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Aliases for ZKSCAN8 Gene

Aliases for ZKSCAN8 Gene

  • Zinc Finger With KRAB And SCAN Domains 8 2 3 5
  • Zinc Finger Protein 192 2 3 4
  • ZNF192 3 4
  • LD5-1 3 4
  • ZSCAN40 3

External Ids for ZKSCAN8 Gene

Previous HGNC Symbols for ZKSCAN8 Gene

  • ZNF192

Previous GeneCards Identifiers for ZKSCAN8 Gene

  • GC06P028115

Summaries for ZKSCAN8 Gene

GeneCards Summary for ZKSCAN8 Gene

ZKSCAN8 (Zinc Finger With KRAB And SCAN Domains 8) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZSCAN16.

UniProtKB/Swiss-Prot for ZKSCAN8 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZKSCAN8 Gene

Genomics for ZKSCAN8 Gene

Regulatory Elements for ZKSCAN8 Gene

Enhancers for ZKSCAN8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZKSCAN8 on UCSC Golden Path with GeneCards custom track

Promoters for ZKSCAN8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZKSCAN8 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZKSCAN8 Gene

28,136,743 bp from pter
28,159,472 bp from pter
22,730 bases
Plus strand

Genomic View for ZKSCAN8 Gene

Genes around ZKSCAN8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZKSCAN8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZKSCAN8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZKSCAN8 Gene

Proteins for ZKSCAN8 Gene

  • Protein details for ZKSCAN8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein with KRAB and SCAN domains 8
    Protein Accession:
    Secondary Accessions:
    • A1L3D4
    • B4DYF1
    • Q4VAR1
    • Q4VAR2
    • Q4VAR3
    • Q9H4T1

    Protein attributes for ZKSCAN8 Gene

    578 amino acids
    Molecular mass:
    65816 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZKSCAN8 Gene


neXtProt entry for ZKSCAN8 Gene

Proteomics data for ZKSCAN8 Gene at MOPED

Post-translational modifications for ZKSCAN8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZKSCAN8 Gene

No data available for DME Specific Peptides for ZKSCAN8 Gene

Domains & Families for ZKSCAN8 Gene

Gene Families for ZKSCAN8 Gene

Suggested Antigen Peptide Sequences for ZKSCAN8 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 9 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Contains 1 SCAN box domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 9 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZKSCAN8: view

Function for ZKSCAN8 Gene

Molecular function for ZKSCAN8 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes for ZKSCAN8 Gene

genes like me logo Genes that share phenotypes with ZKSCAN8: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZKSCAN8 Gene

Localization for ZKSCAN8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZKSCAN8 Gene

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ZKSCAN8 Gene

Pathways & Interactions for ZKSCAN8 Gene

SuperPathways for ZKSCAN8 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZKSCAN8: view

Pathways by source for ZKSCAN8 Gene

2 Reactome pathways for ZKSCAN8 Gene

Gene Ontology (GO) - Biological Process for ZKSCAN8 Gene


No data available for SIGNOR curated interactions for ZKSCAN8 Gene

Drugs & Compounds for ZKSCAN8 Gene

No Compound Related Data Available

Transcripts for ZKSCAN8 Gene

Unigene Clusters for ZKSCAN8 Gene

Zinc finger with KRAB and SCAN domains 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZKSCAN8 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2: -
SP3: - -

Relevant External Links for ZKSCAN8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZKSCAN8 Gene

mRNA expression in normal human tissues for ZKSCAN8 Gene

Protein differential expression in normal tissues from HIPED for ZKSCAN8 Gene

This gene is overexpressed in Ovary (33.4) and Testis (31.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZKSCAN8 Gene

SOURCE GeneReport for Unigene cluster for ZKSCAN8 Gene Hs.57679

genes like me logo Genes that share expression patterns with ZKSCAN8: view

Protein tissue co-expression partners for ZKSCAN8 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZKSCAN8 Gene

Orthologs for ZKSCAN8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZKSCAN8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF192 35
  • 92.96 (n)
  • 92.91 (a)
-- 36
  • 53 (a)
(Canis familiaris)
Mammalia ZKSCAN8 35
  • 92.78 (n)
  • 93.76 (a)
  • 94 (a)
(Mus musculus)
Mammalia Zkscan8 35
  • 87.72 (n)
  • 87.72 (a)
Zkscan8 16
Zkscan8 36
  • 86 (a)
(Pan troglodytes)
Mammalia ZKSCAN8 35
  • 99.6 (n)
  • 98.96 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Zfp192 35
  • 88.41 (n)
  • 87.89 (a)
(Monodelphis domestica)
Mammalia ZKSCAN8 36
  • 66 (a)
Species with no ortholog for ZKSCAN8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZKSCAN8 Gene

Gene Tree for ZKSCAN8 (if available)
Gene Tree for ZKSCAN8 (if available)

Paralogs for ZKSCAN8 Gene

(473) SIMAP similar genes for ZKSCAN8 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZKSCAN8: view

Variants for ZKSCAN8 Gene

Sequence variations from dbSNP and Humsavar for ZKSCAN8 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs62620225 - 28,149,553(+) AGAGC(C/T)TCCAA reference, missense, utr-variant-5-prime
rs1048319 -- 28,148,746(+) AAGGA(A/T)CATCA intron-variant, reference, missense, utr-variant-5-prime
rs1048320 -- 28,148,753(+) ATCAG(C/T)TAGAG intron-variant, reference, synonymous-codon, utr-variant-5-prime
rs1150666 -- 28,156,150(-) CACAT(A/G)TATTT utr-variant-3-prime
rs1150667 -- 28,156,285(-) CATAC(C/T)ACCCT utr-variant-3-prime

Variation tolerance for ZKSCAN8 Gene

Residual Variation Intolerance Score: 43.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.25; 62.45% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ZKSCAN8 Gene

Disorders for ZKSCAN8 Gene

Relevant External Links for ZKSCAN8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZKSCAN8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZKSCAN8 Gene

Publications for ZKSCAN8 Gene

  1. Three genes encoding zinc finger proteins on human chromosome 6p21.3: members of a new subclass of the Kruppel gene family containing the conserved SCAN box domain. (PMID: 9244436) Lee P.L. … Beutler E. (Genomics 1997) 3 4 23 67
  2. KAP1 promotes proliferation and metastatic progression of breast cancer cells. (PMID: 25421577) Addison J.B. … Ivanov A.V. (Cancer Res. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Protein array based interactome analysis of amyloid-I^ indicates an inhibition of protein translation. (PMID: 21244100) Virok D.P. … FA1lAPp L. (J. Proteome Res. 2011) 3

Products for ZKSCAN8 Gene

Sources for ZKSCAN8 Gene