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Aliases for ZMIZ2 Gene

Aliases for ZMIZ2 Gene

  • Zinc Finger MIZ-Type Containing 2 2 3 5
  • PIAS-Like Protein Zimp7 3 4
  • ZIMP7 3 4
  • Zinc Finger MIZ Domain-Containing Protein 2 3
  • TRAFIP20 3
  • KIAA1886 4
  • HZIMP7 3
  • NET27 3

External Ids for ZMIZ2 Gene

Summaries for ZMIZ2 Gene

Entrez Gene Summary for ZMIZ2 Gene

  • ZMIZ2 and ZMIZ1 (MIM 607159) are members of a PIAS (see MIM 603566)-like family of proteins that interact with nuclear hormone receptors. ZMIZ2 interacts with androgen receptor (AR; MIM 313700) and enhances AR-mediated transcription (Huang et al., 2005 [PubMed 16051670]).[supplied by OMIM, May 2010]

GeneCards Summary for ZMIZ2 Gene

ZMIZ2 (Zinc Finger MIZ-Type Containing 2) is a Protein Coding gene. Among its related pathways are Regulation of Androgen receptor activity. GO annotations related to this gene include ligand-dependent nuclear receptor transcription coactivator activity. An important paralog of this gene is ZMIZ1.

UniProtKB/Swiss-Prot for ZMIZ2 Gene

  • Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors.

Gene Wiki entry for ZMIZ2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZMIZ2 Gene

Genomics for ZMIZ2 Gene

Regulatory Elements for ZMIZ2 Gene

Enhancers for ZMIZ2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G044613 1.9 FANTOM5 Ensembl ENCODE dbSUPER 16.6 -128.2 -128156 13.0 HDGF FOXA2 ATF1 WRNIP1 FEZF1 DMAP1 GTF3C2 ZNF121 FOS ZHX2 PURB DDX56 ZMIZ2 SNORA5C ENSG00000228434 SNORA5B SNORA5A ENSG00000228596 TBRG4 MYO1G
GH07G044795 1.2 ENCODE 19.1 +48.9 48895 4.1 CREB3L1 AGO1 ZFP64 DMAP1 YY1 ZNF143 ZNF548 SP3 NFYC TBX21 ZMIZ2 H2AFV SEPT7P2 SNORA5C LINC01952 SNORA5B DDX56 SNHG15 PPIA GC07P044796
GH07G044824 1.1 Ensembl ENCODE 18.1 +77.0 77040 2.0 HDAC1 PKNOX1 SIN3A ZNF2 GATA2 ZNF366 FOS EGR2 SMARCA5 ZNF362 ZMIZ2 DDX56 LINC01952 H2AFV ENSG00000228596 PURB PPIA LOC105375260 PIR39901
GH07G044733 1.5 FANTOM5 Ensembl ENCODE 8.7 -13.1 -13073 4.1 NFIB KLF17 SIN3A RAD21 RFX5 GTF3C2 ZNF121 GATA2 SCRT2 FOS PURB SNORA5C DDX56 ENSG00000228434 SNORA5B SNORA5A MYO1G TBRG4 ZMIZ2 OGDH
GH07G044747 1.3 ENCODE dbSUPER 9.8 +1.8 1811 5.5 HDGF ARNT CREB3L1 AGO1 WRNIP1 ARID4B SIN3A ZNF2 ZNF143 ZNF207 ZMIZ2 GC07M044752
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZMIZ2 on UCSC Golden Path with GeneCards custom track

Promoters for ZMIZ2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000211870 253 1601 HDGF ARNT AGO1 WRNIP1 ZNF133 SIN3A ZNF2 ZNF121 GLIS2 ZNF143

Genomic Location for ZMIZ2 Gene

Chromosome:
7
Start:
44,748,547 bp from pter
End:
44,769,881 bp from pter
Size:
21,335 bases
Orientation:
Plus strand

Genomic View for ZMIZ2 Gene

Genes around ZMIZ2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZMIZ2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZMIZ2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZMIZ2 Gene

Proteins for ZMIZ2 Gene

  • Protein details for ZMIZ2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NF64-ZMIZ2_HUMAN
    Recommended name:
    Zinc finger MIZ domain-containing protein 2
    Protein Accession:
    Q8NF64
    Secondary Accessions:
    • A4D2K7
    • D3DVL1
    • O94790
    • Q0VGB4
    • Q659A8
    • Q6JKL5
    • Q8WTX8
    • Q96Q01
    • Q9BQH7

    Protein attributes for ZMIZ2 Gene

    Size:
    920 amino acids
    Molecular mass:
    96537 Da
    Quaternary structure:
    • Interacts with AR, SMARCA4/BRG1 and SMARCE1/BAF57. Interaction with either SMARCA4 and SMARCE1 enhances AR-mediated transcription.
    SequenceCaution:
    • Sequence=AAH21924.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC03396.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB66507.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZMIZ2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZMIZ2 Gene

Post-translational modifications for ZMIZ2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZMIZ2 Gene

Domains & Families for ZMIZ2 Gene

Gene Families for ZMIZ2 Gene

Protein Domains for ZMIZ2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZMIZ2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NF64

UniProtKB/Swiss-Prot:

ZMIZ2_HUMAN :
  • The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity. This activity is inhibited by the N-terminus in the full-length protein.
Domain:
  • The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity. This activity is inhibited by the N-terminus in the full-length protein.
genes like me logo Genes that share domains with ZMIZ2: view

Function for ZMIZ2 Gene

Molecular function for ZMIZ2 Gene

UniProtKB/Swiss-Prot Function:
Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors.

