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ZHX2 Gene(Protein Coding)

Zinc Fingers And Homeoboxes 2

GCID:
GC08P122781
GIFtS:
55
Genes Participants
UDN Logo

Aliases for ZHX2 Gene

Aliases for ZHX2 Gene

  • Zinc Fingers And Homeoboxes 2 2 3 5
  • Zinc Finger And Homeodomain Protein 2 3 4
  • Alpha-Fetoprotein Regulator 1 3 4
  • Regulator Of AFP 3 4
  • AFP Regulator 1 3 4
  • AFR1 3 4
  • RAF 3 4
  • Zinc Fingers And Homeoboxes Protein 2 3
  • Zinc-Fingers And Homeoboxes 2 2
  • Transcription Factor ZHX2 3
  • KIAA0854 4

External Ids for ZHX2 Gene

Previous GeneCards Identifiers for ZHX2 Gene

  • GC08P123462
  • GC08P123750
  • GC08P123863
  • GC08P123793
  • GC08P119119

Summaries for ZHX2 Gene

Entrez Gene Summary for ZHX2 Gene

  • The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZHX2 Gene

ZHX2 (Zinc Fingers And Homeoboxes 2) is a Protein Coding gene. Diseases associated with ZHX2 include Smallpox and Cryptococcosis. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and identical protein binding. An important paralog of this gene is ZHX1.

UniProtKB/Swiss-Prot for ZHX2 Gene

  • Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA.

Gene Wiki entry for ZHX2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZHX2 Gene

Genomics for ZHX2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for ZHX2 Gene

Enhancers for ZHX2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F122779 1.5 FANTOM5 ENCODE 15.4 +0.6 584 4.4 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZHX2 TBC1D31 DERL1 C8orf76 PIR52073
GH08F122796 1.5 FANTOM5 Ensembl ENCODE 11.4 +17.6 17552 4.2 HDGF ELF3 ARID4B RAD21 RARA CREM SP5 KAT8 RAD51 MAFF ZHX2 C8orf76 PIR52073 ENSG00000253372
GH08F122759 1.3 Ensembl ENCODE 11.8 -21.0 -21040 1.4 ATF1 MLX ARID4B DMAP1 ZNF48 SLC30A9 FOS SP5 MXD4 MIER2 ZHX2 ENSG00000253607 DERL1 TBC1D31 ENSG00000238901 FAM83A-AS1 CDK5P1 GC08M122743
GH08F122909 1.3 Ensembl ENCODE 11.4 +129.1 129134 1.9 PKNOX1 MLX ARNT CREB3L1 ARID4B SIN3A ZNF766 ZNF143 FOS JUNB ZHX2 ENSG00000253607 GC08P122905 PIR45357
GH08F122830 1.1 Ensembl ENCODE 13 +48.9 48852 0.4 CTCF KLF1 CBX3 HINFP DDX20 ZNF175 PTRF PYGO2 RELA IRF9 ZHX2 ENSG00000253372 GC08P122905
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZHX2 on UCSC Golden Path with GeneCards custom track

Promoters for ZHX2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001400457 451 3601 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Transcription factor binding sites by QIAGEN in the ZHX2 gene promoter:

Genomic Location for ZHX2 Gene

Chromosome:
8
Start:
122,781,349 bp from pter
End:
122,974,515 bp from pter
Size:
193,167 bases
Orientation:
Plus strand

Genomic View for ZHX2 Gene

Genes around ZHX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZHX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZHX2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ZHX2 Gene

Proteins for ZHX2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ZHX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6X8-ZHX2_HUMAN
    Recommended name:
    Zinc fingers and homeoboxes protein 2
    Protein Accession:
    Q9Y6X8

    Protein attributes for ZHX2 Gene

    Size:
    837 amino acids
    Molecular mass:
    92307 Da
    Quaternary structure:
    • Forms a homodimer (via homeobox domain). Forms a heterodimer with ZHX1 (via HD1 domain). Forms a heterodimer with ZHX3. Heterodimerization with ZHX1 is not necessary for repressor activity. Interacts (via homeobox domain) with NFYA (via N-terminus).
    SequenceCaution:
    • Sequence=BAA74877.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZHX2 Gene

neXtProt entry for ZHX2 Gene

Protein Expression for ZHX2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ZHX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZHX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZHX2 Gene

Domains & Families for ZHX2 Gene

Gene Families for ZHX2 Gene

HGNC:

Protein Domains for ZHX2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZHX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6X8

UniProtKB/Swiss-Prot:

ZHX2_HUMAN :
  • Contains 4 homeobox DNA-binding domains.
  • Belongs to the ZHX family.
  • Contains 2 C2H2-type zinc fingers.
Domain:
  • Contains 4 homeobox DNA-binding domains.
Family:
  • Belongs to the ZHX family.
Similarity:
  • Contains 2 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZHX2: view

Function for ZHX2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for ZHX2 Gene

UniProtKB/Swiss-Prot Function:
Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA.

