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ZIC4 Gene

protein-coding   GIFtS: 50
GCID: GC03M147103

Zic Family Member 4

(Previous name: zinc finger protein of the cerebellum 4)
  See ZIC4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zic Family Member 41 2
Zinc Finger Protein Of The Cerebellum 41 2 3
Zinc Family Member 4 Protein HZIC42
Zinc Finger Protein ZIC 42

External Ids:    HGNC: 203931   Entrez Gene: 841072   Ensembl: ENSG000001749637   OMIM: 6089485   UniProtKB: Q8N9L13   

Export aliases for ZIC4 gene to outside databases

Previous GC identifers: GC03M143947 GC03M147990 GC03M148386 GC03M148426 GC03M148587 GC03M144480


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZIC4 Gene:
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are
important during development, and have been associated with X-linked visceral heterotaxy and holoprosencephaly
type 5. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 1, a related
family member on chromosome 3. Heterozygous deletion of these linked genes is involved in Dandy-Walker
malformation, which is a congenital cerebellar malformation. Multiple transcript variants have been identified
for this gene. (provided by RefSeq, Dec 2009)

GeneCards Summary for ZIC4 Gene:
ZIC4 (Zic family member 4) is a protein-coding gene. Diseases associated with ZIC4 include isolated dandy-walker malformation with hydrocephalus, and isolated dandy-walker malformation without hydrocephalus. An important paralog of this gene is MTF1.

UniProtKB/Swiss-Prot: ZIC4_HUMAN, Q8N9L1
Function: Binds to DNA (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZIC4 gene promoter:
         Nkx3-1   Nkx3-1 v4   Pbx1a   USF-1:USF-2   Nkx3-1 v1   Nkx3-1 v2   SRY   USF-1   IRF-7A   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZIC4 promoter sequence
   Search Chromatin IP Primers for ZIC4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZIC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q24   Ensembl cytogenetic band:  3q24   HGNC cytogenetic band: 3q24

ZIC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZIC4 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M147103:  view genomic region     (about GC identifiers)

Start:
147,103,833 bp from pter      End:
147,124,647 bp from pter
Size:
20,815 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZIC4_HUMAN, Q8N9L1 (See protein sequence)
Recommended Name: Zinc finger protein ZIC 4  
Size: 334 amino acids; 36567 Da
Caution: It is uncertain whether Met-1 is the initiator
Sequence caution: Sequence=AAH29507.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence starting in position 229; Sequence=AAK06845.1; Type=Erroneous initiation; Note=Translation
N-terminally extended;
Secondary accessions: A0AVA2 B2RMQ8 B4DF89 B7Z2L2 C9J7D5 J3KQG1 Q4G157 Q9BZ94
Alternative splicing: 5 isoforms:  Q8N9L1-1   Q8N9L1-2   Q8N9L1-3   Q8N9L1-4   Q8N9L1-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZIC4: NX_Q8N9L1

Explore proteomics data for ZIC4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZIC4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001161850.1  NP_001161851.1  NP_001230185.1  NP_115529.2  

    ENSEMBL proteins: 
     ENSP00000372553   ENSP00000417855   ENSP00000420775   ENSP00000418277   ENSP00000420627  
     ENSP00000418343   ENSP00000419727   ENSP00000397695   ENSP00000435509  

    ZIC4 Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZIC4

     
    Search eBioscience for Proteins for ZIC4 

     
    antibodies-online proteins for ZIC4 (5 products) 

     
    antibodies-online peptides for ZIC4

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    antibodies-online kits for ZIC4 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8N9L1

    ProtoNet protein and cluster: Q8N9L1

    UniProtKB/Swiss-Prot: ZIC4_HUMAN, Q8N9L1
    Similarity: Belongs to the GLI C2H2-type zinc-finger protein family
    Similarity: Contains 5 C2H2-type zinc fingers


    Find genes that share domains with ZIC4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZIC4_HUMAN, Q8N9L1
    Function: Binds to DNA (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ISS--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZIC4           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for ZIC4:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Zic4):
     behavior/neurological  growth/size/body  mortality/aging  nervous system 

    Find genes that share phenotypes with ZIC4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ZIC4: Zic1/Zic4Zic1/tm1Kjmi Zic4tm2Kjmi

       genOway: Develop your customized and physiologically relevant rodent model for ZIC4

    miRNA
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    Block miRNA regulation of human, mouse, rat ZIC4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZIC4 (see all 40):
    hsa-miR-4317 hsa-miR-4272 hsa-miR-1258 hsa-miR-342-3p hsa-miR-502-3p hsa-miR-890 hsa-miR-3150b-3p hsa-miR-629
    SwitchGear 3'UTR luciferase reporter plasmidZIC4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZIC4

