ZMYM1 Gene
protein-coding GIFtS: 44
GCID: GC01P035526
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|
zinc finger, MYM-type 1(Previous names: zinc finger, MYM domain containing 1 )
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Aliases
for ZMYM1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Zinc Finger, MYM-Type 11 2 | | MYM1 2 | | Zinc Finger, MYM Domain Containing 11 2 | | FLJ231511 | | RP11-181E22.42 | | Zinc Finger MYM-Type Protein 12 |
| External Ids: | HGNC: 262531 | Entrez Gene: 798302 | Ensembl: ENSG000001970567 | UniProtKB: Q5SVZ63 | | ORGUL members: | |
|---|
| NONCODE:n342253 | |
Export aliases for ZMYM1 gene to outside databasesPrevious GC identifers: GC01P034972 GC01P035214 GC01P035317 GC01P033662
|---|
Summaries
for ZMYM1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ZMYM1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZMYM1 gene promoter:
CREB AREB6 MZF-1 Sp1 deltaCREB
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZMYM1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZMYM1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p34.3 Ensembl cytogenetic band: 1p34.3 HGNC cytogenetic band: 1p34.3ZMYM1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P035526: view genomic region
(about GC identifiers)
Start:
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35,525,387 bp from pter |
End:
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35,581,460 bp from pter |
Size:
|
56,074 bases |
Orientation:
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plus strand |
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Proteins
for ZMYM1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZMYM1_HUMAN, Q5SVZ6 (See
protein sequence)Recommended Name: Zinc finger MYM-type protein 1 Size: 1142 amino acids; 128717 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: D3DPR7 Q7Z3Q4Explore the universe of human proteins at neXtProt for ZMYM1: NX_Q5SVZ6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5SVZ6
ZMYM1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079048.3
ENSEMBL proteins: ENSP00000394233 ENSP00000352920 ENSP00000362426 ENSP00000362427
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZMYM1 for ontologies About GeneDecksing
ZMYM1 Antibody Products:
Assay Products for ZMYM1: |
Protein
Domains /
Families
for ZMYM1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZMYM1 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q5SVZ6ProtoNet protein and cluster: Q5SVZ6 2 Blocks protein families: IPB008906 HAT dimerisation IPB011017 TRASH
UniProtKB/Swiss-Prot: ZMYM1_HUMAN, Q5SVZ6Similarity: Contains 4 MYM-type zinc fingersSimilarity: Contains 1 TTF-type zinc finger |
Function
for ZMYM1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZMYM1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZMYM1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZMYM1 (NM_024772) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZMYM1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZMYM1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZMYM1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003676 | nucleic acid binding |
IEA | -- | | GO:0008270 | zinc ion binding |
IEA | -- | | GO:0046983 | protein dimerization activity |
IEA | -- |
ZMYM1 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZMYM1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZMYM1
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for ZMYM1 (ENSP000003529204) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for ZMYM1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZMYM1
Search CenterWatch for drugs/clinical trials and news about ZMYM1
|
Transcripts
for ZMYM1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZMYM1 gene: NM_024772.3 Unigene Cluster for ZMYM1: Zinc finger, MYM-type 1 Hs.471243 [show with all ESTs]Unigene Representative Sequence: CR9368139 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000417119 ENST00000359858(uc001byl.1 uc001bym.3 uc010ohu.2 uc009vut.3)
ENST00000466390 ENST00000488455(uc009vus.1) ENST00000475654 ENST00000373329
ENST00000373330(uc001byn.3 uc001byo.3) ENST00000476269 ENST00000463393
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZMYM1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZMYM1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZMYM1 (NM_024772) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZMYM1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZMYM1 |
Additional cDNA sequence: AK026804.1 AK096206.1 AK125741.1 AK299779.1 AK308655.1 BC037313.1 BX537537.1 BX648307.1 CR936813.1 9 DOTS entries: DT.443319 DT.121356682 DT.100024634 DT.101980075 DT.101970072 DT.121356657 DT.121356683 DT.405279 DT.100725907 24/69 AceView cDNA sequences (see all 69): CB132609 BC037313 AK096206 CB131944 BP338027 CA455078 AK125741 BM552225 AA453867 BU567393 BU568057 AA252901 BU854440 AW197345 AA347587 BU568340 BU561365 AW593217 AA905104 BX473043 BU569739 BG209884 AW276555 W48560
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ZMYM1 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b |
|---|
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| SP1: | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP3: | | | - | | - | | - | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | - | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZMYM1
|
Expression
for ZMYM1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZMYM1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAGTGCCTA
About this image
See ZMYM1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZMYM1
SOURCE GeneReport for Unigene cluster: Hs.471243
SABiosciences Custom PCR Arrays for ZMYM1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZMYM1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZMYM1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZMYM1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZMYM1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZMYM1 |
Orthologs
for ZMYM1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ZMYM1 gene from 5/15 species (see all 15) About this table
ENSEMBL Gene Tree for ZMYM1 (if available)
TreeFam Gene Tree for ZMYM1 (if available) |
Paralogs
for ZMYM1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZMYM1 gene
- ZMYM42 ZMYM52 ZMYM32 ZMYM62 ZMYM22 QRICH12
2 SIMAP similar genes for ZMYM1 using alignment to 3 protein entries: ZMYM1_HUMAN (see all proteins):ZMYM4 ZMYM6
ZMYM1 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for ZMYM1
PGOHUM00000247658 PGOHUM00000240093 PGOHUM00000242054
|
Genomic Variants
for ZMYM1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZMYM1 (35525387 - 35581460 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZMYM1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZMYM1 |
|
Disorders
/ Diseases
for ZMYM1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZMYM1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZMYM1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZMYM1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (2009)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
|
External Searches for ZMYM1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZMYM1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZMYM1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZMYM1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZMYM1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZMYM1 gene:
Search GeneIP for patents involving ZMYM1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZMYM1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZMYM1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZMYM1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZMYM1 | | | OriGene Protein Over-expression Lysate for ZMYM1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for ZMYM1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZMYM1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZMYM1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZMYM1 | | OriGene Custom Protein Services for ZMYM1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZMYM1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZMYM1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZMYM1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZMYM1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZMYM1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZMYM1 |
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 |  |  |  | |
| | | | Search Tocris compounds for ZMYM1 |
| |  |  |  |  | | | | |
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 |
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 | | | ZMYM1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZMYM1 |
|  |  |  | | | | ThermoFisher Antibodies for ZMYM1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZMYM1 |
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