Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZKSCAN4 Gene

Aliases for ZKSCAN4 Gene

  • Zinc Finger With KRAB And SCAN Domains 4 2 3 5
  • Zinc Finger Protein 307 2 3 4
  • Zinc Finger Protein 427 2 3 4
  • ZNF307 3 4
  • ZNF427 3 4
  • P373c6.1 (Novel C2H2 Type Zinc Finger Protein) 3
  • EC 4.2.1.52 63
  • EC 2.1.1.43 63
  • P1P373C6 3
  • P373c6.1 4
  • ZSCAN36 3

External Ids for ZKSCAN4 Gene

Previous HGNC Symbols for ZKSCAN4 Gene

  • ZNF307
  • ZNF427

Previous GeneCards Identifiers for ZKSCAN4 Gene

  • GC06M028324
  • GC06M028212
  • GC06M028021

Summaries for ZKSCAN4 Gene

GeneCards Summary for ZKSCAN4 Gene

ZKSCAN4 (Zinc Finger With KRAB And SCAN Domains 4) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZSCAN16.

UniProtKB/Swiss-Prot for ZKSCAN4 Gene

  • May be involved in the transcriptional activation of MDM2 and EP300 genes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZKSCAN4 Gene

Genomics for ZKSCAN4 Gene

Regulatory Elements for ZKSCAN4 Gene

Promoters for ZKSCAN4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZKSCAN4 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZKSCAN4 Gene

Chromosome:
6
Start:
28,241,705 bp from pter
End:
28,259,271 bp from pter
Size:
17,567 bases
Orientation:
Minus strand

Genomic View for ZKSCAN4 Gene

Genes around ZKSCAN4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZKSCAN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZKSCAN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZKSCAN4 Gene

Proteins for ZKSCAN4 Gene

  • Protein details for ZKSCAN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969J2-ZKSC4_HUMAN
    Recommended name:
    Zinc finger protein with KRAB and SCAN domains 4
    Protein Accession:
    Q969J2
    Secondary Accessions:
    • B2RE32
    • Q5U7L4

    Protein attributes for ZKSCAN4 Gene

    Size:
    545 amino acids
    Molecular mass:
    61579 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZKSCAN4 Gene

Proteomics data for ZKSCAN4 Gene at MOPED

Selected DME Specific Peptides for ZKSCAN4 Gene

Post-translational modifications for ZKSCAN4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZKSCAN4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ZKSCAN4

Domains & Families for ZKSCAN4 Gene

Gene Families for ZKSCAN4 Gene

Suggested Antigen Peptide Sequences for ZKSCAN4 Gene

Graphical View of Domain Structure for InterPro Entry

Q969J2

UniProtKB/Swiss-Prot:

ZKSC4_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 7 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
  • Contains 1 SCAN box domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 7 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZKSCAN4: view

Function for ZKSCAN4 Gene

Molecular function for ZKSCAN4 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the transcriptional activation of MDM2 and EP300 genes.

Enzyme Numbers (IUBMB) for ZKSCAN4 Gene

Gene Ontology (GO) - Molecular Function for ZKSCAN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ZKSCAN4: view
genes like me logo Genes that share phenotypes with ZKSCAN4: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZKSCAN4 Gene

Localization for ZKSCAN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZKSCAN4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZKSCAN4 Gene COMPARTMENTS Subcellular localization image for ZKSCAN4 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZKSCAN4 Gene

Pathways & Interactions for ZKSCAN4 Gene

SuperPathways for ZKSCAN4 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZKSCAN4: view

Pathways by source for ZKSCAN4 Gene

2 Reactome pathways for ZKSCAN4 Gene

Gene Ontology (GO) - Biological Process for ZKSCAN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0007040 lysosome organization IBA --
genes like me logo Genes that share ontologies with ZKSCAN4: view

