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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZIC4 Gene

protein-coding   GIFtS: 52
GCID: GC03M147103

Zic family member 4

(Previous name: zinc finger protein of the cerebellum 4 )
 Explore 10 diseases affiliated with
ZIC4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ZIC4    

Aliases
for ZIC4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Zic Family Member 41 2
Zinc Finger Protein Of The Cerebellum 41 2 3
Zinc Family Member 4 Protein HZIC42
Zinc Finger Protein ZIC 42

External Ids:    HGNC: 203931   Entrez Gene: 841072   Ensembl: ENSG000001749637   OMIM: 6089485   UniProtKB: Q8N9L13   

Export aliases for ZIC4 gene to outside databases

Previous GC identifers: GC03M143947 GC03M147990 GC03M148386 GC03M148426 GC03M148587 GC03M144480


Summaries
for ZIC4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ZIC4:
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important
during development, and have been associated with X-linked visceral heterotaxy and holoprosencephaly type 5. This gene
is closely linked to the gene encoding zinc finger protein of the cerebellum 1, a related family member on chromosome
3. Heterozygous deletion of these linked genes is involved in Dandy-Walker malformation, which is a congenital
cerebellar malformation. Multiple transcript variants have been identified for this gene. (provided by RefSeq, Dec
2009)

UniProtKB/Swiss-Prot: ZIC4_HUMAN, Q8N9L1
Function: Binds to DNA (By similarity)




Genomic Views
for ZIC4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZIC4 gene promoter:
         Nkx3-1   Nkx3-1 v4   Pbx1a   USF-1:USF-2   Nkx3-1 v1   Nkx3-1 v2   SRY   USF-1   IRF-7A   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZIC4 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZIC4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZIC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q24   Ensembl cytogenetic band:  3q24   HGNC cytogenetic band: 3q24

ZIC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZIC4 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M147103:  view genomic region     (about GC identifiers)

Start:
 147,103,833 bp from pter      End:
 147,124,647 bp from pter
Size:
 20,815 bases      Orientation:
 minus strand

Proteins
for ZIC4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ZIC4_HUMAN, Q8N9L1 (See protein sequence)
Recommended Name: Zinc finger protein ZIC 4  
Size: 334 amino acids; 36567 Da
Subcellular location: Nucleus (By similarity)
Caution: It is uncertain whether Met-1 is the initiator
Sequence caution: Sequence=AAH29507.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A
sequence starting in position 229; Sequence=AAK06845.1; Type=Erroneous initiation; Note=Translation N-terminally
extended;
Secondary accessions: A0AVA2 B2RMQ8 B4DF89 B7Z2L2 C9J7D5 J3KQG1 Q4G157 Q9BZ94
Alternative splicing: 5 isoforms:  Q8N9L1-1   Q8N9L1-2   Q8N9L1-3   Q8N9L1-4   Q8N9L1-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZIC4: NX_Q8N9L1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8N9L1

    • ZIC4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001161850.1  NP_001161851.1  NP_001230185.1  NP_115529.2  

    ENSEMBL proteins: 
     ENSP00000372553   ENSP00000417855   ENSP00000420775   ENSP00000418277   ENSP00000420627  
     ENSP00000418343   ENSP00000419727   ENSP00000397695   ENSP00000435509  

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    Novus Biologicals ZIC4 Proteins
    Novus Biologicals ZIC4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ZIC4

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ISS--


    ZIC4 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ZIC4

    Protein Domains /
    Families
    for ZIC4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ZIC4 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8N9L1

    ProtoNet protein and cluster: Q8N9L1

    UniProtKB/Swiss-Prot: ZIC4_HUMAN, Q8N9L1
    Similarity: Belongs to the GLI C2H2-type zinc-finger protein family
    Similarity: Contains 5 C2H2-type zinc fingers


    Function
    for ZIC4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ZIC4_HUMAN, Q8N9L1
    Function: Binds to DNA (By similarity)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZIC4
    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate ZIC4 (see all 40):
    hsa-miR-4317 hsa-miR-4272 hsa-miR-1258 hsa-miR-342-3p hsa-miR-502-3p hsa-miR-890 hsa-miR-3150b-3p hsa-miR-629
    SwitchGear 3'UTR luciferase reporter plasmid: ZIC4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZIC4 (see all 7)
    OriGene shRNA RFP: ZIC4
    OriGene siRNA: ZIC4
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ZIC4

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZIC4 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ZIC4
    Search LifeMap BioReagents cell lines for ZIC4

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZIC4

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding ISS--
    GO:0008270zinc ion binding IEA--


    ZIC4 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for ZIC4:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

    Animal Models:
         Mouse knock-outs for ZIC4: Zic1/Zic4Zic1/tm1Kjmi Zic4tm2Kjmi
         4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Zic4):
     behavior/neurological  growth/size  mortality/aging  nervous system 

