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ZKSCAN3 Gene

protein-coding   GIFtS: 51
GCID: GC06P028317

Zinc Finger With KRAB And SCAN Domains 3

(Previous names: zinc finger protein 306, zinc finger protein 309)
(Previous symbols: ZNF306, ZNF309)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger With KRAB And SCAN Domains 31 2     ZSCAN352
ZNF3061 2 3 5     Zfp472
Zinc Finger Protein 3061 2 3     dJ874C20.12
Zinc Finger Protein 3091 2 3     zfp-472
ZNF3091 2 3     Zinc Finger Protein With KRAB And SCAN Domains 32
Zinc Finger And SCAN Domain-Containing Protein 132 3     Zinc Finger Protein Zfp472
Zinc Finger Protein 47 Homolog2 3     ZFP473
ZSCAN132 3     Zf473
ZF472     Zfp-473
ZFP3062     

External Ids:    HGNC: 138531   Entrez Gene: 803172   Ensembl: ENSG000001892987   OMIM: 6127915   UniProtKB: Q9BRR03   

Export aliases for ZKSCAN3 gene to outside databases

Previous GC identifers: GC06P028426 GC06P028124


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZKSCAN3 Gene:
ZKSCAN3 (zinc finger with KRAB and SCAN domains 3) is a protein-coding gene. Diseases associated with ZKSCAN3 include multiple myeloma, and myeloma. GO annotations related to this gene include chromatin binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF446.

UniProtKB/Swiss-Prot: ZKSC3_HUMAN, Q9BRR0
Function: Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a
repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome
biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters.
Also acts as a transcription activator and promotes cancer cell progression and/or migation in various tumors and
myelomas




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZKSCAN3 gene promoter:
         GCNF   LUN-1   AP-2gamma   c-Ets-1   GCNF-1   Cart-1   AP-2beta   GCNF-2   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZKSCAN3 promoter sequence
   Search Chromatin IP Primers for ZKSCAN3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZKSCAN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p22.1

ZKSCAN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZKSCAN3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P028317:  view genomic region     (about GC identifiers)

Start:
28,317,691 bp from pter      End:
28,336,954 bp from pter
Size:
19,264 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZKSC3_HUMAN, Q9BRR0 (See protein sequence)
Recommended Name: Zinc finger protein with KRAB and SCAN domains 3  
Size: 538 amino acids; 60641 Da
Secondary accessions: B2R8W2 B3KVC0 H7BXX1 Q5VXH3 Q92972 Q9H4T3
Alternative splicing: 2 isoforms:  Q9BRR0-1   Q9BRR0-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZKSCAN3: NX_Q9BRR0

Explore proteomics data for ZKSCAN3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZKSCAN3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001229823.1  NP_001229824.1  NP_077819.2  

    ENSEMBL proteins: 
     ENSP00000341883   ENSP00000366465   ENSP00000252211  
    Reactome Protein details: Q9BRR0

    ZKSCAN3 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    Selected InterPro protein domains (see all 6):
     IPR001909 Krueppel-associated_box
     IPR008916 Retrov_capsid_C
     IPR003309 Tscrpt_reg_SCAN
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd

    Graphical View of Domain Structure for InterPro Entry Q9BRR0

    ProtoNet protein and cluster: Q9BRR0

    3 Blocks protein domains:
    IPB001909 KRAB box
    IPB003309 Transcriptional regulator SCAN
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZKSC3_HUMAN, Q9BRR0
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 7 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain
    Similarity: Contains 1 SCAN box domain


    ZKSCAN3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZKSC3_HUMAN, Q9BRR0
    Function: Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a
    repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome
    biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters.
    Also acts as a transcription activator and promotes cancer cell progression and/or migation in various tumors and
    myelomas
    Induction: Overexpressed in various tumors, such as multiple myeloma, colorectal and prostate cancers (at protein
    level)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IDA18940803
    GO:0003682chromatin binding IDA18940803
    GO:0003700sequence-specific DNA binding transcription factor activity IDA--
    GO:0043565sequence-specific DNA binding IDA--
         
