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Aliases for ZMIZ1 Gene

Aliases for ZMIZ1 Gene

  • Zinc Finger, MIZ-Type Containing 1 2 3
  • ZIMP10 3 4 6
  • RAI17 3 4 6
  • Retinoic Acid Induced 17 2 3
  • KIAA1224 4 6
  • Zinc Finger-Containing, Miz1, PIAS-Like Protein On Chromosome 10 3
  • Zinc Finger MIZ Domain-Containing Protein 1 3
  • Retinoic Acid-Induced Protein 17 4
  • PIAS-Like Protein Zimp10 4
  • FLJ00092 Protein 3
  • RP11-519K18.1 3
  • TRAFIP10 3
  • HZIMP10 3
  • MIZ 3

External Ids for ZMIZ1 Gene

Previous HGNC Symbols for ZMIZ1 Gene

  • RAI17

Previous GeneCards Identifiers for ZMIZ1 Gene

  • GC10P080498
  • GC10P080631
  • GC10P080828
  • GC10P074825

Summaries for ZMIZ1 Gene

Entrez Gene Summary for ZMIZ1 Gene

  • This gene encodes a member of the PIAS (protein inhibitor of activated STAT) family of proteins. The encoded protein regulates the activity of various transcription factors, including the androgen receptor, Smad3/4, and p53. The encoded protein may also play a role in sumoylation. A translocation between this locus on chromosome 10 and the protein tyrosine kinase ABL1 locus on chromosome 9 has been associated with acute lymphoblastic leukemia. [provided by RefSeq, Mar 2010]

GeneCards Summary for ZMIZ1 Gene

ZMIZ1 (Zinc Finger, MIZ-Type Containing 1) is a Protein Coding gene. Diseases associated with ZMIZ1 include lymphoblastic leukemia. Among its related pathways are Coregulation of Androgen receptor activity and Integrated Breast Cancer Pathway. An important paralog of this gene is PIAS2.

UniProtKB/Swiss-Prot for ZMIZ1 Gene

  • Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation

Gene Wiki entry for ZMIZ1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZMIZ1 Gene

Genomics for ZMIZ1 Gene

Regulatory Elements for ZMIZ1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZMIZ1 Gene

79,068,994 bp from pter
79,316,528 bp from pter
247,535 bases
Plus strand

Genomic View for ZMIZ1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZMIZ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZMIZ1 Gene

Proteins for ZMIZ1 Gene

  • Protein details for ZMIZ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger MIZ domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q5JSH9
    • Q7Z7E6

    Protein attributes for ZMIZ1 Gene

    1067 amino acids
    Molecular mass:
    115483 Da
    Quaternary structure:
    • Interacts with AR, but not with ESR1, NR3C1, PGR, THRB nor VDR.

    Alternative splice isoforms for ZMIZ1 Gene


neXtProt entry for ZMIZ1 Gene

Proteomics data for ZMIZ1 Gene at MOPED

Post-translational modifications for ZMIZ1 Gene

  • Ubiquitination at Lys611
  • Modification sites at PhosphoSitePlus

Other Protein References for ZMIZ1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ZMIZ1 Gene

Domains for ZMIZ1 Gene

Gene Families for ZMIZ1 Gene

  • ZMIZ :Zinc fingers, MIZ-type

Protein Domains for ZMIZ1 Gene


Graphical View of Domain Structure for InterPro Entry



  • Q9ULJ6
  • The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity. This activity is inhibited by the N-terminus in the full-length protein
  • Contains 1 SP-RING-type zinc finger.
genes like me logo Genes that share domains with ZMIZ1: view

Function for ZMIZ1 Gene

Molecular function for ZMIZ1 Gene

UniProtKB/Swiss-Prot Function:
Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation

Gene Ontology (GO) - Molecular Function for ZMIZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ZMIZ1: view
genes like me logo Genes that share phenotypes with ZMIZ1: view

Animal Models for ZMIZ1 Gene

MGI Knock Outs for ZMIZ1:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZMIZ1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ZMIZ1 Gene

Localization for ZMIZ1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZMIZ1 Gene

Nucleus speckle. Cytoplasm.

Subcellular locations from

Jensen Localization Image for ZMIZ1 Gene COMPARTMENTS Subcellular localization image for ZMIZ1 gene
Compartment Confidence
nucleus 5
cytosol 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ZMIZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0016607 nuclear speck IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with ZMIZ1: view

Pathways for ZMIZ1 Gene

genes like me logo Genes that share pathways with ZMIZ1: view

Pathways by source for ZMIZ1 Gene

Gene Ontology (GO) - Biological Process for ZMIZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001570 vasculogenesis IEA --
GO:0001701 in utero embryonic development IEA --
GO:0003007 heart morphogenesis IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0007296 vitellogenesis IEA --
genes like me logo Genes that share ontologies with ZMIZ1: view

Transcripts for ZMIZ1 Gene

Unigene Clusters for ZMIZ1 Gene

Zinc finger, MIZ-type containing 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZMIZ1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZMIZ1 Gene

