start:
19,957,432 bp from pter
End:
20,091,845 bp from pter
Size:
134,414 bases
Orientation:
Plus strand

Genomic View for ZMYM2 Gene

Genes around ZMYM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZMYM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZMYM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZMYM2 Gene

Proteins for ZMYM2 Gene

  • Protein details for ZMYM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBW7-ZMYM2_HUMAN
    Recommended name:
    Zinc finger MYM-type protein 2
    Protein Accession:
    Q9UBW7
    Secondary Accessions:
    • A6NDG0
    • A6NI02
    • O43212
    • O43434
    • O60898
    • Q5W0Q4
    • Q5W0T3
    • Q63HP0
    • Q8NE39
    • Q9H0V5
    • Q9H538
    • Q9UEU2

    Protein attributes for ZMYM2 Gene

    Size:
    1377 amino acids
    Molecular mass:
    154911 Da
    Quaternary structure:
    • May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I.
    SequenceCaution:
    • Sequence=AAB88464.1; Type=Frameshift; Positions=330, 966, 1009, 1017; Evidence={ECO:0000305}; Sequence=AAC23591.1; Type=Frameshift; Positions=330; Evidence={ECO:0000305}; Sequence=CAA73875.1; Type=Frameshift; Positions=388, 403, 406, 409, 418; Evidence={ECO:0000305};

    Alternative splice isoforms for ZMYM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZMYM2 Gene

Proteomics data for ZMYM2 Gene at MOPED

Post-translational modifications for ZMYM2 Gene

  • Ubiquitination at Lys 88, Lys 1107, Lys 1280, and Lys 1313
  • Modification sites at PhosphoSitePlus

Other Protein References for ZMYM2 Gene

Antibody Products

No data available for DME Specific Peptides for ZMYM2 Gene

Domains & Families for ZMYM2 Gene

Gene Families for ZMYM2 Gene

Protein Domains for ZMYM2 Gene

Suggested Antigen Peptide Sequences for ZMYM2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UBW7

UniProtKB/Swiss-Prot:

ZMYM2_HUMAN :
  • Contains 9 MYM-type zinc fingers.
Similarity:
  • Contains 9 MYM-type zinc fingers.
genes like me logo Genes that share domains with ZMYM2: view

Function for ZMYM2 Gene

Molecular function for ZMYM2 Gene

UniProtKB/Swiss-Prot Function:
May function as a transcription factor.

Gene Ontology (GO) - Molecular Function for ZMYM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
genes like me logo Genes that share ontologies with ZMYM2: view

Phenotypes for ZMYM2 Gene

MGI mutant phenotypes for ZMYM2:
inferred from 1 alleles
GenomeRNAi human phenotypes for ZMYM2:
genes like me logo Genes that share phenotypes with ZMYM2: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZMYM2 Gene

Localization for ZMYM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZMYM2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZMYM2 Gene COMPARTMENTS Subcellular localization image for ZMYM2 gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 2
chloroplast 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for ZMYM2 Gene

Pathways & Interactions for ZMYM2 Gene

genes like me logo Genes that share pathways with ZMYM2: view

Gene Ontology (GO) - Biological Process for ZMYM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IBA --
GO:0018108 peptidyl-tyrosine phosphorylation TAS --
genes like me logo Genes that share ontologies with ZMYM2: view

No data available for SIGNOR curated interactions for ZMYM2 Gene

Drugs & Compounds for ZMYM2 Gene

(2) Drugs for ZMYM2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZMYM2: view

Transcripts for ZMYM2 Gene

Unigene Clusters for ZMYM2 Gene

Zinc finger, MYM-type 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZMYM2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g ^ 10a ·
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - - - - - - - - -
SP5: - - -
SP6: - -
SP7:
SP8: - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - -
SP10: - - - - - - - - - - -
SP11: - - - - - - -
SP12: - - - -
SP13: - - -
SP14: -

ExUns: 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for ZMYM2 Gene

GeneLoc Exon Structure for
ZMYM2
ECgene alternative splicing isoforms for
ZMYM2

Expression for ZMYM2 Gene

mRNA expression in normal human tissues for ZMYM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZMYM2 Gene

This gene is overexpressed in Lung (23.0), Retina (6.4), CD8 Tcells (6.3), and Fetal ovary (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ZMYM2 Gene



SOURCE GeneReport for Unigene cluster for ZMYM2 Gene Hs.507433

genes like me logo Genes that share expression patterns with ZMYM2: view

Protein tissue co-expression partners for ZMYM2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZMYM2 Gene

