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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZIK1 Gene

protein-coding GIFtS: 49
GCID: GC19P058095

zinc finger protein interacting with K protein 1

(Previous name: zinc finger protein interacting with K protein 1 homolog...)

Explore 1 disease affiliated with
ZIK1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger Protein Interacting With K Protein 1¹ ²
ZNF762¹ ² ³
Zinc Finger Protein 762² ³
Zinc Finger Protein Interacting With K Protein 1 Homolog (Mouse)¹
Zinc Finger Protein Interacting With K Protein 1 Homolog²
Zinc Finger Protein Interacting With Ribonucleoprotein K²

External Ids:	HGNC: 33104¹	Entrez Gene: 284307²	Ensembl: ENSG00000171649⁷	UniProtKB: Q3SY52³

Export aliases for ZIK1 gene to outside databases

Previous GC identifers: GC19P062791 GC19P054408

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZIK1_HUMAN, Q3SY52

Function: May be a transcriptional repressor (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZIK1 gene promoter:
NF-YA CBF-C c-Ets-1 Arnt CBF-A CBF-B CP1A CP1C NF-Y CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZIK1 promoter sequence

Search SABiosciences Chromatin IP Primers for ZIK1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZIK1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43 Ensembl cytogenetic band: 19q13.43 HGNC cytogenetic band: 19q13.43

ZIK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZIK1 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P058095: view genomic region (about GC identifiers)

Start:	58,095,508 bp from pter	End:	58,105,253 bp from pter
Size:	9,746 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZIK1_HUMAN, Q3SY52 (See protein sequence)

Recommended Name: Zinc finger protein interacting with ribonucleoprotein K

Size: 487 amino acids; 54786 Da

Subunit: Interacts with HNRPK (By similarity)

Subcellular location: Nucleus (Probable)

Secondary accessions: O43339 Q3SY51 Q3SY53

Alternative splicing: 3 isoforms: Q3SY52-1 Q3SY52-2 Q3SY52-3

Explore the universe of human proteins at neXtProt for ZIK1: NX_Q3SY52

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q3SY52

ZIK1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001010879.2

ENSEMBL proteins:

ENSP00000438487 ENSP00000303820

Reactome Protein details: Q3SY52
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	Uscn Proteins for ZIK1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IEA	--

ZIK1 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZIK1 for domains About GeneDecksing

4 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR001909 Krueppel-associated_box

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q3SY52

ProtoNet protein and cluster: Q3SY52

1 Blocks protein family: IPB001909 KRAB box

UniProtKB/Swiss-Prot: ZIK1_HUMAN, Q3SY52

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 9 C2H2-type zinc fingers

Similarity: Contains 1 KRAB domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ZIK1_HUMAN, Q3SY52

Function: May be a transcriptional repressor (By similarity)

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

ZIK1 for ontologies About GeneDecksing

Animal Models:

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZIK1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Generic Transcription Pathway

Generic Transcription Pathway

1.00

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Reactome Pathways for ZIK1

	Generic Transcription Pathway
	Gene Expression

ZIK1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZIK1

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for ZIK1 (Q3SY52³ ENSP00000303820⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DEK	P35659³, ENSP00000380414⁴	I2D: score=1 STRING: ENSP00000380414

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

ZIK1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZIK1
Search CenterWatch for drugs/clinical trials and news about ZIK1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for ZIK1 gene:

NM_001010879.2

Unigene Cluster for ZIK1:

Zinc finger protein interacting with K protein 1 homolog (mouse)

Hs.454830 [show with all ESTs]

Unigene Representative Sequence: AK128340

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000536878(uc002qpi.3) ENST00000307468(uc002qpg.3 uc002qph.3 uc002qpj.3)

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Additional cDNA sequence:

AK092538.1 AK128340.1 BC047299.1 BC103957.1 BC103958.1 BC103959.2

5 DOTS entries:

DT.205888 DT.40292377 DT.121498425 DT.121498436 DT.97812339

24/55 AceView cDNA sequences (see all 55):

CB305335 BX116516 BX369717 BX282112 AI383995 BQ652240 CF994400 AK092538

AX747588 AA701434 BX100564 BC047299 BX109193 AA442643 BX109011 AA130267

BC060865 AI018446 BQ021565 AW341462 BU570311 BQ429777 AA694414 CD556110

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ZIK1 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	·	4c	·	4d
SP1:					-
SP2:					-		-
SP3:
SP4:					-		-		-
SP5:							-

ECgene alternative splicing isoforms for ZIK1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZIK1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCACCACGTG

About this image

ZIK1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

5 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Limb Bud

Limb Bud Mesenchyme Cells

Mesoderm

Brain

Brain

Neural Tube

Presumptive Spinal Cord

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ZIK1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZIK1

SOURCE GeneReport for Unigene cluster: Hs.454830

UniProtKB/Swiss-Prot: ZIK1_HUMAN, Q3SY52

Tissue specificity: Expressed at high levels in gastric glands, and at low levels in colon and small intestine.