Gene Ontology (GO) - Molecular Function for ZHX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IDA 12741956
GO:0003714 transcription corepressor activity IDA 12741956
GO:0005515 protein binding IPI 12741956
GO:0042802 identical protein binding IPI 12741956
genes like me logo Genes that share ontologies with ZHX2: view
genes like me logo Genes that share phenotypes with ZHX2: view

Animal Model Products

miRNA for ZHX2 Gene

miRTarBase miRNAs that target ZHX2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZHX2 Gene

Localization for ZHX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZHX2 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZHX2 gene
Compartment Confidence
nucleus 5
plasma membrane 2
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ZHX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 12741956
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with ZHX2: view

Pathways & Interactions for ZHX2 Gene

SuperPathways for ZHX2 Gene

PathCards logo More details on SuperPathways for ZHX2
No Data Available

Gene Ontology (GO) - Biological Process for ZHX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 12741956
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006402 mRNA catabolic process IEA --
genes like me logo Genes that share ontologies with ZHX2: view

No data available for Pathways by source and SIGNOR curated interactions for ZHX2 Gene

Drugs & Compounds for ZHX2 Gene

Products:

  1. Drug

(2) Drugs for ZHX2 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
regorafenib Approved Pharma inhibitor Inhibitor of VEGFR/PDGFR/FGFR/mutant kit/RET/Raf-1, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
Sorafenib Approved, Investigational Pharma inhibitors, inhibitor Raf kinases and tyrosine kinases inhibitor, RAF, VEGFR2, and PDGFR-beta inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 692
genes like me logo Genes that share compounds with ZHX2: view

Transcripts for ZHX2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for ZHX2 Gene

(5) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(121) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZHX2 Gene

Zinc fingers and homeoboxes 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZHX2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9
SP1:
SP2: - - - - - -
SP3:

Relevant External Links for ZHX2 Gene

GeneLoc Exon Structure for
ZHX2
ECgene alternative splicing isoforms for
ZHX2

Expression for ZHX2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZHX2 Gene

mRNA expression in normal human tissues for ZHX2 Gene
mRNA expression by BioGPS for ZHX2 GenemRNA expression by GTEx for ZHX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZHX2 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (54.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZHX2 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZHX2 Gene:

ZHX2

SOURCE GeneReport for Unigene cluster for ZHX2 Gene:

Hs.377090

mRNA Expression by UniProt/SwissProt for ZHX2 Gene:

Q9Y6X8-ZHX2_HUMAN
Tissue specificity: Ubiquitously expressed. Expressed in podocytes.
genes like me logo Genes that share expression patterns with ZHX2: view

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for ZHX2 Gene

Orthologs for ZHX2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZHX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ZHX2 34 35
  • 99.24 (n)
dog
(Canis familiaris)
 Mammalia ZHX2 34 35
  • 88.77 (n)
cow
(Bos Taurus)
 Mammalia ZHX2 34 35
  • 86.94 (n)
mouse
(Mus musculus)
 Mammalia Zhx2 34 16 35
  • 84.93 (n)
rat
(Rattus norvegicus)
 Mammalia Zhx2 34
  • 84.45 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia ZHX2 35
  • 62 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves ZHX2 34 35
  • 69.85 (n)
lizard
(Anolis carolinensis)
 Reptilia ZHX2 35
  • 60 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia zhx2 34
  • 62.87 (n)
Str.1051 34
African clawed frog
(Xenopus laevis)
 Amphibia Xl.13932 34
zebrafish
(Danio rerio)
 Actinopterygii zhx2 34 35
  • 56.85 (n)
Species where no ortholog for ZHX2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZHX2 Gene

ENSEMBL:
Gene Tree for ZHX2 (if available)
TreeFam:
Gene Tree for ZHX2 (if available)

Paralogs for ZHX2 Gene

Paralogs for ZHX2 Gene

(2) SIMAP similar genes for ZHX2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZHX2: view

Variants for ZHX2 Gene

Sequence variations from dbSNP and Humsavar for ZHX2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs138450443 Uncertain significance 122,953,192(+) GGATC(A/G)GCTAA reference, missense
rs10086546 -- 122,920,435(+) gtaca(A/G)ttcta intron-variant
rs10087621 -- 122,936,219(+) AGTTT(G/T)TGCAG intron-variant
rs10088479 -- 122,962,966(+) ttatg(C/T)gggat intron-variant
rs10089605 -- 122,873,461(+) TGTCC(A/G)TACTT intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ZHX2 Gene

Variant ID Type Subtype PubMed ID
esv2737525 CNV deletion 23290073
esv3544137 CNV deletion 23714750
esv3572972 CNV loss 25503493
nsv1032827 CNV gain 25217958
nsv1150054 CNV insertion 26484159

Variation tolerance for ZHX2 Gene

Residual Variation Intolerance Score: 69.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.93; 79.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZHX2 Gene

Human Gene Mutation Database (HGMD)
ZHX2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZHX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZHX2 Gene

Disorders for ZHX2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZHX2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
smallpox
  • ordinary smallpox
cryptococcosis
  • busse-buschke's disease
- elite association - COSMIC cancer census association via MalaCards
Search ZHX2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ZHX2

Genetic Association Database (GAD)
ZHX2
Human Genome Epidemiology (HuGE) Navigator
ZHX2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZHX2
genes like me logo Genes that share disorders with ZHX2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZHX2 Gene

Publications for ZHX2 Gene

  1. Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor. (PMID: 12741956) Kawata H. … Miyamoto K. (Biochem. J. 2003) 2 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PMID: 20080650) Xu J. … Isaacs W.B. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 46 64
  5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64

Products for ZHX2 Gene

Sources for ZHX2 Gene

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