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Aliases for ZKSCAN8 Gene

Aliases for ZKSCAN8 Gene

  • Zinc Finger With KRAB And SCAN Domains 8 2 3 5
  • Zinc Finger Protein 192 2 3 4
  • ZNF192 3 4
  • LD5-1 3 4
  • Zinc Finger Protein With KRAB And SCAN Domains 8 3
  • ZSCAN40 3

External Ids for ZKSCAN8 Gene

Previous HGNC Symbols for ZKSCAN8 Gene

  • ZNF192

Previous GeneCards Identifiers for ZKSCAN8 Gene

  • GC06P028115

Summaries for ZKSCAN8 Gene

GeneCards Summary for ZKSCAN8 Gene

ZKSCAN8 (Zinc Finger With KRAB And SCAN Domains 8) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF397.

UniProtKB/Swiss-Prot for ZKSCAN8 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZKSCAN8 Gene

Genomics for ZKSCAN8 Gene

Regulatory Elements for ZKSCAN8 Gene

Enhancers for ZKSCAN8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F027862 1 Ensembl ENCODE 111.3 -268.1 -268076 12.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 ZKSCAN8 ZKSCAN3 ZSCAN9 GUSBP2 ZSCAN26 ZKSCAN4 ZSCAN23 ZNF391 ZNF603P PGBD1
GH06F027495 0.4 ENCODE 88.1 -641.0 -641010 1.2 PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 ZNF2 ZNF302 ZNF143 FOS ZKSCAN8 ZKSCAN3 ABT1 ZSCAN9 ZKSCAN4 HMGN4 ZNF391 GUSBP2 ZNF322 ZNF204P
GH06F028211 1.2 Ensembl ENCODE 70.5 +75.8 75792 2.2 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 ZNF2 SLC30A9 ZNF143 ZKSCAN8 ZKSCAN3 ZNF603P ZKSCAN4 ZSCAN9 ZSCAN31 NKAPL ZNF311 ZSCAN23 PGBD1
GH06F028349 0.2 ENCODE 62.9 +214.1 214072 3.0 HDGF ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 YY1 ZKSCAN3 ZKSCAN8 ZKSCAN4 ZSCAN23 ZSCAN9 ZNF311 ZNF391 ZNF192P1 ZSCAN31 ZNF603P
GH06F027374 0.2 ENCODE 61 -761.5 -761515 2.0 ATF1 PKNOX1 CREB3L1 ARID4B ETS1 ZNF143 SP3 YY2 REST ZNF623 ZKSCAN8 ZKSCAN3 ZNF391 ABT1 ZSCAN9 GUSBP2 ZKSCAN4 HMGN4 ZNF322 PGBD1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZKSCAN8 on UCSC Golden Path with GeneCards custom track

Promoters for ZKSCAN8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001214481 -43 2201 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC

Genomic Location for ZKSCAN8 Gene

Chromosome:
6
Start:
28,136,743 bp from pter
End:
28,159,472 bp from pter
Size:
22,730 bases
Orientation:
Plus strand

Genomic View for ZKSCAN8 Gene

Genes around ZKSCAN8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZKSCAN8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZKSCAN8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZKSCAN8 Gene

Proteins for ZKSCAN8 Gene

  • Protein details for ZKSCAN8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15776-ZKSC8_HUMAN
    Recommended name:
    Zinc finger protein with KRAB and SCAN domains 8
    Protein Accession:
    Q15776
    Secondary Accessions:
    • A1L3D4
    • B4DYF1
    • Q4VAR1
    • Q4VAR2
    • Q4VAR3
    • Q9H4T1

    Protein attributes for ZKSCAN8 Gene

    Size:
    578 amino acids
    Molecular mass:
    65816 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZKSCAN8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZKSCAN8 Gene

Post-translational modifications for ZKSCAN8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZKSCAN8 Gene

Domains & Families for ZKSCAN8 Gene

Gene Families for ZKSCAN8 Gene

Suggested Antigen Peptide Sequences for ZKSCAN8 Gene

Graphical View of Domain Structure for InterPro Entry

Q15776

UniProtKB/Swiss-Prot:

ZKSC8_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 9 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
  • Contains 1 SCAN box domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 9 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZKSCAN8: view

Function for ZKSCAN8 Gene

Molecular function for ZKSCAN8 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZKSCAN8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0043565 sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZKSCAN8: view
genes like me logo Genes that share phenotypes with ZKSCAN8: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZKSCAN8 Gene

Localization for ZKSCAN8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZKSCAN8 Gene

