Aliases for ZKSCAN3 Gene
External Ids for ZKSCAN3 Gene
Previous HGNC Symbols for ZKSCAN3 Gene
Previous GeneCards Identifiers for ZKSCAN3 Gene
GeneCards Summary for ZKSCAN3 Gene
ZKSCAN3 (Zinc Finger With KRAB And SCAN Domains 3) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is ZNF396.
UniProtKB/Swiss-Prot for ZKSCAN3 Gene
Transcriptional factor that binds to the consensus sequence 5-[GT][AG][AGT]GGGG-3 and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migation in various tumors and myelomas.