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Aliases for ZMIZ2 Gene

Aliases for ZMIZ2 Gene

  • Zinc Finger, MIZ-Type Containing 2 2 3
  • ZIMP7 3 4 6
  • PIAS-Like Protein Zimp7 3 4
  • KIAA1886 4 6
  • Zinc Finger MIZ Domain-Containing Protein 2 3
  • TRAFIP20 3
  • HZIMP7 3
  • NET27 3

External Ids for ZMIZ2 Gene

Summaries for ZMIZ2 Gene

Entrez Gene Summary for ZMIZ2 Gene

  • ZMIZ2 and ZMIZ1 (MIM 607159) are members of a PIAS (see MIM 603566)-like family of proteins that interact with nuclear hormone receptors. ZMIZ2 interacts with androgen receptor (AR; MIM 313700) and enhances AR-mediated transcription (Huang et al., 2005 [PubMed 16051670]).[supplied by OMIM, May 2010]

GeneCards Summary for ZMIZ2 Gene

ZMIZ2 (Zinc Finger, MIZ-Type Containing 2) is a Protein Coding gene. Diseases associated with ZMIZ2 include blepharitis. Among its related pathways are Regulation of Androgen receptor activity. GO annotations related to this gene include ligand-dependent nuclear receptor transcription coactivator activity. An important paralog of this gene is ZMIZ1.

UniProtKB/Swiss-Prot for ZMIZ2 Gene

  • Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors.

Gene Wiki entry for ZMIZ2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZMIZ2 Gene

Genomics for ZMIZ2 Gene

Regulatory Elements for ZMIZ2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZMIZ2 Gene

Start:
44,748,569 bp from pter
End:
44,769,881 bp from pter
Size:
21,313 bases
Orientation:
Plus strand

Genomic View for ZMIZ2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZMIZ2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZMIZ2 Gene

Proteins for ZMIZ2 Gene

  • Protein details for ZMIZ2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NF64-ZMIZ2_HUMAN
    Recommended name:
    Zinc finger MIZ domain-containing protein 2
    Protein Accession:
    Q8NF64
    Secondary Accessions:
    • A4D2K7
    • D3DVL1
    • O94790
    • Q0VGB4
    • Q659A8
    • Q6JKL5
    • Q8WTX8
    • Q96Q01
    • Q9BQH7

    Protein attributes for ZMIZ2 Gene

    Size:
    920 amino acids
    Molecular mass:
    96537 Da
    Quaternary structure:
    • Interacts with AR, SMARCA4/BRG1 and SMARCE1/BAF57. Interaction with either SMARCA4 and SMARCE1 enhances AR-mediated transcription.
    SequenceCaution:
    • Sequence=AAH21924.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC03396.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB66507.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZMIZ2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZMIZ2 Gene

Proteomics data for ZMIZ2 Gene at MOPED

Post-translational modifications for ZMIZ2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZMIZ2 Gene

Domains for ZMIZ2 Gene

Gene Families for ZMIZ2 Gene

HGNC:
  • ZMIZ :Zinc fingers, MIZ-type

Protein Domains for ZMIZ2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZMIZ2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NF64

UniProtKB/Swiss-Prot:

ZMIZ2_HUMAN :
  • Q8NF64
Domain:
  • The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity. This activity is inhibited by the N-terminus in the full-length protein
Similarity:
  • Contains 1 SP-RING-type zinc finger.
genes like me logo Genes that share domains with ZMIZ2: view

Function for ZMIZ2 Gene

Molecular function for ZMIZ2 Gene

UniProtKB/Swiss-Prot Function: Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors.

Gene Ontology (GO) - Molecular Function for ZMIZ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16051670
GO:0008270 zinc ion binding IEA --
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity IDA 16051670
genes like me logo Genes that share ontologies with ZMIZ2: view

Phenotypes for ZMIZ2 Gene

GenomeRNAi human phenotypes for ZMIZ2:
genes like me logo Genes that share phenotypes with ZMIZ2: view

Animal Model Products

CRISPR Products

miRNA for ZMIZ2 Gene

miRTarBase miRNAs that target ZMIZ2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZMIZ2 Gene

Localization for ZMIZ2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZMIZ2 Gene

Nucleus. Note=Detected at replication foci throughout S phase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZMIZ2 Gene COMPARTMENTS Subcellular localization image for ZMIZ2 gene
Compartment Confidence
nucleus 5
mitochondrion 4
plasma membrane 2
cytosol 1

Gene Ontology (GO) - Cellular Components for ZMIZ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16051670
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0043596 nuclear replication fork IDA 16051670
genes like me logo Genes that share ontologies with ZMIZ2: view

