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Aliases for ZKSCAN5 Gene

Aliases for ZKSCAN5 Gene

  • Zinc Finger With KRAB And SCAN Domains 5 2 3
  • ZFP95 3 4 6
  • Zinc Finger Protein Homologous To Zfp95 In Mouse 2 3
  • Zinc Finger Protein 95 Homolog 3 4
  • KIAA1015 4 6
  • Zfp-95 3 4
  • Zinc Finger Protein With KRAB And SCAN Domains 5 3
  • Zinc Finger Protein 95 Homolog (Mouse) 2
  • ZSCAN37 3
  • ZNF914 3

External Ids for ZKSCAN5 Gene

Previous Symbols for ZKSCAN5 Gene

  • ZFP95

Summaries for ZKSCAN5 Gene

Entrez Gene Summary for ZKSCAN5 Gene

  • This gene encodes a zinc finger protein of the Kruppel family. The protein contains a SCAN box and a KRAB A domain. A similar protein in mouse is differentially expressed in spermatogenesis. Two alternatively spliced transcript variants differing only in the 5' UTR have been described. Additional variants have been found, but their full-length sequences have not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZKSCAN5 Gene

ZKSCAN5 (Zinc Finger With KRAB And SCAN Domains 5) is a Protein Coding gene. Diseases associated with ZKSCAN5 include pharyngitis. Among its related pathways are Gene Expression and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF444.

UniProtKB/Swiss-Prot for ZKSCAN5 Gene

  • May be involved in transcriptional regulation

Gene Wiki entry for ZKSCAN5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZKSCAN5 Gene

Genomics for ZKSCAN5 Gene

Genomic Location for ZKSCAN5 Gene

99,504,628 bp from pter
99,534,700 bp from pter
30,073 bases
Plus strand

Genomic View for ZKSCAN5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZKSCAN5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZKSCAN5 Gene

Regulatory Elements for ZKSCAN5 Gene

Proteins for ZKSCAN5 Gene

  • Protein details for ZKSCAN5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein with KRAB and SCAN domains 5
    Protein Accession:
    Secondary Accessions:
    • A4D280
    • D6W5S9

    Protein attributes for ZKSCAN5 Gene

    839 amino acids
    Molecular mass:
    96903 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA76859.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZKSCAN5 Gene

neXtProt entry for ZKSCAN5 Gene

Proteomics data for ZKSCAN5 Gene at MOPED

Post-translational modifications for ZKSCAN5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZKSCAN5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZKSCAN5 Gene

Domains for ZKSCAN5 Gene

Gene Families for ZKSCAN5 Gene

  • ZNF :Zinc fingers, C2H2-type


  • Contains 1 KRAB domain.:
    • Q9Y2L8
  • Contains 1 SCAN box domain.:
    • Q9Y2L8
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q9Y2L8
  • Contains 13 C2H2-type zinc fingers.:
    • Q9Y2L8
genes like me logo Genes that share domains with ZKSCAN5: view

Function for ZKSCAN5 Gene

Molecular function for ZKSCAN5 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZKSCAN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 10585779
GO:0005515 protein binding IPI 23455924
GO:0008270 zinc ion binding NAS 10585779
genes like me logo Genes that share ontologies with ZKSCAN5: view

miRNA for ZKSCAN5 Gene

miRTarBase miRNAs that target ZKSCAN5

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZKSCAN5 Gene

Localization for ZKSCAN5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZKSCAN5 Gene

Subcellular locations from

Jensen Localization Image for ZKSCAN5 Gene COMPARTMENTS Subcellular localization image for ZKSCAN5 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZKSCAN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus NAS 10585779
genes like me logo Genes that share ontologies with ZKSCAN5: view

Pathways for ZKSCAN5 Gene

SuperPathways for ZKSCAN5 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZKSCAN5: view

