Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZMAT4 Gene

Aliases for ZMAT4 Gene

  • Zinc Finger, Matrin-Type 4 2 3

External Ids for ZMAT4 Gene

Previous GeneCards Identifiers for ZMAT4 Gene

  • GC08M040508
  • GC08M040388
  • GC08M038921

Summaries for ZMAT4 Gene

GeneCards Summary for ZMAT4 Gene

ZMAT4 (Zinc Finger, Matrin-Type 4) is a Protein Coding gene. Diseases associated with ZMAT4 include refractive error. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is KRCC1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZMAT4 Gene

Genomics for ZMAT4 Gene

Regulatory Elements for ZMAT4 Gene

Genomic Location for ZMAT4 Gene

40,530,590 bp from pter
40,897,833 bp from pter
367,244 bases
Minus strand

Genomic View for ZMAT4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZMAT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZMAT4 Gene

Proteins for ZMAT4 Gene

  • Protein details for ZMAT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger matrin-type protein 4
    Protein Accession:
    Secondary Accessions:
    • Q8WUT8

    Protein attributes for ZMAT4 Gene

    229 amino acids
    Molecular mass:
    25833 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZMAT4 Gene


neXtProt entry for ZMAT4 Gene

Proteomics data for ZMAT4 Gene at MOPED

Post-translational modifications for ZMAT4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZMAT4 Gene

No data available for DME Specific Peptides for ZMAT4 Gene

Domains & Families for ZMAT4 Gene

Gene Families for ZMAT4 Gene

Protein Domains for ZMAT4 Gene

Suggested Antigen Peptide Sequences for ZMAT4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 matrin-type zinc fingers.
  • Contains 4 matrin-type zinc fingers.
genes like me logo Genes that share domains with ZMAT4: view

Function for ZMAT4 Gene

Gene Ontology (GO) - Molecular Function for ZMAT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IBA --
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ZMAT4: view

Phenotypes for ZMAT4 Gene

genes like me logo Genes that share phenotypes with ZMAT4: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ZMAT4 Gene

Localization for ZMAT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZMAT4 Gene

Subcellular locations from

Jensen Localization Image for ZMAT4 Gene COMPARTMENTS Subcellular localization image for ZMAT4 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZMAT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZMAT4: view

Pathways & Interactions for ZMAT4 Gene

SuperPathways for ZMAT4 Gene

No Data Available

Interacting Proteins for ZMAT4 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000297737 Q9H898-ZMAT4_HUMAN for ZMAT4 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for ZMAT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IBA --
genes like me logo Genes that share ontologies with ZMAT4: view

No data available for Pathways by source and SIGNOR curated interactions for ZMAT4 Gene

Drugs & Compounds for ZMAT4 Gene

No Compound Related Data Available

Transcripts for ZMAT4 Gene

Unigene Clusters for ZMAT4 Gene

Zinc finger, matrin-type 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZMAT4 Gene

No ASD Table

Relevant External Links for ZMAT4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZMAT4 Gene

mRNA expression in normal human tissues for ZMAT4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZMAT4 Gene

This gene is overexpressed in Brain - Cortex (x7.7), Brain - Frontal Cortex (BA9) (x7.6), Brain - Putamen (basal ganglia) (x6.0), Brain - Caudate (basal ganglia) (x5.6), Brain - Nucleus accumbens (basal ganglia) (x5.4), and Brain - Anterior cingulate cortex (BA24) (x5.1).