    ZIC4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ZIC4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZIC4

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ZIC4 (Q8N9L13 ENSP000003725534) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZNF598Q86UK73, ENSP000004114094I2D: score=2 STRING: ENSP00000411409
    About this table

    Drugs & Compounds
    for ZIC4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZIC4
    Search CenterWatch for drugs/clinical trials and news about ZIC4 

    Transcripts
    for ZIC4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ZIC4 gene (4 alternative transcripts): 
    NM_001168378.1  NM_001168379.1  NM_001243256.1  NM_032153.5  

    Unigene Cluster for ZIC4:

    Zic family member 4
    Hs.415766  [show with all ESTs]
    Unigene Representative Sequence: AK124600
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000383075(uc003ewd.2 uc021xfg.1) ENST00000472749(uc021xfc.1 uc021xfd.1 uc021xfe.1)
    ENST00000493664 ENST00000494569 ENST00000484399 ENST00000473123 ENST00000463850
    ENST00000480015 ENST00000464502 ENST00000491672 ENST00000475502 ENST00000462748
    ENST00000484586 ENST00000463250 ENST00000464144 ENST00000425731(uc003ewc.2 uc021xff.1)
    ENST00000525172(uc011bno.2)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZIC4
    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate ZIC4 (see all 40):
    hsa-miR-4317 hsa-miR-4272 hsa-miR-1258 hsa-miR-342-3p hsa-miR-502-3p hsa-miR-890 hsa-miR-3150b-3p hsa-miR-629
    SwitchGear 3'UTR luciferase reporter plasmid: ZIC4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZIC4 (see all 7)
    OriGene shRNA RFP: ZIC4
    OriGene siRNA: ZIC4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZIC4
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZIC4 (see all 3)
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    GenScript: all cDNA clones in your preferred vector (see all 3): ZIC4 (NM_032153)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZIC4 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZIC4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZIC4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZIC4

    Additional cDNA sequence: 

    AK056262.1 AK056394.1 AK094286.1 AK124600.1 AK126595.1 AK127733.1 AK293981.1 AK294831.1 
    BC029507.1 BC126267.1 BC136339.1 NR_033118.2 NR_033119.2 NR_040762.1 

    13 DOTS entries:

    DT.95259753  DT.436847  DT.101970057  DT.101974133  DT.120918384  DT.120918338  DT.97769461  DT.101962759 
    DT.95139468  DT.120918337  DT.120918359  DT.120918335  DT.120918358 

    24/29 AceView cDNA sequences (see all 29):

    Z42187 R13161 NM_032153 Z38442 AK056262 AK094286 AK124600 AK126595 
    AF332509 AI492851 AW206453 AI963981 BI599124 AK127733 BX093756 AK056394 
    BX508506 BC029507 T08356 BX488504 BE673074 AW071663 BE504904 AA621639 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ZIC4 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d ^ 11
    SP1:                    -           -     -                                                                                             
    SP2:                                                                                      -     -     -                                 
    SP3:                    -     -     -     -                                                                                             
    SP4:                    -     -     -     -           -     -     -     -     -     -     -     -     -                                 
    SP5:                          -     -     -                                                                                             


    ECgene alternative splicing isoforms for ZIC4

    Expression
    for ZIC4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZIC4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCGCTGCATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ZIC4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ progenitor Z1 (Embryonic Progenitor Cell)
    Cardiomyocyte-like cells (Spontaneous differen...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ZIC4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZIC4

    SOURCE GeneReport for Unigene cluster: Hs.415766
        SABiosciences Custom PCR Arrays for ZIC4
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZIC4
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZIC4

    Orthologs
    for ZIC4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ZIC4 gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ZIC41 Zic family member 4 75.55(n)
    75.98(a)    		   424885  XM_422698.3  XP_422698.3 
    zebrafish
    (Danio rerio)    		 Actinopterygii zic41 zic family member 4 68.28(n)
    72.58(a)    		   767673  NM_001076612.1  NP_001070080.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta opa6
    		 odd paired
    		 25(a)
    		 1 → many
    		 3R(678535-695709)
    worm
    (Caenorhabditis elegans)    		 Secernentea ref-26
    		 REgulator of Fusion family member (ref-2)
    		 31(a)
    		 possible ortholog
    		 X(7744188-7749959)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT4G066346
    		 uncharacterized zinc finger protein
    		 15(a)
    		 1 → many
    		 4(3764289-3766578)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 ZOS5-01 - C2H2 zinc finger protein, expressed
    		 17(a)
    15(a)
    		 many ↔ many
    many ↔ many
    		 2(20795085-20798606)
    5(321102-324421)


    ENSEMBL Gene Tree for ZIC4 (if available)
    TreeFam Gene Tree for ZIC4 (if available) 

