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Aliases for ZKSCAN5 Gene

Aliases for ZKSCAN5 Gene

  • Zinc Finger With KRAB And SCAN Domains 5 2 3 5
  • Zinc Finger Protein Homologous To Zfp95 In Mouse 2 3
  • Zinc Finger Protein 95 Homolog 3 4
  • ZFP-95 3 4
  • ZFP95 3 4
  • Zinc Finger Protein With KRAB And SCAN Domains 5 3
  • Zinc Finger Protein 95 Homolog (Mouse) 2
  • KIAA1015 4
  • ZSCAN37 3
  • ZNF914 3

External Ids for ZKSCAN5 Gene

Previous HGNC Symbols for ZKSCAN5 Gene

  • ZFP95

Previous GeneCards Identifiers for ZKSCAN5 Gene

  • GC07P098941
  • GC07P099102
  • GC07P093738

Summaries for ZKSCAN5 Gene

Entrez Gene Summary for ZKSCAN5 Gene

  • This gene encodes a zinc finger protein of the Kruppel family. The protein contains a SCAN box and a KRAB A domain and may be involved in transcriptional regulation. A similar protein in mouse is differentially expressed in spermatogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for ZKSCAN5 Gene

ZKSCAN5 (Zinc Finger With KRAB And SCAN Domains 5) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZKSCAN8.

UniProtKB/Swiss-Prot for ZKSCAN5 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZKSCAN5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZKSCAN5 Gene

Genomics for ZKSCAN5 Gene

Regulatory Elements for ZKSCAN5 Gene

Enhancers for ZKSCAN5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G100475 1.4 ENCODE dbSUPER 21.9 +976.5 976458 4.4 HDGF PKNOX1 FOXA2 CREB3L1 ARNT AGO1 ZFP64 WRNIP1 SIN3A ARID4B PILRA ZNF655 GIGYF1 ZSCAN25 ZKSCAN5 STAG3L5P PCOLCE ENSG00000242798 PPP1R35 AP4M1
GH07G099223 1.5 Ensembl ENCODE dbSUPER 12.6 -276.4 -276353 1.9 PKNOX1 ATF1 ARNT YBX1 TCF12 GTF3C2 CBX5 FOS JUNB TSHZ1 ZSCAN25 SMURF1 TRRAP ZNF655 LOC100419643 ENSG00000242798 LOC101927550 ZKSCAN5 AP4M1 LOC100131859
GH07G099692 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.9 +193.0 192952 2.7 HDGF PKNOX1 FOXA2 MLX ARID4B DMAP1 YY1 SLC30A9 ZNF766 CBX5 NYAP1 PDAP1 MBLAC1 ZKSCAN5 CYP3A5 SAP25 ZSCAN25 TMEM225B CYP3A43 CYP3A4
GH07G100427 1.5 ENCODE dbSUPER 10.5 +931.9 931903 10.8 CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 PILRA ZSCAN25 LOC100131859 ZNF655 STAG3L5P GIGYF1 COPS6 MBLAC1 AP4M1 ZNF789
GH07G099471 1.2 ENCODE 12.4 -28.7 -28694 3.0 HDGF PKNOX1 FOXA2 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 ZSCAN25 TMEM225B ZNF655 LOC100419643 STAG3L5P TRRAP ENSG00000242798 LOC101927550 ZKSCAN5 ZNF394
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZKSCAN5 on UCSC Golden Path with GeneCards custom track

Promoters for ZKSCAN5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000215673 -1297 2001 PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1

Genomic Location for ZKSCAN5 Gene

Chromosome:
7
Start:
99,501,297 bp from pter
End:
99,534,700 bp from pter
Size:
33,404 bases
Orientation:
Plus strand

Genomic View for ZKSCAN5 Gene

Genes around ZKSCAN5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZKSCAN5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZKSCAN5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZKSCAN5 Gene

Proteins for ZKSCAN5 Gene

  • Protein details for ZKSCAN5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2L8-ZKSC5_HUMAN
    Recommended name:
    Zinc finger protein with KRAB and SCAN domains 5
    Protein Accession:
    Q9Y2L8
    Secondary Accessions:
    • A4D280
    • D6W5S9

    Protein attributes for ZKSCAN5 Gene

    Size:
    839 amino acids
    Molecular mass:
    96903 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA76859.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZKSCAN5 Gene

neXtProt entry for ZKSCAN5 Gene

Post-translational modifications for ZKSCAN5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZKSCAN5 Gene

Domains & Families for ZKSCAN5 Gene

Gene Families for ZKSCAN5 Gene

Suggested Antigen Peptide Sequences for ZKSCAN5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y2L8

UniProtKB/Swiss-Prot:

ZKSC5_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZKSCAN5: view

Function for ZKSCAN5 Gene

Molecular function for ZKSCAN5 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZKSCAN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding NAS,IEA 10585779
GO:0005515 protein binding IPI 23455924
GO:0008270 zinc ion binding NAS 10585779
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZKSCAN5: view
genes like me logo Genes that share phenotypes with ZKSCAN5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZKSCAN5 Gene

