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Aliases for ZKSCAN8 Gene

Aliases for ZKSCAN8 Gene

  • Zinc Finger With KRAB And SCAN Domains 8 2 3 5
  • Zinc Finger Protein 192 2 3 4
  • ZNF192 3 4
  • LD5-1 3 4
  • Zinc Finger Protein With KRAB And SCAN Domains 8 3
  • ZSCAN40 3

External Ids for ZKSCAN8 Gene

Previous HGNC Symbols for ZKSCAN8 Gene

  • ZNF192

Previous GeneCards Identifiers for ZKSCAN8 Gene

  • GC06P028115

Summaries for ZKSCAN8 Gene

GeneCards Summary for ZKSCAN8 Gene

ZKSCAN8 (Zinc Finger With KRAB And SCAN Domains 8) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZSCAN12.

UniProtKB/Swiss-Prot for ZKSCAN8 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZKSCAN8 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZKSCAN8 Gene

Genomics for ZKSCAN8 Gene

GeneHancer (GH) Regulatory Elements for ZKSCAN8 Gene

Promoters and enhancers for ZKSCAN8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I028141 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 573.1 +5.5 5544 2.2 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF263 SP3 ZFP41 MEF2D ZKSCAN8 ZNF603P ZKSCAN3 ZKSCAN4 ZSCAN12 ZNF391 ZSCAN23 ZSCAN9 ZNF204P ZNF184
GH06I028135 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 578.1 +0.5 455 3.6 ZFP64 YBX1 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZKSCAN8 ENSG00000261839 ZSCAN16-AS1 ZKSCAN3 ZKSCAN4 ZSCAN12 ZNF603P ZSCAN9 TRIM27 ZSCAN31
GH06I028134 Enhancer 1 FANTOM5 Ensembl dbSUPER 550.8 -1.8 -1841 0.2 TAF9B MAFG ZNF384 MAFF ZNF316 KDM1A EMSY MAFK ZBTB17 ENSG00000261839 ZKSCAN8 ZKSCAN3 ZSCAN31 ZNF165 ZSCAN16 ZSCAN16-AS1
GH06I027126 Promoter/Enhancer 2.6 EPDnew Ensembl ENCODE dbSUPER 115.5 -998.7 -998721 23 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC HIST1H2AH GC06P027140 HIST1H2AG HIST1H4I HIST1H2BJ HIST1H2BK ZKSCAN8 ABT1 HMGN4 BTN2A1
GH06I027834 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 62.8 -299.5 -299450 6.4 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 SP3 NFYC MEF2D HIST1H2BN HIST1H2AK GC06M027849 ZKSCAN3 ZKSCAN8 ZKSCAN4 ZSCAN9 ZSCAN12 HIST1H3J GUSBP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZKSCAN8 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZKSCAN8 Gene

Genomic Locations for ZKSCAN8 Gene
chr6:28,136,743-28,159,472
(GRCh38/hg38)
Size:
22,730 bases
Orientation:
Plus strand
chr6:28,109,688-28,127,250
(GRCh37/hg19)

Genomic View for ZKSCAN8 Gene

Genes around ZKSCAN8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZKSCAN8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZKSCAN8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZKSCAN8 Gene

Proteins for ZKSCAN8 Gene

  • Protein details for ZKSCAN8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15776-ZKSC8_HUMAN
    Recommended name:
    Zinc finger protein with KRAB and SCAN domains 8
    Protein Accession:
    Q15776
    Secondary Accessions:
    • A1L3D4
    • B4DYF1
    • Q4VAR1
    • Q4VAR2
    • Q4VAR3
    • Q9H4T1

    Protein attributes for ZKSCAN8 Gene

    Size:
    578 amino acids
    Molecular mass:
    65816 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZKSCAN8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZKSCAN8 Gene

Post-translational modifications for ZKSCAN8 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZKSCAN8 Gene

Domains & Families for ZKSCAN8 Gene

Gene Families for ZKSCAN8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZKSCAN8 Gene

Graphical View of Domain Structure for InterPro Entry

Q15776

UniProtKB/Swiss-Prot:

ZKSC8_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZKSCAN8: view

Function for ZKSCAN8 Gene

Molecular function for ZKSCAN8 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZKSCAN8 Gene

