Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms of Use
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
GeneCards Plus
- Premium Tools
  
  Learn more

Set Analyses:

VarElect

Advanced Search

ZHX2 Gene

protein-coding GIFtS: 57
GCID: GC08P123793

Zinc Fingers And Homeoboxes 2

(Previous name: zinc-fingers and homeoboxes 2)

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

TryGeneCards Plus

Aliases
Zinc Fingers And Homeoboxes 2¹ ²		RAF² ³
Zinc-Fingers And Homeoboxes 2¹ ²		AFP Regulator 1² ³
Alpha-Fetoprotein Regulator 1² ³		Transcription Factor ZHX2²
Regulator Of AFP² ³		Zinc Fingers And Homeoboxes Protein 2²
Zinc Finger And Homeodomain Protein 2² ³		KIAA0854³
AFR1² ³

External Ids:	HGNC: 18513¹	Entrez Gene: 22882²	Ensembl: ENSG00000178764⁷	OMIM: 609185⁵	UniProtKB: Q9Y6X8³

Export aliases for ZHX2 gene to outside databases

Previous GC identifers: GC08P123462 GC08P123750 GC08P123863 GC08P119119

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ZHX2 Gene:

The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that

interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox

DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this

protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. (provided by RefSeq, Jul 2008)

GeneCards Summary for ZHX2 Gene:

ZHX2 (zinc fingers and homeoboxes 2) is a protein-coding gene. Diseases associated with ZHX2 include drug addiction, and usher syndrome. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZHX3.

UniProtKB/Swiss-Prot: ZHX2_HUMAN, Q9Y6X8

Function: Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by

NFYA

Gene Wiki entry for ZHX2 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus

RefSeq DNA sequence:

NC_000008.11 NT_008046.17 NC_018919.2

Regulatory elements:

Regulatory transcription factor binding sites in the ZHX2 gene promoter:
SRF E2F-4 E2F-3a E2F-5 SRF (504 AA) MyoD E2F-2 IRF-2 E2F-1 E2F
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZHX2 promoter sequence

Search Chromatin IP Primers for ZHX2

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZHX2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.13 Ensembl cytogenetic band: 8q24.13 HGNC cytogenetic band: 8q24.13

ZHX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZHX2 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P123793: view genomic region (about GC identifiers)

Start:	123,793,633 bp from pter	End:	123,986,755 bp from pter
Size:	193,123 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ZHX2_HUMAN, Q9Y6X8 (See protein sequence)

Recommended Name: Zinc fingers and homeoboxes protein 2

Size: 837 amino acids; 92307 Da

Subunit: Forms a homodimer (via homeobox domain). Forms a heterodimer with ZHX1 (via HD1 domain). Forms a

heterodimer with ZHX3. Heterodimerization with ZHX1 is not necessary for repressor activity. Interacts (via

homeobox domain) with NFYA (via N-terminus)

Sequence caution: Sequence=BAA74877.2; Type=Erroneous initiation;

2 PDB 3D structures from and Proteopedia for ZHX2:

2DMP (3D)

3NAU (3D)

Explore the universe of human proteins at neXtProt for ZHX2: NX_Q9Y6X8

Explore proteomics data for ZHX2 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See ZHX2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_055758.1

ENSEMBL proteins:

ENSP00000314709 ENSP00000452720

ZHX2 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for ZHX2 OriGene Protein Over-expression Lysate for ZHX2 OriGene MassSpec for ZHX2 OriGene Custom Protein Services for ZHX2
	GenScript Custom Purified and Recombinant Proteins Services for ZHX2
	Novus Biologicals ZHX2 Protein Novus Biologicals ZHX2 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for ZHX2

ZHX2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies for ZHX2 OriGene Custom Antibody Services for ZHX2
	Novus Biologicals ZHX2 Antibodies
	Abcam antibodies for ZHX2
	Cloud-Clone Corp. Antibodies for ZHX2
	ThermoFisher Antibody for ZHX2
	LSBio Antibodies in human, mouse, rat for ZHX2

ZHX2 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for ZHX2
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ZHX2
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for ZHX2 Cloud-Clone Corp. CLIAs for ZHX2

