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ZIC5 Gene

protein-coding   GIFtS: 48
GCID: GC13M100615

Zic Family Member 5

(Previous names: Zic family member 5 (odd-paired homolog, Drosophila))
  See ZIC5-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zic Family Member 51 2
Zic Family Member 5 (Odd-Paired Homolog, Drosophila)1 2
Zinc Finger Protein Of The Cerebellum 52 3
Zinc Family Member 5 Protein2
Zinc Finger Protein ZIC 52

External Ids:    HGNC: 203221   Entrez Gene: 854162   Ensembl: ENSG000001398007   UniProtKB: Q96T253   

Export aliases for ZIC5 gene to outside databases

Previous GC identifers: GC13M098977 GC13M095004 GC13M099454 GC13M098315 GC13M099415 GC13M081209


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZIC5 Gene:
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are
important during development, and have been associated X-linked visceral heterotaxy and holoprosencephaly type 5.
This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 2, a related family member
on chromosome 13. (provided by RefSeq, Jul 2008)

GeneCards Summary for ZIC5 Gene:
ZIC5 (Zic family member 5) is a protein-coding gene. Diseases associated with ZIC5 include visceral heterotaxy, and heterotaxy. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is MTF1.

UniProtKB/Swiss-Prot: ZIC5_HUMAN, Q96T25
Function: Essential for neural crest development, converting cells from an epidermal fate to a neural crest cell
fate. Binds to DNA (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NC_018924.2  NT_009952.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZIC5 gene promoter:
         E2F-3a   E2F-4   COUP-TF1   MyoD   COUP   HNF-4alpha2   HNF-4alpha1   COUP-TF   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZIC5 promoter sequence
   Search Chromatin IP Primers for ZIC5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZIC5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q32.3   Ensembl cytogenetic band:  13q32.3   HGNC cytogenetic band: 13q32.2

ZIC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZIC5 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M100615:  view genomic region     (about GC identifiers)

Start:
100,615,218 bp from pter      End:
100,624,178 bp from pter
Size:
8,961 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZIC5_HUMAN, Q96T25 (See protein sequence)
Recommended Name: Zinc finger protein ZIC 5  
Size: 663 amino acids; 68448 Da
Caution: It is uncertain whether Met-1 or Met-25 is the initiator
Sequence caution: Sequence=AAK55418.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q5VYB0

Explore the universe of human proteins at neXtProt for ZIC5: NX_Q96T25

Explore proteomics data for ZIC5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZIC5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_149123.2  
    ENSEMBL proteins: 
     ENSP00000267294  

    ZIC5 Human Recombinant Protein Products:

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    Browse Sino Biological Recombinant Proteins
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    Cloud-Clone Corp. Proteins for ZIC5

     
    Search eBioscience for Proteins for ZIC5 

     
    antibodies-online proteins for ZIC5 

     
    antibodies-online peptides for ZIC5

    ZIC5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals ZIC5 Antibodies
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    antibodies-online antibodies for ZIC5 (22 products) 

    ZIC5 Assay Products:

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    Cloud-Clone Corp. ELISAs for ZIC5
    Cloud-Clone Corp. CLIAs for ZIC5
    Search eBioscience for ELISAs for ZIC5 
    antibodies-online kits for ZIC5 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q96T25

    ProtoNet protein and cluster: Q96T25

    UniProtKB/Swiss-Prot: ZIC5_HUMAN, Q96T25
    Similarity: Belongs to the GLI C2H2-type zinc-finger protein family
    Similarity: Contains 4 C2H2-type zinc fingers


    Find genes that share domains with ZIC5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZIC5_HUMAN, Q96T25
    Function: Essential for neural crest development, converting cells from an epidermal fate to a neural crest cell
    fate. Binds to DNA (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZIC5           About GenesLikeMe


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Zic5):
     behavior/neurological  craniofacial  embryogenesis  growth/size/body  mortality/aging 
     nervous system  skeleton  vision/eye 