    Paralogs
    for ZIC4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZIC4 gene
    ZNF762  GLI12  ZIC22  YY12  ZIC12  GLIS22  GLI22  ZNF1432  
    GLI32  YY22  MTF12  ZIC32  ZNF4102  ZFP422  GLIS12  GLIS32  
    ZIC52  
    18/21 SIMAP similar genes for ZIC4 using alignment to 4 protein entries:     ZIC4_HUMAN (see all proteins) (see all similar genes):
    ZIC1    ZIC3    ZIC2    GLI1    ZIC5    GLI2
    HZF16    ZNF323    ZNF    ZNF143    GLIS3    ZFS-5
    ZNF702P    ZNF697    kr-znf3    ZNF844    A-328A3.4    KLF1

    ZIC4 for paralogs           About GeneDecksing



    Genomic Variants
    for ZIC4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/276 NCBI SNPs in ZIC4 are shown (see all 276)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1146655631,2
    		C,F,--144480104(+) TGCAGC/AGCCAT 7 -- ut31 nc-transcript-variant1Minor allele frequency- A:0.08NA 120
    rs1157713161,2
    		C,F,--144480113(+) ATGTAC/TACAAA 7 -- ut31 nc-transcript-variant1Minor allele frequency- T:0.02NA 120
    rs769239521,2
    		--144480765(+) ACCTTA/CTAAAC 7 -- ut31 nc-transcript-variant0--------
    rs76376151,2
    		H--144480828(+) CTTCAG/ACTATT 7 -- ut31 nc-transcript-variant4Minor allele frequency- A:0.00NS EA 420
    rs800487581,2
    		--144480838(+) TCTCCT/CTCTTA 7 -- ut31 nc-transcript-variant1Minor allele frequency- C:0.01WA 118
    rs2020493081,2
    		C--144480888(-) TGTGTG/TTTTCT 7 -- ut31 nc-transcript-variant0--------
    rs98547521,2
    		H--144482475(+) TCAAGC/GGGCTC 7 -- ut31 nc-transcript-variant4Minor allele frequency- G:0.00NS EA 420
    rs44522991,2
    		H--144482649(+) ATGTCC/TTTAAT 7 -- ut31 nc-transcript-variant4Minor allele frequency- T:0.00NS EA 418
    rs752731461,2
    		F,--144483398(+) TAAAAT/CTGAGG 7 -- int11Minor allele frequency- C:0.08NA 120
    rs797126211,2
    		--144484028(+) AAGCCC/TCTCTG 7 -- int10--------

    HapMap Linkage Disequilibrium report for ZIC4 (147103833 - 147124647 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ZIC4: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for ZIC4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ZIC4 for disorders           About GeneDecksing

    OMIM gene information: 608948   
    OMIM disorders: 220200  
    10 diseases for ZIC4:    About MalaCards
    dandy-walker malformation    visceral heterotaxy    paraneoplastic neurologic disorders    spina bifida
    heterotaxy    holoprosencephaly    cerebellar degeneration    meningioma
    lung cancer    cerebritis

    1 disease from the University of Copenhagen DISEASES database for ZIC4:
    "blepharophimosis, ptosis, and epicanthus inversus syndrome"
    Human Genome Epidemiology (HuGE) Navigator: ZIC4 (1 document)

    Export disorders for ZIC4 gene to outside databases

    Publications
    for ZIC4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZIC4 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with ZIC4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Comparative analysis of a 229-kb medaka genomic region, containing the zic1 and zic4 genes, with Fugu, human, and mouse. (PubMed id 15177559)1, 9 Ohtsuka M....Kimura M. (2004)
    4. Genome-wide analysis of CpG island methylation in blad der cancer identified TBX2, TBX3, GATA2, and ZIC4 as pTa-specific prognostic mar kers. (PubMed id 22284968)1 Kandimalla R....Zwarthoff E.C. (2012)
    5. Dandy-Walker malformation associated with heterozygou s ZIC1 and ZIC4 deletion: Report of a new patient. (PubMed id 21204220)1 Tohyama J....Matsumoto N. (2011)
    6. [Technology of analysis of epigenetic and structural changes of epithelial tumors genome with NotI-microarrays by the example of human chromosome] (PubMed id 19425501)1 (2009)
    7. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    9. The ZIC gene family in development and disease. (PubMed id 15733262)1 Grinberg I. and Millen K.J. (2005)
    10. Heterozygous deletion of the linked genes ZIC1 and ZIC4 is involved in Dandy-Walker malformation. (PubMed id 15338008)1 Grinberg I....Millen K.J. (2004)

    External Searches for ZIC4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ZIC4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84107 HGNC: 20393 AceView: ZIC4 Ensembl:ENSG00000174963 euGenes: HUgn84107
    ECgene: ZIC4 H-InvDB: ZIC4

    Other Databases showing ZIC4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ZIC4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZIC4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ZIC4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ZIC4 gene:
    Search GeneIP for patents involving ZIC4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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