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Aliases for ZKSCAN1 Gene

Aliases for ZKSCAN1 Gene

  • Zinc Finger With KRAB And SCAN Domains 1 2 3 5
  • Zinc Finger Protein 36 (KOX 18) 2 3
  • Zinc Finger Protein KOX18 3 4
  • Zinc Finger Protein 139 3 4
  • ZNF139 3 4
  • ZNF36 3 4
  • KOX18 3 4
  • Zinc Finger Protein 36 4
  • 9130423L19Rik 3
  • ZSCAN33 3
  • PHZ-37 3

External Ids for ZKSCAN1 Gene

Previous HGNC Symbols for ZKSCAN1 Gene

  • ZNF139
  • ZNF36

Previous GeneCards Identifiers for ZKSCAN1 Gene

  • GC07P099261
  • GC07P099451
  • GC07P099616
  • GC07P094248

Summaries for ZKSCAN1 Gene

Entrez Gene Summary for ZKSCAN1 Gene

  • The ZKSCAN1 gene encodes a transcriptional regulator of the KRAB (Kruppel-associated box) subfamily of zinc finger proteins, which contain repeated Cys2-His2 (C2H2) zinc finger domains that are connected by conserved sequences, called H/C links (summarized by Tommerup and Vissing, 1995 [PubMed 7557990]). Transcriptional regulatory proteins containing tandemly repeated zinc finger domains are thought to be involved in both normal and abnormal cellular proliferation and differentiation. See ZNF91 (MIM 603971) for general information on zinc finger proteins.[supplied by OMIM, Jul 2010]

GeneCards Summary for ZKSCAN1 Gene

ZKSCAN1 (Zinc Finger With KRAB And SCAN Domains 1) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZSCAN16.

UniProtKB/Swiss-Prot for ZKSCAN1 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZKSCAN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZKSCAN1 Gene

Genomics for ZKSCAN1 Gene

Regulatory Elements for ZKSCAN1 Gene

Enhancers for ZKSCAN1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZKSCAN1 on UCSC Golden Path with GeneCards custom track

Promoters for ZKSCAN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZKSCAN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZKSCAN1 Gene

100,015,572 bp from pter
100,045,143 bp from pter
29,572 bases
Plus strand

Genomic View for ZKSCAN1 Gene

Genes around ZKSCAN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZKSCAN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZKSCAN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZKSCAN1 Gene

Proteins for ZKSCAN1 Gene

  • Protein details for ZKSCAN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein with KRAB and SCAN domains 1
    Protein Accession:
    Secondary Accessions:
    • A4D294
    • P52745
    • Q2M1U1
    • Q8TBW5
    • Q8TEK7

    Protein attributes for ZKSCAN1 Gene

    563 amino acids
    Molecular mass:
    63630 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC50264.1; Type=Frameshift; Positions=241; Evidence={ECO:0000305};

neXtProt entry for ZKSCAN1 Gene

Proteomics data for ZKSCAN1 Gene at MOPED

Post-translational modifications for ZKSCAN1 Gene

  • Ubiquitination at Lys 181 and Lys 478
  • Modification sites at PhosphoSitePlus

Other Protein References for ZKSCAN1 Gene

No data available for DME Specific Peptides for ZKSCAN1 Gene

Domains & Families for ZKSCAN1 Gene

Gene Families for ZKSCAN1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 6 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Contains 1 SCAN box domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 6 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZKSCAN1: view

Function for ZKSCAN1 Gene

Molecular function for ZKSCAN1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZKSCAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ZKSCAN1: view
genes like me logo Genes that share phenotypes with ZKSCAN1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZKSCAN1 Gene

Localization for ZKSCAN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZKSCAN1 Gene

Subcellular locations from

Jensen Localization Image for ZKSCAN1 Gene COMPARTMENTS Subcellular localization image for ZKSCAN1 gene
Compartment Confidence
nucleus 5
mitochondrion 2

No data available for Gene Ontology (GO) - Cellular Components for ZKSCAN1 Gene

Pathways & Interactions for ZKSCAN1 Gene

SuperPathways for ZKSCAN1 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZKSCAN1: view

