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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZIC1 Gene

protein-coding   GIFtS: 63
GCID: GC03P147111

Zic family member 1

(Previous names: Zic family member 1 (odd-paired Drosophila homolog), Zic...)
 Explore 19 diseases affiliated with
ZIC1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ZIC1    

Aliases
for ZIC1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Zic Family Member 11 2     Zinc Finger Protein 2012 3
ZIC1 2 3     Zinc Finger Protein Of The Cerebellum 12 3
ZNF2011 2 3     Zic Family Member 1 (Odd-Paired Drosophila Homolog)1
Zic Family Member 1 (Odd-Paired Homolog, Drosophila)1 2     Zinc Finger Protein ZIC 12

External Ids:    HGNC: 128721   Entrez Gene: 75452   Ensembl: ENSG000001529777   OMIM: 6004705   UniProtKB: Q159153   

Export aliases for ZIC1 gene to outside databases

Previous GC identifers: GC03P143961 GC03P148012 GC03P148408 GC03P148448 GC03P148609 GC03P144503


Summaries
for ZIC1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ZIC1:
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important
during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is
closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3.
This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ZIC1_HUMAN, Q15915
Function: Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of
organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved
in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the
regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May
have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to
the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity)

Gene Wiki entry for ZIC1


Genomic Views
for ZIC1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZIC1 gene promoter:
         Pbx1a   USF-1:USF-2   Nkx2-5   PPAR-gamma1   SRY   POU2F1   USF-1   POU2F1a   IRF-7A   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZIC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZIC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZIC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q24   Ensembl cytogenetic band:  3q24   HGNC cytogenetic band: 3q24

ZIC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZIC1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P147111:  view genomic region     (about GC identifiers)

Start:
 147,111,209 bp from pter      End:
 147,228,080 bp from pter
Size:
 116,872 bases      Orientation:
 plus strand

Proteins
for ZIC1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ZIC1_HUMAN, Q15915 (See protein sequence)
Recommended Name: Zinc finger protein ZIC 1  
Size: 447 amino acids; 48309 Da
Subunit: Interacts (via the C2H2-type domains 3, 4 and 5) with MDFIC (via the C2H2-type domains 3, 4 and 5). Interacts
with GLI1; the interaction enhances transcription activation. Interacts with GLI2. Interacts with GLI3; the
interaction enhances transcription activation (By similarity)
Subcellular location: Nucleus. Cytoplasm (By similarity). Note=Localizes in the cytoplasm in presence of MDFIC
overexpression (By similarity)
Secondary accessions: Q2M3N1

Explore the universe of human proteins at neXtProt for ZIC1: NX_Q15915

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15915

    • ZIC1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003403.2  
    ENSEMBL proteins: 
     ENSP00000419664   ENSP00000282928  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: ZIC1
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    Novus Biologicals ZIC1 Protein
    Novus Biologicals ZIC1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ZIC1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--


    ZIC1 for ontologies           About GeneDecksing



    ZIC1 Antibody Products: 
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    Assay Products for ZIC1: 
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    Uscn ELISAs and CLIAs for ZIC1

    Protein Domains /
    Families
    for ZIC1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ZIC1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q15915

    ProtoNet protein and cluster: Q15915

    1 Blocks protein family: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZIC1_HUMAN, Q15915
    Domain: The C2H2-type 3, 4 and 5 zinc finger domains are necessary for transcription activation (By similarity)
    Similarity: Belongs to the GLI C2H2-type zinc-finger protein family
    Similarity: Contains 5 C2H2-type zinc fingers


    Function
    for ZIC1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ZIC1_HUMAN, Q15915
    Function: Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of
    organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved
    in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the
    regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May
    have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to
    the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity)

         Genatlas biochemistry entry for ZIC1:
    zinc finger protein of the cerebellum,mouse Zic homolog,potential marker for medulloblastoma and cellular granular cell
    lineage

    miRNA
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    8/116 QIAGEN miScript miRNA Assays for microRNAs that regulate ZIC1 (see all 116):
    hsa-miR-579 hsa-miR-323-3p hsa-miR-548j hsa-miR-300 hsa-miR-106a hsa-miR-632 hsa-miR-3653 hsa-miR-3122
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZIC1 (see all 7)
    OriGene shRNA RFP: ZIC1
    OriGene siRNA: ZIC1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZIC1

