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Aliases for ZIK1 Gene

Aliases for ZIK1 Gene

  • Zinc Finger Protein Interacting With K Protein 1 2 3 5
  • Zinc Finger Protein 762 3 4
  • ZNF762 3 4
  • Zinc Finger Protein Interacting With K Protein 1 Homolog (Mouse) 2
  • Zinc Finger Protein Interacting With K Protein 1 Homolog 3

External Ids for ZIK1 Gene

Previous GeneCards Identifiers for ZIK1 Gene

  • GC19P062791
  • GC19P058095
  • GC19P054408

Summaries for ZIK1 Gene

GeneCards Summary for ZIK1 Gene

ZIK1 (Zinc Finger Protein Interacting With K Protein 1) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF17.

UniProtKB/Swiss-Prot for ZIK1 Gene

  • May be a transcriptional repressor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZIK1 Gene

Genomics for ZIK1 Gene

Regulatory Elements for ZIK1 Gene

Promoters for ZIK1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZIK1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZIK1 Gene

Chromosome:
19
Start:
57,578,456 bp from pter
End:
57,593,888 bp from pter
Size:
15,433 bases
Orientation:
Plus strand

Genomic View for ZIK1 Gene

Genes around ZIK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZIK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZIK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZIK1 Gene

Proteins for ZIK1 Gene

  • Protein details for ZIK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3SY52-ZIK1_HUMAN
    Recommended name:
    Zinc finger protein interacting with ribonucleoprotein K
    Protein Accession:
    Q3SY52
    Secondary Accessions:
    • O43339
    • Q3SY51
    • Q3SY53

    Protein attributes for ZIK1 Gene

    Size:
    487 amino acids
    Molecular mass:
    54786 Da
    Quaternary structure:
    • Interacts with HNRPK.

    Alternative splice isoforms for ZIK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZIK1 Gene

Proteomics data for ZIK1 Gene at MOPED

Post-translational modifications for ZIK1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZIK1 Gene

Domains & Families for ZIK1 Gene

Gene Families for ZIK1 Gene

Protein Domains for ZIK1 Gene

Suggested Antigen Peptide Sequences for ZIK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3SY52

UniProtKB/Swiss-Prot:

ZIK1_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 9 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 9 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZIK1: view

Function for ZIK1 Gene

Molecular function for ZIK1 Gene

UniProtKB/Swiss-Prot Function:
May be a transcriptional repressor.

Gene Ontology (GO) - Molecular Function for ZIK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with ZIK1: view
genes like me logo Genes that share phenotypes with ZIK1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZIK1 Gene

Localization for ZIK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZIK1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZIK1 Gene COMPARTMENTS Subcellular localization image for ZIK1 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZIK1 Gene

Pathways & Interactions for ZIK1 Gene

SuperPathways for ZIK1 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZIK1: view

Pathways by source for ZIK1 Gene

2 Reactome pathways for ZIK1 Gene

Gene Ontology (GO) - Biological Process for ZIK1 Gene

None

No data available for SIGNOR curated interactions for ZIK1 Gene

Drugs & Compounds for ZIK1 Gene

No Compound Related Data Available

Transcripts for ZIK1 Gene

Unigene Clusters for ZIK1 Gene

Zinc finger protein interacting with K protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZIK1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d
SP1: -
SP2: - -
SP3:
SP4: - - -
SP5: -
SP6: - - - - -

Relevant External Links for ZIK1 Gene

GeneLoc Exon Structure for
ZIK1
ECgene alternative splicing isoforms for
ZIK1

Expression for ZIK1 Gene

mRNA expression in normal human tissues for ZIK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for ZIK1 Gene Hs.454830

mRNA Expression by UniProt/SwissProt for ZIK1 Gene

Q3SY52-ZIK1_HUMAN
Tissue specificity: Expressed at high levels in gastric glands, and at low levels in colon and small intestine. Silenced through promoter methylation in gastric glands with intestinal metaplasia.
genes like me logo Genes that share expression patterns with ZIK1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ZIK1 Gene

Orthologs for ZIK1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZIK1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Zik1 35
  • 79.8 (n)
  • 74.46 (a)
Zik1 16
Zik1 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZIK1 35
  • 99.45 (n)
  • 99.18 (a)
ZIK1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 48 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 42 (a)
ManyToMany
Species with no ortholog for ZIK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZIK1 Gene

ENSEMBL:
Gene Tree for ZIK1 (if available)
TreeFam:
Gene Tree for ZIK1 (if available)

Paralogs for ZIK1 Gene

(525) SIMAP similar genes for ZIK1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ZIK1 Gene

genes like me logo Genes that share paralogs with ZIK1: view

Variants for ZIK1 Gene

Sequence variations from dbSNP and Humsavar for ZIK1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2074205 -- 57,589,942(+) TGGTA(C/T)GTGTG intron-variant
rs2240023 -- 57,592,027(+) TCTAA(G/T)TTGTG utr-variant-3-prime
rs6510091 -- 57,582,108(+) TTGAT(C/G)TGATG upstream-variant-2KB
rs10402083 -- 57,593,614(+) attct(C/T)atcaa utr-variant-3-prime
rs10403092 -- 57,593,879(+) tagac(A/G)tataa utr-variant-3-prime

Variation tolerance for ZIK1 Gene

Residual Variation Intolerance Score: 70.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.15; 23.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZIK1 Gene

HapMap Linkage Disequilibrium report
ZIK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZIK1 Gene

Disorders for ZIK1 Gene

Relevant External Links for ZIK1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZIK1

No disorders were found for ZIK1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZIK1 Gene

Publications for ZIK1 Gene

  1. Methylation of multiple genes in gastric glands with intestinal metaplasia: a disorder with polyclonal origins. (PMID: 17071588) Mihara M. … Ushijima T. (Am. J. Pathol. 2006) 4 67
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Zik1, a transcriptional repressor that interacts with the heterogeneous nuclear ribonucleoprotein particle K protein. (PMID: 8910362) Denisenko O.N. … Bomsztyk K. (J. Biol. Chem. 1996) 3

Products for ZIK1 Gene

Sources for ZIK1 Gene

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