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Aliases for ZMIZ1 Gene

Aliases for ZMIZ1 Gene

  • Zinc Finger MIZ-Type Containing 1 2 3 5
  • Retinoic Acid Induced 17 2 3
  • ZIMP10 3 4
  • RAI17 3 4
  • Zinc Finger-Containing, Miz1, PIAS-Like Protein On Chromosome 10 3
  • Zinc Finger MIZ Domain-Containing Protein 1 3
  • Retinoic Acid-Induced Protein 17 4
  • PIAS-Like Protein Zimp10 4
  • TRAFIP10 3
  • KIAA1224 4
  • MIZ 3

External Ids for ZMIZ1 Gene

Previous HGNC Symbols for ZMIZ1 Gene

  • RAI17

Previous GeneCards Identifiers for ZMIZ1 Gene

  • GC10P080498
  • GC10P080631
  • GC10P080828
  • GC10P074825

Summaries for ZMIZ1 Gene

Entrez Gene Summary for ZMIZ1 Gene

  • This gene encodes a member of the PIAS (protein inhibitor of activated STAT) family of proteins. The encoded protein regulates the activity of various transcription factors, including the androgen receptor, Smad3/4, and p53. The encoded protein may also play a role in sumoylation. A translocation between this locus on chromosome 10 and the protein tyrosine kinase ABL1 locus on chromosome 9 has been associated with acute lymphoblastic leukemia. [provided by RefSeq, Mar 2010]

GeneCards Summary for ZMIZ1 Gene

ZMIZ1 (Zinc Finger MIZ-Type Containing 1) is a Protein Coding gene. Among its related pathways are Coregulation of Androgen receptor activity and Androgen receptor signaling pathway. An important paralog of this gene is ZMIZ2.

UniProtKB/Swiss-Prot for ZMIZ1 Gene

  • Acts as transcriptional coactivator. Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation (PubMed:14609956, PubMed:26522984). Involved in transcriptional activation of a subset of NOTCH1 target genes including MYC. Involved in thymocyte and T cell development (By similarity).

Gene Wiki entry for ZMIZ1 Gene

Additional gene information for ZMIZ1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZMIZ1 Gene

Genomics for ZMIZ1 Gene

Regulatory Elements for ZMIZ1 Gene

Enhancers for ZMIZ1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H079066 2.1 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +7.5 7491 20 MLX FEZF1 DMAP1 YY1 ZNF143 SP3 ZC3H11A MEF2D ZNF610 ZNF585B LOC642361 NPAP1P2 PGGT1BP2 ENSG00000272489 ENSG00000224886 ZMIZ1 SFTPD-AS1 ZMIZ1-AS1 GC10M079169
GH10H079346 1.4 ENCODE dbSUPER 16.2 +279.9 279916 4 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF143 ZMIZ1 NPAP1P2 PGGT1BP2 ZNF519P1 ENSG00000272489 PPIF ZCCHC24 ENSG00000235426
GH10H079442 1.4 ENCODE dbSUPER 16.2 +375.8 375780 5 HDGF FOXA2 PKNOX1 ARNT SIN3A FEZF1 YBX1 ZNF2 YY1 ZNF143 ENSG00000272489 ZMIZ1 NPAP1P2 PGGT1BP2 ZNF519P1 ZMIZ1-AS1 NUTM2B-AS1 ZCCHC24 GC10M079406
GH10H079263 1.9 FANTOM5 Ensembl ENCODE dbSUPER 8 +198.6 198565 8 PKNOX1 SIN3A GTF3C2 ZNF766 GATA2 FOS ATF7 RUNX3 JUNB REST PPIF ENSG00000272489 ZMIZ1-AS1 ZMIZ1 GC10P079375
GH10H079326 0.8 FANTOM5 17.3 +257.3 257285 0 ZNF146 ZSCAN4 TSC22D4 ZNF175 ZNF266 GLI4 CDC5L CTBP1 ZNF791 ZNF157 ENSG00000272489 ZMIZ1-AS1 ZMIZ1 ENSG00000235426 NUTM2B-AS1 LOC642361 PPIF GC10P079375
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZMIZ1 on UCSC Golden Path with GeneCards custom track

Promoters for ZMIZ1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000030595 236 4801 HDGF FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B

Genomic Location for ZMIZ1 Gene

Chromosome:
10
Start:
79,068,964 bp from pter
End:
79,316,528 bp from pter
Size:
247,565 bases
Orientation:
Plus strand

Genomic View for ZMIZ1 Gene

Genes around ZMIZ1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZMIZ1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZMIZ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZMIZ1 Gene