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for ZIC4 (see all 16)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ZIC4 (NM_032153)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZIC4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZIC4

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZIC4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZIC4_HUMAN, Q8N9L1: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    cytoskeleton1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--

    Find genes that share ontologies with ZIC4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZIC4
    Interactions:

        Search GeneGlobe Interaction Network for ZIC4

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for ZIC4 (Q8N9L13 ENSP000003725534) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZNF598Q86UK73, ENSP000004114094I2D: score=2 STRING: ENSP00000411409
    TCF7L1ENSP000002821114STRING: ENSP00000282111
    TCF7L2ENSP000003584044STRING: ENSP00000358404
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZIC4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZIC4 gene (4 alternative transcripts): 
    NM_001168378.1  NM_001168379.1  NM_001243256.1  NM_032153.5  

    Unigene Cluster for ZIC4:

    Zic family member 4
    Hs.415766  [show with all ESTs]
    Unigene Representative Sequence: AK124600
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000383075(uc003ewd.2 uc021xfg.1) ENST00000472749(uc021xfc.1 uc021xfd.1 uc021xfe.1)
    ENST00000494569 ENST00000493664 ENST00000484399 ENST00000473123 ENST00000463850
    ENST00000480015 ENST00000464502 ENST00000491672 ENST00000475502 ENST00000462748
    ENST00000484586 ENST00000463250 ENST00000464144 ENST00000425731(uc003ewc.2 uc021xff.1)
    ENST00000525172(uc011bno.2)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ZIC4 (see all 40):
    hsa-miR-4317 hsa-miR-4272 hsa-miR-1258 hsa-miR-342-3p hsa-miR-502-3p hsa-miR-890 hsa-miR-3150b-3p hsa-miR-629
    SwitchGear 3'UTR luciferase reporter plasmidZIC4 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ZIC4
    Predesigned siRNA for gene silencing in human, mouse, rat ZIC4
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): ZIC4 (NM_032153)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZIC4
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZIC4
      QuantiTect SYBR Green Assays in human, mouse, rat ZIC4
      QuantiFast Probe-based Assays in human, mouse, rat ZIC4

    Additional mRNA sequence: 

    AK056262.1 AK056394.1 AK094286.1 AK124600.1 AK126595.1 AK127733.1 AK293981.1 AK294831.1 
    BC029507.1 BC126267.1 BC136339.1 NR_033118.2 NR_033119.2 NR_040762.1 

    13 DOTS entries:

    DT.95259753  DT.436847  DT.101970057  DT.101974133  DT.120918384  DT.120918338  DT.97769461  DT.101962759 
    DT.95139468  DT.120918337  DT.120918359  DT.120918335  DT.120918358 

    Selected AceView cDNA sequences (see all 29):

    AK094286 AK056262 NM_032153 AK126595 Z42187 R13161 Z38442 AK124600 
    BX093756 AK127733 AW206453 AI963981 AF332509 BE504904 BE673074 AW071663 
    BC029507 AK056394 BI599124 BX508506 T08356 AI492851 BX488504 AA621639 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZIC4 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d ^ 11
    SP1:                    -           -     -                                                                                             
    SP2:                                                                                      -     -     -                                 
    SP3:                    -     -     -     -                                                                                             
    SP4:                    -     -     -     -           -     -     -     -     -     -     -     -     -                                 
    SP5:                          -     -     -                                                                                             


    ECgene alternative splicing isoforms for ZIC4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZIC4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGCTGCATT
    ZIC4 Expression
    About this image


    ZIC4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 15 entries
             Thalamus
             Human Brain Vascular Pericyte (HBVP)   
             cerebellum   
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
             Floor plate-like cells
     
     Spinal Cord (Nervous System)
    ZIC4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZIC4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.415766
        Custom PCR Arrays for ZIC4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZIC4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZIC4 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zic41 , 5 zinc finger protein of the cerebellum 41, 5 87.03(n)1
    87.43(a)1
      9 (48.26 cM)5
    227741  NM_009576.21  NP_033602.21 
     913624135 
    chicken
    (Gallus gallus)
    Aves ZIC41 Zic family member 4 74.84(n)
    77.64(a)
      424885  XM_422698.4  XP_422698.4 
    lizard
    (Anolis carolinensis)
    Reptilia ZIC46
    Zic family member 4
    62(a)
    1 ↔ 1
    3(19999913-20010193)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia zic41 Zic family member 4 73.19(n)
    76.45(a)
      100493609  XM_004914356.1  XP_004914413.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zic41 zic family member 4 73.21(n)
    81.92(a)
      767673  NM_001076612.1  NP_001070080.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta opa6
    odd paired
    28(a)
    1 → many
    3R(678535-695709)


