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Aliases for ZIM2 Gene

Aliases for ZIM2 Gene

  • Zinc Finger Imprinted 2 2 3 5
  • Zinc Finger Protein 656 3 4
  • ZNF656 3 4

External Ids for ZIM2 Gene

Previous GeneCards Identifiers for ZIM2 Gene

  • GC19M058168
  • GC19M057740
  • GC19M061851
  • GC19M061978
  • GC19M061395
  • GC19M061979
  • GC19M061980
  • GC19M057289
  • GC19M057290

Summaries for ZIM2 Gene

Entrez Gene Summary for ZIM2 Gene

  • In human, ZIM2 and PEG3 (GeneID:5178) are two distinct genes that share a set of 5' exons and have a common promoter, and both genes are paternally expressed. Alternative splicing events connect the shared exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. This is in contrast to mouse and cow, where ZIM2 and PEG3 genes do not share exons in common, and the imprinting status of ZIM2 is also not conserved amongst mammals. Additional 5' alternatively spliced transcripts encoding the same protein have been found for the human ZIM2 gene. [provided by RefSeq, Oct 2010]

GeneCards Summary for ZIM2 Gene

ZIM2 (Zinc Finger Imprinted 2) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF215.

UniProtKB/Swiss-Prot for ZIM2 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZIM2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZIM2 Gene

Genomics for ZIM2 Gene

Regulatory Elements for ZIM2 Gene

Enhancers for ZIM2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H056403 1.1 ENCODE 29.2 +436.6 436580 2 HDGF ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF416 ZNF143 ZNF207 ZNF582-AS1 ZNF582 ZFP28 ZNF264 ZNF470 ZNF471 FIZ1 U2AF2 ZNF548 LOC105372476
GH19H056594 1 ENCODE 28.5 +245.3 245289 1.4 HDGF PKNOX1 ZNF133 ARID4B SIN3A FEZF1 YBX1 GLI4 YY1 ETS1 U2AF2 ZNF17 ZNF264 ZNF773 ZNF543 ZNF549 ENSG00000269696 ZNF550 ZFP28 ZNF470
GH19H057599 1.1 ENCODE 19.2 -759.3 -759309 1.5 PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 SP3 ZHX2 MXD4 ZNF606 ZNF549 ZNF135 ZNF132 ZNF418 ZNF417 ZNF446 ZNF17 LOC105372482 LOC100128398
GH19H056916 1.2 ENCODE dbSUPER 11.5 -78.4 -78412 4.5 ELF3 FOXA2 RAD21 DNMT3B THRB ZSCAN9 RARA CREM MIXL1 THAP11 ZIM2 PEG3 ZNF444 ENSG00000269786 GC19P056968
GH19H056899 1.2 ENCODE dbSUPER 11.3 -60.6 -60557 3.6 FOXA2 ATF1 MLX ZFP64 ARID4B DMAP1 SLC30A9 SP5 MXD4 NFYC ZNF805 ZNF264 ENSG00000268392 PEG3 ZIM2 TRAPPC2B GC19P056968 LOC105372474
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZIM2 on UCSC Golden Path with GeneCards custom track

Promoters for ZIM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for ZIM2 Gene

Genomic Locations for ZIM2 Gene
66,183 bases
Minus strand

Genomic View for ZIM2 Gene

Genes around ZIM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZIM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZIM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZIM2 Gene

Proteins for ZIM2 Gene

  • Protein details for ZIM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger imprinted 2
    Protein Accession:
    Secondary Accessions:
    • Q2M3K1

    Protein attributes for ZIM2 Gene

    527 amino acids
    Molecular mass:
    61164 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZIM2 Gene

Post-translational modifications for ZIM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZIM2 Gene

Domains & Families for ZIM2 Gene

Gene Families for ZIM2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZIM2 Gene

Suggested Antigen Peptide Sequences for ZIM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZIM2: view

Function for ZIM2 Gene

Molecular function for ZIM2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZIM2 Gene

Gene Ontology (GO) - Molecular Function for ZIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0008270 zinc ion binding NAS 10708526
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZIM2: view
genes like me logo Genes that share phenotypes with ZIM2: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZIM2 Gene

Localization for ZIM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZIM2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZIM2 gene
Compartment Confidence
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZIM2: view

Pathways & Interactions for ZIM2 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZIM2: view

Pathways by source for ZIM2 Gene

2 Reactome pathways for ZIM2 Gene

Interacting Proteins for ZIM2 Gene

Gene Ontology (GO) - Biological Process for ZIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS,IBA 10708526
genes like me logo Genes that share ontologies with ZIM2: view

No data available for SIGNOR curated interactions for ZIM2 Gene

Drugs & Compounds for ZIM2 Gene

No Compound Related Data Available

Transcripts for ZIM2 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZIM2 Gene

No ASD Table

Relevant External Links for ZIM2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZIM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZIM2 Gene

mRNA differential expression in normal tissues according to GTEx for ZIM2 Gene

This gene is overexpressed in Testis (x17.4) and Ovary (x5.2).

NURSA nuclear receptor signaling pathways regulating expression of ZIM2 Gene:


mRNA Expression by UniProt/SwissProt for ZIM2 Gene:

Tissue specificity: Highest levels of expression in adult testis; modest levels in fetal kidney and brain.

Evidence on tissue expression from TISSUES for ZIM2 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with ZIM2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZIM2 Gene

Orthologs for ZIM2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZIM2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia LOC102154522 33
  • 80.75 (n)
ZIM2 34
  • 63 (a)
(Bos Taurus)
Mammalia ZIM2 33 34
  • 76.32 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 29 (a)
Species where no ortholog for ZIM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZIM2 Gene

Gene Tree for ZIM2 (if available)
Gene Tree for ZIM2 (if available)

Paralogs for ZIM2 Gene

Paralogs for ZIM2 Gene

(15) SIMAP similar genes for ZIM2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZIM2: view

Variants for ZIM2 Gene

Sequence variations from dbSNP and Humsavar for ZIM2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000023409 -- 56,778,090(+) CAACC(G/T)CCCAT intron-variant
rs1000033448 -- 56,778,340(+) GGAGT(C/T)TTCCT intron-variant
rs1000036135 -- 56,822,269(+) ATTTC(C/G/T)AGCAG intron-variant
rs1000158955 -- 56,808,422(+) ACATT(A/C)CTGAG intron-variant
rs1000211714 -- 56,808,151(+) ATGAG(A/G)GAGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZIM2 Gene

Variant ID Type Subtype PubMed ID
nsv833884 CNV loss 17160897
nsv478290 CNV novel sequence insertion 20440878
nsv474697 CNV novel sequence insertion 20440878
esv3644878 CNV loss 21293372

Variation tolerance for ZIM2 Gene

Residual Variation Intolerance Score: 89.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.89; 59.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZIM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZIM2 Gene

Disorders for ZIM2 Gene

Relevant External Links for ZIM2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZIM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZIM2 Gene

Publications for ZIM2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  2. Exon sharing of a novel human zinc-finger gene, ZIM2, and paternally expressed gene 3 (PEG3). (PMID: 10708526) Kim J … Stubbs L (Genomics 2000) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Lineage-specific imprinting and evolution of the zinc-finger gene ZIM2. (PMID: 15203203) Kim J … Stubbs L (Genomics 2004) 3 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for ZIM2 Gene

Sources for ZIM2 Gene

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