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Aliases for ZKSCAN7 Gene

Aliases for ZKSCAN7 Gene

  • Zinc Finger With KRAB And SCAN Domains 7 2 3 5
  • Zinc Finger Protein 448 2 3 4
  • Zinc Finger Protein 167 2 3 4
  • Zinc Finger Protein 64 2 3 4
  • ZNF167 3 4
  • ZNF448 3 4
  • ZNF64 3 4
  • ZSCAN39 3
  • ZFP 3

External Ids for ZKSCAN7 Gene

Previous HGNC Symbols for ZKSCAN7 Gene

  • ZNF64
  • ZNF448
  • ZNF167

Previous GeneCards Identifiers for ZKSCAN7 Gene

  • GC03P044597

Summaries for ZKSCAN7 Gene

GeneCards Summary for ZKSCAN7 Gene

ZKSCAN7 (Zinc Finger With KRAB And SCAN Domains 7) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF70.

UniProtKB/Swiss-Prot for ZKSCAN7 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZKSCAN7 Gene

Genomics for ZKSCAN7 Gene

Regulatory Elements for ZKSCAN7 Gene

Enhancers for ZKSCAN7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZKSCAN7 on UCSC Golden Path with GeneCards custom track

Promoters for ZKSCAN7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZKSCAN7 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZKSCAN7 Gene

Chromosome:
3
Start:
44,555,175 bp from pter
End:
44,594,173 bp from pter
Size:
38,999 bases
Orientation:
Plus strand

Genomic View for ZKSCAN7 Gene

Genes around ZKSCAN7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZKSCAN7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZKSCAN7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZKSCAN7 Gene

Proteins for ZKSCAN7 Gene

  • Protein details for ZKSCAN7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0L1-ZKSC7_HUMAN
    Recommended name:
    Zinc finger protein with KRAB and SCAN domains 7
    Protein Accession:
    Q9P0L1
    Secondary Accessions:
    • A0PJV3
    • A8K5H0
    • Q6WL09
    • Q96FQ2

    Protein attributes for ZKSCAN7 Gene

    Size:
    754 amino acids
    Molecular mass:
    85033 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZKSCAN7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZKSCAN7 Gene

Proteomics data for ZKSCAN7 Gene at MOPED

Post-translational modifications for ZKSCAN7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZKSCAN7 Gene

Domains & Families for ZKSCAN7 Gene

Gene Families for ZKSCAN7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P0L1

UniProtKB/Swiss-Prot:

ZKSC7_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
  • Contains 1 SCAN box domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZKSCAN7: view

Function for ZKSCAN7 Gene

Molecular function for ZKSCAN7 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZKSCAN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with ZKSCAN7: view
genes like me logo Genes that share phenotypes with ZKSCAN7: view

Animal Model Products

CRISPR Products

miRNA for ZKSCAN7 Gene

miRTarBase miRNAs that target ZKSCAN7

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZKSCAN7 Gene

Localization for ZKSCAN7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZKSCAN7 Gene

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ZKSCAN7 Gene

Pathways & Interactions for ZKSCAN7 Gene

SuperPathways for ZKSCAN7 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZKSCAN7: view

Pathways by source for ZKSCAN7 Gene

2 Reactome pathways for ZKSCAN7 Gene

Gene Ontology (GO) - Biological Process for ZKSCAN7 Gene

None

No data available for SIGNOR curated interactions for ZKSCAN7 Gene

Drugs & Compounds for ZKSCAN7 Gene

(3) Drugs for ZKSCAN7 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for ZKSCAN7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZKSCAN7: view

Transcripts for ZKSCAN7 Gene

Unigene Clusters for ZKSCAN7 Gene

Zinc finger with KRAB and SCAN domains 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZKSCAN7 Gene

No ASD Table

Relevant External Links for ZKSCAN7 Gene

GeneLoc Exon Structure for
ZKSCAN7
ECgene alternative splicing isoforms for
ZKSCAN7

Expression for ZKSCAN7 Gene

mRNA expression in normal human tissues for ZKSCAN7 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZKSCAN7 Gene



SOURCE GeneReport for Unigene cluster for ZKSCAN7 Gene Hs.529512

genes like me logo Genes that share expression patterns with ZKSCAN7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZKSCAN7 Gene

Orthologs for ZKSCAN7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZKSCAN7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF167 35
  • 84.68 (n)
  • 81.01 (a)
-- 36
  • 81 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zkscan7 35
  • 79.53 (n)
  • 72.42 (a)
Zkscan7 16
Zkscan7 36
  • 73 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ZNF167 35
  • 99.42 (n)
  • 99.2 (a)
ZKSCAN7 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp167 35
  • 80.21 (n)
  • 75.31 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 58 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 52 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ZNF167 35
  • 56.96 (n)
  • 52.02 (a)
-- 36
  • 46 (a)
OneToMany
Species with no ortholog for ZKSCAN7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZKSCAN7 Gene

ENSEMBL:
Gene Tree for ZKSCAN7 (if available)
TreeFam:
Gene Tree for ZKSCAN7 (if available)

Paralogs for ZKSCAN7 Gene

(530) SIMAP similar genes for ZKSCAN7 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZKSCAN7 Gene

genes like me logo Genes that share paralogs with ZKSCAN7: view

Variants for ZKSCAN7 Gene

Sequence variations from dbSNP and Humsavar for ZKSCAN7 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs35696191 - 44,557,117(+) AGGGG(C/T)GCCTG intron-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs13081859 - 44,565,521(+) GCATT(C/T)TGAGG intron-variant, reference, synonymous-codon, missense, utr-variant-5-prime
rs34396823 - 44,570,135(+) AATAA(C/T)AGATG intron-variant, reference, missense
rs34181686 - 44,570,185(+) ATAAG(A/G)AAGTT intron-variant, reference, missense
rs9835485 - 44,570,404(+) TCAGA(A/G)CCCAC intron-variant, reference, missense

Variation tolerance for ZKSCAN7 Gene

Residual Variation Intolerance Score: 72.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.57; 86.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZKSCAN7 Gene

HapMap Linkage Disequilibrium report
ZKSCAN7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZKSCAN7 Gene

Disorders for ZKSCAN7 Gene

Relevant External Links for ZKSCAN7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZKSCAN7

No disorders were found for ZKSCAN7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZKSCAN7 Gene

Publications for ZKSCAN7 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Positional cloning of cDNAs from the human chromosome 3p21-22 region identifies a clustered organization of zinc-finger genes. (PMID: 7814019) CalabrA^ V. … Lania L. (Hum. Genet. 1995) 2 3
  3. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PMID: 1505991) Lichter P. … Ward D.C. (Genomics 1992) 2 3
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for ZKSCAN7 Gene

Sources for ZKSCAN7 Gene

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