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Aliases for ZIC5 Gene

Aliases for ZIC5 Gene

  • Zic Family Member 5 2 3
  • Zic Family Member 5 (Odd-Paired Homolog, Drosophila) 2
  • Zinc Finger Protein Of The Cerebellum 5 4

External Ids for ZIC5 Gene

Previous GeneCards Identifiers for ZIC5 Gene

  • GC13M098977
  • GC13M095004
  • GC13M099454
  • GC13M098315
  • GC13M099415
  • GC13M100615
  • GC13M081209

Summaries for ZIC5 Gene

Entrez Gene Summary for ZIC5 Gene

  • This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development, and have been associated X-linked visceral heterotaxy and holoprosencephaly type 5. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 2, a related family member on chromosome 13. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZIC5 Gene

ZIC5 (Zic Family Member 5) is a Protein Coding gene. Diseases associated with ZIC5 include visceral heterotaxy and heterotaxy. Among its related pathways are Neural Crest Differentiation. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZIC4.

UniProtKB/Swiss-Prot for ZIC5 Gene

  • Essential for neural crest development, converting cells from an epidermal fate to a neural crest cell fate. Binds to DNA (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZIC5 Gene

Genomics for ZIC5 Gene

Regulatory Elements for ZIC5 Gene

Genomic Location for ZIC5 Gene

Start:
99,962,964 bp from pter
End:
99,971,924 bp from pter
Size:
8,961 bases
Orientation:
Minus strand

Genomic View for ZIC5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZIC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZIC5 Gene

Proteins for ZIC5 Gene

  • Protein details for ZIC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96T25-ZIC5_HUMAN
    Recommended name:
    Zinc finger protein ZIC 5
    Protein Accession:
    Q96T25
    Secondary Accessions:
    • Q5VYB0

    Protein attributes for ZIC5 Gene

    Size:
    663 amino acids
    Molecular mass:
    68448 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK55418.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ZIC5 Gene

Proteomics data for ZIC5 Gene at MOPED

Post-translational modifications for ZIC5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZIC5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZIC5 Gene

Domains for ZIC5 Gene

Gene Families for ZIC5 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZIC5 Gene

Suggested Antigen Peptide Sequences for ZIC5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96T25

UniProtKB/Swiss-Prot:

ZIC5_HUMAN :
  • Q96T25
Family:
  • Belongs to the GLI C2H2-type zinc-finger protein family.
Similarity:
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZIC5: view

Function for ZIC5 Gene

Molecular function for ZIC5 Gene

UniProtKB/Swiss-Prot Function: Essential for neural crest development, converting cells from an epidermal fate to a neural crest cell fate. Binds to DNA (By similarity).

Gene Ontology (GO) - Molecular Function for ZIC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZIC5: view
genes like me logo Genes that share phenotypes with ZIC5: view

Animal Models for ZIC5 Gene

MGI Knock Outs for ZIC5:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ZIC5 Gene

Localization for ZIC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZIC5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZIC5 Gene COMPARTMENTS Subcellular localization image for ZIC5 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZIC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZIC5: view

Pathways for ZIC5 Gene

SuperPathways for ZIC5 Gene

genes like me logo Genes that share pathways with ZIC5: view

Pathways by source for ZIC5 Gene

1 BioSystems pathway for ZIC5 Gene

Interacting Proteins for ZIC5 Gene

Gene Ontology (GO) - Biological Process for ZIC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001843 neural tube closure IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0030154 cell differentiation IEA --
GO:0030900 forebrain development IEA --
genes like me logo Genes that share ontologies with ZIC5: view

Transcripts for ZIC5 Gene

mRNA/cDNA for ZIC5 Gene

(1) REFSEQ mRNAs :
(6) Selected AceView cDNA sequences:
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZIC5 Gene