Orthologs for ZMYM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZMYM2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ZMYM2 35
  • 95.47 (n)
  • 98.26 (a)
ZMYM2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zmym2 35
  • 92.68 (n)
  • 96.15 (a)
Zmym2 16
Zmym2 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZMYM2 35
  • 99.76 (n)
  • 99.78 (a)
ZMYM2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zmym2 35
  • 89.91 (n)
  • 92.72 (a)
cow
(Bos Taurus)
Mammalia ZMYM2 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZMYM2 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZMYM2 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZMYM2 35
  • 82.83 (n)
  • 85.56 (a)
-- 36
  • 86 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 84 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.31166 35
zebrafish
(Danio rerio)
Actinopterygii zmym2 35
  • 60.68 (n)
  • 59.31 (a)
zmym2 36
  • 53 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta woc 36
  • 20 (a)
OneToMany
Species with no ortholog for ZMYM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZMYM2 Gene

ENSEMBL:
Gene Tree for ZMYM2 (if available)
TreeFam:
Gene Tree for ZMYM2 (if available)

Paralogs for ZMYM2 Gene

Paralogs for ZMYM2 Gene

(2) SIMAP similar genes for ZMYM2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZMYM2: view

Variants for ZMYM2 Gene

Sequence variations from dbSNP and Humsavar for ZMYM2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs9889 -- 20,086,332(+) AGAAA(C/T)ATCCA utr-variant-3-prime
rs15639 -- 20,022,425(-) CACAA(C/T)AATGG intron-variant
rs166323 -- 20,085,521(+) attgt(C/T)gcatc intron-variant
rs259777 -- 20,092,035(+) AAAAA(C/T)CACTT downstream-variant-500B
rs259778 -- 20,086,976(+) CTGCA(A/G)TGTTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZMYM2 Gene

Variant ID Type Subtype PubMed ID
nsv832557 CNV Gain 17160897
nsv455828 CNV Loss 19166990
esv268973 CNV Insertion 20981092
nsv523961 CNV Loss 19592680
esv2560456 CNV Deletion 19546169
esv1929634 CNV Deletion 18987734
esv2674061 CNV Deletion 23128226
esv24803 CNV Loss 19812545
nsv899868 CNV Gain 21882294

Variation tolerance for ZMYM2 Gene

Residual Variation Intolerance Score: 4.45% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.66; 31.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZMYM2 Gene

HapMap Linkage Disequilibrium report
ZMYM2
Human Gene Mutation Database (HGMD)
ZMYM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZMYM2 Gene

Disorders for ZMYM2 Gene

MalaCards: The human disease database

(15) MalaCards diseases for ZMYM2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lymphoblastic lymphoma
  • lymphoma, lymphoblastic
8p11 myeloproliferative syndrome
  • chromosome 8p11 myeloproliferative syndrome
bone marrow cancer
  • bone marrow neoplasm
ideomotor apraxia
  • classic apraxia [ambiguous]
neurogenic bowel
- elite association - COSMIC cancer census association via MalaCards
Search ZMYM2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ZMYM2_HUMAN
  • Note=A chromosomal aberration involving ZMYM2 may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Translocation t(8;13)(p11;q12) with FGFR1. SCLL usually presents as lymphoblastic lymphoma in association with a myeloproliferative disorder, often accompanied by pronounced peripheral eosinophilia and/or prominent eosinophilic infiltrates in the affected bone marrow. {ECO:0000269 PubMed:9716603}.

Relevant External Links for ZMYM2

Genetic Association Database (GAD)
ZMYM2
Human Genome Epidemiology (HuGE) Navigator
ZMYM2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZMYM2
genes like me logo Genes that share disorders with ZMYM2: view

No data available for Genatlas for ZMYM2 Gene

Publications for ZMYM2 Gene

  1. The t(8;13)(p11;q11-12) rearrangement associated with an atypical myeloproliferative disorder fuses the fibroblast growth factor receptor 1 gene to a novel gene RAMP. (PMID: 9499416) Smedley D. … Shipley J. (Hum. Mol. Genet. 1998) 2 3 4 23 67
  2. FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome. (PMID: 9425908) Xiao S. … Fletcher J.A. (Nat. Genet. 1998) 2 3 23
  3. ZNF198 stabilizes the LSD1-CoREST-HDAC1 complex on chromatin through its MYM-type zinc fingers. (PMID: 18806873) Gocke C.B. … Yu H. (PLoS ONE 2008) 3 23
  4. HSPA1A is an important regulator of the stability and function of ZNF198 and its oncogenic derivative, ZNF198-FGFR1. (PMID: 17471537) Kasyapa C.S. … Cowell J.K. (J. Cell. Biochem. 2007) 3 23
  5. Mass spectroscopy identifies the splicing-associated proteins, PSF, hnRNP H3, hnRNP A2/B1, and TLS/FUS as interacting partners of the ZNF198 protein associated with rearrangement in myeloproliferative disease. (PMID: 15975576) Kasyapa C.S. … Cowell J.K. (Exp. Cell Res. 2005) 3 23

Products for ZMYM2 Gene

Sources for ZMYM2 Gene

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