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Aliases for ZMAT2 Gene

Aliases for ZMAT2 Gene

  • Zinc Finger Matrin-Type 2 2 3 5
  • Zinc Finger Matrin-Type Protein 2 3
  • Ptg-12 3
  • Snu23 3

External Ids for ZMAT2 Gene

Previous GeneCards Identifiers for ZMAT2 Gene

  • GC05P140060
  • GC05P135225
  • GC05P140083
  • GC05P140084
  • GC05P140089
  • GC05P140097
  • GC05P141420
  • GC05P141564
  • GC05P141666
  • GC05P141767
  • GC05P141867
  • GC05P141976

Summaries for ZMAT2 Gene

GeneCards Summary for ZMAT2 Gene

ZMAT2 (Zinc Finger Matrin-Type 2) is a Protein Coding gene. Diseases associated with ZMAT2 include Chondrosarcoma, Extraskeletal Myxoid. Among its related pathways are mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleic acid binding.

Additional gene information for ZMAT2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZMAT2 Gene

Genomics for ZMAT2 Gene

Regulatory Elements for ZMAT2 Gene

Enhancers for ZMAT2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H140672 0.5 Ensembl 10.9 -25.5 -25487 1.7 POLR2A ZBTB33 SUPT5H SRA1 PCDHA4 NDUFA2 IK ZMAT2 SLC35A4 APBB3 DND1 PIR42041
GH05H140609 1.7 FANTOM5 Ensembl ENCODE 2.1 -87.8 -87780 3.8 PKNOX1 ATF1 FOXA2 ARNT TCF12 ZNF766 CBX5 GATA2 ATF7 NCOA1 CD14 APBB3 TMCO6 SLC35A4 IK EIF4EBP3 ANKHD1 NDUFA2 SRA1 HBEGF
GH05H140257 1.9 FANTOM5 Ensembl ENCODE dbSUPER 1.2 -438.5 -438543 5.5 PKNOX1 FOXA2 ATF1 FEZF1 YY1 ELK1 ZNF548 FOS ATF7 NCOA1 PFDN1 HBEGF ANKHD1 APBB3 HARS2 CD14 SLC4A9 ENSG00000253965 WDR55 SRA1
GH05H140594 1.4 FANTOM5 Ensembl ENCODE 1.5 -102.7 -102680 4 TAF1 MAX CEBPG ZIC2 RAD21 YY1 POLR2A SOX6 NFIA CEBPB CD14 APBB3 SRA1 TMCO6 SLC35A4 EIF4EBP3 ANKHD1 PFDN1 HBEGF IK
GH05H140553 1.2 FANTOM5 ENCODE 1.2 -144.3 -144254 1.7 HDAC1 LEF1 CEBPG FOSL1 TCF12 IRF9 CTBP1 POLR2A NCOR1 EGR1 SRA1 PCDHA9 ANKHD1 IK APBB3 HARS2 CD14 ZMAT2 EIF4EBP3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZMAT2 on UCSC Golden Path with GeneCards custom track

Promoters for ZMAT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000187818 1920 1201 HDGF FOXA2 PKNOX1 ATF1 ARID4B SIN3A ZNF2 YY1 ETS1 SLC30A9

Genomic Locations for ZMAT2 Gene

Genomic Locations for ZMAT2 Gene
chr5:140,698,680-140,706,676
(GRCh38/hg38)
Size:
7,997 bases
Orientation:
Plus strand
chr5:140,078,265-140,086,248
(GRCh37/hg19)

Genomic View for ZMAT2 Gene

Genes around ZMAT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZMAT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZMAT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZMAT2 Gene

Proteins for ZMAT2 Gene

  • Protein details for ZMAT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NC0-ZMAT2_HUMAN
    Recommended name:
    Zinc finger matrin-type protein 2
    Protein Accession:
    Q96NC0

    Protein attributes for ZMAT2 Gene

    Size:
    199 amino acids
    Molecular mass:
    23612 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZMAT2 Gene

Post-translational modifications for ZMAT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZMAT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZMAT2 Gene

Domains & Families for ZMAT2 Gene

Gene Families for ZMAT2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZMAT2 Gene

Suggested Antigen Peptide Sequences for ZMAT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZMAT2: view

No data available for UniProtKB/Swiss-Prot for ZMAT2 Gene

Function for ZMAT2 Gene

Gene Ontology (GO) - Molecular Function for ZMAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IBA --
GO:0005515 protein binding IPI 23275563
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ZMAT2: view
genes like me logo Genes that share phenotypes with ZMAT2: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZMAT2 Gene

Localization for ZMAT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZMAT2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZMAT2 gene
Compartment Confidence
nucleus 5
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZMAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0046540 U4/U6 x U5 tri-snRNP complex IBA --
genes like me logo Genes that share ontologies with ZMAT2: view

