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ZMIZ1 Gene

protein-coding   GIFtS: 58
GCID: GC10P080828

Zinc Finger, MIZ-Type Containing 1

(Previous name: retinoic acid induced 17)
(Previous symbol: RAI17)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger, MIZ-Type Containing 11 2     TRAFIP102
RAI171 2 3 5     FLJ00092 Protein2
ZIMP102 3 5     hZIMP102
Retinoic Acid Induced 171 2     Zinc Finger MIZ Domain-Containing Protein 12
KIAA12243 5     Zinc Finger-Containing, Miz1, PIAS-Like Protein On Chromosome 102
MIZ2     PIAS-Like Protein Zimp103
RP11-519K18.12     Retinoic Acid-Induced Protein 173

External Ids:    HGNC: 164931   Entrez Gene: 571782   Ensembl: ENSG000001081757   OMIM: 6071595   UniProtKB: Q9ULJ63   

Export aliases for ZMIZ1 gene to outside databases

Previous GC identifers: GC10P080498 GC10P080631 GC10P074825


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZMIZ1 Gene:
This gene encodes a member of the PIAS (protein inhibitor of activated STAT) family of proteins. The encoded
protein regulates the activity of various transcription factors, including the androgen receptor, Smad3/4, and
p53. The encoded protein may also play a role in sumoylation. A translocation between this locus on chromosome 10
and the protein tyrosine kinase ABL1 locus on chromosome 9 has been associated with acute lymphoblastic leukemia.
(provided by RefSeq, Mar 2010)

GeneCards Summary for ZMIZ1 Gene:
ZMIZ1 (zinc finger, MIZ-type containing 1) is a protein-coding gene. Diseases associated with ZMIZ1 include lymphoblastic leukemia, and vitiligo. An important paralog of this gene is PIAS3.

UniProtKB/Swiss-Prot: ZMIZ1_HUMAN, Q9ULJ6
Function: Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation
of AR activity is dependent upon sumoylation

Gene Wiki entry for ZMIZ1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZMIZ1 gene promoter:
         Pax-5   MyoD   MIF-1   RORalpha2   MEF-2A   PPAR-gamma1   POU2F1   POU2F1a   PPAR-gamma2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZMIZ1 promoter sequence
   Search Chromatin IP Primers for ZMIZ1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZMIZ1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.3   Ensembl cytogenetic band:  10q22.3   HGNC cytogenetic band: 10q22.3

ZMIZ1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZMIZ1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P080828:  view genomic region     (about GC identifiers)

Start:
80,828,792 bp from pter      End:
81,076,285 bp from pter
Size:
247,494 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for ZMIZ1

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZMIZ1_HUMAN, Q9ULJ6 (See protein sequence)
Recommended Name: Zinc finger MIZ domain-containing protein 1  
Size: 1067 amino acids; 115483 Da
Subunit: Interacts with AR, but not with ESR1, NR3C1, PGR, THRB nor VDR
Secondary accessions: Q5JSH9 Q7Z7E6
Alternative splicing: 2 isoforms:  Q9ULJ6-1   Q9ULJ6-2   (Incomplete sequence. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZMIZ1: NX_Q9ULJ6

Explore proteomics data for ZMIZ1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys611
  • Modification sites at PhosphoSitePlus

  • See ZMIZ1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065071.1  
    ENSEMBL proteins: 
     ENSP00000334474   ENSP00000401558  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZMIZ: Zinc fingers, MIZ-type

    2 InterPro protein domains:
     IPR013083 Znf_RING/FYVE/PHD
     IPR004181 Znf_MIZ

    Graphical View of Domain Structure for InterPro Entry Q9ULJ6

    ProtoNet protein and cluster: Q9ULJ6

    UniProtKB/Swiss-Prot: ZMIZ1_HUMAN, Q9ULJ6
    Domain: The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity. This
    activity is inhibited by the N-terminus in the full-length protein
    Similarity: Contains 1 SP-RING-type zinc finger


    ZMIZ1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZMIZ1_HUMAN, Q9ULJ6
    Function: Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation
    of AR activity is dependent upon sumoylation

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--
         
    ZMIZ1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ZMIZ1:
     Decreased viability with pacli  Increased gamma-H2AX phosphory 

         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Zmiz1):
     cardiovascular system  cellular  craniofacial  embryogenesis  growth/size/body 
     hematopoietic system  integument  mortality/aging 

    ZMIZ1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Zmiz1tm1Zsu for ZMIZ1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZMIZ1
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZMIZ1

    miRNA
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    miRTarBase miRNAs that target ZMIZ1:
    hsa-mir-1301-3p (MIRT036014), hsa-mir-93-5p (MIRT028022), hsa-mir-1180-3p (MIRT035934), hsa-mir-96-5p (MIRT027882), hsa-mir-335-5p (MIRT017830)

    Block miRNA regulation of human, mouse, rat ZMIZ1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZMIZ1 (see all 100):
    hsa-miR-548j hsa-miR-300 hsa-miR-605 hsa-miR-138-2* hsa-miR-759 hsa-miR-3162-5p hsa-miR-409-5p hsa-miR-3622b-3p
    SwitchGear 3'UTR luciferase reporter plasmidZMIZ1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZMIZ1