Gene Ontology (GO) - Molecular Function for ZKSCAN8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZKSCAN8: view
genes like me logo Genes that share phenotypes with ZKSCAN8: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZKSCAN8 Gene

Localization for ZKSCAN8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZKSCAN8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZKSCAN8 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZKSCAN8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZKSCAN8: view

Pathways & Interactions for ZKSCAN8 Gene

SuperPathways for ZKSCAN8 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZKSCAN8: view

Pathways by source for ZKSCAN8 Gene

2 Reactome pathways for ZKSCAN8 Gene

Gene Ontology (GO) - Biological Process for ZKSCAN8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZKSCAN8: view

No data available for SIGNOR curated interactions for ZKSCAN8 Gene

Drugs & Compounds for ZKSCAN8 Gene

No Compound Related Data Available

Transcripts for ZKSCAN8 Gene

Unigene Clusters for ZKSCAN8 Gene

Zinc finger with KRAB and SCAN domains 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZKSCAN8 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2: -
SP3: - -

Relevant External Links for ZKSCAN8 Gene

GeneLoc Exon Structure for
ZKSCAN8
ECgene alternative splicing isoforms for
ZKSCAN8

Expression for ZKSCAN8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZKSCAN8 Gene

Protein differential expression in normal tissues from HIPED for ZKSCAN8 Gene

This gene is overexpressed in Ovary (33.4) and Testis (31.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZKSCAN8 Gene



Protein tissue co-expression partners for ZKSCAN8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZKSCAN8 Gene:

ZKSCAN8

SOURCE GeneReport for Unigene cluster for ZKSCAN8 Gene:

Hs.57679
genes like me logo Genes that share expression patterns with ZKSCAN8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZKSCAN8 Gene

Orthologs for ZKSCAN8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZKSCAN8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZKSCAN8 33 34
  • 99.6 (n)
cow
(Bos Taurus)
Mammalia ZNF192 33
  • 92.96 (n)
-- 34
  • 53 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia ZKSCAN8 33 34
  • 92.78 (n)
rat
(Rattus norvegicus)
Mammalia Zfp192 33
  • 88.41 (n)
mouse
(Mus musculus)
Mammalia Zkscan8 33 16 34
  • 87.72 (n)
oppossum
(Monodelphis domestica)
Mammalia ZKSCAN8 34
  • 66 (a)
OneToOne
Species where no ortholog for ZKSCAN8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZKSCAN8 Gene

ENSEMBL:
Gene Tree for ZKSCAN8 (if available)
TreeFam:
Gene Tree for ZKSCAN8 (if available)

Paralogs for ZKSCAN8 Gene

(473) SIMAP similar genes for ZKSCAN8 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ZKSCAN8 Gene

genes like me logo Genes that share paralogs with ZKSCAN8: view

Variants for ZKSCAN8 Gene

Sequence variations from dbSNP and Humsavar for ZKSCAN8 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000068062 -- 28,150,862(+) A/C intron_variant
rs1000205924 -- 28,141,947(+) G/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000233662 -- 28,144,265(+) G/A intron_variant
rs1000566792 -- 28,143,467(+) G/T intron_variant
rs1000596222 -- 28,143,858(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZKSCAN8 Gene

Variant ID Type Subtype PubMed ID
esv3309390 CNV mobile element insertion 20981092
esv3352251 CNV insertion 20981092
esv3363151 CNV insertion 20981092

Variation tolerance for ZKSCAN8 Gene

Residual Variation Intolerance Score: 43.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.25; 62.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZKSCAN8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZKSCAN8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZKSCAN8 Gene

Disorders for ZKSCAN8 Gene

Additional Disease Information for ZKSCAN8

No disorders were found for ZKSCAN8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZKSCAN8 Gene

Publications for ZKSCAN8 Gene

  1. Three genes encoding zinc finger proteins on human chromosome 6p21.3: members of a new subclass of the Kruppel gene family containing the conserved SCAN box domain. (PMID: 9244436) Lee PL … Beutler E (Genomics 1997) 3 4 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  4. A strategy for cloning the hereditary hemochromatosis gene. (PMID: 8673473) Beutler E … Lee P (Blood cells, molecules & diseases 1995) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZKSCAN8 Gene

Sources for ZKSCAN8 Gene

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