Pathways by source for ZKSCAN5 Gene

2 Reactome pathways for ZKSCAN5 Gene

Gene Ontology (GO) - Biological Process for ZKSCAN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 10585779
genes like me logo Genes that share ontologies with ZKSCAN5: view

Transcripts for ZKSCAN5 Gene

Unigene Clusters for ZKSCAN5 Gene

Zinc finger with KRAB and SCAN domains 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZKSCAN5 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8
SP1: - -
SP2: -
SP3: -
SP4: - - - -
SP5: -

Relevant External Links for ZKSCAN5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZKSCAN5 Gene

mRNA expression in normal human tissues for ZKSCAN5 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZKSCAN5 Gene

SOURCE GeneReport for Unigene cluster for ZKSCAN5 Gene Hs.110839

genes like me logo Genes that share expressions with ZKSCAN5: view

Orthologs for ZKSCAN5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZKSCAN5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZKSCAN5 36
  • 99.6 (n)
  • 99.64 (a)
  • 100 (a)
(Bos Taurus)
Mammalia -- 37
  • 42 (a)
  • 84.6 (n)
  • 85.56 (a)
(Canis familiaris)
Mammalia ZKSCAN5 36
  • 86.59 (n)
  • 87.2 (a)
  • 89 (a)
(Mus musculus)
Mammalia Zkscan5 36
  • 80.4 (n)
  • 80.93 (a)
Zkscan5 16
Zkscan5 37
  • 81 (a)
(Monodelphis domestica)
Mammalia ZKSCAN5 37
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 29 (a)
(Rattus norvegicus)
Mammalia Zkscan5 36
  • 79.65 (n)
  • 78.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7368 37
  • 15 (a)
l(3)neo38 37
  • 17 (a)
Species with no ortholog for ZKSCAN5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZKSCAN5 Gene

Gene Tree for ZKSCAN5 (if available)
Gene Tree for ZKSCAN5 (if available)

Paralogs for ZKSCAN5 Gene

Paralogs for ZKSCAN5 Gene

Selected SIMAP similar genes for ZKSCAN5 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with ZKSCAN5: view

Variants for ZKSCAN5 Gene

Sequence variations from dbSNP and Humsavar for ZKSCAN5 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs3137 -- 99,533,252(-) GCTCA(C/T)GACTG utr-variant-3-prime
rs3138 -- 99,533,134(-) TGGGA(C/T)CAGGA utr-variant-3-prime
rs2272168 -- 99,505,154(-) TCGCA(C/G)GGGGG utr-variant-5-prime, intron-variant, upstream-variant-2KB
rs3843540 -- 99,529,017(+) CTTGT(C/T)GGCTC intron-variant
rs3901286 -- 99,510,104(-) ttttt(G/T)tttaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZKSCAN5 Gene

Variant ID Type Subtype PubMed ID
nsv831069 CNV Loss 17160897
esv2675875 CNV Deletion 23128226
esv2662144 CNV Deletion 23128226
esv2734884 CNV Deletion 23290073
nsv824229 CNV Loss 20364138
nsv819741 CNV Gain 19587683

Relevant External Links for ZKSCAN5 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for ZKSCAN5 Gene

(1) MalaCards Diseases for ZKSCAN5 Gene

Search for ZKSCAN5 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ZKSCAN5 Gene

Relevant External Links for ZKSCAN5

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with ZKSCAN5: view

No data available for UniProtKB/Swiss-Prot for ZKSCAN5 Gene

Publications for ZKSCAN5 Gene

  1. Isolation, characterization, and mapping of a zinc finger gene, ZFP95, containing both a SCAN box and an alternatively spliced KRAB A domain. (PMID: 10585779) Dreyer S.D. … Lee B. (Genomics 1999) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 3 4
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  4. Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms. (PMID: 21533175) Zhai G. … Wallaschofski H. (PLoS Genet. 2011) 3 49
  5. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3

Products for ZKSCAN5 Gene

Sources for ZKSCAN5 Gene

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