Proteins for ZMIZ1 Gene

  • Protein details for ZMIZ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULJ6-ZMIZ1_HUMAN
    Recommended name:
    Zinc finger MIZ domain-containing protein 1
    Protein Accession:
    Q9ULJ6
    Secondary Accessions:
    • Q5JSH9
    • Q7Z7E6

    Protein attributes for ZMIZ1 Gene

    Size:
    1067 amino acids
    Molecular mass:
    115483 Da
    Quaternary structure:
    • Interacts with AR, but not with ESR1, NR3C1, PGR, THRB nor VDR. Interacts with NOTCH1 and RBPJ (PubMed:14609956, PubMed:26522984). Interacts with SMARCA4 (By similarity).

    Three dimensional structures from OCA and Proteopedia for ZMIZ1 Gene

    Alternative splice isoforms for ZMIZ1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZMIZ1 Gene

Post-translational modifications for ZMIZ1 Gene

  • Ubiquitination at isoforms=2611
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZMIZ1 Gene

Domains & Families for ZMIZ1 Gene

Gene Families for ZMIZ1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZMIZ1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9ULJ6

UniProtKB/Swiss-Prot:

ZMIZ1_HUMAN :
  • The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity. This activity is inhibited by the N-terminus in the full-length protein.
Domain:
  • The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity. This activity is inhibited by the N-terminus in the full-length protein.
genes like me logo Genes that share domains with ZMIZ1: view

Function for ZMIZ1 Gene

Molecular function for ZMIZ1 Gene

UniProtKB/Swiss-Prot Function:
Acts as transcriptional coactivator. Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation (PubMed:14609956, PubMed:26522984). Involved in transcriptional activation of a subset of NOTCH1 target genes including MYC. Involved in thymocyte and T cell development (By similarity).

Phenotypes From GWAS Catalog for ZMIZ1 Gene

Gene Ontology (GO) - Molecular Function for ZMIZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZMIZ1: view
genes like me logo Genes that share phenotypes with ZMIZ1: view

Animal Models for ZMIZ1 Gene

MGI Knock Outs for ZMIZ1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZMIZ1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZMIZ1 Gene

Localization for ZMIZ1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZMIZ1 Gene

Nucleus speckle. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZMIZ1 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZMIZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0016607 nuclear speck IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with ZMIZ1: view

Pathways & Interactions for ZMIZ1 Gene

genes like me logo Genes that share pathways with ZMIZ1: view

Pathways by source for ZMIZ1 Gene

Gene Ontology (GO) - Biological Process for ZMIZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001570 vasculogenesis IEA --
GO:0001701 in utero embryonic development IEA --
GO:0003007 heart morphogenesis IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZMIZ1: view

No data available for SIGNOR curated interactions for ZMIZ1 Gene

Drugs & Compounds for ZMIZ1 Gene

No Compound Related Data Available

Transcripts for ZMIZ1 Gene

Unigene Clusters for ZMIZ1 Gene

Zinc finger, MIZ-type containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZMIZ1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZMIZ1 Gene

No ASD Table

Relevant External Links for ZMIZ1 Gene

GeneLoc Exon Structure for
ZMIZ1
ECgene alternative splicing isoforms for
ZMIZ1

Expression for ZMIZ1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZMIZ1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZMIZ1 Gene

This gene is overexpressed in Placenta (17.4), Ovary (14.7), Fetal ovary (14.6), Peripheral blood mononuclear cells (9.2), and CD8 Tcells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZMIZ1 Gene



Protein tissue co-expression partners for ZMIZ1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZMIZ1 Gene:

ZMIZ1

SOURCE GeneReport for Unigene cluster for ZMIZ1 Gene:

Hs.193118

mRNA Expression by UniProt/SwissProt for ZMIZ1 Gene:

Q9ULJ6-ZMIZ1_HUMAN
Tissue specificity: Expressed most abundantly in ovary and, at lower levels, in prostate, spleen and testis. Weak expression, if any, in thymus, small intestine, colon and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for ZMIZ1 Gene

  • Nervous system(4.9)
  • Blood(2)
genes like me logo Genes that share expression patterns with ZMIZ1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZMIZ1 Gene