    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZIC1 (see all 3)
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    Cell Line
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    LifeMap BioReagents: cell line associated with ZIC1: PureStem Progenitor E68

    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS8542595
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--


    ZIC1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ZIC1:
     Decreased Wnt reporter activit 

    Animal Models:
         Mouse knock-outs for ZIC1: Zic1/Zic4Zic1/tm1Kjmi Zic1tm1Jaru
         6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Zic1):
     behavior/neurological  growth/size  mortality/aging  muscle  nervous system 
     skeleton 

    ZIC1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ZIC1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Transcription factors in neurogenesis
    		Transcription factors in neurogenesis1.00
    2Neural Crest Differentiation
    		Neural Crest Differentiation1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for ZIC1
        Transcription factors in neurogenesis


    1 BioSystems Pathway for ZIC1 
        Neural Crest Differentiation



    ZIC1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZIC1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for ZIC1 (Q159153 ENSP000002829284) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GLI1P081513, ENSP000002286824I2D: score=2 STRING: ENSP00000228682
    GLI2P100703, ENSP000003545864I2D: score=2 STRING: ENSP00000354586
    GLI3P100713I2D: score=1 
    --ENSP000003792554STRING: ENSP00000379255
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007389pattern specification process ISS--
    GO:0007417central nervous system development ----
    GO:0007420brain development IDA8542595


    ZIC1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ZIC1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ZIC1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZIC1
    1 Novoseek chemical compound relationship for ZIC1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 53.8 22 7931345 (3), 16574373 (2), 11238441 (2), 11053430 (2) (see all 14)

    Search CenterWatch for drugs/clinical trials and news about ZIC1 

    Transcripts
    for ZIC1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ZIC1 gene: 
    NM_003412.3  

    Unigene Clusters for ZIC1:

    Zic family member 1
    Hs.598590 , Hs.647962  [show with all ESTs]
    Unigene Representative Sequences: U79264, NM_003412
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000472523 ENST00000488404 ENST00000282928(uc003ewe.3) ENST00000474034
    ENST00000481840

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZIC1
    8/116 QIAGEN miScript miRNA Assays for microRNAs that regulate ZIC1 (see all 116):
    hsa-miR-579 hsa-miR-323-3p hsa-miR-548j hsa-miR-300 hsa-miR-106a hsa-miR-632 hsa-miR-3653 hsa-miR-3122
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZIC1 (see all 7)
    OriGene shRNA RFP: ZIC1
    OriGene siRNA: ZIC1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZIC1
    Clone
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    GenScript: all cDNA clones in your preferred vector: ZIC1 (NM_003412)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZIC1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZIC1

    Additional cDNA sequence: 

    BC104848.1 BC104850.1 

    2 DOTS entries:

    DT.308923  DT.120918334 

    24/27 AceView cDNA sequences (see all 27):

    AA443320 BQ187871 BQ186222 H88479 NM_003412 AA569960 BE047875 AW022181 
    D76435 BE501345 CA336098 BC041954 AW275004 BQ027790 U79264 AI367357 
    AW292953 BI598990 AI963983 AI358916 AW956214 AW235209 H88478 BQ345031 

    GeneLoc Exon Structure


    Expression
    for ZIC1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZIC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATAATAGTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ZIC1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/75 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 75) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainAnterior MeningesMeningeal CellsMeninges
    AdiposeCervical Brown Adipose DepotCervical Brown Adipocyte CellsAdipose
    AdiposeCervical Brown Adipose DepotCervical Committed Brown PreadipocytesAdipose
    AdiposeLumbar Brown Adipose DepotLumbar Brown Adipocyte CellsAdipose
    AdiposeLumbar Brown Adipose DepotLumbar Committed Brown PreadipocytesAdipose
    AdiposeSacral Brown Adipose DepotSacral Brown Adipocyte CellsAdipose
    AdiposeSacral Brown Adipose DepotSacral Committed Brown PreadipocytesAdipose
    AdiposeThoracic Brown Adipose DepotThoracic Brown Adipocyte CellsAdipose
    AdiposeThoracic Brown Adipose DepotThoracic Committed Brown PreadipocytesAdipose
    BrainAnterior MeningesMeningeal Progenitor CellsMeninges
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Neural crest-like cells (Directed differentia...)

