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Aliases for ZKSCAN1 Gene

Aliases for ZKSCAN1 Gene

  • Zinc Finger With KRAB And SCAN Domains 1 2 3 5
  • Zinc Finger Protein 36 (KOX 18) 2 3
  • Zinc Finger Protein 139 3 4
  • ZNF139 3 4
  • ZNF36 3 4
  • KOX18 3 4
  • Zinc Finger Protein With KRAB And SCAN Domains 1 3
  • Zinc Finger Protein KOX18 4
  • Zinc Finger Protein 36 4
  • ZSCAN33 3
  • PHZ-37 3

External Ids for ZKSCAN1 Gene

Previous HGNC Symbols for ZKSCAN1 Gene

  • ZNF139
  • ZNF36

Previous GeneCards Identifiers for ZKSCAN1 Gene

  • GC07P099261
  • GC07P099451
  • GC07P099616
  • GC07P094248

Summaries for ZKSCAN1 Gene

Entrez Gene Summary for ZKSCAN1 Gene

  • This gene encodes a member of the Kruppel C2H2-type zinc-finger family of proteins. This encoded protein may function as a transcription factor that regulates the expression of GABA type-A receptors in the brain. Transcripts from this gene have been shown to form stable and abundant circular RNAs. Elevated expression of this gene has been observed in gastric cancer and the encoded protein may stimulate migration and invasion of human gastric cancer cells. [provided by RefSeq, Oct 2016]

GeneCards Summary for ZKSCAN1 Gene

ZKSCAN1 (Zinc Finger With KRAB And SCAN Domains 1) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZKSCAN8.

UniProtKB/Swiss-Prot for ZKSCAN1 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZKSCAN1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZKSCAN1 Gene

Genomics for ZKSCAN1 Gene

Regulatory Elements for ZKSCAN1 Gene

Enhancers for ZKSCAN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G100034 1.5 Ensembl ENCODE dbSUPER 12 +20.6 20611 3.9 ATF1 FOXA2 MLX ARID4B YY1 GATA2 FOS REST PPARG TBX21 AP4M1 TRIM4 ZKSCAN1 GC07P100035 GC07P100039
GH07G099943 0.9 Ensembl ENCODE 16.2 -71.1 -71114 2.3 CBX3 MAX ZNF140 CHD1 RBBP5 ATF2 ETS1 CBX1 BCL11A SCRT2 TRIM4 ZKSCAN1 ZSCAN21 ENSG00000199711 ENSG00000222966
GH07G100076 1.2 ENCODE 11.5 +64.5 64532 6.7 CREB3L1 MLX DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 MEF2D SSRP1 AP4M1 ZSCAN25 ZNF655 SMURF1 MBLAC1 PPP1R35 ZSCAN21 GIGYF1 STAG3L5P ENSG00000242798
GH07G100040 1.1 ENCODE dbSUPER 12.2 +26.1 26126 1.6 BCOR CTCF PKNOX1 ESRRA FOXA2 TAL1 JUN ZNF644 THRB RAD21 AP4M1 ZSCAN21 ZKSCAN1 COPS6 MIR93 MIR25 MIR106B MCM7 PILRA GC07P100039
GH07G100061 0.8 ENCODE 11.7 +46.3 46257 0.8 BCOR HDGF PKNOX1 CBX3 ARNT TAL1 TCF12 FOXM1 POLR2A GATA2 COPS6 MIR93 MIR106B MIR25 MCM7 ZKSCAN1 TRIM4 GC07M100084 PIR44616 PIR43713
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZKSCAN1 on UCSC Golden Path with GeneCards custom track

Promoters for ZKSCAN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000215726 728 1801 PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF207 ZNF143

Genomic Location for ZKSCAN1 Gene

Chromosome:
7
Start:
100,015,572 bp from pter
End:
100,045,143 bp from pter
Size:
29,572 bases
Orientation:
Plus strand

Genomic View for ZKSCAN1 Gene

Genes around ZKSCAN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZKSCAN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZKSCAN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZKSCAN1 Gene

Proteins for ZKSCAN1 Gene

  • Protein details for ZKSCAN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17029-ZKSC1_HUMAN
    Recommended name:
    Zinc finger protein with KRAB and SCAN domains 1
    Protein Accession:
    P17029
    Secondary Accessions:
    • A4D294
    • P52745
    • Q2M1U1
    • Q8TBW5
    • Q8TEK7

    Protein attributes for ZKSCAN1 Gene

    Size:
    563 amino acids
    Molecular mass:
    63630 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC50264.1; Type=Frameshift; Positions=241; Evidence={ECO:0000305};

neXtProt entry for ZKSCAN1 Gene

Post-translational modifications for ZKSCAN1 Gene

  • Ubiquitination at isoforms=181 and posLast=478478
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZKSCAN1 Gene

Domains & Families for ZKSCAN1 Gene

Gene Families for ZKSCAN1 Gene

Graphical View of Domain Structure for InterPro Entry

P17029

UniProtKB/Swiss-Prot:

