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Aliases for ZIM3 Gene

Aliases for ZIM3 Gene

  • Zinc Finger Imprinted 3 2 3
  • Zinc Finger, Imprinted 3 3 5
  • Zinc Finger Protein 657 3 4
  • ZNF657 3 4

External Ids for ZIM3 Gene

Previous GeneCards Identifiers for ZIM3 Gene

  • GC19M058544
  • GC19M058099
  • GC19M062321
  • GC19M062337
  • GC19M057645
  • GC19M053958

Summaries for ZIM3 Gene

GeneCards Summary for ZIM3 Gene

ZIM3 (Zinc Finger Imprinted 3) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF793.

UniProtKB/Swiss-Prot for ZIM3 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZIM3 Gene

Genomics for ZIM3 Gene

Genomic Location for ZIM3 Gene

57,134,096 bp from pter
57,145,202 bp from pter
11,107 bases
Minus strand

Genomic View for ZIM3 Gene

Genes around ZIM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZIM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZIM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZIM3 Gene

No data available for Regulatory Elements for ZIM3 Gene

Proteins for ZIM3 Gene

  • Protein details for ZIM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger imprinted 3
    Protein Accession:
    Secondary Accessions:
    • Q14CA6

    Protein attributes for ZIM3 Gene

    472 amino acids
    Molecular mass:
    54498 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZIM3 Gene

Proteomics data for ZIM3 Gene at MOPED

Post-translational modifications for ZIM3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZIM3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZIM3 Gene

Domains & Families for ZIM3 Gene

Gene Families for ZIM3 Gene

Protein Domains for ZIM3 Gene

Suggested Antigen Peptide Sequences for ZIM3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZIM3: view

Function for ZIM3 Gene

Molecular function for ZIM3 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZIM3: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZIM3 Gene

Localization for ZIM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZIM3 Gene

Subcellular locations from

Jensen Localization Image for ZIM3 Gene COMPARTMENTS Subcellular localization image for ZIM3 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZIM3 Gene

Pathways & Interactions for ZIM3 Gene

SuperPathways for ZIM3 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZIM3: view

Pathways by source for ZIM3 Gene

2 Reactome pathways for ZIM3 Gene

Interacting Proteins for ZIM3 Gene

Gene Ontology (GO) - Biological Process for ZIM3 Gene


No data available for SIGNOR curated interactions for ZIM3 Gene

Drugs & Compounds for ZIM3 Gene

No Compound Related Data Available

Transcripts for ZIM3 Gene

mRNA/cDNA for ZIM3 Gene

(1) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ZIM3 Gene

No ASD Table

Relevant External Links for ZIM3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZIM3 Gene

mRNA expression in normal human tissues for ZIM3 Gene

mRNA differential expression in normal tissues according to GTEx for ZIM3 Gene

This gene is overexpressed in Testis (x46.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZIM3 Gene

SOURCE GeneReport for Unigene cluster for ZIM3 Gene Hs.348622

genes like me logo Genes that share expression patterns with ZIM3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZIM3 Gene

Orthologs for ZIM3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZIM3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZIM3 35
  • 98.87 (n)
  • 98.73 (a)
ZIM3 36
  • 99 (a)
(Mus musculus)
Mammalia Zfp819 36
  • 29 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 30 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10543 37
  • 33 (a)
Species with no ortholog for ZIM3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZIM3 Gene

Gene Tree for ZIM3 (if available)
Gene Tree for ZIM3 (if available)

Paralogs for ZIM3 Gene

Paralogs for ZIM3 Gene

(493) SIMAP similar genes for ZIM3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZIM3: view

Variants for ZIM3 Gene

Sequence variations from dbSNP and Humsavar for ZIM3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10407445 - 57,138,594(+) TCACT(C/T)TTCCC reference, missense
rs2370134 - 57,138,532(-) ATCCC(A/G)AACAG reference, missense
rs7252632 - 57,135,868(+) ATTAT(A/C/G/T)GCCAA reference, missense
rs4801433 - 57,135,202(+) TTGAA(C/T)GAGGT reference, missense
rs4801200 - 57,136,909(+) CTCCA(A/T)CCATG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZIM3 Gene

Variant ID Type Subtype PubMed ID
nsv912523 CNV Gain 21882294
nsv528378 CNV Loss 19592680
nsv817876 CNV Gain 17921354
esv2280796 CNV Deletion 18987734
esv2719067 CNV Deletion 23290073

Variation tolerance for ZIM3 Gene

Residual Variation Intolerance Score: 95.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.24; 92.48% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZIM3 Gene

Disorders for ZIM3 Gene

Relevant External Links for ZIM3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZIM3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZIM3 Gene

Publications for ZIM3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Imprinting and evolution of two Kruppel-type zinc-finger genes, ZIM3 and ZNF264, located in the PEG3/USP29 imprinted domain. (PMID: 11543637) Kim J. … Stubbs L. (Genomics 2001) 3

Products for ZIM3 Gene

Sources for ZIM3 Gene