Gene Ontology (GO) - Molecular Function for ZMIZ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16051670
GO:0008270 zinc ion binding IEA --
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity IDA 16051670
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZMIZ2: view
genes like me logo Genes that share phenotypes with ZMIZ2: view

Animal Models for ZMIZ2 Gene

MGI Knock Outs for ZMIZ2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZMIZ2 Gene

Localization for ZMIZ2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZMIZ2 Gene

Nucleus. Note=Detected at replication foci throughout S phase.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZMIZ2 gene
Compartment Confidence
mitochondrion 5
nucleus 5
plasma membrane 2
cytosol 1

Gene Ontology (GO) - Cellular Components for ZMIZ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 16051670
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0043596 nuclear replication fork IDA 16051670
genes like me logo Genes that share ontologies with ZMIZ2: view

Pathways & Interactions for ZMIZ2 Gene

genes like me logo Genes that share pathways with ZMIZ2: view

Pathways by source for ZMIZ2 Gene

1 BioSystems pathway for ZMIZ2 Gene

Gene Ontology (GO) - Biological Process for ZMIZ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 16051670
genes like me logo Genes that share ontologies with ZMIZ2: view

No data available for SIGNOR curated interactions for ZMIZ2 Gene

Drugs & Compounds for ZMIZ2 Gene

No Compound Related Data Available

Transcripts for ZMIZ2 Gene

Unigene Clusters for ZMIZ2 Gene

Zinc finger, MIZ-type containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZMIZ2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a ·
SP1: - - - -
SP2: - - - - - -
SP3: -
SP4: - -
SP5:
SP6:
SP7: -
SP8: -
SP9:
SP10:
SP11:
SP12:

ExUns: 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b · 20c ^ 21a · 21b · 21c · 21d ^ 22a · 22b
SP1: - -
SP2: - -
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: - -
SP11: -
SP12:

Relevant External Links for ZMIZ2 Gene

GeneLoc Exon Structure for
ZMIZ2
ECgene alternative splicing isoforms for
ZMIZ2

Expression for ZMIZ2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZMIZ2 Gene

Protein differential expression in normal tissues from HIPED for ZMIZ2 Gene

This gene is overexpressed in CD8 Tcells (49.5) and Blymphocyte (19.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZMIZ2 Gene



Protein tissue co-expression partners for ZMIZ2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZMIZ2 Gene:

ZMIZ2

SOURCE GeneReport for Unigene cluster for ZMIZ2 Gene:

Hs.77978

mRNA Expression by UniProt/SwissProt for ZMIZ2 Gene:

Q8NF64-ZMIZ2_HUMAN
Tissue specificity: Expressed most abundantly in testis with lower levels in heart, brain, pancreas, prostate and ovary.

Evidence on tissue expression from TISSUES for ZMIZ2 Gene

  • Nervous system(4.8)
  • Spleen(4.3)
  • Kidney(4.2)
  • Lung(2.6)
genes like me logo Genes that share expression patterns with ZMIZ2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZMIZ2 Gene

Orthologs for ZMIZ2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZMIZ2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZMIZ2 34 35
  • 99.42 (n)
rat
(Rattus norvegicus)
Mammalia Zmiz2 34
  • 88.55 (n)
mouse
(Mus musculus)
Mammalia Zmiz2 34 16 35
  • 88.15 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 87 (a)
OneToMany
-- 35
  • 82 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ZMIZ2 34 35
  • 86.64 (n)
oppossum
(Monodelphis domestica)
Mammalia ZMIZ2 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 66 (a)
OneToMany
-- 35
  • 7 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia ZMIZ2 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zmiz2 34
  • 68.71 (n)
Str.6695 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.24338 34
zebrafish
(Danio rerio)
Actinopterygii zmiz2 34 35
  • 71.6 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13373 34
fruit fly
(Drosophila melanogaster)
Insecta tna 35
  • 28 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NFI1 35
  • 15 (a)
ManyToMany
SIZ1 35
  • 14 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
OneToMany
Species where no ortholog for ZMIZ2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZMIZ2 Gene

ENSEMBL:
Gene Tree for ZMIZ2 (if available)
TreeFam:
Gene Tree for ZMIZ2 (if available)

Paralogs for ZMIZ2 Gene

Paralogs for ZMIZ2 Gene

(4) SIMAP similar genes for ZMIZ2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZMIZ2: view

Variants for ZMIZ2 Gene

Sequence variations from dbSNP and Humsavar for ZMIZ2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000119424 -- 44,756,647(+) GTGAG(A/G)ACAGA intron-variant
rs1000178890 -- 44,760,540(+) GTCTC(C/T)CTTCT nc-transcript-variant, reference, missense
rs1000345049 -- 44,750,540(+) TTGAG(A/G)AGCGT intron-variant, utr-variant-5-prime
rs1000346062 -- 44,750,227(+) GTTAA(A/G)GTTGT intron-variant, utr-variant-5-prime
rs1000402711 -- 44,756,958(+) GGGAA(C/G)CCCAT intron-variant, nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZMIZ2 Gene

Variant ID Type Subtype PubMed ID
esv3401081 CNV duplication 20981092
nsv5722 CNV insertion 18451855
nsv951639 CNV deletion 24416366

Variation tolerance for ZMIZ2 Gene

Residual Variation Intolerance Score: 3.66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.62; 82.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZMIZ2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZMIZ2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZMIZ2 Gene

Disorders for ZMIZ2 Gene

Relevant External Links for ZMIZ2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZMIZ2

No disorders were found for ZMIZ2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZMIZ2 Gene

Publications for ZMIZ2 Gene

  1. hZimp7, a novel PIAS-like protein, enhances androgen receptor- mediated transcription and interacts with SWI/SNF-like BAF complexes. (PMID: 16051670) Huang C.-Y. … Sun Z. (Mol. Endocrinol. 2005) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64

Products for ZMIZ2 Gene

Sources for ZMIZ2 Gene

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