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Aliases for ZIC5 Gene

Aliases for ZIC5 Gene

  • Zic Family Member 5 2 3 5
  • Zic Family Member 5 (Odd-Paired Homolog, Drosophila) 2
  • Zinc Finger Protein Of The Cerebellum 5 4

External Ids for ZIC5 Gene

Previous GeneCards Identifiers for ZIC5 Gene

  • GC13M098977
  • GC13M095004
  • GC13M099454
  • GC13M098315
  • GC13M099415
  • GC13M100615
  • GC13M081209

Summaries for ZIC5 Gene

Entrez Gene Summary for ZIC5 Gene

  • This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development, and have been associated X-linked visceral heterotaxy and holoprosencephaly type 5. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 2, a related family member on chromosome 13. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZIC5 Gene

ZIC5 (Zic Family Member 5) is a Protein Coding gene. Diseases associated with ZIC5 include Visceral Heterotaxy. Among its related pathways are Neural Crest Differentiation. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZIC3.

UniProtKB/Swiss-Prot for ZIC5 Gene

  • Essential for neural crest development, converting cells from an epidermal fate to a neural crest cell fate. Binds to DNA (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZIC5 Gene

Genomics for ZIC5 Gene

Regulatory Elements for ZIC5 Gene

Enhancers for ZIC5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZIC5 on UCSC Golden Path with GeneCards custom track

Promoters for ZIC5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZIC5 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZIC5 Gene

99,962,964 bp from pter
99,971,924 bp from pter
8,961 bases
Minus strand

Genomic View for ZIC5 Gene

Genes around ZIC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZIC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZIC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZIC5 Gene

Proteins for ZIC5 Gene

  • Protein details for ZIC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein ZIC 5
    Protein Accession:
    Secondary Accessions:
    • Q5VYB0

    Protein attributes for ZIC5 Gene

    663 amino acids
    Molecular mass:
    68448 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAK55418.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ZIC5 Gene

Proteomics data for ZIC5 Gene at MOPED

Post-translational modifications for ZIC5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZIC5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZIC5 Gene

Domains & Families for ZIC5 Gene

Gene Families for ZIC5 Gene

Protein Domains for ZIC5 Gene

Suggested Antigen Peptide Sequences for ZIC5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GLI C2H2-type zinc-finger protein family.
  • Contains 4 C2H2-type zinc fingers.
  • Belongs to the GLI C2H2-type zinc-finger protein family.
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZIC5: view

Function for ZIC5 Gene

Molecular function for ZIC5 Gene

UniProtKB/Swiss-Prot Function:
Essential for neural crest development, converting cells from an epidermal fate to a neural crest cell fate. Binds to DNA (By similarity).
genes like me logo Genes that share phenotypes with ZIC5: view

Animal Models for ZIC5 Gene

MGI Knock Outs for ZIC5:

Animal Model Products

miRNA for ZIC5 Gene

miRTarBase miRNAs that target ZIC5

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZIC5 Gene

Localization for ZIC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZIC5 Gene

Subcellular locations from

Jensen Localization Image for ZIC5 Gene COMPARTMENTS Subcellular localization image for ZIC5 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZIC5 Gene

Pathways & Interactions for ZIC5 Gene

SuperPathways for ZIC5 Gene

genes like me logo Genes that share pathways with ZIC5: view

Pathways by source for ZIC5 Gene

1 BioSystems pathway for ZIC5 Gene

Interacting Proteins for ZIC5 Gene

Gene Ontology (GO) - Biological Process for ZIC5 Gene


No data available for SIGNOR curated interactions for ZIC5 Gene

Drugs & Compounds for ZIC5 Gene

No Compound Related Data Available

Transcripts for ZIC5 Gene

mRNA/cDNA for ZIC5 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZIC5 Gene

Zic family member 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZIC5 Gene

No ASD Table

Relevant External Links for ZIC5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZIC5 Gene

mRNA expression in normal human tissues for ZIC5 Gene

mRNA differential expression in normal tissues according to GTEx for ZIC5 Gene

This gene is overexpressed in Brain - Cerebellum (x21.9) and Brain - Cerebellar Hemisphere (x18.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZIC5 Gene