    ENSEMBL Gene Tree for ZIC4 (if available)
    TreeFam Gene Tree for ZIC4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZIC4 gene
    MTF12  ZIC32  ZNF4102  ZNF762  GLI12  ZIC22  ZIC12  GLIS22  
    GLI22  GLIS12  ZNF1432  GLIS32  ZIC52  GLI32  
    Selected SIMAP similar genes for ZIC4 using alignment to 4 protein entries:     ZIC4_HUMAN (see all proteins) (see all similar genes):
    ZIC1    ZIC3    ZIC2    GLI1    ZIC5    GLI2
    HZF16    ZNF323    ZNF    ZNF143    GLIS3    ZFS-5
    ZNF702P    ZNF697    kr-znf3    ZNF844    A-328A3.4    KLF1

    Find genes that share paralogs with ZIC4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZIC4 (see all 407)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1877201481,2
    --147086920(+) GATGAG/TGTCAG 7 -- ds50010--------
    rs1160328241,2
    F--147086925(+) TGTCAG/CTGCCA 7 -- ds50011Minor allele frequency- C:0.01NA 120
    rs1905306821,2
    --147087037(+) TGAAGC/TGGTGA 7 -- ds50010--------
    rs1827184311,2
    --147087135(+) AAAGAA/GGAAGA 7 -- ut31 nc-transcript-variant0--------
    rs1883450091,2
    --147087139(+) AGGAAA/GAGAAA 7 -- ut31 nc-transcript-variant0--------
    rs1397834051,2
    C--147087175(+) AATAGA/CCAAAT 7 -- ut31 nc-transcript-variant0--------
    rs1146655631,2
    C,F--147087185(+) TGCAGC/AGCCAT 7 -- ut31 nc-transcript-variant1Minor allele frequency- A:0.08NA 120
    rs1157713161,2
    C,F--147087194(+) ATGTAC/TACAAA 7 -- ut31 nc-transcript-variant1Minor allele frequency- T:0.02NA 120
    rs1429097681,2
    C--147087408(+) ATAGTC/GTAAAG 7 -- ut31 nc-transcript-variant0--------
    rs1925798751,2
    --147087518(+) TTAGCA/CATATA 7 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for ZIC4 (147103833 - 147124647 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZIC4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv822285CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZIC4
    DNA2.0 Custom Variant and Variant Library Synthesis for ZIC4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608948    OMIM disorders: --

    6 diseases for ZIC4:    
    About MalaCards
    isolated dandy-walker malformation with hydrocephalus    isolated dandy-walker malformation without hydrocephalus    visceral heterotaxy    paraneoplastic neurologic disorders
    blepharophimosis, ptosis, and epicanthus inversus syndrome    heterotaxy

    1 disease from the University of Copenhagen DISEASES database for ZIC4:
    blepharophimosis, ptosis, and epicanthus inversus syndrome

    Find genes that share disorders with ZIC4           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: ZIC4 (1 document)

    Export disorders for ZIC4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZIC4 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with ZIC4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Comparative analysis of a 229-kb medaka genomic region, containing the zic1 and zic4 genes, with Fugu, human, and mouse. (PubMed id 15177559)1, 9 Ohtsuka M....Kimura M. (Genomics 2004)
    4. Genome-wide analysis of CpG island methylation in bladder cancer identified TBX2, TBX3, GATA2, and ZIC4 as pTa-specific prognostic markers. (PubMed id 22284968)1 Kandimalla R....Zwarthoff E.C. (Eur. Urol. 2012)
    5. Dandy-Walker malformation associated with heterozygous ZIC1 and ZIC4 deletion: Report of a new patient. (PubMed id 21204220)1 Tohyama J....Matsumoto N. (Am. J. Med. Genet. A 2011)
    6. [Technology of analysis of epigenetic and structural changes of epithelial tumors genome with NotI-microarrays by the example of human chromosome]. (PubMed id 19425501)1 Pavlova T.V....ZabarovskiA- E.R. (Mol. Biol. (Mosk.) 2009)
    7. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (Nature 2006)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. The ZIC gene family in development and disease. (PubMed id 15733262)1 Grinberg I. and Millen K.J. (Clin. Genet. 2005)
    10. Heterozygous deletion of the linked genes ZIC1 and ZIC4 is involved in Dandy-Walker malformation. (PubMed id 15338008)1 Grinberg I....Millen K.J. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 84107 HGNC: 20393 AceView: ZIC4 Ensembl:ENSG00000174963 euGenes: HUgn84107
    ECgene: ZIC4 H-InvDB: ZIC4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ZIC4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ZIC4 gene:
    Search GeneIP for patents involving ZIC4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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