Zic family member 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZIC5 Gene

No ASD Table

Relevant External Links for ZIC5 Gene

GeneLoc Exon Structure for
ZIC5
ECgene alternative splicing isoforms for
ZIC5

Expression for ZIC5 Gene

mRNA expression in normal human tissues for ZIC5 Gene

mRNA differential expression in normal tissues according to GTEx for ZIC5 Gene

This gene is overexpressed in Brain - Cerebellum (21.9) and Brain - Cerebellar Hemisphere (18.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZIC5 Gene

SOURCE GeneReport for Unigene cluster for ZIC5 Gene Hs.508570

genes like me logo Genes that share expressions with ZIC5: view

No data available for mRNA Expression by UniProt/SwissProt for ZIC5 Gene

Orthologs for ZIC5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZIC5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZIC5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZIC5 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZIC5 35
  • 93.55 (n)
  • 93.34 (a)
ZIC5 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zic5 35
  • 89.96 (n)
  • 88.41 (a)
Zic5 16
Zic5 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZIC5 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZIC5 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zic5 35
  • 92.7 (n)
  • 93.96 (a)
lizard
(Anolis carolinensis)
Reptilia ZIC5 36
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia zic5-A 35
zebrafish
(Danio rerio)
Actinopterygii Dr.27091 35
zic5 36
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta opa 36
  • 34 (a)
OneToMany
opa 37
  • 62 (a)
lmd 37
  • 54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4381 36
  • 33 (a)
ManyToMany
Species with no ortholog for ZIC5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZIC5 Gene

ENSEMBL:
Gene Tree for ZIC5 (if available)
TreeFam:
Gene Tree for ZIC5 (if available)

Paralogs for ZIC5 Gene

Paralogs for ZIC5 Gene

Selected SIMAP similar genes for ZIC5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZIC5: view

Variants for ZIC5 Gene

Sequence variations from dbSNP and Humsavar for ZIC5 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs1855579 -- 99,972,320(-) GAGCG(C/T)TAGGC upstream-variant-2KB
rs3742253 -- 99,962,942(-) GGTCT(C/G)TTGAT downstream-variant-500B
rs3809368 -- 99,972,636(+) GTGGC(A/G)GGGCA upstream-variant-2KB
rs3809369 -- 99,972,830(+) TATTT(A/G)CTGAT upstream-variant-2KB
rs3809370 -- 99,973,697(+) TTATG(A/G)AGAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZIC5 Gene

Variant ID Type Subtype PubMed ID
esv2747875 CNV Deletion 23290073
dgv345n67 CNV Gain 20364138
nsv826757 CNV Loss 20364138
nsv832697 CNV Loss 17160897
nsv510622 CNV Loss 20534489
dgv346n67 CNV Gain 20364138
nsv900950 CNV Loss 21882294
dgv347n67 CNV Gain 20364138
dgv1784n71 CNV Loss 21882294
nsv826766 CNV Gain 20364138
nsv456093 CNV Loss 19166990

Relevant External Links for ZIC5 Gene

HapMap Linkage Disequilibrium report
ZIC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZIC5 Gene

Disorders for ZIC5 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for ZIC5 Gene including...

Search for ZIC5 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ZIC5 Gene

Relevant External Links for ZIC5

Genetic Association Database (GAD)
ZIC5
genes like me logo Genes that share disorders with ZIC5: view

No data available for UniProtKB/Swiss-Prot for ZIC5 Gene

Publications for ZIC5 Gene

  1. A new murine zinc finger gene, Opr. (PMID: 11044622) Furushima K. … Aizawa S. (Mech. Dev. 2000) 3
  2. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3
  3. Molecular properties of Zic4 and Zic5 proteins: functional diversity within Zic family. (PMID: 15465018) Ishiguro A. … Aruga J. (Biochem. Biophys. Res. Commun. 2004) 3
  4. Expression of ZIC family genes in meningiomas and other brain tumors. (PMID: 20199689) Aruga J. … Yokota N. (BMC Cancer 2010) 3
  5. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PMID: 20467438) Arbuckle M.I. … Grant S.G. (EMBO Rep. 2010) 3

Products for ZIC5 Gene

Sources for ZIC5 Gene

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