    See ZIC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZIC1

    SOURCE GeneReport for Unigene clusters: Hs.598590 Hs.647962

    UniProtKB/Swiss-Prot: ZIC1_HUMAN, Q15915
    Tissue specificity: CNS. A high level expression is seen in the cerebellum. Detected in the nuclei of the cerebellar
    granule cell lineage from the progenitor cells of the external germinal layer to the postmigrated cells of the
    internal granular layer. Detected in medulloblastoma (26/29 cases), but not present in all other tumors examined

        SABiosciences Expression via Pathway-Focused PCR Arrays including ZIC1: 
              Cell Lineage Identification in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              Hedgehog Signaling Pathway in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZIC1

    Orthologs
    for ZIC1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ZIC1 gene from 8/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ZIC11 Zic family member 1 83.11(n)
    94.14(a)    		   374103  NM_204254.1  NP_989585.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ZIC16
    		 --
    		 91(a)
    		 1 ↔ 1
    		 3(19988362-19992389)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.17962 Xenopus laevis mRNA for Zic1 protein, complete cds 81.61(n)    AF028805.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zic12 zic1 82.24(n)   30096  AF052435.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta opa3 midgut development specific RNA polymerase
    II more    		 66(a)
    (best of 2)    		   3 82E1   --
    worm
    (Caenorhabditis elegans)    		 Secernentea ref-26
    		 REgulator of Fusion family member (ref-2)
    		 32(a)
    		 possible ortholog
    		 X(7744188-7749959)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT4G066346
    		 uncharacterized zinc finger protein
    		 14(a)
    		 1 → many
    		 4(3764289-3766578)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 ZOS5-01 - C2H2 zinc finger protein, expressed
    		 17(a)
    14(a)
    		 many ↔ many
    many ↔ many
    		 2(20795085-20798606)
    5(321102-324421)


    ENSEMBL Gene Tree for ZIC1 (if available)
    TreeFam Gene Tree for ZIC1 (if available) 

    Paralogs
    for ZIC1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZIC1 gene
    ZNF762  GLI12  ZIC22  YY12  GLIS22  GLI22  ZNF1432  GLI32  
    YY22  MTF12  ZIC32  ZNF4102  ZFP422  GLIS12  ZIC42  GLIS32  
    ZIC52  
    18/76 SIMAP similar genes for ZIC1 using alignment to 2 protein entries:     ZIC1_HUMAN (see all proteins) (see all similar genes):
    ZIC2    ZIC3    ZIC4    ZNF555    ZFP69B    MECOM
    YY1    ZNF888    DKFZp686N0199    HZF16    KLF4    KLF7
    ZNF878    ZNF573    ZNF324    ZNF84    KLF1    PRDM16

    ZIC1 for paralogs           About GeneDecksing



    Genomic Variants
    for ZIC1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/111 NCBI SNPs in ZIC1 are shown (see all 111)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1121961911,2
    		C,--144502528(+) TGTGAGT/-GTGTG 2 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs730046451,2
    		C,--144506723(+) ACAGGC/AGGTGG 1 -- int11Minor allele frequency- A:0.50WA 2
    rs776675441,2
    		F,--144506938(+) TGCGGA/TAACTG 1 -- int11Minor allele frequency- T:0.03NA 120
    rs759929391,2
    		C,--144507436(+) CGCCCC/TCCTCC 2 P S mis10--------
    rs763104621,2
    		F,--144508748(+) TGCAGA/TTGTAG 1 -- ut311Minor allele frequency- T:0.08NA 120
    rs2015755491,2
    		C--144508753(+) ATGTAA/GAATAA 1 -- ut310--------
    rs756981651,2
    		C,F,--144509145(+) TAGTTC/TTCTCA 1 -- ut311Minor allele frequency- T:0.05WA 118
    rs1117363911,2
    		C,--144509413(+) GCTGCG/ACTGGT 1 -- ut312Minor allele frequency- A:0.03CSA WA 120
    rs1134057761,2
    		C,--144509580(+) GGCCAC/TGGACC 1 -- ut311Minor allele frequency- T:0.50NA 2
    rs731499071,2
    		C,--144510174(+) TCTCTA/GGAAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZIC1 (147111209 - 147228080 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ZIC1: --
    Human Gene Mutation Database (HGMD): ZIC1

