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Aliases for ZKSCAN3 Gene

Aliases for ZKSCAN3 Gene

  • Zinc Finger With KRAB And SCAN Domains 3 2 3
  • Zinc Finger Protein 306 2 3 4
  • Zinc Finger Protein 309 2 3 4
  • ZNF306 3 4 6
  • Zinc Finger And SCAN Domain-Containing Protein 13 3 4
  • Zinc Finger Protein 47 Homolog 3 4
  • ZSCAN13 3 4
  • Zfp-47 3 4
  • ZNF309 3 4
  • Zfp47 3 4
  • ZF47 3 4
  • Zinc Finger Protein With KRAB And SCAN Domains 3 3
  • Zinc Finger Protein Zfp47 3
  • DJ874C20.1. 3
  • DJ874C20.1 3
  • ZSCAN35 3
  • ZFP306 3

External Ids for ZKSCAN3 Gene

Previous HGNC Symbols for ZKSCAN3 Gene

  • ZNF306
  • ZNF309

Previous GeneCards Identifiers for ZKSCAN3 Gene

  • GC06P028426
  • GC06P028124

Summaries for ZKSCAN3 Gene

GeneCards Summary for ZKSCAN3 Gene

ZKSCAN3 (Zinc Finger With KRAB And SCAN Domains 3) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is ZNF396.

UniProtKB/Swiss-Prot for ZKSCAN3 Gene

  • Transcriptional factor that binds to the consensus sequence 5-[GT][AG][AGT]GGGG-3 and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migation in various tumors and myelomas.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZKSCAN3 Gene

Genomics for ZKSCAN3 Gene

Regulatory Elements for ZKSCAN3 Gene

Genomic Location for ZKSCAN3 Gene

Start:
28,349,913 bp from pter
End:
28,369,177 bp from pter
Size:
19,265 bases
Orientation:
Plus strand

Genomic View for ZKSCAN3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZKSCAN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZKSCAN3 Gene

Proteins for ZKSCAN3 Gene

  • Protein details for ZKSCAN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRR0-ZKSC3_HUMAN
    Recommended name:
    Zinc finger protein with KRAB and SCAN domains 3
    Protein Accession:
    Q9BRR0
    Secondary Accessions:
    • B2R8W2
    • B3KVC0
    • H7BXX1
    • Q5VXH3
    • Q92972
    • Q9H4T3

    Protein attributes for ZKSCAN3 Gene

    Size:
    538 amino acids
    Molecular mass:
    60641 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZKSCAN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZKSCAN3 Gene

Proteomics data for ZKSCAN3 Gene at MOPED

Post-translational modifications for ZKSCAN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZKSCAN3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ZKSCAN3 Gene

Domains for ZKSCAN3 Gene

Gene Families for ZKSCAN3 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZKSCAN3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BRR0

UniProtKB/Swiss-Prot:

ZKSC3_HUMAN :
  • Q9BRR0
Domain:
  • Contains 1 KRAB domain.
  • Contains 1 SCAN box domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 7 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZKSCAN3: view

Function for ZKSCAN3 Gene

Molecular function for ZKSCAN3 Gene

UniProtKB/Swiss-Prot Function: Transcriptional factor that binds to the consensus sequence 5-[GT][AG][AGT]GGGG-3 and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migation in various tumors and myelomas.
UniProtKB/Swiss-Prot Induction: Overexpressed in various tumors, such as multiple myeloma, colorectal and prostate cancers (at protein level).

Gene Ontology (GO) - Molecular Function for ZKSCAN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 18940803
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA 18940803
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IDA 18940803
GO:0003682 chromatin binding IDA 18940803
genes like me logo Genes that share ontologies with ZKSCAN3: view

Animal Model Products

CRISPR Products

miRNA for ZKSCAN3 Gene

miRTarBase miRNAs that target ZKSCAN3

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZKSCAN3 Gene

Localization for ZKSCAN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZKSCAN3 Gene

Nucleus. Cytoplasm. Note=Mainly localizes in the nucleus. Under starvation conditions translocates to the cytoplasm, allowing expression of target genes involved in autophagy and lysosome biogenesis/function.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZKSCAN3 Gene COMPARTMENTS Subcellular localization image for ZKSCAN3 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ZKSCAN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 18940803
GO:0005737 cytoplasm IDA 23434374
genes like me logo Genes that share ontologies with ZKSCAN3: view

