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Aliases for ZKSCAN4 Gene

Aliases for ZKSCAN4 Gene

  • Zinc Finger With KRAB And SCAN Domains 4 2 3 5
  • Zinc Finger Protein 307 2 3 4
  • Zinc Finger Protein 427 2 3 4
  • ZNF307 3 4
  • ZNF427 3 4
  • Zinc Finger Protein With KRAB And SCAN Domains 4 3
  • P373c6.1 (Novel C2H2 Type Zinc Finger Protein) 3
  • EC 4.2.1.52 61
  • EC 2.1.1.43 61
  • P1P373C6 3
  • P373c6.1 4
  • ZSCAN36 3

External Ids for ZKSCAN4 Gene

Previous HGNC Symbols for ZKSCAN4 Gene

  • ZNF307
  • ZNF427

Previous GeneCards Identifiers for ZKSCAN4 Gene

  • GC06M028324
  • GC06M028212
  • GC06M028021

Summaries for ZKSCAN4 Gene

GeneCards Summary for ZKSCAN4 Gene

ZKSCAN4 (Zinc Finger With KRAB And SCAN Domains 4) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZKSCAN3.

UniProtKB/Swiss-Prot for ZKSCAN4 Gene

  • May be involved in the transcriptional activation of MDM2 and EP300 genes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZKSCAN4 Gene

Genomics for ZKSCAN4 Gene

Regulatory Elements for ZKSCAN4 Gene

Enhancers for ZKSCAN4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F027862 1.5 Ensembl ENCODE 54.7 +390.6 390604 12.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 ZKSCAN8 ZKSCAN3 ZSCAN9 GUSBP2 ZSCAN26 ZKSCAN4 ZSCAN23 ZNF391 ZNF603P PGBD1
GH06F028211 1.4 Ensembl ENCODE 43.3 +46.7 46737 2.2 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 ZNF2 SLC30A9 ZNF143 ZKSCAN8 ZKSCAN3 ZNF603P ZKSCAN4 ZSCAN9 ZSCAN31 NKAPL ZNF311 ZSCAN23 PGBD1
GH06F027495 1.2 ENCODE 49.9 +763.5 763538 1.2 PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 ZNF2 ZNF302 ZNF143 FOS ZKSCAN8 ZKSCAN3 ABT1 ZSCAN9 ZKSCAN4 HMGN4 ZNF391 GUSBP2 ZNF322 ZNF204P
GH06F028977 1.4 Ensembl ENCODE 41.8 -721.2 -721204 6.7 CREB3L1 MLX FEZF1 DMAP1 YBX1 YY1 ZNF143 SP3 NFYC MEF2D ZKSCAN3 ZKSCAN8 ZKSCAN4 TRIM27 HLA-K ZNF311 MICD ZSCAN9 HLA-W HCG4B
GH06F027293 1.7 FANTOM5 Ensembl ENCODE 32.9 +963.2 963193 5.4 HDGF PKNOX1 ARNT CREB3L1 ZNF2 YY1 FOS KLF13 ZNF263 SP3 ABT1 ZKSCAN4 ZNF391 ZKSCAN8 HMGN4 ZSCAN9 ZNF204P ZSCAN26 BTN3A2 HCG11
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZKSCAN4 on UCSC Golden Path with GeneCards custom track

Promoters for ZKSCAN4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001214506 -29 1000 HDAC1 CEBPG JUND POLR2A EGR1 ATF3 EED IKZF1 ZBTB33 ETV6

Genomic Location for ZKSCAN4 Gene

Chromosome:
6
Start:
28,241,705 bp from pter
End:
28,259,271 bp from pter
Size:
17,567 bases
Orientation:
Minus strand

Genomic View for ZKSCAN4 Gene

Genes around ZKSCAN4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZKSCAN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZKSCAN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZKSCAN4 Gene

Proteins for ZKSCAN4 Gene

  • Protein details for ZKSCAN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969J2-ZKSC4_HUMAN
    Recommended name:
    Zinc finger protein with KRAB and SCAN domains 4
    Protein Accession:
    Q969J2
    Secondary Accessions:
    • B2RE32
    • Q5U7L4

    Protein attributes for ZKSCAN4 Gene

    Size:
    545 amino acids
    Molecular mass:
    61579 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZKSCAN4 Gene

Selected DME Specific Peptides for ZKSCAN4 Gene

Q969J2:
  • RLRELCG
  • HQRTHTGEKPY

Post-translational modifications for ZKSCAN4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for ZKSCAN4 Gene

Gene Families for ZKSCAN4 Gene

Suggested Antigen Peptide Sequences for ZKSCAN4 Gene

Graphical View of Domain Structure for InterPro Entry

Q969J2

UniProtKB/Swiss-Prot:

ZKSC4_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 7 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
  • Contains 1 SCAN box domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 7 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZKSCAN4: view

Function for ZKSCAN4 Gene

Molecular function for ZKSCAN4 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the transcriptional activation of MDM2 and EP300 genes.