Silenced through promoter methylation in gastric glands with intestinal metaplasia

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for ZIK1 (if available)
TreeFam Gene Tree for ZIK1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZIK1 gene

ZNF549² ZNF211² ZNF417² ZNF792² ZNF749² ZNF551² ZNF776² ZNF547²

ZNF17² ZNF416² ZNF548² ZNF304² ZNF587B² ZNF773² ZNF132² ZNF134²

ZNF671² ZNF418² ZNF256² ZNF154² ZNF552² ZNF772² ZNF530² ZNF419²

18/516 SIMAP similar genes for ZIK1 using alignment to 5 protein entries: ZIK1_HUMAN (see all proteins) (see all similar genes):

ZNF78L1 ZFP41 ZNF397 ZNF56 ZNF24 HZF36

zf30 ZNF483 FLJ00301 HZF30 ZNF79 ZSCAN22

DKFZp686D2168 DKFZp686H10254 DKFZp686M04222 ZNF391 ZNF501 ZNF818P

ZIK1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for ZIK1
PGOHUM00000241528

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs185022544^1,2		--	58093740(+)	`CAATAG/TGGGGT`	1	--	us2k¹		0	--	--	--	--
rs190220858^1,2		--	58093877(+)	`TCAGAC/GACAAC`	1	--	us2k¹		0	--	--	--	--
rs76000248^1,2	F	--	58094058(+)	`ATTTAT/CTGAGA`	1	--	us2k¹		1		NA	120
rs143692926^1,2		--	58094115(+)	`TAACTC/GACTGT`	1	--	us2k¹		0	--	--	--	--
rs148123494^1,2		--	58094399(+)	`ATGTTA/GCCAAC`	1	--	us2k¹		0	--	--	--	--
rs55877867^1,2	C,F	--	58094627(+)	`AACCCG/ACCTAC`	1	--	us2k¹		6		WA CSA NA EA	364
rs75005698^1,2	F	--	58094643(+)	`TACTGC/ACCTGA`	1	--	us2k¹		1		WA	118
rs182607174^1,2		--	58094723(+)	`TCATCA/TGGACC`	1	--	us2k¹		0	--	--	--	--
rs185333904^1,2		--	58094888(+)	`GTGGAA/GCTACG`	1	--	us2k¹		0	--	--	--	--
rs191628856^1,2		--	58094958(+)	`GGCTCA/CGGTCA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZIK1 (58095508 - 58105253 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZIK1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZIK1

DNA2.0 Custom Variant and Variant Library Synthesis for ZIK1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZIK1 for disorders About GeneDecksing

1 disease for ZIK1: About MalaCards

intestinal neoplasm

Export disorders for ZIK1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZIK1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZIK1)

Utopia: connect your pdf to the dynamic
world of online information

Methylation of multiple genes in gastric glands with intestinal metaplasia: a disorder with polyclonal origins. (PubMed id 17071588)² Mihara M.... Ushijima T. (2006)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)² Grimwood J.... Lucas S.M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Zik1, a transcriptional repressor that interacts with the heterogeneous nuclear ribonucleoprotein particle K protein. (PubMed id 8910362)¹ Denisenko O.N....Bomsztyk K. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 284307	HGNC: 33104	AceView: ZNF530	Ensembl:ENSG00000171649	euGenes: HUgn284307
ECgene: ZIK1	H-InvDB: ZIK1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZIK1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZIK1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZIK1 gene:
Search GeneIP for patents involving ZIK1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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	Browse OriGene Antibodies		OriGene shRNA RFP for ZIK1
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZIK1
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	GenScript Custom Purified and Recombinant Proteins Services for ZIK1		GenScript cDNA clones with any tag delivered in your preferred vector for ZIK1
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	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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ThermoFisher Antibodies for ZIK1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZIK1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ZIK1

Sirion Biotech Customized:

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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZIK1 gene at Home site.

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ZIK1 Gene

zinc finger protein interacting with K protein 1

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ZIK1 Gene

zinc finger protein interacting with K protein 1

Aliasesfor ZIK1 gene

Summariesfor ZIK1 gene

Genomic Viewsfor ZIK1 gene

Proteinsfor ZIK1 gene

Protein Domains /Familiesfor ZIK1 gene

Functionfor ZIK1 gene

Pathways & Interactionsfor ZIK1 gene

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for ZIK1 gene

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for ZIK1 gene

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for ZIK1 gene

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Families
for ZIK1 gene

Function
for ZIK1 gene

Pathways & Interactions
for ZIK1 gene

Drugs & Compounds
for ZIK1 gene

Transcripts
for ZIK1 gene

Expression
for ZIK1 gene

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for ZIK1 gene

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for ZIK1 gene

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for ZIK1 gene

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for ZIK1 gene