    Find genes that share phenotypes with ZIC5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Zic5tm1Jaru for ZIC5

       genOway: Develop your customized and physiologically relevant rodent model for ZIC5

    miRNA
    Products:
        
    miRTarBase miRNAs that target ZIC5:
    hsa-mir-192-5p (MIRT026278), hsa-mir-23b-3p (MIRT023467), hsa-mir-324-5p (MIRT043243), hsa-mir-186-5p (MIRT021085), hsa-mir-93-5p (MIRT027950), hsa-mir-340-5p (MIRT019534), hsa-mir-128-3p (MIRT021906), hsa-mir-215-5p (MIRT024611)

    Block miRNA regulation of human, mouse, rat ZIC5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZIC5 (see all 31):
    hsa-miR-323-3p hsa-miR-21* hsa-miR-4272 hsa-miR-29c hsa-miR-29a hsa-miR-767-5p hsa-miR-301a hsa-miR-449a
    SwitchGear 3'UTR luciferase reporter plasmidZIC5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ZIC5
    Predesigned siRNA for gene silencing in human, mouse, rat ZIC5

    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZIC5 (NM_033132)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZIC5
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZIC5

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for ZIC5
    Browse ESI BIO Cell Lines and PureStem Progenitors for ZIC5 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZIC5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZIC5_HUMAN, Q96T25: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZIC5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZIC5 About    
    See pathways by source

    SuperPathContained pathways About
    1Neural Crest Differentiation
    Neural Crest Differentiation


    1 BioSystems Pathway for ZIC5
        Neural Crest Differentiation


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZIC5
    Interactions:

        Search GeneGlobe Interaction Network for ZIC5

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for ZIC5 (Q96T252 ENSP000002672944) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TCF7L1ENSP000002821114STRING: ENSP00000282111
    TCF7L2ENSP000003584044STRING: ENSP00000358404
    TCF7ENSP000003403474STRING: ENSP00000340347
    --P310162MINT-8106021
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001843neural tube closure IEA--
    GO:0030154cell differentiation IEA--
    GO:0030900forebrain development IEA--

    Find genes that share ontologies with ZIC5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZIC5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZIC5 gene: 
    NM_033132.3  

    Unigene Cluster for ZIC5:

    Zic family member 5
    Hs.508570  [show with all ESTs]
    Unigene Representative Sequence: NM_033132
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000267294(uc001vom.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ZIC5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZIC5 (see all 31):
    hsa-miR-323-3p hsa-miR-21* hsa-miR-4272 hsa-miR-29c hsa-miR-29a hsa-miR-767-5p hsa-miR-301a hsa-miR-449a
    SwitchGear 3'UTR luciferase reporter plasmidZIC5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZIC5
    Predesigned siRNA for gene silencing in human, mouse, rat ZIC5
    Clone
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    OriGene clones in human, mouse for ZIC5 (see all 6)
    OriGene ORF clones in mouse, rat for ZIC5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZIC5 (NM_033132)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZIC5
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZIC5
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ZIC5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZIC5
      QuantiTect SYBR Green Assays in human, mouse, rat ZIC5
      QuantiFast Probe-based Assays in human, mouse, rat ZIC5

    Additional mRNA sequence: AF378304.1 

    3 DOTS entries:

    DT.405334  DT.102835927  DT.40211565 

    6 AceView cDNA sequences:

    BE552258 NM_033132 AI699626 AF378304 BF057226 BF511233 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZIC5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATAGGTTAA
    ZIC5 Expression
    About this image


    ZIC5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 15 entries
             Thalamus
             Septum   
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 2 entries
             Epiblast Cells Epiblast
             Epiblast Stem Cell line 5
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Dermis (Integumentary System)
    ZIC5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZIC5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.508570
        Custom PCR Arrays for ZIC5
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZIC5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ZIC5 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zic51 , 5 zinc finger protein of the cerebellum 51, 5 89.96(n)1
    88.41(a)1
      14 (65.96 cM)5
    651001  NM_022987.31  NP_075363.11 
     1224567955 
    lizard
    (Anolis carolinensis)
    Reptilia ZIC56
    Zic family member 5
    86(a)
    1 ↔ 1
    3(99260063-99269560)
    African clawed frog
    (Xenopus laevis)
    Amphibia zic5-A2 Zic family member 5 80.13(n)    AB034983.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.270912 Danio rerio zinc finger protein Zic5 (zic5) mRNA, complete more 80.04(n)    AY326458.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta opa3 midgut development specific RNA
    polymerase II more
    62(a)
    (best of 2)
      3 82E1   --
    rice
    (Oryza sativa)
    Liliopsida NM_188290.12   -- 72.5(n)    NM_188290.1 