    ZKSCAN3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZKSCAN3
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    miRNA
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    miRTarBase miRNAs that target ZKSCAN3:
    hsa-mir-26b-5p (MIRT029358)

    Block miRNA regulation of human, mouse, rat ZKSCAN3 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate ZKSCAN3:
    hsa-miR-374b* hsa-miR-3910 hsa-miR-549 hsa-miR-124 hsa-miR-561 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidZKSCAN3 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat ZKSCAN3

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: ZKSCAN3 (NM_024493)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZKSCAN3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZKSC3_HUMAN, Q9BRR0: Nucleus. Cytoplasm. Note=Mainly localizes in the nucleus. Under starvation conditions
    translocates to the cytoplasm, allowing expression of target genes involved in autophagy and lysosome
    biogenesis/function
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA18940803
    GO:0005737cytoplasm IDA--

    ZKSCAN3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZKSCAN3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZKSCAN3
        Generic Transcription Pathway



    ZKSCAN3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZKSCAN3
    Interactions:

        Search GeneGlobe Interaction Network for ZKSCAN3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ZKSCAN3 (Q9BRR03 ENSP000002522114) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629933, ENSP000003390074I2D: score=1 STRING: ENSP00000339007
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006914autophagy IEA--
    GO:0007040lysosome organization IMP--
    GO:0010507negative regulation of autophagy IMP--

    ZKSCAN3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZKSCAN3 (ZKSC3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZKSCAN3 gene (3 alternative transcripts): 
    NM_001242894.1  NM_001242895.1  NM_024493.3  

    Unigene Cluster for ZKSCAN3:

    Zinc finger with KRAB and SCAN domains 3
    Hs.380930  [show with all ESTs]
    Unigene Representative Sequence: NM_001242894
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341464 ENST00000377255 ENST00000252211(uc010jrc.3 uc003nle.4 uc003nlf.4)

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate ZKSCAN3:
    hsa-miR-374b* hsa-miR-3910 hsa-miR-549 hsa-miR-124 hsa-miR-561 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidZKSCAN3 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat ZKSCAN3
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZKSCAN3 (NM_024493)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZKSCAN3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZKSCAN3
    Primer
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    OriGene qPCR primer pairs and template standards for ZKSCAN3
    OriGene qSTAR qPCR primer pairs in human, mouse for ZKSCAN3
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      QuantiTect SYBR Green Assays in human, mouse, rat ZKSCAN3
      QuantiFast Probe-based Assays in human, mouse, rat ZKSCAN3

    Additional mRNA sequence: 

    AK091225.1 AK122790.1 AK313532.1 BC006118.1 BT007427.1 U71601.1 

    9 DOTS entries:

    DT.208564  DT.305121  DT.100020799  DT.97833050  DT.91716187  DT.97785867  DT.92420792  DT.121321685 
    DT.97790119 

    Selected AceView cDNA sequences (see all 33):

    BM918366 BM762243 BX098589 AI299042 AI678222 BE278730 BT007427 BG390695 
    BF896711 AK091225 AI222318 BC006118 AA580382 NM_024493 AK122790 AX746861 
    CA395711 BU678604 AA987348 BQ423950 U71601 AI124541 M86009 AA304455 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZKSCAN3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZKSCAN3 Expression
    About this image

    ZKSCAN3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZKSCAN3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.380930
        Custom PCR Arrays for ZKSCAN3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZKSCAN3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZKSCAN3 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zkscan31 , 5 zinc finger with KRAB and SCAN domains 31, 5 79.8(n)1
    73.3(a)1
      13 (7.78 cM)5
    727391  NM_023685.41  NP_076174.31 
     213870135 


    ENSEMBL Gene Tree for ZKSCAN3 (if available)
    TreeFam Gene Tree for ZKSCAN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZKSCAN3 gene
    ZNF4462  ZSCAN92  ZKSCAN12  ZNF3972  ZNF5002  ZNF2132  ZNF2322  ZSCAN302  
    ZNF1742  ZNF32  ZKSCAN42  ZNF3962  ZSCAN122  ZNF3942  ZSCAN212  ZSCAN232  
    ZNF1652  ZSCAN162  ZKSCAN82  ZSCAN222  ZSCAN312  ZNF242  ZNF182  
    Selected SIMAP similar genes for ZKSCAN3 using alignment to 1 protein entry:     ZKSC3_HUMAN(see all similar genes):
    ZKSCAN4    DKFZp686G16228    ZNF883    HZF36    ZNF320    ZNF502
    HZF30    ZNF134    ZNF135    ZNF253    ZNF585B    ZNF71
    ZNF772    ZNF782    ZNF98    DKFZp686B16128    KIAA1829    ZFS-1

