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Aliases for ZKSCAN4 Gene

Aliases for ZKSCAN4 Gene

  • Zinc Finger With KRAB And SCAN Domains 4 2 3
  • Zinc Finger Protein 307 2 3 4
  • Zinc Finger Protein 427 2 3 4
  • ZNF307 3 4 6
  • ZNF427 3 4
  • Zinc Finger Protein With KRAB And SCAN Domains 4 3
  • P373c6.1 (Novel C2H2 Type Zinc Finger Protein) 3
  • EC 4.2.1.52 63
  • EC 2.1.1.43 63
  • P1P373C6 3
  • P373c6.1 4
  • ZSCAN36 3

External Ids for ZKSCAN4 Gene

Previous HGNC Symbols for ZKSCAN4 Gene

  • ZNF307
  • ZNF427

Previous GeneCards Identifiers for ZKSCAN4 Gene

  • GC06M028324
  • GC06M028212
  • GC06M028021

Summaries for ZKSCAN4 Gene

GeneCards Summary for ZKSCAN4 Gene

ZKSCAN4 (Zinc Finger With KRAB And SCAN Domains 4) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF396.

UniProtKB/Swiss-Prot for ZKSCAN4 Gene

  • May be involved in the transcriptional activation of MDM2 and EP300 genes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZKSCAN4 Gene

Genomics for ZKSCAN4 Gene

Regulatory Elements for ZKSCAN4 Gene

Genomic Location for ZKSCAN4 Gene

Start:
28,244,623 bp from pter
End:
28,259,252 bp from pter
Size:
14,630 bases
Orientation:
Minus strand

Genomic View for ZKSCAN4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZKSCAN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZKSCAN4 Gene

Proteins for ZKSCAN4 Gene

  • Protein details for ZKSCAN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969J2-ZKSC4_HUMAN
    Recommended name:
    Zinc finger protein with KRAB and SCAN domains 4
    Protein Accession:
    Q969J2
    Secondary Accessions:
    • B2RE32
    • Q5U7L4

    Protein attributes for ZKSCAN4 Gene

    Size:
    545 amino acids
    Molecular mass:
    61579 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZKSCAN4 Gene

Proteomics data for ZKSCAN4 Gene at MOPED

Selected DME Specific Peptides for ZKSCAN4 Gene

Post-translational modifications for ZKSCAN4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZKSCAN4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ZKSCAN4 Gene

Gene Families for ZKSCAN4 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZKSCAN4 Gene

Graphical View of Domain Structure for InterPro Entry

Q969J2

UniProtKB/Swiss-Prot:

ZKSC4_HUMAN :
  • Q969J2
Domain:
  • Contains 1 KRAB domain.
  • Contains 1 SCAN box domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 7 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZKSCAN4: view

Function for ZKSCAN4 Gene

Molecular function for ZKSCAN4 Gene

UniProtKB/Swiss-Prot Function: May be involved in the transcriptional activation of MDM2 and EP300 genes.

Enzyme Numbers (IUBMB) for ZKSCAN4 Gene

Gene Ontology (GO) - Molecular Function for ZKSCAN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZKSCAN4: view

Phenotypes for ZKSCAN4 Gene

GenomeRNAi human phenotypes for ZKSCAN4:
genes like me logo Genes that share phenotypes with ZKSCAN4: view

Animal Model Products

CRISPR Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZKSCAN4 Gene

Localization for ZKSCAN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZKSCAN4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZKSCAN4 Gene COMPARTMENTS Subcellular localization image for ZKSCAN4 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ZKSCAN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZKSCAN4: view

Pathways for ZKSCAN4 Gene

SuperPathways for ZKSCAN4 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZKSCAN4: view

Pathways by source for ZKSCAN4 Gene

2 Reactome pathways for ZKSCAN4 Gene

Gene Ontology (GO) - Biological Process for ZKSCAN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZKSCAN4: view

Transcripts for ZKSCAN4 Gene

mRNA/cDNA for ZKSCAN4 Gene

Unigene Clusters for ZKSCAN4 Gene

Zinc finger with KRAB and SCAN domains 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZKSCAN4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZKSCAN4 Gene

No ASD Table

Relevant External Links for ZKSCAN4 Gene

GeneLoc Exon Structure for
ZKSCAN4
ECgene alternative splicing isoforms for
ZKSCAN4

Expression for ZKSCAN4 Gene

mRNA expression in normal human tissues for ZKSCAN4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZKSCAN4 Gene

SOURCE GeneReport for Unigene cluster for ZKSCAN4 Gene Hs.44720

mRNA Expression by UniProt/SwissProt for ZKSCAN4 Gene

Q969J2-ZKSC4_HUMAN
Tissue specificity: Expressed in adult heart, brain, placenta, lung and kidney, but not in adult liver and skeletal muscle. In 17-day old embryo, detected in liver, skeletal muscle, brain, heart and small intestine.
genes like me logo Genes that share expressions with ZKSCAN4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZKSCAN4 Gene

Orthologs for ZKSCAN4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZKSCAN4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZKSCAN4 35
  • 99.51 (n)
  • 99.27 (a)
ZKSCAN4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 82 (a)
OneToMany
LOC539620 35
  • 86.32 (n)
  • 82.26 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 76 (a)
OneToMany
ZKSCAN4 35
  • 82.9 (n)
  • 76.29 (a)
mouse
(Mus musculus)
Mammalia Zkscan4 36
  • 75 (a)
ManyToMany
Species with no ortholog for ZKSCAN4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZKSCAN4 Gene

ENSEMBL:
Gene Tree for ZKSCAN4 (if available)
TreeFam:
Gene Tree for ZKSCAN4 (if available)

Paralogs for ZKSCAN4 Gene

Selected SIMAP similar genes for ZKSCAN4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZKSCAN4: view

Variants for ZKSCAN4 Gene

Sequence variations from dbSNP and Humsavar for ZKSCAN4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs13408 -- 28,244,970(-) TGAGA(C/T)GATGA utr-variant-3-prime
rs1150712 -- 28,245,461(-) AAGCC(A/C/G/T)TACCA reference, synonymous-codon
rs1233710 -- 28,247,668(+) AGGGC(C/T)AGGCC intron-variant
rs1679732 -- 28,253,486(+) GGTAG(A/G)GGGCA upstream-variant-2KB, intron-variant
rs1736895 -- 28,252,048(-) CCACC(C/T)TTCCA utr-variant-5-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZKSCAN4 Gene

Variant ID Type Subtype PubMed ID
nsv830620 CNV Loss 17160897

Relevant External Links for ZKSCAN4 Gene

HapMap Linkage Disequilibrium report
ZKSCAN4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZKSCAN4 Gene

Disorders for ZKSCAN4 Gene

Relevant External Links for ZKSCAN4

Genetic Association Database (GAD)
ZKSCAN4
genes like me logo Genes that share disorders with ZKSCAN4: view

No data available for UniProtKB/Swiss-Prot for ZKSCAN4 Gene

Publications for ZKSCAN4 Gene

  1. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. ZNF307, a novel zinc finger gene suppresses p53 and p21 pathway. (PMID: 17910948) Li J. … Wu X. (Biochem. Biophys. Res. Commun. 2007) 3 4
  5. A RAS recruitment screen identifies ZKSCAN4 as a glucocorticoid receptor-interacting protein. (PMID: 19008334) Ecker K. … Helmberg A. (J. Mol. Endocrinol. 2009) 2 3

Products for ZKSCAN4 Gene

Sources for ZKSCAN4 Gene

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