Pathways for ZMIZ2 Gene

genes like me logo Genes that share pathways with ZMIZ2: view

Pathways by source for ZMIZ2 Gene

1 BioSystems pathway for ZMIZ2 Gene

Gene Ontology (GO) - Biological Process for ZMIZ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 16051670
genes like me logo Genes that share ontologies with ZMIZ2: view

Transcripts for ZMIZ2 Gene

Unigene Clusters for ZMIZ2 Gene

Zinc finger, MIZ-type containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZMIZ2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZMIZ2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZMIZ2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a ·
SP1: - - - -
SP2: - - - - - -
SP3: -
SP4: - -
SP5:
SP6:
SP7: -
SP8: -
SP9:
SP10:
SP11:
SP12:

ExUns: 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b · 20c ^ 21a · 21b · 21c · 21d ^ 22a · 22b
SP1: - -
SP2: - -
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: - -
SP11: -
SP12:

Relevant External Links for ZMIZ2 Gene

GeneLoc Exon Structure for
ZMIZ2
ECgene alternative splicing isoforms for
ZMIZ2

Expression for ZMIZ2 Gene

mRNA expression in normal human tissues for ZMIZ2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZMIZ2 Gene

SOURCE GeneReport for Unigene cluster for ZMIZ2 Gene Hs.77978

mRNA Expression by UniProt/SwissProt for ZMIZ2 Gene

Q8NF64-ZMIZ2_HUMAN
Tissue specificity: Expressed most abundantly in testis with lower levels in heart, brain, pancreas, prostate and ovary.
genes like me logo Genes that share expressions with ZMIZ2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZMIZ2 Gene

Orthologs for ZMIZ2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZMIZ2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZMIZ2 35
  • 99.42 (n)
  • 99.57 (a)
ZMIZ2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZMIZ2 35
  • 86.64 (n)
  • 88.45 (a)
ZMIZ2 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 87 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zmiz2 35
  • 88.15 (n)
  • 90.87 (a)
Zmiz2 16
Zmiz2 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZMIZ2 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
OneToMany
-- 36
  • 7 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zmiz2 35
  • 88.55 (n)
  • 91.63 (a)
lizard
(Anolis carolinensis)
Reptilia ZMIZ2 36
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24338 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6695 35
zmiz2 35
  • 68.71 (n)
  • 71.65 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13373 35
zebrafish
(Danio rerio)
Actinopterygii zmiz2 35
  • 71.6 (n)
  • 72.95 (a)
zmiz2 36
  • 68 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta tna 36
  • 28 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NFI1 36
  • 15 (a)
ManyToMany
SIZ1 36
  • 14 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for ZMIZ2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZMIZ2 Gene

ENSEMBL:
Gene Tree for ZMIZ2 (if available)
TreeFam:
Gene Tree for ZMIZ2 (if available)

Paralogs for ZMIZ2 Gene

Paralogs for ZMIZ2 Gene

Selected SIMAP similar genes for ZMIZ2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZMIZ2: view

Variants for ZMIZ2 Gene

Sequence variations from dbSNP and Humsavar for ZMIZ2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs799451 -- 44,751,389(+) GCTGC(A/G)AGCTG intron-variant
rs799452 -- 44,752,942(+) tgttt(C/T)ccaga intron-variant
rs1050327 -- 44,768,418(+) TGGCC(A/C/G)AGGTG utr-variant-3-prime
rs1050331 -- 44,768,492(+) CCCCT(G/T)CTCTG utr-variant-3-prime
rs1050333 -- 44,768,551(+) TCTCC(A/C)CCCCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZMIZ2 Gene

Variant ID Type Subtype PubMed ID
nsv5722 CNV Insertion 18451855
nsv887999 CNV Loss 21882294

Relevant External Links for ZMIZ2 Gene

HapMap Linkage Disequilibrium report
ZMIZ2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZMIZ2 Gene

Disorders for ZMIZ2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ZMIZ2 Gene including...

Search for ZMIZ2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ZMIZ2 Gene

genes like me logo Genes that share disorders with ZMIZ2: view

No data available for UniProtKB/Swiss-Prot for ZMIZ2 Gene

Publications for ZMIZ2 Gene

  1. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. hZimp7, a novel PIAS-like protein, enhances androgen receptor- mediated transcription and interacts with SWI/SNF-like BAF complexes. (PMID: 16051670) Huang C.-Y. … Sun Z. (Mol. Endocrinol. 2005) 3 4

Products for ZMIZ2 Gene

Sources for ZMIZ2 Gene

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