    ZKSCAN3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZKSCAN3 (see all 443)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs755303531,2
    C,F--28315728(+) TTTGCC/TTTTAT 3 -- us2k11Minor allele frequency- T:0.07EA 120
    rs1457901901,2
    C--28315739(+) TTAATG/TGCTAA 3 -- us2k10--------
    rs1910282291,2
    C--28315825(+) ATTTTG/TTTTCT 3 -- us2k10--------
    rs1477447311,2
    C--28315829(+) TTTTT-/CTGTAT 3 -- us2k10--------
    rs1117494411,2
    C--28315837(+) TATGATTGT/-  
            
    TGGCT
    3 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs2132401,2
    C,F,A,H--28315875(+) atgttC/Tattat 3 -- us2k1 tfbs320Minor allele frequency- T:0.39NS EA NA WA CSA 1894
    rs69420301,2
    C,F,A,H--28315958(+) tctttA/Tccatt 3 -- us2k115Minor allele frequency- T:0.49NS EA NA WA CSA 792
    rs1477886641,2
    C--28315974(+) CTAGTA/CTCTTT 3 -- us2k10--------
    rs606986361,2
    C,F--28316045(+) TGTTTA/GTGCAG 3 -- us2k15Minor allele frequency- G:0.14WA NA EA 362
    rs1469709661,2
    --28316357(+) AGTTCG/TGTTTC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZKSCAN3 (28317691 - 28336954 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZKSCAN3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830620CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZKSCAN3
    DNA2.0 Custom Variant and Variant Library Synthesis for ZKSCAN3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612791    OMIM disorders: --

    6 diseases for ZKSCAN3:    About MalaCards
    multiple myeloma    myeloma    colorectal cancer    prostate cancer
    prostatitis    endotheliitis


    ZKSCAN3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZKSCAN3

    Export disorders for ZKSCAN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZKSCAN3 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with ZKSCAN3)
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    1. The zinc finger transcription factor ZKSCAN3 promotes prostate cancer cell migration. (PubMed id 22531714)1, 2, 3 Zhang X.... Yang L. (Int. J. Biochem. Cell Biol. 2012)
    2. Computer sequence analysis of human highly conserved zinc finger modules. (PubMed id 10520746)1, 2, 3 Petroni D.... Comi P. (DNA Seq. 1998)
    3. ZKSCAN3 is a master transcriptional repressor of autophagy. (PubMed id 23434374)1, 2 Chauhan S....Boyd D.D. (Mol. Cell 2013)
    4. Evidence of a role for the novel zinc-finger transcription factor ZKSCAN3 in modulating Cyclin D2 expression in multiple myeloma. (PubMed id 21057542)1, 2 Yang L.... Orlowski R.Z. (Oncogene 2011)
    5. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. (PubMed id 21946350)1, 4 Soler Artigas M....Tobin M.D. (Nat. Genet. 2011)
    6. Unbiased screening for transcriptional targets of ZKSCAN3 identifies integrin beta 4 and vascular endothelial growth factor as downstream targets. (PubMed id 18940803)1, 2 Yang L.... Boyd D.D. (J. Biol. Chem. 2008)
    7. The previously undescribed ZKSCAN3 (ZNF306) is a novel 'driver' of colorectal cancer progression. (PubMed id 18519692)1, 2 Yang L.... Boyd D.D. (Cancer Res. 2008)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80317 HGNC: 13853 AceView: ZNF306 Ensembl:ENSG00000189298 euGenes: HUgn80317
    ECgene: ZKSCAN3 H-InvDB: ZKSCAN3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZKSCAN3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZKSCAN3 gene:
    Search GeneIP for patents involving ZKSCAN3

    GeneCards and IP:
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