ZIM2 Gene
protein-coding GIFtS: 34
GCID: GC19M057290
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zinc finger, imprinted 2
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Aliases
for ZIM2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger, Imprinted 21 2 | | ZNF6561 2 3 | | Zinc Finger Protein 6562 3 | | Zinc Finger Imprinted 22 |
Export aliases for ZIM2 gene to outside databasesPrevious GC identifers: GC19M058168 GC19M057740 GC19M061851 GC19M061978 GC19M061395 GC19M061979 GC19M061980 GC19M057289 |
Summaries
for ZIM2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZIM2:
In human, ZIM2 and PEG3 (GeneID:5178) are two distinct genes that share a set of 5' exons and have a common promoter,and both genes are paternally expressed. Alternative splicing events connect the shared exons either with theremaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. This is in contrast to mouse and cow,where ZIM2 and PEG3 genes do not share exons in common, and the imprinting status of ZIM2 is also not conservedamongst mammals. Additional 5' alternatively spliced transcripts encoding the same protein have been found for thehuman ZIM2 gene. (provided by RefSeq, Oct 2010)
UniProtKB/Swiss-Prot: ZIM2_HUMAN, Q9NZV7Function: May be involved in transcriptional regulation
|
Genomic Views
for ZIM2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZIM2 gene promoter:
CREB AML1a FOXF2 Sp1 deltaCREB GATA-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZIM2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZIM2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.4 HGNC cytogenetic band: 19q13.4ZIM2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M057290: view genomic region
(about GC identifiers)
Start:
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57,285,915 bp from pter |
End:
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57,352,097 bp from pter |
Size:
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66,183 bases |
Orientation:
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minus strand |
ZIM2 has overlapping exons with:
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PEG3 |
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Proteins
for ZIM2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZIM2_HUMAN, Q9NZV7 (See
protein sequence)Recommended Name: Zinc finger imprinted 2 Size: 527 amino acids; 61164 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q2M3K1Explore the universe of human proteins at neXtProt for ZIM2: NX_Q9NZV7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NZV7
ZIM2 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins (3 alternative transcripts):
NP_001139798.1 NP_001139799.1 NP_056178.3 Reactome Protein details: Q9NZV7
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZIM2 for ontologies About GeneDecksing
ZIM2 Antibody Products:
Assay Products for ZIM2: |
Protein
Domains /
Families
for ZIM2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZIM2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NZV7ProtoNet protein and cluster: Q9NZV7 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZIM2_HUMAN, Q9NZV7Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 5 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZIM2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZIM2_HUMAN, Q9NZV7Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZIM2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZIM2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZIM2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZIM2 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZIM2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | | | 2 | TNF-alpha/NF-kB Signaling Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for ZIM2
2 
Reactome Pathways for ZIM2
ZIM2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZIM2
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
NAS | 10708526 |
ZIM2 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZIM2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZIM2
Search CenterWatch for drugs/clinical trials and news about ZIM2
|
Transcripts
for ZIM2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZIM2 gene (3 alternative transcripts): NM_001146326.1 NM_001146327.1 NM_015363.4
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZIM2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZIM2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): ZIM2 (NM_015363) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZIM2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZIM2 |
24/273 AceView cDNA sequences (see all 273): AF208968 NM_015363 BM967197 BE501949 AA449586 AI609061 AI802306 BE502379 AA460030 BM723658 BM697482 AI693079 AA350686 AL699133 BM512435 AI744690 AF166122 AA580928 BQ023924 BF732186 BU753605 CA950554 AF208969 AA033956
GeneLoc Exon Structure
|
Expression
for ZIM2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZIM2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
Genevestigator expression for ZIM2
UniProtKB/Swiss-Prot: ZIM2_HUMAN, Q9NZV7Tissue specificity: Highest levels of expression in adult testis; modest levels in fetal kidney and brain
SABiosciences Custom PCR Arrays for ZIM2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZIM2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZIM2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZIM2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZIM2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZIM2 |
Orthologs
for ZIM2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for ZIM2 gene from 1 species (see representative species ) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Zim25 |
zinc finger, imprinted 2 |
-- |
|
7 - |
|
Paralogs
for ZIM2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ZIM2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZIM2 (57285915 - 57352097 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZIM2: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for ZIM2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZIM2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZIM2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZIM2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Exon sharing of a novel human zinc-finger gene, ZIM2, and paternally expressed gene 3 (PEG3). (PubMed id 10708526)1, 2 Kim J.... Stubbs L. (2000)
- Lineage-specific imprinting and evolution of the zinc-finger gene ZIM2. (PubMed id 15203203)1 Kim J....Stubbs L. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for ZIM2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZIM2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZIM2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZIM2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZIM2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZIM2 gene:
Search GeneIP for patents involving ZIM2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZIM2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for ZIM2 | | OriGene shRNA RFP for ZIM2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZIM2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZIM2 | | | OriGene Protein Over-expression Lysate for ZIM2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZIM2 | | OriGene 3'-UTR Clone for ZIM2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZIM2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZIM2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZIM2 | | OriGene Custom Protein Services for ZIM2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZIM2 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZIM2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZIM2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZIM2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZIM2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZIM2 |
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 | | | ZIM2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZIM2 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZIM2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZIM2 |
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