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Aliases for ZMAT3 Gene

Aliases for ZMAT3 Gene

  • Zinc Finger Matrin-Type 3 2 3
  • P53-Activated Gene 608 Protein 3 4
  • Zinc Finger, Matrin-Type 3 3 5
  • Zinc Finger Protein WIG-1 3 4
  • PAG608 3 4
  • WIG1 3 4
  • P53 Target Zinc Finger Protein 3
  • Zinc Finger, Matrin Type 3 3
  • Zinc Finger Protein WIG1 3
  • WIG-1/PAG608 Protein 3
  • WIG-1 3

External Ids for ZMAT3 Gene

Previous GeneCards Identifiers for ZMAT3 Gene

  • GC03M180225
  • GC03M178735
  • GC03M176139

Summaries for ZMAT3 Gene

Entrez Gene Summary for ZMAT3 Gene

  • This gene encodes a protein containing three zinc finger domains and a nuclear localization signal. The mRNA and the protein of this gene are upregulated by wildtype p53 and overexpression of this gene inhibits tumor cell growth, suggesting that this gene may have a role in the p53-dependent growth regulatory pathway. Alternative splicing of this gene results in two transcript variants encoding two isoforms differing in only one amino acid. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZMAT3 Gene

ZMAT3 (Zinc Finger Matrin-Type 3) is a Protein Coding gene. Among its related pathways are p53 signaling pathway. GO annotations related to this gene include nucleic acid binding and poly(A) RNA binding.

UniProtKB/Swiss-Prot for ZMAT3 Gene

  • Acts as a bona fide target gene of p53/TP53. May play a role in the TP53-dependent growth regulatory pathway. May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZMAT3 Gene

Genomics for ZMAT3 Gene

Regulatory Elements for ZMAT3 Gene

Promoters for ZMAT3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZMAT3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZMAT3 Gene

Chromosome:
3
Start:
179,017,223 bp from pter
End:
179,072,279 bp from pter
Size:
55,057 bases
Orientation:
Minus strand

Genomic View for ZMAT3 Gene

Genes around ZMAT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZMAT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZMAT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZMAT3 Gene

Proteins for ZMAT3 Gene

  • Protein details for ZMAT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HA38-ZMAT3_HUMAN
    Recommended name:
    Zinc finger matrin-type protein 3
    Protein Accession:
    Q9HA38
    Secondary Accessions:
    • B3KVA6
    • D3DNR1
    • Q96A21

    Protein attributes for ZMAT3 Gene

    Size:
    289 amino acids
    Molecular mass:
    32059 Da
    Quaternary structure:
    • Interacts with dsRNA.

    Alternative splice isoforms for ZMAT3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZMAT3 Gene

Proteomics data for ZMAT3 Gene at MOPED

Post-translational modifications for ZMAT3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZMAT3 Gene

Antibody Products

No data available for DME Specific Peptides for ZMAT3 Gene

Domains & Families for ZMAT3 Gene

Gene Families for ZMAT3 Gene

Protein Domains for ZMAT3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZMAT3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HA38

UniProtKB/Swiss-Prot:

ZMAT3_HUMAN :
  • Contains 3 matrin-type zinc fingers.
Similarity:
  • Contains 3 matrin-type zinc fingers.
genes like me logo Genes that share domains with ZMAT3: view

Function for ZMAT3 Gene

Molecular function for ZMAT3 Gene

UniProtKB/Swiss-Prot Function:
Acts as a bona fide target gene of p53/TP53. May play a role in the TP53-dependent growth regulatory pathway. May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus.
UniProtKB/Swiss-Prot Induction:
By DNA damage in a p53/TP53-dependent manner. Up-regulated following ionizing radiation in primary squamous cell carcinoma of the lung and in various colon cancer cell lines.

Gene Ontology (GO) - Molecular Function for ZMAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18519039
GO:0008270 zinc ion binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with ZMAT3: view

Phenotypes for ZMAT3 Gene

GenomeRNAi human phenotypes for ZMAT3:
genes like me logo Genes that share phenotypes with ZMAT3: view

Animal Model Products

miRNA for ZMAT3 Gene

miRTarBase miRNAs that target ZMAT3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZMAT3 Gene

Localization for ZMAT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZMAT3 Gene

Nucleus. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZMAT3 Gene COMPARTMENTS Subcellular localization image for ZMAT3 gene
Compartment Confidence
nucleus 5
cytosol 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for ZMAT3 Gene

Pathways & Interactions for ZMAT3 Gene

SuperPathways for ZMAT3 Gene

Superpath Contained pathways
1 p53 signaling pathway
genes like me logo Genes that share pathways with ZMAT3: view

