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Aliases for ZMAT4 Gene

Aliases for ZMAT4 Gene

  • Zinc Finger Matrin-Type 4 2 3
  • Zinc Finger, Matrin-Type 4 5

External Ids for ZMAT4 Gene

Previous GeneCards Identifiers for ZMAT4 Gene

  • GC08M040508
  • GC08M040388
  • GC08M038921

Summaries for ZMAT4 Gene

GeneCards Summary for ZMAT4 Gene

ZMAT4 (Zinc Finger Matrin-Type 4) is a Protein Coding gene. Diseases associated with ZMAT4 include Refractive Error. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is KRCC1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZMAT4 Gene

Genomics for ZMAT4 Gene

Regulatory Elements for ZMAT4 Gene

Enhancers for ZMAT4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZMAT4 on UCSC Golden Path with GeneCards custom track

Promoters for ZMAT4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZMAT4 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZMAT4 Gene

Chromosome:
8
Start:
40,530,590 bp from pter
End:
40,897,833 bp from pter
Size:
367,244 bases
Orientation:
Minus strand

Genomic View for ZMAT4 Gene

Genes around ZMAT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZMAT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZMAT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZMAT4 Gene

Proteins for ZMAT4 Gene

  • Protein details for ZMAT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H898-ZMAT4_HUMAN
    Recommended name:
    Zinc finger matrin-type protein 4
    Protein Accession:
    Q9H898
    Secondary Accessions:
    • Q8WUT8

    Protein attributes for ZMAT4 Gene

    Size:
    229 amino acids
    Molecular mass:
    25833 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZMAT4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZMAT4 Gene

Proteomics data for ZMAT4 Gene at MOPED

Post-translational modifications for ZMAT4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZMAT4 Gene

No data available for DME Specific Peptides for ZMAT4 Gene

Domains & Families for ZMAT4 Gene

Gene Families for ZMAT4 Gene

Protein Domains for ZMAT4 Gene

Suggested Antigen Peptide Sequences for ZMAT4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H898

UniProtKB/Swiss-Prot:

ZMAT4_HUMAN :
  • Contains 4 matrin-type zinc fingers.
Similarity:
  • Contains 4 matrin-type zinc fingers.
genes like me logo Genes that share domains with ZMAT4: view

Function for ZMAT4 Gene

Gene Ontology (GO) - Molecular Function for ZMAT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ZMAT4: view

Phenotypes for ZMAT4 Gene

genes like me logo Genes that share phenotypes with ZMAT4: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZMAT4 Gene

Localization for ZMAT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZMAT4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZMAT4 Gene COMPARTMENTS Subcellular localization image for ZMAT4 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZMAT4 Gene

Pathways & Interactions for ZMAT4 Gene

SuperPathways for ZMAT4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZMAT4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZMAT4 Gene

Drugs & Compounds for ZMAT4 Gene

(1) Drugs for ZMAT4 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Atenolol Approved Pharma Antagonist 99
genes like me logo Genes that share compounds with ZMAT4: view

Transcripts for ZMAT4 Gene

Unigene Clusters for ZMAT4 Gene

Zinc finger, matrin-type 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZMAT4 Gene

No ASD Table

Relevant External Links for ZMAT4 Gene

GeneLoc Exon Structure for
ZMAT4
ECgene alternative splicing isoforms for
ZMAT4

Expression for ZMAT4 Gene

mRNA expression in normal human tissues for ZMAT4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZMAT4 Gene

This gene is overexpressed in Brain - Cortex (x7.7), Brain - Frontal Cortex (BA9) (x7.6), Brain - Putamen (basal ganglia) (x6.0), Brain - Caudate (basal ganglia) (x5.6), Brain - Nucleus accumbens (basal ganglia) (x5.4), and Brain - Anterior cingulate cortex (BA24) (x5.1).

