Aliases for ZIC3 Gene
External Ids for ZIC3 Gene
Previous HGNC Symbols for ZIC3 Gene
Previous GeneCards Identifiers for ZIC3 Gene
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs. [provided by RefSeq, Jul 2008]
GeneCards Summary for ZIC3 Gene
ZIC3 (Zic Family Member 3) is a Protein Coding gene. Diseases associated with ZIC3 include heterotaxy, visceral, 1, x-linked and vacterl association, x-linked. Among its related pathways are Transcriptional Regulatory Network in Embryonic Stem Cell. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is ZIC4.
UniProtKB/Swiss-Prot for ZIC3 Gene
Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5-GGGTGGTC-3.