    ENSEMBL Gene Tree for ZIC5 (if available)
    TreeFam Gene Tree for ZIC5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZIC5 gene
    MTF12  ZIC32  ZNF4102  ZNF762  GLI12  ZIC22  ZIC12  GLIS22  
    GLI22  ZIC42  GLIS12  ZNF1432  GLIS32  GLI32  
    7 SIMAP similar genes for ZIC5 using alignment to 1 protein entry:     ZIC5_HUMAN:
    GLIS3    ZNF    ZIC4    ZNF323    ZNF844    ZIC1
    ZIC2

    Find genes that share paralogs with ZIC5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZIC5 (see all 225)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1919261461,2
    --100614911(+) CTCACC/TGTCCC 1 -- int10--------
    rs1826862571,2
    --100614927(+) CCACAC/TTTTCT 1 -- int10--------
    rs1477005201,2
    C--100615052(+) AGTAAC/GCCAAA 1 -- int10--------
    rs1428299061,2
    C--100615110(+) ATATC-/TGTGTTT 1 -- int10--------
    rs1870163401,2
    --100615111(+) TATCTA/GTGTTT 1 -- int10--------
    rs1180071661,2
    F--100615179(+) TGGGGA/GGAGGC 1 -- int11Minor allele frequency- G:0.01NA 120
    rs37422531,2
    C,F,A,H--100615196(-) GGTCTC/GTTGAT 1 -- int129Minor allele frequency- N:0.00EA NS NA CSA WA 3354
    rs1142788571,2
    F--100615221(+) ACTCCA/CTTAGC 1 -- int11Minor allele frequency- C:0.03WA 118
    rs169571001,2
    C,F,H--100615239(+) TCTATT/GTGTAT 1 -- int114Minor allele frequency- G:0.03NA NS EA WA 1526
    rs1467446351,2
    C--100615349(+) TACAC-/ATTTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZIC5 (100615218 - 100624178 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZIC5 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2747875CNV Deletion23290073
    nsv510622CNV Loss20534489
    nsv456093CNV Loss19166990
    nsv832697CNV Loss17160897
    nsv900950CNV Loss21882294
    dgv1784n71CNV Loss21882294
    nsv826757CNV Loss20364138
    nsv826766CNV Gain20364138
    dgv346n67CNV Gain20364138
    dgv345n67CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZIC5
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for ZIC5:    
    About MalaCards
    visceral heterotaxy    heterotaxy

    1 disease from the University of Copenhagen DISEASES database for ZIC5:
    Holoprosencephaly

    Find genes that share disorders with ZIC5           About GenesLikeMe

    Genetic Association Database (GAD): ZIC5

    Export disorders for ZIC5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZIC5 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with ZIC5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    2. Expression of ZIC family genes in meningiomas and other brain tumors. (PubMed id 20199689)1 Aruga J....Yokota N. (BMC Cancer 2010)
    3. Description of the smallest critical region for Dandy-Walker malformation in chromosome 13 in a girl with a cryptic deletion related to t(6;13)(q23;q32). (PubMed id 20683983)1 Mademont-Soler I....SA!nchez A. (Am. J. Med. Genet. A 2010)
    4. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (EMBO Rep. 2010)
    5. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    6. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)4 Benjamin E.J....Vasan R.S. (BMC Med. Genet. 2007)
    7. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)2 Dunham A.... Ross M.T. (Nature 2004)
    8. Molecular properties of Zic4 and Zic5 proteins: functional diversity within Zic family. (PubMed id 15465018)1 Ishiguro A....Aruga J. (Biochem. Biophys. Res. Commun. 2004)
    9. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)
    10. A new murine zinc finger gene, Opr. (PubMed id 11044622)1 Furushima K....Aizawa S. (Mech. Dev. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 85416 HGNC: 20322 AceView: ZIC5 Ensembl:ENSG00000139800 euGenes: HUgn85416
    ECgene: ZIC5 H-InvDB: ZIC5

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ZIC5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZIC5 gene:
    Search GeneIP for patents involving ZIC5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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