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Aliases for ZKSCAN2 Gene

Aliases for ZKSCAN2 Gene

  • Zinc Finger With KRAB And SCAN Domains 2 2 3
  • Zinc Finger Protein 694 2 3 4
  • ZNF694 3 4
  • Zinc Finger Protein With KRAB And SCAN Domains 2 3
  • Zinc Finger And SCAN Domain Containing 31 3
  • ZSCAN31 3
  • ZSCAN34 3

External Ids for ZKSCAN2 Gene

Previous HGNC Symbols for ZKSCAN2 Gene

  • ZNF694

Previous GeneCards Identifiers for ZKSCAN2 Gene

  • GC16M025157
  • GC16M023340
  • GC16M025248

Summaries for ZKSCAN2 Gene

GeneCards Summary for ZKSCAN2 Gene

ZKSCAN2 (Zinc Finger With KRAB And SCAN Domains 2) is a Protein Coding gene. GO annotations related to this gene include chromatin binding and sequence-specific DNA binding RNA polymerase II transcription factor activity. An important paralog of this gene is ZSCAN32.

UniProtKB/Swiss-Prot for ZKSCAN2 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZKSCAN2 Gene

Genomics for ZKSCAN2 Gene

Regulatory Elements for ZKSCAN2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZKSCAN2 Gene

Start:
25,236,001 bp from pter
End:
25,257,931 bp from pter
Size:
21,931 bases
Orientation:
Minus strand

Genomic View for ZKSCAN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZKSCAN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZKSCAN2 Gene

Proteins for ZKSCAN2 Gene

  • Protein details for ZKSCAN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q63HK3-ZKSC2_HUMAN
    Recommended name:
    Zinc finger protein with KRAB and SCAN domains 2
    Protein Accession:
    Q63HK3
    Secondary Accessions:
    • A1L3B4
    • Q6ZN77

    Protein attributes for ZKSCAN2 Gene

    Size:
    967 amino acids
    Molecular mass:
    110941 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZKSCAN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZKSCAN2 Gene

Proteomics data for ZKSCAN2 Gene at MOPED

Post-translational modifications for ZKSCAN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZKSCAN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZKSCAN2 Gene

Domains for ZKSCAN2 Gene

Gene Families for ZKSCAN2 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZKSCAN2 Gene

Graphical View of Domain Structure for InterPro Entry

Q63HK3

UniProtKB/Swiss-Prot:

ZKSC2_HUMAN :
  • Q63HK3
Domain:
  • Contains 1 KRAB domain.
  • Contains 1 SCAN box domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 6 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZKSCAN2: view

Function for ZKSCAN2 Gene

Molecular function for ZKSCAN2 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZKSCAN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
genes like me logo Genes that share ontologies with ZKSCAN2: view

Phenotypes for ZKSCAN2 Gene

GenomeRNAi human phenotypes for ZKSCAN2:
genes like me logo Genes that share phenotypes with ZKSCAN2: view

Animal Model Products

CRISPR Products

miRNA for ZKSCAN2 Gene

miRTarBase miRNAs that target ZKSCAN2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZKSCAN2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZKSCAN2 Gene

Localization for ZKSCAN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZKSCAN2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZKSCAN2 Gene COMPARTMENTS Subcellular localization image for ZKSCAN2 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZKSCAN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular --
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with ZKSCAN2: view

Pathways for ZKSCAN2 Gene

SuperPathways for ZKSCAN2 Gene

No Data Available

Interacting Proteins for ZKSCAN2 Gene

Gene Ontology (GO) - Biological Process for ZKSCAN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter IBA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZKSCAN2: view

No data available for Pathways by source for ZKSCAN2 Gene

Transcripts for ZKSCAN2 Gene

Unigene Clusters for ZKSCAN2 Gene

Zinc finger with KRAB and SCAN domains 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZKSCAN2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZKSCAN2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZKSCAN2 Gene

No ASD Table

Relevant External Links for ZKSCAN2 Gene

GeneLoc Exon Structure for
ZKSCAN2
ECgene alternative splicing isoforms for
ZKSCAN2

Expression for ZKSCAN2 Gene

mRNA expression in normal human tissues for ZKSCAN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for ZKSCAN2 Gene Hs.513451

genes like me logo Genes that share expressions with ZKSCAN2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for ZKSCAN2 Gene

Orthologs for ZKSCAN2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZKSCAN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZKSCAN2 35
  • 99.72 (n)
  • 99.59 (a)
ZKSCAN2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZKSCAN2 35
  • 86.69 (n)
  • 85.94 (a)
ZKSCAN2 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZKSCAN2 35
  • 87.09 (n)
  • 88.1 (a)
ZKSCAN2 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zkscan2 35
  • 83.59 (n)
  • 81.92 (a)
Zkscan2 16
Zkscan2 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZKSCAN2 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 41 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Zkscan2 35
  • 83.42 (n)
  • 81.5 (a)
Species with no ortholog for ZKSCAN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZKSCAN2 Gene

ENSEMBL:
Gene Tree for ZKSCAN2 (if available)
TreeFam:
Gene Tree for ZKSCAN2 (if available)

Paralogs for ZKSCAN2 Gene

Paralogs for ZKSCAN2 Gene

Selected SIMAP similar genes for ZKSCAN2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZKSCAN2: view

Variants for ZKSCAN2 Gene

Sequence variations from dbSNP and Humsavar for ZKSCAN2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1019487 -- 25,251,099(-) TTGGG(G/T)TACaa intron-variant
rs2112811 - 25,251,957(-) GGGAC(C/T)TCTAC reference, missense
rs2112812 -- 25,236,955(-) CCCAC(C/T)TCAAC utr-variant-3-prime
rs2277961 -- 25,236,443(-) CGGCC(C/T)AGCTG utr-variant-3-prime
rs2345122 -- 25,237,373(+) TAGAG(A/G)TAGGG utr-variant-3-prime

Relevant External Links for ZKSCAN2 Gene

HapMap Linkage Disequilibrium report
ZKSCAN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZKSCAN2 Gene

Disorders for ZKSCAN2 Gene

No disorders were found for ZKSCAN2 Gene.

No data available for UniProtKB/Swiss-Prot for ZKSCAN2 Gene

Publications for ZKSCAN2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 4
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4

Products for ZKSCAN2 Gene

Sources for ZKSCAN2 Gene

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