Localization for ZKSCAN5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZKSCAN5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZKSCAN5 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZKSCAN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus NAS 10585779
genes like me logo Genes that share ontologies with ZKSCAN5: view

Pathways & Interactions for ZKSCAN5 Gene

SuperPathways for ZKSCAN5 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZKSCAN5: view

Pathways by source for ZKSCAN5 Gene

2 Reactome pathways for ZKSCAN5 Gene

Gene Ontology (GO) - Biological Process for ZKSCAN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS,IEA 10585779
genes like me logo Genes that share ontologies with ZKSCAN5: view

No data available for SIGNOR curated interactions for ZKSCAN5 Gene

Drugs & Compounds for ZKSCAN5 Gene

No Compound Related Data Available

Transcripts for ZKSCAN5 Gene

Unigene Clusters for ZKSCAN5 Gene

Zinc finger with KRAB and SCAN domains 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZKSCAN5 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8
SP1: - -
SP2: -
SP3: -
SP4: - - - -
SP5: -

Relevant External Links for ZKSCAN5 Gene

GeneLoc Exon Structure for
ZKSCAN5
ECgene alternative splicing isoforms for
ZKSCAN5

Expression for ZKSCAN5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZKSCAN5 Gene

Protein differential expression in normal tissues from HIPED for ZKSCAN5 Gene

This gene is overexpressed in Neutrophil (25.7), Pancreatic juice (24.2), and Tlymphocyte (18.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZKSCAN5 Gene



Protein tissue co-expression partners for ZKSCAN5 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZKSCAN5 Gene:

ZKSCAN5

SOURCE GeneReport for Unigene cluster for ZKSCAN5 Gene:

Hs.110839

Evidence on tissue expression from TISSUES for ZKSCAN5 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZKSCAN5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZKSCAN5 Gene

Orthologs for ZKSCAN5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZKSCAN5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZKSCAN5 34 35
  • 99.6 (n)
dog
(Canis familiaris)
Mammalia ZKSCAN5 34 35
  • 86.59 (n)
cow
(Bos Taurus)
Mammalia ZKSCAN5 34
  • 84.6 (n)
-- 35
  • 42 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Zkscan5 34 16 35
  • 80.4 (n)
rat
(Rattus norvegicus)
Mammalia Zkscan5 34
  • 79.65 (n)
oppossum
(Monodelphis domestica)
Mammalia ZKSCAN5 35
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 29 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta l(3)neo38 35
  • 17 (a)
ManyToMany
CG7368 35
  • 15 (a)
ManyToMany
Species where no ortholog for ZKSCAN5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZKSCAN5 Gene

ENSEMBL:
Gene Tree for ZKSCAN5 (if available)
TreeFam:
Gene Tree for ZKSCAN5 (if available)

Paralogs for ZKSCAN5 Gene

(278) SIMAP similar genes for ZKSCAN5 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with ZKSCAN5: view

Variants for ZKSCAN5 Gene

Sequence variations from dbSNP and Humsavar for ZKSCAN5 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000031988 -- 99,524,869(+) TATTA(A/C)GAATA intron-variant
rs1000139139 -- 99,526,988(+) TATAT(A/G)CTTTT intron-variant
rs1000171680 -- 99,508,258(+) TGTGC(C/T)ACTGC intron-variant
rs1000243877 -- 99,502,019(+) GCTAA(C/T)TTTTT intron-variant, upstream-variant-2KB
rs1000350807 -- 99,520,774(+) GCGGG(G/T)GGATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZKSCAN5 Gene

Variant ID Type Subtype PubMed ID
esv2662144 CNV deletion 23128226
esv2675875 CNV deletion 23128226
esv2734884 CNV deletion 23290073
esv3576408 CNV gain 25503493
esv3614279 CNV loss 21293372
esv3614280 CNV loss 21293372
nsv819741 CNV gain 19587683
nsv824229 CNV loss 20364138
nsv831069 CNV loss 17160897

Variation tolerance for ZKSCAN5 Gene

Residual Variation Intolerance Score: 24.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZKSCAN5 Gene

Human Gene Mutation Database (HGMD)
ZKSCAN5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZKSCAN5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZKSCAN5 Gene

Disorders for ZKSCAN5 Gene

Relevant External Links for ZKSCAN5

Genetic Association Database (GAD)
ZKSCAN5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZKSCAN5

No disorders were found for ZKSCAN5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZKSCAN5 Gene

Publications for ZKSCAN5 Gene

  1. Isolation, characterization, and mapping of a zinc finger gene, ZFP95, containing both a SCAN box and an alternatively spliced KRAB A domain. (PMID: 10585779) Dreyer S.D. … Lee B. (Genomics 1999) 2 3 4 22 64
  2. Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms. (PMID: 21533175) Zhai G. … Wallaschofski H. (PLoS Genet. 2011) 3 46 64
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  4. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 3 4 64
  5. Macaca specific exon creation event generates a novel ZKSCAN5 transcript. (PMID: 26657034) Kim Y.H. … Chang K.T. (Gene 2016) 3 64

Products for ZKSCAN5 Gene

Sources for ZKSCAN5 Gene

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