Pathways for ZKSCAN3 Gene

SuperPathways for ZKSCAN3 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZKSCAN3: view

Pathways by source for ZKSCAN3 Gene

2 Reactome pathways for ZKSCAN3 Gene

Gene Ontology (GO) - Biological Process for ZKSCAN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 18940803
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006914 autophagy IEA --
GO:0007040 lysosome organization IMP 23434374
genes like me logo Genes that share ontologies with ZKSCAN3: view

Transcripts for ZKSCAN3 Gene

Unigene Clusters for ZKSCAN3 Gene

Zinc finger with KRAB and SCAN domains 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZKSCAN3

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZKSCAN3 Gene

No ASD Table

Relevant External Links for ZKSCAN3 Gene

GeneLoc Exon Structure for
ZKSCAN3
ECgene alternative splicing isoforms for
ZKSCAN3

Expression for ZKSCAN3 Gene

mRNA expression in normal human tissues for ZKSCAN3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZKSCAN3 Gene

SOURCE GeneReport for Unigene cluster for ZKSCAN3 Gene Hs.380930

genes like me logo Genes that share expressions with ZKSCAN3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZKSCAN3 Gene

Orthologs for ZKSCAN3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZKSCAN3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZKSCAN3 35
  • 99.26 (n)
  • 99.07 (a)
ZKSCAN3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 75 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 72 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zkscan3 35
  • 79.8 (n)
  • 73.3 (a)
Zkscan3 16
Zkscan3 36
  • 70 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Zkscan3 35
  • 80.01 (n)
  • 74.38 (a)
Species with no ortholog for ZKSCAN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZKSCAN3 Gene

ENSEMBL:
Gene Tree for ZKSCAN3 (if available)
TreeFam:
Gene Tree for ZKSCAN3 (if available)

Paralogs for ZKSCAN3 Gene

Selected SIMAP similar genes for ZKSCAN3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZKSCAN3: view

Variants for ZKSCAN3 Gene

Sequence variations from dbSNP and Humsavar for ZKSCAN3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs213227 - 28,363,796(+) AACCA(A/T)GGCAG missense, reference
rs213228 -- 28,363,475(-) AGGAT(G/T)GGGGT intron-variant
rs213229 -- 28,362,910(+) AGGAT(C/T)TTCAG intron-variant
rs213230 -- 28,362,487(+) AAGAT(A/G)TACAT intron-variant
rs213231 -- 28,359,211(+) GGTTG(G/T)TAATG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZKSCAN3 Gene

Variant ID Type Subtype PubMed ID
nsv830620 CNV Loss 17160897

Relevant External Links for ZKSCAN3 Gene

HapMap Linkage Disequilibrium report
ZKSCAN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZKSCAN3 Gene

Disorders for ZKSCAN3 Gene

Relevant External Links for ZKSCAN3

Genetic Association Database (GAD)
ZKSCAN3
genes like me logo Genes that share disorders with ZKSCAN3: view

No data available for UniProtKB/Swiss-Prot for ZKSCAN3 Gene

Publications for ZKSCAN3 Gene

  1. Computer sequence analysis of human highly conserved zinc finger modules. (PMID: 10520746) Petroni D. … Comi P. (DNA Seq. 1998) 2 3 4
  2. The zinc finger transcription factor ZKSCAN3 promotes prostate cancer cell migration. (PMID: 22531714) Zhang X. … Yang L. (Int. J. Biochem. Cell Biol. 2012) 2 3 4
  3. ZKSCAN3 is a master transcriptional repressor of autophagy. (PMID: 23434374) Chauhan S. … Boyd D.D. (Mol. Cell 2013) 3 4
  4. The previously undescribed ZKSCAN3 (ZNF306) is a novel 'driver' of colorectal cancer progression. (PMID: 18519692) Yang L. … Boyd D.D. (Cancer Res. 2008) 3 4
  5. Unbiased screening for transcriptional targets of ZKSCAN3 identifies integrin beta 4 and vascular endothelial growth factor as downstream targets. (PMID: 18940803) Yang L. … Boyd D.D. (J. Biol. Chem. 2008) 3 4

Products for ZKSCAN3 Gene

Sources for ZKSCAN3 Gene

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