ZKSCAN4 Gene
protein-coding GIFtS: 49
GCID: GC06M028212
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zinc finger with KRAB and SCAN domains 4(Previous names: zinc finger protein 307, zinc finger protein 427 ) (Previous symbols: ZNF307, ZNF427)
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Aliases for ZKSCAN4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Zinc Finger With KRAB And SCAN Domains 41 2 | | P373c6.13 | | ZNF3071 2 3 5 | | FLJ321361 | | Zinc Finger Protein 3071 2 3 | | P373c6.1 (Novel C2H2 Type Zinc Finger Protein)2 | | Zinc Finger Protein 4271 2 3 | | Zinc Finger Protein With KRAB And SCAN Domains 42 | | ZNF4271 2 3 | | P373c6.13 | | P1P373C61 2 | | EC 2.1.1.438 | | ZSCAN361 2 | | EC 4.2.1.528 |
Export aliases for ZKSCAN4 gene to outside databasesPrevious GC identifers: GC06M028324 GC06M028021 |
Summaries for ZKSCAN4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: ZKSC4_HUMAN, Q969J2Function: May be involved in the transcriptional activation of MDM2 and EP300 genes
|
Genomic Views for ZKSCAN4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ZKSCAN4 gene promoter: p53 Brachyury p300 LUN-1 LCR-F1 Roaz c-Ets-1 C/EBPalpha GATA-1 AREB6 Other transcription factors
Search SABiosciences Chromatin IP Primers for ZKSCAN4
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZKSCAN4 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21 Ensembl cytogenetic band: 6p22.1 HGNC cytogenetic band: 6p21ZKSCAN4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M028212: view genomic region
(about GC identifiers)
Start:
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28,212,401 bp from pter |
End:
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28,227,011 bp from pter |
Size:
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14,611 bases |
Orientation:
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minus strand |
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Proteins for ZKSCAN4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: ZKSC4_HUMAN, Q969J2 (See
protein sequence)Recommended Name: Zinc finger protein with KRAB and SCAN domains 4 Size: 545 amino acids; 61579 Da
Subcellular location: Nucleus
Secondary accessions: B2RE32 Q5U7L4Explore the universe of human proteins at neXtProt for ZKSCAN4: NX_Q969J2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q969J2 2 DME Specific Peptides for ZKSCAN4 (Q969J2)
ZKSCAN4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_061983.2 ENSEMBL proteins: ENSP00000366509 ENSP00000401978 Reactome Protein details: Q969J2 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZKSCAN4 for ontologies About GeneDecksing
ZKSCAN4 Antibody Products: Assay Products for ZKSCAN4: |
Protein
Domains / Families for ZKSCAN4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZKSCAN4 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q969J2ProtoNet protein and cluster: Q969J2 3 Blocks protein families: IPB001909 KRAB box IPB003309 Transcriptional regulator SCAN IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZKSC4_HUMAN, Q969J2Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 7 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domainSimilarity: Contains 1 SCAN box domain |
Function for ZKSCAN4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: ZKSC4_HUMAN, Q969J2Function: May be involved in the transcriptional activation of MDM2 and EP300 genesEnzyme Numbers (IUBMB): EC 2.1.1.432 EC 4.2.1.522
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZKSCAN4 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZKSCAN4 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZKSCAN4 (NM_019110) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZKSCAN4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZKSCAN4  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZKSCAN4 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003676 | nucleic acid binding |
-- | -- | | GO:0003677 | DNA binding |
IEA | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
ZKSCAN4 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZKSCAN4:
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Pathways & Interactions for ZKSCAN4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources See GeneCards unified pathways Show all pathways
2
Reactome Pathways for ZKSCAN4
ZKSCAN4 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZKSCAN4
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
 1 Interacting protein for ZKSCAN4 (Q969J23 ENSP000003665094) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- | | GO:0016032 | viral reproduction |
IEA | -- |
ZKSCAN4 for ontologies About GeneDecksing
|
Drugs & Compounds for ZKSCAN4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for ZKSCAN4 Search CenterWatch for drugs/clinical trials and news about ZKSCAN4 / ZKSC4 
|
Transcripts for ZKSCAN4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for ZKSCAN4 gene: NM_019110.3 Unigene Cluster for ZKSCAN4: Zinc finger with KRAB and SCAN domains 4 Hs.44720 [show with all ESTs]Unigene Representative Sequence: AY7817782 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000377294(uc003nks.1 uc011dlb.1) ENST00000423974
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZKSCAN4 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZKSCAN4 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZKSCAN4 (NM_019110) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZKSCAN4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZKSCAN4  |