No ASD Table

Relevant External Links for ZMIZ1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZMIZ1 Gene

mRNA expression in normal human tissues for ZMIZ1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for ZMIZ1 Gene

This gene is overexpressed in Placenta (17.4), Ovary (14.7), Fetal ovary (14.6), Peripheral blood mononuclear cells (9.2), and CD8 Tcells (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZMIZ1 Gene

SOURCE GeneReport for Unigene cluster for ZMIZ1 Gene Hs.193118

mRNA Expression by UniProt/SwissProt for ZMIZ1 Gene

Tissue specificity: Expressed most abundantly in ovary and, at lower levels, in prostate, spleen and testis. Weak expression, if any, in thymus, small intestine, colon and peripheral blood leukocytes.
genes like me logo Genes that share expressions with ZMIZ1: view

Expression partners for ZMIZ1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ZMIZ1 Gene

Orthologs for ZMIZ1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZMIZ1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZMIZ1 35
  • 94.5 (n)
  • 99.06 (a)
ZMIZ1 36
  • 99 (a)
(Canis familiaris)
Mammalia ZMIZ1 35
  • 94.43 (n)
  • 99.25 (a)
ZMIZ1 36
  • 99 (a)
(Mus musculus)
Mammalia Zmiz1 35
  • 91.71 (n)
  • 98.12 (a)
Zmiz1 16
Zmiz1 36
  • 98 (a)
(Pan troglodytes)
Mammalia ZMIZ1 35
  • 99.41 (n)
  • 99.91 (a)
ZMIZ1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Zmiz1 35
  • 91.46 (n)
  • 98.12 (a)
(Monodelphis domestica)
Mammalia ZMIZ1 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 95 (a)
(Gallus gallus)
Aves ZMIZ1 35
  • 80.98 (n)
  • 93.92 (a)
ZMIZ1 36
  • 91 (a)
(Anolis carolinensis)
Reptilia ZMIZ1 36
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7446 35
zmiz1 35
  • 76.3 (n)
  • 85.33 (a)
(Danio rerio)
Actinopterygii wufb80e10 35
zmiz1a 35
  • 75.85 (n)
  • 83.93 (a)
zmiz1a 36
  • 84 (a)
zmiz1b 36
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta tna 36
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NFI1 36
  • 14 (a)
SIZ1 36
  • 12 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3350 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
Species with no ortholog for ZMIZ1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZMIZ1 Gene

Gene Tree for ZMIZ1 (if available)
Gene Tree for ZMIZ1 (if available)

Paralogs for ZMIZ1 Gene

Paralogs for ZMIZ1 Gene

Selected SIMAP similar genes for ZMIZ1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZMIZ1: view

Variants for ZMIZ1 Gene

Sequence variations from dbSNP and Humsavar for ZMIZ1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs9448 -- 79,316,151(-) CACCT(A/G)TGATC utr-variant-3-prime
rs697237 -- 79,194,929(+) AGACC(A/G)AGCTG intron-variant
rs697238 -- 79,187,911(+) TTGTG(G/T)ATAGT intron-variant
rs697239 -- 79,187,681(+) CAGTA(C/T)GCATG intron-variant
rs697240 -- 79,181,047(+) GACAG(C/T)GTGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZMIZ1 Gene

Variant ID Type Subtype PubMed ID
nsv467384 CNV Gain 19166990
nsv469807 CNV Loss 16826518
nsv895741 CNV Loss 21882294
esv26238 CNV Loss 19812545
esv2738596 CNV Deletion 23290073
esv988762 CNV Loss 20482838
nsv470965 CNV Loss 18288195
esv269188 CNV Insertion 20981092
nsv25450 CNV Insertion 16902084
nsv895742 CNV Loss 21882294
nsv895743 CNV Loss 21882294
esv2677565 CNV Deletion 23128226
nsv831921 CNV Loss 17160897
esv28147 CNV Loss 19812545
esv33105 CNV Loss 17666407
nsv521285 CNV Loss 19592680
nsv525995 CNV Loss 19592680
nsv523745 CNV Loss 19592680

Relevant External Links for ZMIZ1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZMIZ1 Gene

Disorders for ZMIZ1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ZMIZ1 Gene in MalaCards »

(1) Diseases for ZMIZ1 Gene including...

Relevant External Links for ZMIZ1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ZMIZ1: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ZMIZ1 Gene

Publications for ZMIZ1 Gene

  1. The novel PIAS-like protein hZimp10 enhances Smad transcriptional activity. (PMID: 16777850) Li X. … Sun Z. (J. Biol. Chem. 2006) 3 23
  2. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 3 4
  3. Are gene expression microarray analyses reliable? A review of studies of retinoic acid responsive genes. (PMID: 15626329) van der Spek P.J. … Walker M.G. (Genomics Proteomics Bioinformatics 2003) 2 3
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48
  5. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. (PMID: 18711365) Ferreira M.A. … Craddock N. (Nat. Genet. 2008) 3 48

Products for ZMIZ1 Gene

Sources for ZMIZ1 Gene

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