Enzyme Numbers (IUBMB) for ZKSCAN4 Gene

Gene Ontology (GO) - Molecular Function for ZKSCAN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZKSCAN4: view
genes like me logo Genes that share phenotypes with ZKSCAN4: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZKSCAN4 Gene

Localization for ZKSCAN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZKSCAN4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZKSCAN4 gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for ZKSCAN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with ZKSCAN4: view

Pathways & Interactions for ZKSCAN4 Gene

SuperPathways for ZKSCAN4 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZKSCAN4: view

Pathways by source for ZKSCAN4 Gene

2 Reactome pathways for ZKSCAN4 Gene

Gene Ontology (GO) - Biological Process for ZKSCAN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007040 lysosome organization IBA --
GO:0010507 negative regulation of autophagy IBA --
genes like me logo Genes that share ontologies with ZKSCAN4: view

No data available for SIGNOR curated interactions for ZKSCAN4 Gene

Transcripts for ZKSCAN4 Gene

mRNA/cDNA for ZKSCAN4 Gene

Unigene Clusters for ZKSCAN4 Gene

Zinc finger with KRAB and SCAN domains 4:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZKSCAN4 Gene

No ASD Table

Relevant External Links for ZKSCAN4 Gene

GeneLoc Exon Structure for
ZKSCAN4
ECgene alternative splicing isoforms for
ZKSCAN4

Expression for ZKSCAN4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZKSCAN4 Gene

Protein differential expression in normal tissues from HIPED for ZKSCAN4 Gene

This gene is overexpressed in Pancreas (20.2), Tlymphocyte (19.6), Rectum (13.1), and CD8 Tcells (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZKSCAN4 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZKSCAN4 Gene:

ZKSCAN4

SOURCE GeneReport for Unigene cluster for ZKSCAN4 Gene:

Hs.44720

mRNA Expression by UniProt/SwissProt for ZKSCAN4 Gene:

Q969J2-ZKSC4_HUMAN
Tissue specificity: Expressed in adult heart, brain, placenta, lung and kidney, but not in adult liver and skeletal muscle. In 17-day old embryo, detected in liver, skeletal muscle, brain, heart and small intestine.
genes like me logo Genes that share expression patterns with ZKSCAN4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for ZKSCAN4 Gene

Orthologs for ZKSCAN4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZKSCAN4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZKSCAN4 34 35
  • 99.51 (n)
cow
(Bos Taurus)
Mammalia LOC539620 34
  • 86.32 (n)
-- 35
  • 82 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ZKSCAN4 34
  • 82.9 (n)
-- 35
  • 76 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zkscan4 35
  • 75 (a)
ManyToMany
Species where no ortholog for ZKSCAN4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZKSCAN4 Gene

ENSEMBL:
Gene Tree for ZKSCAN4 (if available)
TreeFam:
Gene Tree for ZKSCAN4 (if available)

Paralogs for ZKSCAN4 Gene

(487) SIMAP similar genes for ZKSCAN4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZKSCAN4: view

Variants for ZKSCAN4 Gene

Sequence variations from dbSNP and Humsavar for ZKSCAN4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10456362 -- 28,254,038(+) atcca(A/G)catgt intron-variant, upstream-variant-2KB
rs10537472 -- 28,258,769(+) TCTCC(-/A)AAAAA intron-variant, upstream-variant-2KB
rs10708573 -- 28,258,394(+) AGTCT(-/C)CCTAG intron-variant, upstream-variant-2KB
rs111310846 -- 28,257,170(+) TCTTT(-/TGTTA)TAAGT intron-variant
rs111419901 -- 28,244,589(+) GGCAT(A/G)AGTTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZKSCAN4 Gene

Variant ID Type Subtype PubMed ID
nsv830620 CNV loss 17160897

Variation tolerance for ZKSCAN4 Gene

Residual Variation Intolerance Score: 77% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.41; 71.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZKSCAN4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZKSCAN4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZKSCAN4 Gene

Disorders for ZKSCAN4 Gene

Relevant External Links for ZKSCAN4

Genetic Association Database (GAD)
ZKSCAN4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZKSCAN4

No disorders were found for ZKSCAN4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZKSCAN4 Gene

Publications for ZKSCAN4 Gene

  1. A RAS recruitment screen identifies ZKSCAN4 as a glucocorticoid receptor-interacting protein. (PMID: 19008334) Ecker K. … Helmberg A. (J. Mol. Endocrinol. 2009) 2 3 64
  2. ZNF307, a novel zinc finger gene suppresses p53 and p21 pathway. (PMID: 17910948) Li J. … Wu X. (Biochem. Biophys. Res. Commun. 2007) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64

Products for ZKSCAN4 Gene

Sources for ZKSCAN4 Gene

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