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for ZIC1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ZIC1 for disorders           About GeneDecksing

    OMIM gene information: 600470   
    OMIM disorders: 220200  
    19 diseases for ZIC1:    About MalaCards
    dandy-walker malformation    medulloblastoma    neural tube defect    spina bifida
    paraneoplastic cerebellar degeneration    paraneoplastic neurologic disorders    cerebellar degeneration    oral squamous cell carcinoma
    holoprosencephaly    squamous cell carcinoma    joubert syndrome    liposarcoma
    multiple sclerosis    gastric cancer    meningioma    lung cancer
    carcinoma    cerebritis    neuronitis

    4 diseases from the University of Copenhagen DISEASES database for ZIC1:
    Spina bifida     Holoprosencephaly     "blepharophimosis, ptosis, and epicanthus inversus syndrome"     Medulloblastoma

    9 Novoseek disease relationships for ZIC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    holoprosencephaly 78.1 5 15207846 (1), 17251188 (1), 11699604 (1), 15733262 (1) (see all 5)
    neural tube defects 57.8 2 14679585 (1), 15733262 (1)
    cerebellar dysfunction 57.1 1 12499499 (1)
    medulloblastoma 52.1 8 8542595 (3), 20199689 (2), 12499499 (2)
    spina bifida 35.3 1 11699604 (1)
    congenital malformation 34.1 4 15207846 (1), 10861288 (1), 15733262 (1)
    neurological disorders 28.8 4 11699604 (1), 12499499 (1), 8542595 (1)
    autoimmunity 10.9 1 15007130 (1)
    tumors 0 12 19135984 (2), 9879461 (1), 20199689 (1), 8542595 (1) (see all 5)

    Genetic Association Database (GAD): ZIC1
    Human Genome Epidemiology (HuGE) Navigator: ZIC1 (2 documents)

    Export disorders for ZIC1 gene to outside databases

    Publications
    for ZIC1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZIC1 gene, integrated from 9 sources (see all 69):
    (articles sorted by number of sources associating them with ZIC1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Predominant expression of human zic in cerebellar granule cell lineage and medulloblastoma. (PubMed id 8542595)1, 2, 3, 9 Yokota N.... Mikoshiba K. (1996)
    2. Genetic variants in ZIC1, ZIC2, and ZIC3 are not major risk factors for neural tube defects in humans. (PubMed id 14679585)1, 4, 9 Klootwijk R....Franke B. (2004)
    3. ZIC1 is downregulated through promoter hypermethylation in gastric cancer. (PubMed id 19135984)1, 9 Wang L.J....Sung J.J. (2009)
    4. Physical and functional interactions between Zic and Gli proteins. (PubMed id 11238441)1, 9 Koyabu Y....Mikoshiba K. (2001)
    5. ZIC1 gene expression is controlled by DNA and histone methylation in mesenchymal proliferations. (PubMed id 17936758)1, 9 Pourebrahim R....Tejpar S. (2007)
    6. Expression of ZIC family genes in meningiomas and oth er brain tumors. (PubMed id 20199689)1, 9 Aruga J....Yokota N. (2010)
    7. Transcription factors Zic1 and Zic2 bind and transactivate the apolipoprotein E gene promoter. (PubMed id 11038359)1, 9 Salero E....Zafra F. (2001)
    8. Inhibition of translation in living eukaryotic cells by an RNA G-quadruplex motif. (PubMed id 18515550)1, 9 Arora A....Kurreck J. (2008)
    9. The ZIC gene family in development and disease. (PubMed id 15733262)1, 9 Grinberg I. and Millen K.J. (2005)
    10. The intracellular domain of teneurin-2 has a nuclear function and represses zic-1-mediated transcription. (PubMed id 12783990)1, 9 Bagutti C....Chiquet-Ehrismann R. (2003)

    External Searches for ZIC1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ZIC1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7545 HGNC: 12872 AceView: ZIC1 Ensembl:ENSG00000152977 euGenes: HUgn7545
    ECgene: ZIC1 H-InvDB: ZIC1

    Other Databases showing ZIC1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ZIC1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZIC1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ZIC1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for ZIC1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ZIC1 gene:
    Search GeneIP for patents involving ZIC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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     ZIC1 Proteins, Antibodies, CLIAs, and ELISAs
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