    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZMIZ1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZMIZ1_HUMAN, Q9ULJ6: Nucleus speckle. Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0016607nuclear speck IEA--

    ZMIZ1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZMIZ1 About    
    See pathways by source

    SuperPathContained pathways About
    1Integrated Breast Cancer Pathway
    Integrated Breast Cancer Pathway
    2Coregulation of Androgen receptor activity
    Coregulation of Androgen receptor activity
    3Androgen receptor signaling pathway
    Androgen receptor signaling pathway


    3 BioSystems Pathways for ZMIZ1
        Integrated Breast Cancer Pathway
    Androgen receptor signaling pathway
    Coregulation of Androgen receptor activity


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZMIZ1
    Interactions:

        Search GeneGlobe Interaction Network for ZMIZ1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ZMIZ1 (Q9ULJ62, 3 ENSP000003344744) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARP102753, ENSP000003638224I2D: score=2 STRING: ENSP00000363822
    CACHD1Q5VU973, ENSP000002900394I2D: score=2 STRING: ENSP00000290039
    TP53P046373, ENSP000002693054I2D: score=1 STRING: ENSP00000269305
    PIAS3Q9Y6X23, ENSP000003767654I2D: score=1 STRING: ENSP00000376765
    CNTNAP2Q9UHC63, ENSP000003547784I2D: score=2 STRING: ENSP00000354778
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001570vasculogenesis IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0003007heart morphogenesis IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0007296vitellogenesis IEA--

    ZMIZ1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZMIZ1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZMIZ1 gene: 
    NM_020338.3  

    Unigene Cluster for ZMIZ1:

    Zinc finger, MIZ-type containing 1
    Hs.193118  [show with all ESTs]
    Unigene Representative Sequence: NM_020338
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000334512(uc001kaf.2 uc001kae.3 uc001kag.2 uc010qlq.1)
    ENST00000472035 ENST00000478357(uc001kah.1) ENST00000446377
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ZMIZ1 (see all 100):
    hsa-miR-548j hsa-miR-300 hsa-miR-605 hsa-miR-138-2* hsa-miR-759 hsa-miR-3162-5p hsa-miR-409-5p hsa-miR-3622b-3p
    SwitchGear 3'UTR luciferase reporter plasmidZMIZ1 3' UTR sequence
    Inhib. RNA
    Products:
         
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      QuantiTect SYBR Green Assays in human, mouse, rat ZMIZ1
      QuantiFast Probe-based Assays in human, mouse, rat ZMIZ1

    Additional mRNA sequence: 

    AB033050.2 AF070622.1 AF357909.1 AK023603.1 AK024490.1 AK025812.1 AL049432.1 AY235683.1 
    BC007288.1 BC025342.1 BC035890.1 BC049845.1 BC117687.2 

    16 DOTS entries:

    DT.318444  DT.100786689  DT.99935422  DT.97864176  DT.100786692  DT.75189419  DT.97792558  DT.100786696 
    DT.121274709  DT.121274846  DT.121274884  DT.430051  DT.86846869  DT.95111872  DT.95204015  DT.91804110 

    Selected AceView cDNA sequences (see all 272):

    AA443116 F01605 AI125915 AI937270 AA954680 NM_020338 AI870797 AI139371 
    AW129048 BQ631840 AW504502 BU633603 AJ346314 BG059981 CA446702 AA977527 
    BQ214716 BU787553 AA306791 AU157689 AU119651 AF070622 AW118823 AW119171 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZMIZ1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZMIZ1 Expression
    About this image


    ZMIZ1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Surface Ectoderm (Integumentary System)    fully expand to see all 2 entries
             Surface Ectoderm Cells Surface Ectoderm
             Surface Ectoderm
     
     Epidermis (Integumentary System)
             Surface Ectoderm Cells Surface Ectoderm
     
     Ectoderm (Gastrulation Derivatives)
             Surface Ectoderm Cells Surface Ectoderm
     
     Thyroid (Endocrine System)
     
     Ovary (Reproductive System)
    ZMIZ1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZMIZ1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.193118

    UniProtKB/Swiss-Prot: ZMIZ1_HUMAN, Q9ULJ6
    Tissue specificity: Expressed most abundantly in ovary and, at lower levels, in prostate, spleen and testis. Weak
    expression, if any, in thymus, small intestine, colon and peripheral blood leukocytes

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZMIZ1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ZMIZ1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zmiz11 , 5 zinc finger, MIZ-type containing 11, 5 91.71(n)1
    98.12(a)1
      14 (15.03 cM)5
    3283651  NM_183208.31  NP_899031.21 
     254591855 
    chicken
    (Gallus gallus)
    Aves ZMIZ11 zinc finger, MIZ-type containing 1 80.98(n)
    93.92(a)
      423724  XM_004942063.1  XP_004942120.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZMIZ16
    zinc finger, MIZ-type containing 1
    91(a)
    1 ↔ 1
    GL343468.1(362685-568740)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.74462 Transcribed sequence with weak similarity to protein more 82.27(n)    AL846714.2 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb80e102 wufb80e10 81.22(n)   323065  57046570 
    fruit fly
    (Drosophila melanogaster)
    Insecta tna6
    tonalli
    32(a)
    1 → many
    3L(10850989-10869596)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NFI16
    SIZ16
    SUMO E3 ligase, catalyzes the covalent attachment ...
    SUMO/Smt3 ligase that promotes the attachment of s...
    14(a)
    12(a)
    many ↔ many
    many ↔ many
    XV(628360-630540) YOR156C
    IV(1289406-1292120) YDR409W


