ZKSCAN2 Gene
protein-coding GIFtS: 40
GCID: GC16M025248
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zinc finger with KRAB and SCAN domains 2(Previous name: zinc finger protein 694 )
(Previous symbol: ZNF694)
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Aliases
for ZKSCAN2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger With KRAB And SCAN Domains 21 2 | | FLJ231991 | | Zinc Finger Protein 6941 2 3 | | ZSCAN312 | | ZNF6941 2 3 | | Zinc Finger And SCAN Domain Containing 312 | | ZSCAN341 2 | | Zinc Finger Protein With KRAB And SCAN Domains 22 |
Export aliases for ZKSCAN2 gene to outside databasesPrevious GC identifers: GC16M025157 GC16M023340 |
Summaries
for ZKSCAN2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZKSC2_HUMAN, Q63HK3Function: May be involved in transcriptional regulation
|
Genomic Views
for ZKSCAN2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZKSCAN2 gene promoter:
p300 NRSF form 1 STAT5A NRSF form 2 YY1 HEN1 POU2F1 POU2F1a FOXJ2 (long isoform) FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZKSCAN2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZKSCAN2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p12.1 Ensembl cytogenetic band: 16p12.1 HGNC cytogenetic band: 16p12.1ZKSCAN2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M025248: view genomic region
(about GC identifiers)
Start:
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25,247,322 bp from pter |
End:
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25,269,252 bp from pter |
Size:
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21,931 bases |
Orientation:
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minus strand |
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Proteins
for ZKSCAN2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZKSC2_HUMAN, Q63HK3 (See
protein sequence)Recommended Name: Zinc finger protein with KRAB and SCAN domains 2 Size: 967 amino acids; 110941 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: A1L3B4 Q6ZN77Alternative splicing: 2 isoforms: Q63HK3-1 Q63HK3-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZKSCAN2: NX_Q63HK3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q63HK3
ZKSCAN2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001012999.3
ENSEMBL proteins: ENSP00000331626 ENSP00000455586
Human Recombinant Protein Products for ZKSCAN2:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZKSCAN2 for ontologies About GeneDecksing
ZKSCAN2 Antibody Products:
Assay Products for ZKSCAN2: |
Protein
Domains /
Families
for ZKSCAN2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZKSCAN2 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q63HK3ProtoNet protein and cluster: Q63HK3 3 Blocks protein families: IPB001005 Myb DNA-binding domain IPB001909 KRAB box IPB003309 Transcriptional regulator SCAN
UniProtKB/Swiss-Prot: ZKSC2_HUMAN, Q63HK3Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 6 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domainSimilarity: Contains 1 SCAN box domain |
Function
for ZKSCAN2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ZKSC2_HUMAN, Q63HK3Function: May be involved in transcriptional regulation Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
ZKSCAN2 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for ZKSCAN2:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZKSCAN2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZKSCAN2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZKSCAN2 (NM_001012981) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZKSCAN2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZKSCAN2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZKSCAN2 |
|
Pathways & Interactions
for ZKSCAN2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZKSCAN2
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0008150 | biological_process |
ND | -- | | GO:0016032 | viral reproduction |
IEA | -- |
ZKSCAN2 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZKSCAN2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZKSCAN2
Search CenterWatch for drugs/clinical trials and news about ZKSCAN2 / ZKSC2
|
Transcripts
for ZKSCAN2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZKSCAN2 gene: NM_001012981.4 Unigene Cluster for ZKSCAN2: Zinc finger with KRAB and SCAN domains 2 Hs.513451 [show with all ESTs]Unigene Representative Sequence: NM_0010129813 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000328086(uc002dod.4 uc010vcl.2) ENST00000569150 ENST00000565590(uc002doe.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZKSCAN2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZKSCAN2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZKSCAN2 (NM_001012981) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZKSCAN2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZKSCAN2 |
Additional cDNA sequence: AK026852.1 AK131342.1 AK302399.1 AK303472.1 BC130006.1 BC130007.1 BC151139.1 BX648785.1 4 DOTS entries: DT.97827205 DT.102821522 DT.120721995 DT.452435 24/36 AceView cDNA sequences (see all 36): AK131342 BM729201 BQ012184 BQ011452 BM682122 BQ011044 AK026852 BQ229357 BQ888909 BQ011586 BX648785 AA488123 AW965088 AA344007 AW449769 BM468762 BG290840 R19421 BQ011600 AA359984 BU165900 BQ773763 BU102138 BF328520
GeneLoc Exon Structure
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Expression
for ZKSCAN2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZKSCAN2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTCAGGAAA
About this image
See ZKSCAN2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZKSCAN2
SOURCE GeneReport for Unigene cluster: Hs.513451
SABiosciences Custom PCR Arrays for ZKSCAN2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZKSCAN2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZKSCAN2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZKSCAN2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZKSCAN2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZKSCAN2 |
Orthologs
for ZKSCAN2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZKSCAN2 (if available)
TreeFam Gene Tree for ZKSCAN2 (if available) |
Paralogs
for ZKSCAN2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZKSCAN2 gene
- ZSCAN322 SCAND12 ZSCAN202 ZSCAN292
18/291 SIMAP similar genes for ZKSCAN2 using alignment to 2 protein entries: ZKSC2_HUMAN (see all proteins)
(see all similar genes):ZNF78L1 ZNF483 ZNF818P ZSCAN31 DKFZp571N1833 ZFS-5
ZNF782 HZF16 ZFP41 ZNF211 ZNF286A ZNF702P
ZNF263 HZF36 ZNF329 ZNF585B ZNF ZFP1
ZKSCAN2 for paralogs About GeneDecksing
|
Genomic Variants
for ZKSCAN2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZKSCAN2 (25247322 - 25269252 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZKSCAN2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZKSCAN2 |
|
Disorders
/ Diseases
for ZKSCAN2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZKSCAN2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZKSCAN2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZKSCAN2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZKSCAN2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing ZKSCAN2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZKSCAN2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZKSCAN2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZKSCAN2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZKSCAN2 gene:
Search GeneIP for patents involving ZKSCAN2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZKSCAN2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZKSCAN2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZKSCAN2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZKSCAN2 | | | OriGene Protein Over-expression Lysate for ZKSCAN2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZKSCAN2 | | OriGene 3'-UTR Clone for ZKSCAN2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZKSCAN2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZKSCAN2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZKSCAN2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZKSCAN2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZKSCAN2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZKSCAN2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZKSCAN2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZKSCAN2 |
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 |  |  |  | |
| | | | Search Tocris compounds for ZKSCAN2 |
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 | | | ZKSCAN2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZKSCAN2 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for ZKSCAN2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZKSCAN2 |
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