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Aliases for ZIM2 Gene

Aliases for ZIM2 Gene

  • Zinc Finger, Imprinted 2 2 3
  • Zinc Finger Protein 656 3 4
  • ZNF656 3 4
  • Zinc Finger Imprinted 2 3

External Ids for ZIM2 Gene

Previous GeneCards Identifiers for ZIM2 Gene

  • GC19M058168
  • GC19M057740
  • GC19M061851
  • GC19M061978
  • GC19M061395
  • GC19M061979
  • GC19M061980
  • GC19M057289
  • GC19M057290

Summaries for ZIM2 Gene

Entrez Gene Summary for ZIM2 Gene

  • In human, ZIM2 and PEG3 (GeneID:5178) are two distinct genes that share a set of 5' exons and have a common promoter, and both genes are paternally expressed. Alternative splicing events connect the shared exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. This is in contrast to mouse and cow, where ZIM2 and PEG3 genes do not share exons in common, and the imprinting status of ZIM2 is also not conserved amongst mammals. Additional 5' alternatively spliced transcripts encoding the same protein have been found for the human ZIM2 gene. [provided by RefSeq, Oct 2010]

GeneCards Summary for ZIM2 Gene

ZIM2 (Zinc Finger, Imprinted 2) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZFP69.

UniProtKB/Swiss-Prot for ZIM2 Gene

  • May be involved in transcriptional regulation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZIM2 Gene

Genomics for ZIM2 Gene

Regulatory Elements for ZIM2 Gene

Genomic Location for ZIM2 Gene

Start:
56,774,547 bp from pter
End:
56,840,729 bp from pter
Size:
66,183 bases
Orientation:
Minus strand

Genomic View for ZIM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZIM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZIM2 Gene

Proteins for ZIM2 Gene

  • Protein details for ZIM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZV7-ZIM2_HUMAN
    Recommended name:
    Zinc finger imprinted 2
    Protein Accession:
    Q9NZV7
    Secondary Accessions:
    • Q2M3K1

    Protein attributes for ZIM2 Gene

    Size:
    527 amino acids
    Molecular mass:
    61164 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZIM2 Gene

Proteomics data for ZIM2 Gene at MOPED

Post-translational modifications for ZIM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZIM2 Gene

Antibody Products

No data available for DME Specific Peptides for ZIM2 Gene

Domains for ZIM2 Gene

Gene Families for ZIM2 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZIM2 Gene

Suggested Antigen Peptide Sequences for ZIM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZV7

UniProtKB/Swiss-Prot:

ZIM2_HUMAN :
  • Q9NZV7
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZIM2: view

Function for ZIM2 Gene

Molecular function for ZIM2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0008270 zinc ion binding NAS 10708526
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with ZIM2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZIM2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZIM2 Gene

Localization for ZIM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZIM2 Gene

Gene Ontology (GO) - Cellular Components for ZIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZIM2: view

No data available for Subcellular locations from COMPARTMENTS for ZIM2 Gene

Pathways for ZIM2 Gene

SuperPathways for ZIM2 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZIM2: view

Pathways by source for ZIM2 Gene

2 Reactome pathways for ZIM2 Gene

Interacting Proteins for ZIM2 Gene

Gene Ontology (GO) - Biological Process for ZIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 10708526
genes like me logo Genes that share ontologies with ZIM2: view

Transcripts for ZIM2 Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZIM2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZIM2 Gene

No ASD Table

Relevant External Links for ZIM2 Gene

GeneLoc Exon Structure for
ZIM2
ECgene alternative splicing isoforms for
ZIM2

Expression for ZIM2 Gene

mRNA expression in normal human tissues for ZIM2 Gene

mRNA differential expression in normal tissues according to GTEx for ZIM2 Gene

This gene is overexpressed in Testis (17.4) and Ovary (5.2).

mRNA Expression by UniProt/SwissProt for ZIM2 Gene

Q9NZV7-ZIM2_HUMAN
Tissue specificity: Highest levels of expression in adult testis; modest levels in fetal kidney and brain
genes like me logo Genes that share expressions with ZIM2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Expression partners for ZIM2 Gene

Orthologs for ZIM2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZIM2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZIM2 35
  • 76.32 (n)
  • 65.53 (a)
ZIM2 36
  • 56 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC102154522 35
  • 80.75 (n)
  • 71.93 (a)
ZIM2 36
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zim2 16
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 29 (a)
OneToMany
Species with no ortholog for ZIM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZIM2 Gene

ENSEMBL:
Gene Tree for ZIM2 (if available)
TreeFam:
Gene Tree for ZIM2 (if available)

Paralogs for ZIM2 Gene

Paralogs for ZIM2 Gene

Selected SIMAP similar genes for ZIM2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZIM2: view

Variants for ZIM2 Gene

Sequence variations from dbSNP and Humsavar for ZIM2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs758750 -- 56,803,860(+) AAGGC(C/G)ACCAA intron-variant
rs7260644 -- 56,802,414(+) CCCCA(A/G)TGATT intron-variant
rs8107113 -- 56,803,739(+) TAAAG(C/G)CAACC intron-variant
rs10401139 -- 56,808,849(+) TATGG(C/T)CTATT intron-variant
rs10406501 -- 56,802,531(+) taagg(A/G)caatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZIM2 Gene

Variant ID Type Subtype PubMed ID
nsv833884 CNV Loss 17160897

Relevant External Links for ZIM2 Gene

HapMap Linkage Disequilibrium report
ZIM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZIM2 Gene

Disorders for ZIM2 Gene

No disorders were found for ZIM2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ZIM2 Gene

Publications for ZIM2 Gene

  1. Exon sharing of a novel human zinc-finger gene, ZIM2, and paternally expressed gene 3 (PEG3). (PMID: 10708526) Kim J. … Stubbs L. (Genomics 2000) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Lineage-specific imprinting and evolution of the zinc-finger gene ZIM2. (PMID: 15203203) Kim J. … Stubbs L. (Genomics 2004) 3

Products for ZIM2 Gene

Sources for ZIM2 Gene

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