Protein differential expression in normal tissues from HIPED for ZMAT4 Gene

This gene is overexpressed in Fetal Brain (44.2) and Fetal testis (19.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZMAT4 Gene



SOURCE GeneReport for Unigene cluster for ZMAT4 Gene Hs.591850

genes like me logo Genes that share expression patterns with ZMAT4: view

Protein tissue co-expression partners for ZMAT4 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ZMAT4 Gene

Orthologs for ZMAT4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZMAT4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZMAT4 35
  • 91.7 (n)
  • 97.82 (a)
ZMAT4 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZMAT4 35
  • 92.29 (n)
  • 97.82 (a)
ZMAT4 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zmat4 35
  • 87.05 (n)
  • 94.76 (a)
Zmat4 16
Zmat4 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zmat4 35
  • 87.77 (n)
  • 94.32 (a)
oppossum
(Monodelphis domestica)
Mammalia ZMAT4 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZMAT4 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZMAT4 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZMAT4 35
  • 76.61 (n)
  • 83.33 (a)
ZMAT4 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZMAT4 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494386 35
  • 65.01 (n)
  • 66.52 (a)
zebrafish
(Danio rerio)
Actinopterygii zmat4a 35
  • 70.32 (n)
  • 75 (a)
zmat4a 36
  • 62 (a)
OneToMany
zmat4b 36
  • 67 (a)
OneToMany
Species with no ortholog for ZMAT4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZMAT4 Gene

ENSEMBL:
Gene Tree for ZMAT4 (if available)
TreeFam:
Gene Tree for ZMAT4 (if available)

Paralogs for ZMAT4 Gene

Paralogs for ZMAT4 Gene

(2) SIMAP similar genes for ZMAT4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZMAT4: view

Variants for ZMAT4 Gene

Sequence variations from dbSNP and Humsavar for ZMAT4 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs17851751 - 40,581,238(+) GATGG(C/T)ACATC intron-variant, reference, missense
rs2036957 -- 40,835,966(+) TGGCC(A/G)AGACA intron-variant
rs2044895 -- 40,665,763(+) AGAAA(C/T)TGTGA intron-variant
rs2055950 -- 40,815,012(-) CAGGC(A/G)TGAGC intron-variant
rs2060796 -- 40,640,941(-) TCCCC(C/T)ATCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZMAT4 Gene

Variant ID Type Subtype PubMed ID
nsv890841 CNV Loss 21882294
esv33641 CNV Gain 17666407
esv2736913 CNV Deletion 23290073
esv2736914 CNV Deletion 23290073
esv2024539 CNV Deletion 18987734
esv2736915 CNV Deletion 23290073
esv2736916 CNV Deletion 23290073
esv5394 CNV Deletion 18987735
esv2736919 CNV Deletion 23290073
esv2662604 CNV Deletion 23128226
esv2736920 CNV Deletion 23290073
esv23484 CNV Gain 19812545
nsv821546 CNV Deletion 20802225
esv33198 CNV Loss 17666407
esv33015 CNV Gain 17666407
nsv519446 CNV Gain 19592680
nsv890842 CNV Loss 21882294
nsv523192 CNV Gain 19592680
esv2664427 CNV Deletion 23128226
nsv523193 CNV Gain 19592680
nsv512951 CNV Insertion 21212237
nsv465638 CNV Loss 19166990
nsv522210 CNV Loss 19592680
esv2736921 CNV Deletion 23290073

Variation tolerance for ZMAT4 Gene

Residual Variation Intolerance Score: 31.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.23; 76.20% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZMAT4 Gene

Disorders for ZMAT4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZMAT4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
refractive error
  • refractive errors
- elite association - COSMIC cancer census association via MalaCards
Search ZMAT4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ZMAT4

Genetic Association Database (GAD)
ZMAT4
Human Genome Epidemiology (HuGE) Navigator
ZMAT4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZMAT4
genes like me logo Genes that share disorders with ZMAT4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZMAT4 Gene

Publications for ZMAT4 Gene

  1. The association between the copy-number variations of ZMAT4 and hematological malignancy. (PMID: 21269563) Wan J. … Zhang W. (Hematology 2011) 2 3 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. (PMID: 23396134) Verhoeven V.J. … Hammond C.J. (Nat. Genet. 2013) 3
  4. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3
  5. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PMID: 24163370) Lu L. … Zhang L. (J. Biol. Chem. 2013) 3

Products for ZMAT4 Gene

Sources for ZMAT4 Gene

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