Orthologs for ZMIZ1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZMIZ1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZMIZ1 33 34
  • 99.41 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 95 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia ZMIZ1 33 34
  • 94.5 (n)
dog
(Canis familiaris)
Mammalia ZMIZ1 33 34
  • 94.43 (n)
mouse
(Mus musculus)
Mammalia Zmiz1 33 16 34
  • 91.71 (n)
rat
(Rattus norvegicus)
Mammalia Zmiz1 33
  • 91.46 (n)
oppossum
(Monodelphis domestica)
Mammalia ZMIZ1 34
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZMIZ1 33 34
  • 80.98 (n)
lizard
(Anolis carolinensis)
Reptilia ZMIZ1 34
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zmiz1 33
  • 76.3 (n)
Str.7446 33
zebrafish
(Danio rerio)
Actinopterygii zmiz1a 33 34
  • 75.85 (n)
zmiz1b 34
  • 58 (a)
OneToMany
wufb80e10 33
fruit fly
(Drosophila melanogaster)
Insecta tna 34
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NFI1 34
  • 14 (a)
ManyToMany
SIZ1 34
  • 12 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 43 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3350 33
Species where no ortholog for ZMIZ1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZMIZ1 Gene

ENSEMBL:
Gene Tree for ZMIZ1 (if available)
TreeFam:
Gene Tree for ZMIZ1 (if available)

Paralogs for ZMIZ1 Gene

Paralogs for ZMIZ1 Gene

(4) SIMAP similar genes for ZMIZ1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZMIZ1: view

Variants for ZMIZ1 Gene

Sequence variations from dbSNP and Humsavar for ZMIZ1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_036326 A breast cancer sample
rs1000001186 -- 79,196,558(+) CCAGA(A/C)AAGAC intron-variant
rs1000032175 -- 79,274,602(+) AACAT(C/T)CACTG intron-variant
rs1000038447 -- 79,233,239(+) CTGGG(A/G)AGACT intron-variant
rs1000042508 -- 79,077,048(+) GAAGC(A/G)GGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZMIZ1 Gene

Variant ID Type Subtype PubMed ID
dgv1274n54 CNV loss 21841781
dgv1275n54 CNV loss 21841781
dgv1276n54 CNV gain 21841781
dgv1277n54 CNV gain+loss 21841781
dgv1278n54 CNV loss 21841781
dgv151e214 CNV loss 21293372
esv26238 CNV loss 19812545
esv2677565 CNV deletion 23128226
esv2738596 CNV deletion 23290073
esv2761606 CNV gain 21179565
esv28147 CNV loss 19812545
esv33105 CNV loss 17666407
esv3335392 CNV insertion 20981092
esv3412399 CNV insertion 20981092
esv3546542 CNV deletion 23714750
esv3623908 CNV loss 21293372
esv988762 CNV loss 20482838
nsv1045078 CNV gain 25217958
nsv1051195 CNV gain 25217958
nsv1070878 CNV deletion 25765185
nsv1118179 CNV deletion 24896259
nsv1118180 CNV deletion 24896259
nsv1131001 CNV deletion 24896259
nsv1161981 CNV duplication 26073780
nsv25450 CNV insertion 16902084
nsv467384 CNV gain 19166990
nsv469807 CNV loss 16826518
nsv470965 CNV loss 18288195
nsv521285 CNV loss 19592680
nsv523745 CNV loss 19592680
nsv525995 CNV loss 19592680
nsv551561 CNV gain 21841781
nsv551568 CNV gain 21841781
nsv551569 CNV loss 21841781
nsv551571 CNV gain+loss 21841781
nsv551579 CNV gain 21841781
nsv551580 CNV loss 21841781
nsv831921 CNV loss 17160897
nsv950981 CNV deletion 24416366

Variation tolerance for ZMIZ1 Gene

Residual Variation Intolerance Score: 0.855% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.61; 30.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZMIZ1 Gene

Human Gene Mutation Database (HGMD)
ZMIZ1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZMIZ1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZMIZ1 Gene

Disorders for ZMIZ1 Gene

Relevant External Links for ZMIZ1

Genetic Association Database (GAD)
ZMIZ1
Human Genome Epidemiology (HuGE) Navigator
ZMIZ1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZMIZ1

No disorders were found for ZMIZ1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZMIZ1 Gene

Publications for ZMIZ1 Gene

  1. The PIAS-like Coactivator Zmiz1 Is a Direct and Selective Cofactor of Notch1 in T Cell Development and Leukemia. (PMID: 26522984) Pinnell N … Chiang MY (Immunity 2015) 3 4 60
  2. Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. (PMID: 22190364) Patsopoulos NA … de Bakker PI (Annals of neurology 2011) 3 45 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. (PMID: 21102463) Franke A … Parkes M (Nature genetics 2010) 3 45 60
  5. Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC. (PMID: 20526339) Quan C … Zhang XJ (Nature genetics 2010) 3 45 60

Products for ZMIZ1 Gene

Sources for ZMIZ1 Gene

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