Protein differential expression in normal tissues from HIPED for ZMAT4 Gene

This gene is overexpressed in Fetal Brain (44.2) and Fetal testis (19.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZMAT4 Gene

SOURCE GeneReport for Unigene cluster for ZMAT4 Gene Hs.591850

genes like me logo Genes that share expression patterns with ZMAT4: view

Protein tissue co-expression partners for ZMAT4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ZMAT4 Gene

Orthologs for ZMAT4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZMAT4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZMAT4 35
  • 91.7 (n)
  • 97.82 (a)
ZMAT4 36
  • 98 (a)
(Canis familiaris)
Mammalia ZMAT4 35
  • 92.29 (n)
  • 97.82 (a)
ZMAT4 36
  • 98 (a)
(Mus musculus)
Mammalia Zmat4 35
  • 87.05 (n)
  • 94.76 (a)
Zmat4 16
Zmat4 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Zmat4 35
  • 87.77 (n)
  • 94.32 (a)
(Monodelphis domestica)
Mammalia ZMAT4 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia ZMAT4 36
  • 85 (a)
(Pan troglodytes)
Mammalia ZMAT4 36
  • 100 (a)
(Gallus gallus)
Aves ZMAT4 35
  • 76.61 (n)
  • 83.33 (a)
ZMAT4 36
  • 82 (a)
(Anolis carolinensis)
Reptilia ZMAT4 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494386 35
  • 65.01 (n)
  • 66.52 (a)
(Danio rerio)
Actinopterygii zmat4a 35
  • 70.32 (n)
  • 75 (a)
zmat4a 36
  • 62 (a)
zmat4b 36
  • 67 (a)
Species with no ortholog for ZMAT4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZMAT4 Gene

Gene Tree for ZMAT4 (if available)
Gene Tree for ZMAT4 (if available)

Paralogs for ZMAT4 Gene

Paralogs for ZMAT4 Gene

(2) SIMAP similar genes for ZMAT4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZMAT4: view

Variants for ZMAT4 Gene

Sequence variations from dbSNP and Humsavar for ZMAT4 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs715029 -- 40,566,707(+) CAAAA(A/G/T)CTAGA intron-variant
rs721176 -- 40,541,550(+) tatta(A/G)caatc intron-variant
rs721177 -- 40,541,755(+) AGAAA(C/T)GAGCC intron-variant
rs722103 -- 40,641,600(+) TAAAT(A/G)TACAC intron-variant
rs722104 -- 40,641,594(+) TGGAG(A/C)TAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZMAT4 Gene

Variant ID Type Subtype PubMed ID
nsv890841 CNV Loss 21882294
esv33641 CNV Gain 17666407
esv2736913 CNV Deletion 23290073
esv2736914 CNV Deletion 23290073
esv2024539 CNV Deletion 18987734
esv2736915 CNV Deletion 23290073
esv2736916 CNV Deletion 23290073
esv5394 CNV Deletion 18987735
esv2736919 CNV Deletion 23290073
esv2662604 CNV Deletion 23128226
esv2736920 CNV Deletion 23290073
esv23484 CNV Gain 19812545
nsv821546 CNV Deletion 20802225
esv33198 CNV Loss 17666407
esv33015 CNV Gain 17666407
nsv519446 CNV Gain 19592680
nsv890842 CNV Loss 21882294
nsv523192 CNV Gain 19592680
esv2664427 CNV Deletion 23128226
nsv523193 CNV Gain 19592680
nsv512951 CNV Insertion 21212237
nsv465638 CNV Loss 19166990
nsv522210 CNV Loss 19592680
esv2736921 CNV Deletion 23290073

Variation tolerance for ZMAT4 Gene

Residual Variation Intolerance Score: 31.32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.23; 76.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZMAT4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZMAT4 Gene

Disorders for ZMAT4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZMAT4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
refractive error
  • eye refraction disorder
- elite association
Search ZMAT4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ZMAT4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ZMAT4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZMAT4 Gene

Publications for ZMAT4 Gene

  1. The association between the copy-number variations of ZMAT4 and hematological malignancy. (PMID: 21269563) Wan J. … Zhang W. (Hematology 2011) 2 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  3. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 67
  4. Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. (PMID: 23396134) Verhoeven V.J. … Hammond C.J. (Nat. Genet. 2013) 67
  5. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PMID: 24163370) Lu L. … Zhang L. (J. Biol. Chem. 2013) 67

Products for ZMAT4 Gene

Sources for ZMAT4 Gene

Back to Top