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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZMAT3 Gene

protein-coding   GIFtS: 52
GCID: GC03M178735

zinc finger, matrin-type 3

 Explore 5 diseases affiliated with
ZMAT3 via our new
 Human Malady Compendium 
Biological research products
for ZMAT3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Zinc Finger, Matrin-Type 31 2     MGC106131
WIG11 2 3 5     P53 Target Zinc Finger Protein2
PAG6081 2 3     WIG-1/PAG608 Protein2
WIG-11 2     Zinc Finger Matrin-Type Protein 32
Zinc Finger Protein WIG-12 3     Zinc Finger Protein WIG12
P53-Activated Gene 608 Protein2 3     Zinc Finger, Matrin Type 32
FLJ122961     

External Ids:    HGNC: 299831   Entrez Gene: 643932   Ensembl: ENSG000001726677   OMIM: 6064525   UniProtKB: Q9HA383   

Export aliases for ZMAT3 gene to outside databases

Previous GC identifers: GC03M180225 GC03M176139


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZMAT3:
This gene encodes a protein containing three zinc finger domains and a nuclear localization signal. The mRNA and the
protein of this gene are upregulated by wildtype p53 and overexpression of this gene inhibits tumor cell growth,
suggesting that this gene may have a role in the p53-dependent growth regulatory pathway. Alternative splicing of this
gene results in two transcript variants encoding two isoforms differing in only one amino acid. (provided by RefSeq,
Jul 2008)

UniProtKB/Swiss-Prot: ZMAT3_HUMAN, Q9HA38
Function: Acts as a bona fide target gene of p53/TP53. May play a role in the TP53-dependent growth regulatory pathway.
May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and
nucleolus




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZMAT3 gene promoter:
         Sox5   Elk-1   FOXF2   Nkx2-2   E47   GATA-1   FOXL1   AREB6   PPAR-alpha   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZMAT3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZMAT3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZMAT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.32   Ensembl cytogenetic band:  3q26.32   HGNC cytogenetic band: 3q26.32

ZMAT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZMAT3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M178735:  view genomic region     (about GC identifiers)

Start:
178,735,011 bp from pter      End:
178,790,067 bp from pter
Size:
55,057 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZMAT3_HUMAN, Q9HA38 (See protein sequence)
Recommended Name: Zinc finger matrin-type protein 3  
Size: 289 amino acids; 32059 Da
Subunit: Interacts with dsRNA
Subcellular location: Nucleus. Nucleus, nucleolus
Secondary accessions: B3KVA6 D3DNR1 Q96A21
Alternative splicing: 2 isoforms:  Q9HA38-1   Q9HA38-2   

Explore the universe of human proteins at neXtProt for ZMAT3: NX_Q9HA38

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9HA38

  • ZMAT3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_071915.1  NP_689426.1  

    ENSEMBL proteins: 
     ENSP00000311221   ENSP00000396506   ENSP00000398920  

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    Uscn Proteins for ZMAT3

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IEA--


    ZMAT3 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZMAT3 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR003604 Znf_U1
     IPR022755 Znf_C2H2_jaz

    Graphical View of Domain Structure for InterPro Entry Q9HA38

    ProtoNet protein and cluster: Q9HA38

    UniProtKB/Swiss-Prot: ZMAT3_HUMAN, Q9HA38
    Similarity: Contains 3 matrin-type zinc fingers


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ZMAT3_HUMAN, Q9HA38
    Function: Acts as a bona fide target gene of p53/TP53. May play a role in the TP53-dependent growth regulatory pathway.
    May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and
    nucleolus
    Induction: By DNA damage in a p53/TP53-dependent manner. Up-regulated following ionizing radiation in primary squamous
    cell carcinoma of the lung and in various colon cancer cell lines

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    hsa-miR-411* hsa-miR-576-3p hsa-miR-193a-3p hsa-miR-361-5p hsa-miR-1914* hsa-miR-106a hsa-miR-128 hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidZMAT3 3' UTR sequence
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0008270zinc ion binding IEA--


    ZMAT3 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ZMAT3:
     Increased circadian period len 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1p53 signaling pathway
    p53 signaling pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for ZMAT3):
        p53 signaling pathway


    ZMAT3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZMAT3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/8 Interacting proteins for ZMAT3 (Q9HA382, 3 ENSP000003112214) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HNRNPA2B1P226262, 3, ENSP000003466944MINT-6542879 MINT-6542899 MINT-6542926 I2D: score=1 STRING: ENSP00000346694
    DHX9Q082112, 3, ENSP000003565204MINT-6542891 MINT-6542867 MINT-6542918 I2D: score=1 STRING: ENSP00000356520
    AGO2Q9UKV82MINT-8410974 MINT-8410991 MINT-8410958 MINT-8410942 MINT-8411008
    SMARCA2P515313, ENSP000002657734I2D: score=1 STRING: ENSP00000265773
    SNW1Q135733, ENSP000002615314I2D: score=1 STRING: ENSP00000261531
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0006917induction of apoptosis IEA--
    GO:0006974response to DNA damage stimulus IEA--
    GO:0015031protein transport IEA--
    GO:0040008regulation of growth IEA--


    ZMAT3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZMAT3
    Search CenterWatch for drugs/clinical trials and news about ZMAT3 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZMAT3 gene (2 alternative transcripts): 
    NM_022470.3  NM_152240.2  

    Unigene Cluster for ZMAT3:

    Zinc finger, matrin-type 3
    Hs.371609  [show with all ESTs]
    Unigene Representative Sequence: NM_152240
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311417(uc003fji.3 uc003fjg.3) ENST00000432729 ENST00000414084