Gene Ontology (GO) - Cellular Components for ZKSCAN8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IBA --
genes like me logo Genes that share ontologies with ZKSCAN8: view

No data available for Subcellular locations from COMPARTMENTS for ZKSCAN8 Gene

Pathways & Interactions for ZKSCAN8 Gene

SuperPathways for ZKSCAN8 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZKSCAN8: view

Pathways by source for ZKSCAN8 Gene

2 Reactome pathways for ZKSCAN8 Gene

Gene Ontology (GO) - Biological Process for ZKSCAN8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZKSCAN8: view

No data available for SIGNOR curated interactions for ZKSCAN8 Gene

Transcripts for ZKSCAN8 Gene

Unigene Clusters for ZKSCAN8 Gene

Zinc finger with KRAB and SCAN domains 8:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZKSCAN8 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2: -
SP3: - -

Relevant External Links for ZKSCAN8 Gene

GeneLoc Exon Structure for
ZKSCAN8
ECgene alternative splicing isoforms for
ZKSCAN8

Expression for ZKSCAN8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZKSCAN8 Gene

Protein differential expression in normal tissues from HIPED for ZKSCAN8 Gene

This gene is overexpressed in Ovary (33.4) and Testis (31.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZKSCAN8 Gene



Protein tissue co-expression partners for ZKSCAN8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZKSCAN8 Gene:

ZKSCAN8

SOURCE GeneReport for Unigene cluster for ZKSCAN8 Gene:

Hs.57679
genes like me logo Genes that share expression patterns with ZKSCAN8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZKSCAN8 Gene

Orthologs for ZKSCAN8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZKSCAN8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZKSCAN8 34 35
  • 99.6 (n)
cow
(Bos Taurus)
Mammalia ZNF192 34
  • 92.96 (n)
-- 35
  • 53 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia ZKSCAN8 34 35
  • 92.78 (n)
rat
(Rattus norvegicus)
Mammalia Zfp192 34
  • 88.41 (n)
mouse
(Mus musculus)
Mammalia Zkscan8 34 16 35
  • 87.72 (n)
oppossum
(Monodelphis domestica)
Mammalia ZKSCAN8 35
  • 66 (a)
OneToOne
Species where no ortholog for ZKSCAN8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZKSCAN8 Gene

ENSEMBL:
Gene Tree for ZKSCAN8 (if available)
TreeFam:
Gene Tree for ZKSCAN8 (if available)

Paralogs for ZKSCAN8 Gene

(473) SIMAP similar genes for ZKSCAN8 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ZKSCAN8 Gene

genes like me logo Genes that share paralogs with ZKSCAN8: view

Variants for ZKSCAN8 Gene

Sequence variations from dbSNP and Humsavar for ZKSCAN8 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1048319 -- 28,148,746(+) AAGGA(A/T)CATCA intron-variant, reference, missense, utr-variant-5-prime
rs1048320 -- 28,148,753(+) ATCAG(C/T)TAGAG intron-variant, reference, synonymous-codon, utr-variant-5-prime
rs111376442 -- 28,150,899(+) CCTCC(C/T)GGGTT intron-variant
rs111518336 -- 28,148,757(+) GCTAG(A/G)GAACG intron-variant, reference, missense, utr-variant-5-prime
rs111684560 -- 28,148,841(+) GAGGT(A/G)TGCGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZKSCAN8 Gene

Variant ID Type Subtype PubMed ID
esv3309390 CNV mobile element insertion 20981092
esv3352251 CNV insertion 20981092
esv3363151 CNV insertion 20981092

Variation tolerance for ZKSCAN8 Gene

Residual Variation Intolerance Score: 43.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.25; 62.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZKSCAN8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZKSCAN8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZKSCAN8 Gene

Disorders for ZKSCAN8 Gene

Relevant External Links for ZKSCAN8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZKSCAN8

No disorders were found for ZKSCAN8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZKSCAN8 Gene

Publications for ZKSCAN8 Gene

  1. Three genes encoding zinc finger proteins on human chromosome 6p21.3: members of a new subclass of the Kruppel gene family containing the conserved SCAN box domain. (PMID: 9244436) Lee P.L. … Beutler E. (Genomics 1997) 3 4 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  4. A strategy for cloning the hereditary hemochromatosis gene. (PMID: 8673473) Beutler E. … Lee P. (Blood Cells Mol. Dis. 1995) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for ZKSCAN8 Gene

Sources for ZKSCAN8 Gene

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