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Aliases for ZMAT4 Gene

Aliases for ZMAT4 Gene

  • Zinc Finger Matrin-Type 4 2 3 5

External Ids for ZMAT4 Gene

Previous GeneCards Identifiers for ZMAT4 Gene

  • GC08M040508
  • GC08M040388
  • GC08M038921

Summaries for ZMAT4 Gene

GeneCards Summary for ZMAT4 Gene

ZMAT4 (Zinc Finger Matrin-Type 4) is a Protein Coding gene. Diseases associated with ZMAT4 include Refractive Error. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF346.

Additional gene information for ZMAT4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZMAT4 Gene

Genomics for ZMAT4 Gene

GeneHancer (GH) Regulatory Elements for ZMAT4 Gene

Promoters and enhancers for ZMAT4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I040897 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 550.8 +0.1 50 0.8 SP1 GATA3 PKNOX1 POLR2A REST ZBTB17 ZMAT4 GC08P040557
GH08I040896 Enhancer 0.2 Ensembl 550.8 +1.2 1232 0.4 ZMAT4 GC08P040557
GH08I040523 Enhancer 0.8 Ensembl ENCODE 11.4 +373.4 373439 2.4 JUN MAFG EP300 SP1 JUND POLR2A NFE2 FOS FOSL2 NFE2L2 ZMAT4 ENSG00000272479 GC08P040557
GH08I040412 Enhancer 0.5 Ensembl ENCODE 11.6 +484.1 484140 2.2 REST ZMAT4 GC08P040409 PIR60225
GH08I040485 Enhancer 0.5 ENCODE 11 +411.4 411386 2.5 SP1 ZNF512B YBX1 FOSL2 FOS ZMAT4 PIR60225 GC08P040409
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZMAT4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZMAT4 gene promoter:

Genomic Locations for ZMAT4 Gene

Genomic Locations for ZMAT4 Gene
chr8:40,530,590-40,897,833
(GRCh38/hg38)
Size:
367,244 bases
Orientation:
Minus strand
chr8:40,388,109-40,755,352
(GRCh37/hg19)

Genomic View for ZMAT4 Gene

Genes around ZMAT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZMAT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZMAT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZMAT4 Gene

Proteins for ZMAT4 Gene

  • Protein details for ZMAT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H898-ZMAT4_HUMAN
    Recommended name:
    Zinc finger matrin-type protein 4
    Protein Accession:
    Q9H898
    Secondary Accessions:
    • Q8WUT8

    Protein attributes for ZMAT4 Gene

    Size:
    229 amino acids
    Molecular mass:
    25833 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZMAT4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZMAT4 Gene

Post-translational modifications for ZMAT4 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZMAT4 Gene

Domains & Families for ZMAT4 Gene

Gene Families for ZMAT4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ZMAT4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZMAT4: view

No data available for UniProtKB/Swiss-Prot for ZMAT4 Gene

Function for ZMAT4 Gene

Phenotypes From GWAS Catalog for ZMAT4 Gene

Gene Ontology (GO) - Molecular Function for ZMAT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ZMAT4: view

Phenotypes for ZMAT4 Gene

genes like me logo Genes that share phenotypes with ZMAT4: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZMAT4 Gene

Localization for ZMAT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZMAT4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZMAT4 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZMAT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZMAT4: view

Pathways & Interactions for ZMAT4 Gene

SuperPathways for ZMAT4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZMAT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IBA --
genes like me logo Genes that share ontologies with ZMAT4: view

No data available for Pathways by source and SIGNOR curated interactions for ZMAT4 Gene

Drugs & Compounds for ZMAT4 Gene

(1) Drugs for ZMAT4 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Atenolol Approved Pharma Antagonist 108
genes like me logo Genes that share compounds with ZMAT4: view

Transcripts for ZMAT4 Gene

Unigene Clusters for ZMAT4 Gene

Zinc finger, matrin-type 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZMAT4 Gene

No ASD Table

Relevant External Links for ZMAT4 Gene

GeneLoc Exon Structure for
ZMAT4
ECgene alternative splicing isoforms for
ZMAT4

Expression for ZMAT4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZMAT4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZMAT4 Gene

This gene is overexpressed in Brain - Cortex (x7.7), Brain - Frontal Cortex (BA9) (x7.6), Brain - Putamen (basal ganglia) (x6.0), Brain - Caudate (basal ganglia) (x5.6), Brain - Nucleus accumbens (basal ganglia) (x5.4), and Brain - Anterior cingulate cortex (BA24) (x5.1).