Pathways & Interactions for ZMAT2 Gene

SuperPathways for ZMAT2 Gene

SuperPathway Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with ZMAT2: view

Pathways by source for ZMAT2 Gene

1 KEGG pathway for ZMAT2 Gene

Gene Ontology (GO) - Biological Process for ZMAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IBA --
genes like me logo Genes that share ontologies with ZMAT2: view

No data available for SIGNOR curated interactions for ZMAT2 Gene

Drugs & Compounds for ZMAT2 Gene

No Compound Related Data Available

Transcripts for ZMAT2 Gene

mRNA/cDNA for ZMAT2 Gene

Unigene Clusters for ZMAT2 Gene

Zinc finger, matrin-type 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZMAT2 Gene

No ASD Table

Relevant External Links for ZMAT2 Gene

GeneLoc Exon Structure for
ZMAT2
ECgene alternative splicing isoforms for
ZMAT2

Expression for ZMAT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZMAT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZMAT2 Gene

This gene is overexpressed in NK cells (12.4), CD4 Tcells (8.9), and CD8 Tcells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZMAT2 Gene



Protein tissue co-expression partners for ZMAT2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZMAT2 Gene:

ZMAT2

SOURCE GeneReport for Unigene cluster for ZMAT2 Gene:

Hs.350194

Evidence on tissue expression from TISSUES for ZMAT2 Gene

  • Liver(4.4)
  • Nervous system(3.3)
  • Kidney(2.2)
  • Spleen(2.2)
  • Heart(2.1)
  • Muscle(2.1)
  • Lung(2)
genes like me logo Genes that share expression patterns with ZMAT2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZMAT2 Gene

Orthologs for ZMAT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZMAT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZMAT2 33 34
  • 99.83 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 99 (a)
OneToMany
-- 34
  • 99 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ZMAT2 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZMAT2 33 34
  • 95.81 (n)
cow
(Bos Taurus)
Mammalia ZMAT2 33 34
  • 95.14 (n)
rat
(Rattus norvegicus)
Mammalia Zmat2 33
  • 93.63 (n)
mouse
(Mus musculus)
Mammalia Zmat2 33 16 34
  • 91.79 (n)
chicken
(Gallus gallus)
Aves ZMAT2 33 34
  • 86.43 (n)
lizard
(Anolis carolinensis)
Reptilia ZMAT2 34
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zmat2 33
  • 77.55 (n)
Str.6883 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.3637 33
zebrafish
(Danio rerio)
Actinopterygii zmat2 33 34
  • 77.95 (n)
wufc30d10 33
fruit fly
(Drosophila melanogaster)
Insecta CG11586 33 34
  • 67.03 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006245 33
  • 63.99 (n)
worm
(Caenorhabditis elegans)
Secernentea ZK686.4 33
  • 56.07 (n)
snu-23 34
  • 44 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G05760 33
  • 57.07 (n)
soybean
(Glycine max)
eudicotyledons Gma.8365 33
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.4536 33
rice
(Oryza sativa)
Liliopsida Os03g0831900 33
  • 58.25 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.5951 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9251 34
  • 65 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1075 33
Species where no ortholog for ZMAT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZMAT2 Gene

ENSEMBL:
Gene Tree for ZMAT2 (if available)
TreeFam:
Gene Tree for ZMAT2 (if available)

Paralogs for ZMAT2 Gene

No data available for Paralogs for ZMAT2 Gene

Variants for ZMAT2 Gene

Sequence variations from dbSNP and Humsavar for ZMAT2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs863224041 Uncertain significance 140,698,543(+) TGTCT(-/T)GAGTC upstream-variant-2KB, reference, frameshift-variant
rs1000368237 -- 140,705,272(+) GATTT(A/C)CCATA intron-variant
rs1000440110 -- 140,704,886(+) CTATC(A/G)TCAAG intron-variant
rs1000909244 -- 140,701,953(+) TCCTT(G/T)CTGGT intron-variant
rs1000984694 -- 140,699,872(+) AATTA(C/T)GTTCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZMAT2 Gene

Variant ID Type Subtype PubMed ID
nsv830508 CNV loss 17160897
esv3570455 CNV loss 25503493

Variation tolerance for ZMAT2 Gene

Residual Variation Intolerance Score: 39.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 2.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZMAT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZMAT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZMAT2 Gene

Disorders for ZMAT2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZMAT2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chondrosarcoma, extraskeletal myxoid
  • extraskeletal myxoid chondrosarcoma
- elite association - COSMIC cancer census association via MalaCards
Search ZMAT2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ZMAT2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZMAT2
genes like me logo Genes that share disorders with ZMAT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZMAT2 Gene

Publications for ZMAT2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60

Products for ZMAT2 Gene

Sources for ZMAT2 Gene

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