Pathways by source for ZMAT3 Gene

1 KEGG pathway for ZMAT3 Gene

Gene Ontology (GO) - Biological Process for ZMAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0040008 regulation of growth IEA --
genes like me logo Genes that share ontologies with ZMAT3: view

No data available for SIGNOR curated interactions for ZMAT3 Gene

Drugs & Compounds for ZMAT3 Gene

No Compound Related Data Available

Transcripts for ZMAT3 Gene

Unigene Clusters for ZMAT3 Gene

Zinc finger, matrin-type 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZMAT3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: - -
SP2:
SP3:
SP4:

Relevant External Links for ZMAT3 Gene

GeneLoc Exon Structure for
ZMAT3
ECgene alternative splicing isoforms for
ZMAT3

Expression for ZMAT3 Gene

mRNA expression in normal human tissues for ZMAT3 Gene

Protein differential expression in normal tissues from HIPED for ZMAT3 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZMAT3 Gene



SOURCE GeneReport for Unigene cluster for ZMAT3 Gene Hs.371609

mRNA Expression by UniProt/SwissProt for ZMAT3 Gene

Q9HA38-ZMAT3_HUMAN
Tissue specificity: Highly expressed in adult brain, and moderately in adult kidney and testis. Not detected in fetal brain, heart, pancreas, adrenal gland, liver or small intestine.
genes like me logo Genes that share expression patterns with ZMAT3: view

Protein tissue co-expression partners for ZMAT3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZMAT3 Gene

Orthologs for ZMAT3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZMAT3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZMAT3 35
  • 92.85 (n)
  • 93.08 (a)
ZMAT3 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZMAT3 35
  • 93.43 (n)
  • 95.16 (a)
ZMAT3 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zmat3 35
  • 84.84 (n)
  • 87.5 (a)
Zmat3 16
Zmat3 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZMAT3 35
  • 100 (n)
  • 100 (a)
ZMAT3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zmat3 35
  • 84.84 (n)
  • 88.19 (a)
oppossum
(Monodelphis domestica)
Mammalia ZMAT3 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZMAT3 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZMAT3 35
  • 77.89 (n)
  • 80.56 (a)
ZMAT3 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZMAT3 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zmat3 35
  • 69.67 (n)
  • 74.59 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC561535 35
  • 64.31 (n)
  • 70.2 (a)
BX548160.2 36
  • 49 (a)
OneToOne
Species with no ortholog for ZMAT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZMAT3 Gene

ENSEMBL:
Gene Tree for ZMAT3 (if available)
TreeFam:
Gene Tree for ZMAT3 (if available)

Paralogs for ZMAT3 Gene

No data available for Paralogs for ZMAT3 Gene

Variants for ZMAT3 Gene

Sequence variations from dbSNP and Humsavar for ZMAT3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1542 -- 179,021,806(+) TGTAT(C/G)TATTT utr-variant-3-prime
rs7424 -- 179,017,424(+) AGTAG(C/T)TTCAA utr-variant-3-prime
rs1071618 -- 179,023,852(-) TCCCA(A/G)CTACT utr-variant-3-prime
rs4311260 -- 179,052,104(-) agtca(A/G)tgtct intron-variant
rs4377526 -- 179,039,019(-) caatg(A/G)ctgag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZMAT3 Gene

Variant ID Type Subtype PubMed ID
nsv461026 CNV Gain 19166990

Variation tolerance for ZMAT3 Gene

Residual Variation Intolerance Score: 27.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.57; 12.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZMAT3 Gene

HapMap Linkage Disequilibrium report
ZMAT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZMAT3 Gene

Disorders for ZMAT3 Gene

Relevant External Links for ZMAT3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZMAT3

No disorders were found for ZMAT3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZMAT3 Gene

Publications for ZMAT3 Gene

  1. Cloning and chromosomal localization of human WIG-1/PAG608 and demonstration of amplification with increased expression in primary squamous cell carcinoma of the lung. (PMID: 11689294) Varmeh-Ziaie S. … Collins V.P. (Cancer Lett. 2001) 2 3 4 67
  2. Wig-1, a new p53-induced gene encoding a zinc finger protein. (PMID: 9400996) Varmeh-Ziaie S. … Wiman K.G. (Oncogene 1997) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Expression of the p53 target Wig-1 is associated with HPV status and patient survival in cervical carcinoma. (PMID: 25379706) Xu L.D. … Andersson S. (PLoS ONE 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for ZMAT3 Gene

Sources for ZMAT3 Gene

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