    ENSEMBL Gene Tree for ZMIZ1 (if available)
    TreeFam Gene Tree for ZMIZ1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZMIZ1 gene
    PIAS32  ZMIZ22  PIAS12  PIAS22  PIAS42  
    4 SIMAP similar genes for ZMIZ1 using alignment to 4 protein entries:     ZMIZ1_HUMAN (see all proteins):
    FLJ00092    TRAFIP10    ZMIZ2    TRAFIP20

    ZMIZ1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZMIZ1 (see all 5294)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0363264
    A breast cancer sample4--see VAR_0363262 L V mis40--------
    rs114054051,2
    C--74823417(+) TCTCG-/G/GG  
            
    GGGGG
    1 -- us2k1 trp30--------
    rs769087381,2
    C,F--74824646(+) CTACCC/TGGCGG 1 -- ut511Minor allele frequency- T:0.44EA 120
    rs1847561821,2
    C--74824918(+) CGGAGC/GCGGCT 1 -- int10--------
    rs105924401,2
    C--74835781(+) ttttt-/T/TT  
            
    gagac
    1 -- int11NA 2
    rs667634581,2
    C--74902369(+) TGTAC-/GTGTGTG 1 -- int11Minor allele frequency- GT:0.00NA 2
    rs24856971,2
    C,F,A,H--74902395(-) GGATAC/TACACA 1 -- int12Minor allele frequency- T:0.50WA NA 4
    rs762814501,2
    --74904073(+) TTTTTA/TATAAA 1 -- int10--------
    rs105739551,2
    C--74912789(+) AAGGG-/GTGT  
            
    GTGTG
    1 -- int10--------
    rs797510501,2
    C--74919858(+) GCGTC-/TTCTAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for ZMIZ1 (80828792 - 81076285 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZMIZ1 (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2677565CNV Deletion23128226
    esv2738596CNV Deletion23290073
    nsv25450CNV Insertion16902084
    esv269188CNV Insertion20981092
    nsv895741CNV Loss21882294
    nsv831921CNV Loss17160897
    esv28147CNV Loss19812545
    esv26238CNV Loss19812545
    nsv521285CNV Loss19592680
    nsv525995CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 607159    OMIM disorders: --

    17 diseases for ZMIZ1:    
    About MalaCards
    lymphoblastic leukemia    vitiligo    leukemia    celiac disease
    bipolar disorder    inflammatory bowel disease    crohn's disease    psoriasis
    type 1 diabetes    multiple sclerosis    breast and colorectal cancer    diabetes mellitus
    alzheimer's disease    colorectal cancer    breast cancer    prostatitis
    malaria


    ZMIZ1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZMIZ1
    Human Genome Epidemiology (HuGE) Navigator: ZMIZ1 (7 documents)

    Export disorders for ZMIZ1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZMIZ1 gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with ZMIZ1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. (PubMed id 22190364)1, 4 Patsopoulos N.A....de Bakker P.I. (Ann. Neurol. 2011)
    2. Association between genome-wide association studies reported SNPs and pediatric-onset Crohn's disease in Canadian children. (PubMed id 20473688)1, 4 Amre D.K....Levy E. (Hum. Genet. 2010)
    3. Multiple common variants for celiac disease influencing immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (Nat. Genet. 2010)
    4. Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC. (PubMed id 20526339)1, 4 Quan C....Zhang X.J. (Nat. Genet. 2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. (PubMed id 21102463)1, 4 Franke A....Parkes M. (Nat. Genet. 2010)
    7. Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. (PubMed id 19525953)1, 4 De Jager P.L....Oksenberg J.R. (Nat. Genet. 2009)
    8. Common variants at five new loci associated with early-onset inflammatory bowel disease. (PubMed id 19915574)1, 4 Imielinski M....Hakonarson H. (Nat. Genet. 2009)
    9. Genome-wide SNP genotyping study using pooled DNA to identify candidate markers mediating susceptibility to end-stage renal disease attributed to Type 1 diabetes. (PubMed id 19929986)1, 4 Craig D.W....DiStefano J.K. (Diabet. Med. 2009)
    10. Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score. (PubMed id 19879194)1, 4 De Jager P.L....Karlson E.W. (Lancet Neurol 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 57178 HGNC: 16493 AceView: RAI17 Ensembl:ENSG00000108175 euGenes: HUgn57178
    ECgene: ZMIZ1 H-InvDB: ZMIZ1

    (According to HUGE)
    About This Section

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    HUGE: KIAA1224

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ZMIZ1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ZMIZ1 gene:
    Search GeneIP for patents involving ZMIZ1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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