Pathways by source for ZKSCAN1 Gene

2 Reactome pathways for ZKSCAN1 Gene

Gene Ontology (GO) - Biological Process for ZKSCAN1 Gene


No data available for SIGNOR curated interactions for ZKSCAN1 Gene

Drugs & Compounds for ZKSCAN1 Gene

(1) Drugs for ZKSCAN1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 2102
genes like me logo Genes that share compounds with ZKSCAN1: view

Transcripts for ZKSCAN1 Gene

mRNA/cDNA for ZKSCAN1 Gene

Unigene Clusters for ZKSCAN1 Gene

Zinc finger with KRAB and SCAN domains 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZKSCAN1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: -
SP2: - -
SP3: -
SP4: -

Relevant External Links for ZKSCAN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZKSCAN1 Gene

mRNA expression in normal human tissues for ZKSCAN1 Gene

Protein differential expression in normal tissues from HIPED for ZKSCAN1 Gene

This gene is overexpressed in Plasma (24.9), Islet of Langerhans (13.9), and Pancreas (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZKSCAN1 Gene

SOURCE GeneReport for Unigene cluster for ZKSCAN1 Gene Hs.615360

genes like me logo Genes that share expression patterns with ZKSCAN1: view

Protein tissue co-expression partners for ZKSCAN1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZKSCAN1 Gene

Orthologs for ZKSCAN1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZKSCAN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZKSCAN1 35
  • 87.69 (n)
  • 90.94 (a)
  • 91 (a)
(Canis familiaris)
Mammalia ZKSCAN1 35
  • 89.88 (n)
  • 93.61 (a)
  • 94 (a)
(Mus musculus)
Mammalia Zkscan1 35
  • 86.07 (n)
  • 90.36 (a)
Zkscan1 16
Zkscan1 36
  • 90 (a)
(Pan troglodytes)
Mammalia ZKSCAN1 35
  • 99.76 (n)
  • 99.64 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Zkscan1 35
  • 85.8 (n)
  • 90.02 (a)
(Monodelphis domestica)
Mammalia ZKSCAN1 36
  • 79 (a)
Species with no ortholog for ZKSCAN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZKSCAN1 Gene

Gene Tree for ZKSCAN1 (if available)
Gene Tree for ZKSCAN1 (if available)

Paralogs for ZKSCAN1 Gene

(515) SIMAP similar genes for ZKSCAN1 Gene using alignment to 5 proteins: Pseudogenes for ZKSCAN1 Gene

genes like me logo Genes that share paralogs with ZKSCAN1: view

Variants for ZKSCAN1 Gene

Sequence variations from dbSNP and Humsavar for ZKSCAN1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs17851996 - 100,023,583(+) AATAG(C/T)GAAGG intron-variant, nc-transcript-variant, reference, missense, utr-variant-5-prime
rs1015538 -- 100,028,412(-) cttgg(C/T)ctccc intron-variant
rs1060544 -- 100,015,853(+) GAGTC(C/T)ATGCC intron-variant
rs1128879 -- 100,041,648(+) CTCTT(C/T)TGAGT intron-variant, utr-variant-3-prime
rs1133790 -- 100,035,359(+) TGGAA(C/T)GTCAG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZKSCAN1 Gene

Variant ID Type Subtype PubMed ID
nsv433391 CNV Gain 18776910
esv23518 CNV Gain 19812545
esv32694 CNV Loss 17666407
nsv469687 CNV Loss 16826518
esv2734888 CNV Deletion 23290073
nsv510966 CNV Complex 20534489
nsv819817 CNV Loss 19587683

Variation tolerance for ZKSCAN1 Gene

Residual Variation Intolerance Score: 47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 29.03% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZKSCAN1 Gene

Disorders for ZKSCAN1 Gene

Relevant External Links for ZKSCAN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZKSCAN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZKSCAN1 Gene

Publications for ZKSCAN1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Regulatory mechanism of ZNF139 in multi-drug resistance of gastric cancer cells. (PMID: 24515389) Li Y. … Wang D. (Mol. Biol. Rep. 2014) 3

Products for ZKSCAN1 Gene

Sources for ZKSCAN1 Gene