SOURCE GeneReport for Unigene cluster for ZIC5 Gene Hs.508570

genes like me logo Genes that share expression patterns with ZIC5: view

Protein tissue co-expression partners for ZIC5 Gene

- Elite partner

Primer Products

No data available for Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZIC5 Gene

Orthologs for ZIC5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZIC5 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia ZIC5 35
  • 93.55 (n)
  • 93.34 (a)
ZIC5 36
  • 92 (a)
(Mus musculus)
Mammalia Zic5 35
  • 89.96 (n)
  • 88.41 (a)
Zic5 16
Zic5 36
  • 89 (a)
(Rattus norvegicus)
Mammalia Zic5 35
  • 92.7 (n)
  • 93.96 (a)
(Bos Taurus)
Mammalia ZIC5 36
  • 89 (a)
(Monodelphis domestica)
Mammalia ZIC5 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia ZIC5 36
  • 91 (a)
(Pan troglodytes)
Mammalia ZIC5 36
  • 100 (a)
(Anolis carolinensis)
Reptilia ZIC5 36
  • 86 (a)
African clawed frog
(Xenopus laevis)
Amphibia zic5-A 35
(Danio rerio)
Actinopterygii Dr.27091 35
zic5 36
  • 67 (a)
fruit fly
(Drosophila melanogaster)
Insecta lmd 37
  • 54 (a)
opa 37
  • 62 (a)
opa 36
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4381 36
  • 33 (a)
Species with no ortholog for ZIC5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZIC5 Gene

Gene Tree for ZIC5 (if available)
Gene Tree for ZIC5 (if available)

Paralogs for ZIC5 Gene

(7) SIMAP similar genes for ZIC5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZIC5: view

Variants for ZIC5 Gene

Sequence variations from dbSNP and Humsavar for ZIC5 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1855579 -- 99,972,320(-) GAGCG(C/T)TAGGC upstream-variant-2KB
rs3809368 -- 99,972,636(+) GTGGC(A/G)GGGCA upstream-variant-2KB
rs3809369 -- 99,972,830(+) TATTT(A/G)CTGAT upstream-variant-2KB
rs3809370 -- 99,973,697(+) TTATG(A/G)AGAAA upstream-variant-2KB
rs3825508 -- 99,963,900(-) CACCC(A/C)CTCCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZIC5 Gene

Variant ID Type Subtype PubMed ID
esv2747875 CNV Deletion 23290073
dgv345n67 CNV Gain 20364138
nsv826757 CNV Loss 20364138
nsv832697 CNV Loss 17160897
nsv510622 CNV Loss 20534489
dgv346n67 CNV Gain 20364138
nsv900950 CNV Loss 21882294
dgv347n67 CNV Gain 20364138
dgv1784n71 CNV Loss 21882294
nsv826766 CNV Gain 20364138
nsv456093 CNV Loss 19166990

Variation tolerance for ZIC5 Gene

Gene Damage Index Score: 3.67; 57.01% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZIC5 Gene

Disorders for ZIC5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZIC5 Gene - From: GeneCards

Disorder Aliases PubMed IDs
visceral heterotaxy
  • heterotaxia
- elite association - COSMIC cancer census association via MalaCards
Search ZIC5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ZIC5

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ZIC5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZIC5 Gene

Publications for ZIC5 Gene

  1. Genome-wide meta-analysis of myopia and hyperopia provides evidence for replication of 11 loci. (PMID: 25233373) Simpson C.L. … Stambolian D. (PLoS ONE 2014) 3 67
  2. Expression of ZIC family genes in meningiomas and other brain tumors. (PMID: 20199689) Aruga J. … Yokota N. (BMC Cancer 2010) 3
  3. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PMID: 20467438) Arbuckle M.I. … Grant S.G. (EMBO Rep. 2010) 3
  4. Description of the smallest critical region for Dandy-Walker malformation in chromosome 13 in a girl with a cryptic deletion related to t(6;13)(q23;q32). (PMID: 20683983) Mademont-Soler I. … SA!nchez A. (Am. J. Med. Genet. A 2010) 3
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3

Products for ZIC5 Gene

Sources for ZIC5 Gene