No data available for SIGNOR curated interactions for ZKSCAN4 Gene

Drugs & Compounds for ZKSCAN4 Gene

No Compound Related Data Available

Transcripts for ZKSCAN4 Gene

mRNA/cDNA for ZKSCAN4 Gene

Unigene Clusters for ZKSCAN4 Gene

Zinc finger with KRAB and SCAN domains 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZKSCAN4 Gene

No ASD Table

Relevant External Links for ZKSCAN4 Gene

GeneLoc Exon Structure for
ZKSCAN4
ECgene alternative splicing isoforms for
ZKSCAN4

Expression for ZKSCAN4 Gene

mRNA expression in normal human tissues for ZKSCAN4 Gene

Protein differential expression in normal tissues from HIPED for ZKSCAN4 Gene

This gene is overexpressed in Pancreas (20.2), Tlymphocyte (19.6), Rectum (13.1), and CD8 Tcells (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZKSCAN4 Gene



SOURCE GeneReport for Unigene cluster for ZKSCAN4 Gene Hs.44720

mRNA Expression by UniProt/SwissProt for ZKSCAN4 Gene

Q969J2-ZKSC4_HUMAN
Tissue specificity: Expressed in adult heart, brain, placenta, lung and kidney, but not in adult liver and skeletal muscle. In 17-day old embryo, detected in liver, skeletal muscle, brain, heart and small intestine.
genes like me logo Genes that share expression patterns with ZKSCAN4: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for ZKSCAN4 Gene

Orthologs for ZKSCAN4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZKSCAN4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC539620 35
  • 86.32 (n)
  • 82.26 (a)
-- 36
  • 82 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ZKSCAN4 35
  • 82.9 (n)
  • 76.29 (a)
-- 36
  • 76 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ZKSCAN4 35
  • 99.51 (n)
  • 99.27 (a)
ZKSCAN4 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zkscan4 36
  • 75 (a)
ManyToMany
Species with no ortholog for ZKSCAN4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZKSCAN4 Gene

ENSEMBL:
Gene Tree for ZKSCAN4 (if available)
TreeFam:
Gene Tree for ZKSCAN4 (if available)

Paralogs for ZKSCAN4 Gene

(487) SIMAP similar genes for ZKSCAN4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZKSCAN4: view

Variants for ZKSCAN4 Gene

Sequence variations from dbSNP and Humsavar for ZKSCAN4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs9986596 - 28,251,883(+) AGGCG(A/G/T)AGGCT intron-variant, upstream-variant-2KB, reference, missense
rs13408 -- 28,244,970(-) TGAGA(C/T)GATGA utr-variant-3-prime
rs967005 -- 28,242,910(-) ACTAA(A/G)GACCA utr-variant-3-prime
rs1150712 -- 28,245,461(-) AAGCC(A/C/G/T)TACCA reference, synonymous-codon
rs1233710 -- 28,247,668(+) AGGGC(C/T)AGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZKSCAN4 Gene

Variant ID Type Subtype PubMed ID
nsv830620 CNV Loss 17160897

Variation tolerance for ZKSCAN4 Gene

Residual Variation Intolerance Score: 77% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.41; 71.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZKSCAN4 Gene

HapMap Linkage Disequilibrium report
ZKSCAN4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZKSCAN4 Gene

Disorders for ZKSCAN4 Gene

Relevant External Links for ZKSCAN4

Genetic Association Database (GAD)
ZKSCAN4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZKSCAN4

No disorders were found for ZKSCAN4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZKSCAN4 Gene

Publications for ZKSCAN4 Gene

  1. A RAS recruitment screen identifies ZKSCAN4 as a glucocorticoid receptor-interacting protein. (PMID: 19008334) Ecker K. … Helmberg A. (J. Mol. Endocrinol. 2009) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2. (PMID: 22037552) Yue W.H. … Zhang D. (Nat. Genet. 2011) 3
  5. The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1. (PMID: 20811636) Giannone R.J. … Liu Y. (PLoS ONE 2010) 3

Products for ZKSCAN4 Gene

Sources for ZKSCAN4 Gene

Back to Top

Content