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    hsa-miR-411* hsa-miR-576-3p hsa-miR-193a-3p hsa-miR-361-5p hsa-miR-1914* hsa-miR-106a hsa-miR-128 hsa-miR-200b
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    Inhib. RNA
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    Additional cDNA sequence: 

    AF355465.1 AK022358.1 AK056245.1 AK122768.1 AY037945.1 BC002896.2 BC036485.1 

    8 DOTS entries:

    DT.315675  DT.86997342  DT.92423327  DT.100811484  DT.100804576  DT.120871152  DT.92420955  DT.40299787 

    24/50 AceView cDNA sequences (see all 50):

    BE794892 AI085719 NM_152240 CA443928 AL515795 BU168772 NM_022470 BE207688 
    BQ775038 AU122184 CA443021 BE206443 AK022358 CN482717 AK122768 BF591406 
    BU179951 BU570977 AY037945 AF355465 BC002896 BG750099 BX376738 BF797456 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZMAT3    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
    SP1:              -     -                                                   
    SP2:                                                                        
    SP3:                                                                        
    SP4:                                                                        


    ECgene alternative splicing isoforms for ZMAT3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZMAT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGATTAAAAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ZMAT3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZMAT3

    SOURCE GeneReport for Unigene cluster: Hs.371609

    UniProtKB/Swiss-Prot: ZMAT3_HUMAN, Q9HA38
    Tissue specificity: Highly expressed in adult brain, and moderately in adult kidney and testis. Not detected in fetal
    brain, heart, pancreas, adrenal gland, liver or small intestine

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZMAT3 gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ZMAT31 zinc finger, matrin-type 3 78.75(n)
    81.88(a)
      425428  XM_423190.3  XP_423190.2 
    lizard
    (Anolis carolinensis)
    Reptilia ZMAT36
    --
    78(a)
    1 ↔ 1
    3(2369187-2379336)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL890450.22   -- 78.38(n)    AL890450.2 
    zebrafish
    (Danio rerio)
    Actinopterygii BX548160.26
    --
    49(a)
    1 ↔ 1
    11(35360087-35374653)


    ENSEMBL Gene Tree for ZMAT3 (if available)
    TreeFam Gene Tree for ZMAT3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZMAT3 gene
    KRCC12  ZNF3462  ZMAT42  ZMAT12  

    ZMAT3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/886 NCBI SNPs in ZMAT3 are shown (see all 886    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1903391581,2
    --178734550(+) CTGTAC/TACAGA 2 -- ds50010--------
    rs1816707131,2
    --178734622(+) GTAAGA/CGTATT 2 -- ds50010--------
    rs1473146001,2
    --178734637(+) ATGTAA/GAACAC 2 -- ds50010--------
    rs1400396661,2
    --178734812(+) GAGAAC/TGGGCA 2 -- ds50010--------
    rs766800431,2
    --178734813(+) AGAACG/AGGCAG 2 -- ds50012Minor allele frequency- A:0.02CSA WA 120
    rs1123779821,2
    C,--178734930(+) ACAGTC/TATCGA 2 -- ds50013Minor allele frequency- T:0.13CSA WA NA 240
    rs1498195341,2
    --178734966(+) GTGATA/GACAAT 2 -- ds50010--------
    rs1448048881,2
    --178734971(+) GACAAC/TTTACC 2 -- ds50010--------
    rs1866571951,2
    --178735051(+) TGGAAC/TACAAA 2 -- ut310--------
    rs1910013501,2
    --178735060(+) AAATGC/TGTGTT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for ZMAT3 (178735011 - 178790067 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ZMAT3
         1 CNV: 80010

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZMAT3 for disorders           About GeneDecksing

    OMIM gene information: 606452    OMIM disorders: --

    5 diseases for ZMAT3:    About MalaCards
    squamous cell carcinoma    esophageal carcinoma    esophagitis    colon cancer
    carcinoma


    Export disorders for ZMAT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZMAT3 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with ZMAT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and chromosomal localization of human WIG-1/PAG608 and demonstration of amplification with increased expression in primary squamous cell carcinoma of the lung. (PubMed id 11689294)1, 2, 3 Varmeh-Ziaie S.... Collins V.P. (2001)
    2. The p53-induced Wig-1 protein binds double-stranded RNAs with structural characteristics of siRNAs and miRNAs. (PubMed id 16844115)1, 2 Mendez Vidal C.... Wiman K.G. (2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Human wig-1, a p53 target gene that encodes a growth inhibitory zinc finger protein. (PubMed id 11571644)1, 2 Hellborg F.... Wiman K.G. (2001)
    5. Wig-1, a new p53-induced gene encoding a zinc finger protein. (PubMed id 9400996)1, 3 Varmeh-Ziaie S....Wiman K.G. (1997)
    6. Wig-1, a novel regulator of N-Myc mRNA and N-Myc-drive n tumor growth. (PubMed id 22513872)1 Vilborg A....Wiman K.G. (2012)
    7. Wig1 prevents cellular senescence by regulating p21 mR NA decay through control of RISC recruitment. (PubMed id 23085987)1 Kim B.C....Lee J.S. (2012)
    8. Zinc induces cell cycle arrest and apoptosis by upreg ulation of WIG-1 in esophageal squamous cancer cell line EC109. (PubMed id 21559779)1 Guo W....Ma Z. (2011)
    9. The alphaherpesvirus US3/ORF66 protein kinases direct phosphorylation of the nuclear matrix protein matrin 3. (PubMed id 20962082)1 Erazo A....Kinchington P.R. (2011)
    10. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64393 HGNC: 29983 AceView: WIG1 Ensembl:ENSG00000172667 euGenes: HUgn64393
    ECgene: ZMAT3 Kegg: 64393 H-InvDB: ZMAT3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZMAT3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZMAT3 gene:
    Search GeneIP for patents involving ZMAT3

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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