Protein differential expression in normal tissues from HIPED for ZMAT4 Gene

This gene is overexpressed in Fetal Brain (44.2) and Fetal testis (19.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZMAT4 Gene



Protein tissue co-expression partners for ZMAT4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZMAT4 Gene:

ZMAT4

SOURCE GeneReport for Unigene cluster for ZMAT4 Gene:

Hs.591850

Evidence on tissue expression from TISSUES for ZMAT4 Gene

  • Thyroid gland(4.3)
  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZMAT4: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZMAT4 Gene

Orthologs for ZMAT4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZMAT4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZMAT4 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZMAT4 33 34
  • 92.29 (n)
cow
(Bos Taurus)
Mammalia ZMAT4 33 34
  • 91.7 (n)
rat
(Rattus norvegicus)
Mammalia Zmat4 33
  • 87.77 (n)
mouse
(Mus musculus)
Mammalia Zmat4 33 16 34
  • 87.05 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZMAT4 34
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZMAT4 34
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZMAT4 33 34
  • 76.61 (n)
lizard
(Anolis carolinensis)
Reptilia ZMAT4 34
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494386 33
  • 65.01 (n)
zebrafish
(Danio rerio)
Actinopterygii zmat4a 33 34
  • 70.32 (n)
zmat4b 34
  • 67 (a)
OneToMany
Species where no ortholog for ZMAT4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZMAT4 Gene

ENSEMBL:
Gene Tree for ZMAT4 (if available)
TreeFam:
Gene Tree for ZMAT4 (if available)

Paralogs for ZMAT4 Gene

Paralogs for ZMAT4 Gene

(2) SIMAP similar genes for ZMAT4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZMAT4: view

Variants for ZMAT4 Gene

Sequence variations from dbSNP and Humsavar for ZMAT4 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000001268 -- 40,541,481(-) T/A genic_downstream_transcript_variant, intron_variant
rs1000004792 -- 40,690,470(-) C/G intron_variant
rs1000014750 -- 40,711,574(-) T/C intron_variant
rs1000017310 -- 40,869,048(-) C/G genic_upstream_transcript_variant, intron_variant
rs1000021379 -- 40,830,385(-) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZMAT4 Gene

Variant ID Type Subtype PubMed ID
dgv4134e59 CNV duplication 20981092
esv2024539 CNV deletion 18987734
esv23484 CNV gain 19812545
esv2662604 CNV deletion 23128226
esv2664427 CNV deletion 23128226
esv2736913 CNV deletion 23290073
esv2736914 CNV deletion 23290073
esv2736915 CNV deletion 23290073
esv2736916 CNV deletion 23290073
esv2736919 CNV deletion 23290073
esv2736920 CNV deletion 23290073
esv2736921 CNV deletion 23290073
esv33015 CNV gain 17666407
esv33198 CNV loss 17666407
esv3342559 CNV insertion 20981092
esv33641 CNV gain 17666407
esv3543407 CNV deletion 23714750
esv3572703 CNV loss 25503493
esv3572704 CNV loss 25503493
esv3572705 CNV loss 25503493
esv3616974 CNV loss 21293372
esv3616975 CNV loss 21293372
esv3616977 CNV loss 21293372
esv5394 CNV loss 18987735
nsv1076080 CNV deletion 25765185
nsv1077036 CNV deletion 25765185
nsv1120932 CNV deletion 24896259
nsv1121403 CNV deletion 24896259
nsv1126115 CNV deletion 24896259
nsv1132141 CNV deletion 24896259
nsv1144226 CNV deletion 24896259
nsv1151015 CNV deletion 26484159
nsv465638 CNV loss 19166990
nsv472016 CNV novel sequence insertion 20440878
nsv477844 CNV novel sequence insertion 20440878
nsv512951 CNV insertion 21212237
nsv519446 CNV gain 19592680
nsv522210 CNV loss 19592680
nsv523192 CNV gain 19592680
nsv523193 CNV gain 19592680
nsv611120 CNV loss 21841781
nsv611121 CNV loss 21841781
nsv611122 CNV loss 21841781
nsv821546 CNV deletion 20802225

Variation tolerance for ZMAT4 Gene

Residual Variation Intolerance Score: 31.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.23; 76.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZMAT4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZMAT4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZMAT4 Gene

Disorders for ZMAT4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZMAT4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
refractive error
  • refractive errors
- elite association - COSMIC cancer census association via MalaCards
Search ZMAT4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZMAT4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ZMAT4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZMAT4 Gene

Publications for ZMAT4 Gene

  1. The association between the copy-number variations of ZMAT4 and hematological malignancy. (PMID: 21269563) Wan J … Zhang W (Hematology (Amsterdam, Netherlands) 2011) 2 3 58
  2. Genome-wide association with diabetes-related traits in the Framingham Heart Study. (PMID: 17903298) Meigs JB … Dupuis J (BMC medical genetics 2007) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for ZMAT4 Gene

Sources for ZMAT4 Gene

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