Additional cDNA sequence: AK302017.1 AK315783.1 AY781778.1 BC014031.2 4 DOTS entries: DT.309108 DT.95286179 DT.100702103 DT.102821185 24/57 AceView cDNA sequences (see all 57): T08471 AW594039 AI139333 BM973187 BQ006541 NM_019110 AW135346 AI251024 AL040316 BG431384 AI638854 BC014031 AK056698 CA424165 CR625010 AA580929 AA808566 BE549809 BM546455 AA226879 F06540 AL555537 BG614793 T08470 GeneLoc Exon Structure
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Expression for ZKSCAN4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZKSCAN4 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: AGGTCTTTTA
About this image See ZKSCAN4 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ZKSCAN4
SOURCE GeneReport for Unigene cluster: Hs.44720 UniProtKB/Swiss-Prot: ZKSC4_HUMAN, Q969J2Tissue specificity: Expressed in adult heart, brain, placenta, lung and kidney, but not in adult liver and skeletalmuscle. In 17-day old embryo, detected in liver, skeletal muscle, brain, heart and small intestine SABiosciences Custom PCR Arrays for ZKSCAN4
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZKSCAN4 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZKSCAN4 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZKSCAN4 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZKSCAN4 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZKSCAN4 |
Orthologs for ZKSCAN4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZKSCAN4 (if available) TreeFam Gene Tree for ZKSCAN4 (if available)  |
Paralogs for ZKSCAN4 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for ZKSCAN4 gene
- ZNF4962 ZNF4492 ZNF4462 ZSCAN92 ZKSCAN12 ZNF3972 ZNF5002 ZNF2132
- ZSCAN302 ZNF2322 ZNF2632 ZNF2022 ZNF1742 ZSCAN252 ZNF3962 ZSCAN122
- ZNF3942 ZSCAN212 ZSCAN232 ZNF1652 ZSCAN162 ZKSCAN82 ZSCAN312 ZSCAN222
- ZKSCAN32 ZNF242 ZNF182
18/487 SIMAP similar genes for ZKSCAN4 using alignment to 2 protein entries: ZKSC4_HUMAN (see all proteins)
(see all similar genes):ZKSCAN3 ZNF78L1 ZNF56 ZNF826P HZF16 ZNF883 ZNF ZFP41 ZFS-6 ZNF595 ZNF345 HZF40 HZF41 ZFS-4 ZNF180 smap-7 ZFP2 ZFS-5
ZKSCAN4 for paralogs About GeneDecksing
|
Genomic Variants for ZKSCAN4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 6 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for ZKSCAN4 (28212401 - 28227011 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for ZKSCAN4 1 CNV: 4491  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZKSCAN4 |
|
Disorders
/ Diseases for ZKSCAN4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZKSCAN4 for disorders About MalaCards
ZKSCAN4 for disorders About GeneDecksing
OMIM gene information: 611643
OMIM disorders: --
Export disorders for ZKSCAN4 gene to outside databases
|
Publications for ZKSCAN4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZKSCAN4 gene integrated from 9 sources: (articles sorted by number of sources associating them with ZKSCAN4) | |  | Utopia: connect your pdf to the dynamic world of online information |
- ZNF307, a novel zinc finger gene suppresses p53 and p21 pathway. (PubMed id 17910948)1, 2 Li J.... Wu X. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- The protein network surrounding the human telomere re peat binding factors TRF1, TRF2, and POT1. (PubMed id 20811636)1 Giannone R.J....Liu Y. (2010)
- A RAS recruitment screen identifies ZKSCAN4 as a glucocorticoid receptor-interacting protein. (PubMed id 19008334)1 Ecker K....Helmberg A. (2009)
- ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)2 Matsuoka S.... Elledge S.J. (2007)
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External Searches for ZKSCAN4 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
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Genome Databases showing ZKSCAN4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZKSCAN4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZKSCAN4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for ZKSCAN4 | Pharmacogenomics, SNPs, Pathways |
|
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About This Section
| Patent Information for ZKSCAN4 gene: Search GeneIP for patents involving ZKSCAN4
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for ZKSCAN4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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variant library, vector shuttling | | OriGene Custom Antibody Services for ZKSCAN4 | | OriGene Custom Protein Services for ZKSCAN4 | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZKSCAN4 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZKSCAN4 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZKSCAN4 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZKSCAN4 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZKSCAN4 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZKSCAN4 |
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| | | Search Tocris compounds for ZKSCAN4 |
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 | | ZKSCAN4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZKSCAN4 |
|  |  |  | | | Search ThermoFisher Antibodies for ZKSCAN4 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZKSCAN4 |
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