ZKSC1_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZKSCAN1: view

Function for ZKSCAN1 Gene

Molecular function for ZKSCAN1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZKSCAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA,NAS 7557990
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZKSCAN1: view
genes like me logo Genes that share phenotypes with ZKSCAN1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZKSCAN1 Gene

Localization for ZKSCAN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZKSCAN1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZKSCAN1 gene
Compartment Confidence
nucleus 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for ZKSCAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus NAS,IEA 7557990
genes like me logo Genes that share ontologies with ZKSCAN1: view

Pathways & Interactions for ZKSCAN1 Gene

SuperPathways for ZKSCAN1 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZKSCAN1: view

Pathways by source for ZKSCAN1 Gene

2 Reactome pathways for ZKSCAN1 Gene

Gene Ontology (GO) - Biological Process for ZKSCAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS,IEA 7557990
genes like me logo Genes that share ontologies with ZKSCAN1: view

No data available for SIGNOR curated interactions for ZKSCAN1 Gene

Drugs & Compounds for ZKSCAN1 Gene

(1) Drugs for ZKSCAN1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 2296
genes like me logo Genes that share compounds with ZKSCAN1: view

Transcripts for ZKSCAN1 Gene

mRNA/cDNA for ZKSCAN1 Gene

Unigene Clusters for ZKSCAN1 Gene

Zinc finger with KRAB and SCAN domains 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZKSCAN1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: -
SP2: - -
SP3: -
SP4: -

Relevant External Links for ZKSCAN1 Gene

GeneLoc Exon Structure for
ZKSCAN1
ECgene alternative splicing isoforms for
ZKSCAN1

Expression for ZKSCAN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZKSCAN1 Gene

Protein differential expression in normal tissues from HIPED for ZKSCAN1 Gene

This gene is overexpressed in Plasma (24.9), Islet of Langerhans (13.9), and Pancreas (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZKSCAN1 Gene



Protein tissue co-expression partners for ZKSCAN1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZKSCAN1 Gene:

ZKSCAN1

SOURCE GeneReport for Unigene cluster for ZKSCAN1 Gene:

Hs.615360

Evidence on tissue expression from TISSUES for ZKSCAN1 Gene

  • Nervous system(4.7)
  • Liver(4.5)
  • Spleen(4.3)
  • Lung(4.2)
  • Stomach(2.3)
genes like me logo Genes that share expression patterns with ZKSCAN1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZKSCAN1 Gene

Orthologs for ZKSCAN1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZKSCAN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZKSCAN1 34 35
  • 99.76 (n)
dog
(Canis familiaris)
Mammalia ZKSCAN1 34 35
  • 89.88 (n)
cow
(Bos Taurus)
Mammalia ZKSCAN1 34 35
  • 87.69 (n)
mouse
(Mus musculus)
Mammalia Zkscan1 34 16 35
  • 86.07 (n)
rat
(Rattus norvegicus)
Mammalia Zkscan1 34
  • 85.8 (n)
oppossum
(Monodelphis domestica)
Mammalia ZKSCAN1 35
  • 79 (a)
OneToOne
Species where no ortholog for ZKSCAN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZKSCAN1 Gene

ENSEMBL:
Gene Tree for ZKSCAN1 (if available)
TreeFam:
Gene Tree for ZKSCAN1 (if available)

Paralogs for ZKSCAN1 Gene

(515) SIMAP similar genes for ZKSCAN1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZKSCAN1: view

Variants for ZKSCAN1 Gene

Sequence variations from dbSNP and Humsavar for ZKSCAN1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs193920886 Uncertain significance 100,033,959(+) CACGG(A/G)GGAGA intron-variant, nc-transcript-variant, reference, missense
rs1000094701 -- 100,035,060(+) GATTC(A/G)GTTGT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1000162849 -- 100,032,242(+) GTTAG(A/C)AATGG intron-variant
rs1000170649 -- 100,017,111(+) GGAGT(A/G)TCAAT intron-variant, upstream-variant-2KB
rs1000231357 -- 100,038,657(+) TAAAC(C/T)GTAGT intron-variant, nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZKSCAN1 Gene

Variant ID Type Subtype PubMed ID
esv23518 CNV gain 19812545
esv2734888 CNV deletion 23290073
esv32694 CNV loss 17666407
nsv433391 CNV gain 18776910
nsv469687 CNV loss 16826518
nsv510966 OTHER complex 20534489
nsv819817 CNV loss 19587683

Variation tolerance for ZKSCAN1 Gene

Residual Variation Intolerance Score: 47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 29.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZKSCAN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZKSCAN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZKSCAN1 Gene

Disorders for ZKSCAN1 Gene

Relevant External Links for ZKSCAN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZKSCAN1

No disorders were found for ZKSCAN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZKSCAN1 Gene

Publications for ZKSCAN1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  3. Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. (PMID: 12693554) Jikuya H. … Ohara O. (DNA Res. 2003) 3 4 64
  4. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PMID: 7557990) Tommerup N. … Vissing H. (Genomics 1995) 3 4 64
  5. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen H.-J. (New Biol. 1990) 3 4 64

Products for ZKSCAN1 Gene

Sources for ZKSCAN1 Gene

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