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus

HGNC Gene Families:

ZFHX: Homeoboxes / ZF class

ZNF: Zinc fingers, C2H2-type

4 InterPro protein domains:

IPR015880 Znf_C2H2-like

IPR001356 Homeobox_dom

IPR009057 Homeodomain-like

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q9Y6X8

ProtoNet protein and cluster: Q9Y6X8

UniProtKB/Swiss-Prot: ZHX2_HUMAN, Q9Y6X8

Similarity: Belongs to the ZHX family

Similarity: Contains 2 C2H2-type zinc fingers

Similarity: Contains 4 homeobox DNA-binding domains

ZHX2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

UniProtKB/Swiss-Prot Summary: ZHX2_HUMAN, Q9Y6X8

Function: Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by

NFYA

Gene Ontology (GO): Selected molecular function terms (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IDA	12741956
GO:0003714	transcription corepressor activity	IDA	12741956
GO:0005515	protein binding	IPI	12741956
GO:0042803	protein homodimerization activity	IDA	12741956

ZHX2 for ontologies About GeneDecksing

Phenotypes:
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Zhx2):

homeostasis/metabolism

ZHX2 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZHX2

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ZHX2

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZHX2

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZHX2

miRNA Products:		Block miRNA regulation of human, mouse, rat ZHX2 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate ZHX2 (see all 53):
		hsa-miR-106a hsa-miR-199a-3p hsa-miR-1258 hsa-miR-1260b hsa-let-7a-2* hsa-miR-624 hsa-miR-519a hsa-miR-548m

		SwitchGear 3'UTR luciferase reporter plasmid: ZHX2 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for ZHX2
		Predesigned siRNA for gene silencing in human, mouse, rat ZHX2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ZHX2

Clone Products:		OriGene clones in human, mouse for ZHX2 (see all 7) OriGene ORF clones in mouse, rat for ZHX2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ZHX2 (NM_014943)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZHX2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZHX2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ZHX2
		Browse ESI BIO Cell Lines and PureStem Progenitors for ZHX2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZHX2

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot

ZHX2_HUMAN, Q9Y6X8: Nucleus

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	5
cytosol	4
plasma membrane	4
cytoskeleton	2
extracellular	2
mitochondrion	2
endoplasmic reticulum	1
golgi apparatus	1

About this image

Gene Ontology (GO): 4 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005886	plasma membrane	IDA	--

ZHX2 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for ZHX2 About

See pathways by source

SuperPath

Contained pathways About

Hypothetical Network for Drug Addiction

Hypothetical Network for Drug Addiction

1 BioSystems Pathway for ZHX2

Hypothetical Network for Drug Addiction

Pathway & Disease-focused RT² Profiler PCR Array including ZHX2:

Oncogenes & Tumor Suppressor Genes in human mouse rat

Interactions:

GeneGlobe Interaction Network for ZHX2

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

Selected Interacting proteins for ZHX2 (Q9Y6X8^{2, 3} ENSP00000314709⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 19)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATXN1	P54253²^,³, ENSP00000244769⁴	MINT-2869952 I2D: score=3 STRING: ENSP00000244769
PARP2	Q9UGN5²^,³, ENSP00000250416⁴	MINT-8202110 I2D: score=1 STRING: ENSP00000250416
ZHX3	Q9H4I2³, ENSP00000312222⁴	I2D: score=5 STRING: ENSP00000312222
ZHX1	Q9UKY1³, ENSP00000297857⁴	I2D: score=2 STRING: ENSP00000297857
HRAS	P01112³, ENSP00000309845⁴	I2D: score=1 STRING: ENSP00000309845

About this table

Gene Ontology (GO): Selected biological process terms (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IDA	12741956
GO:0006351	transcription, DNA-templated	IEA	--
GO:0006355	regulation of transcription, DNA-templated	--	--
GO:0006357	regulation of transcription from RNA polymerase II promoter	--	--
GO:0006402	mRNA catabolic process	IEA	--

ZHX2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for ZHX2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for ZHX2 gene:

NM_014943.3

Unigene Clusters for ZHX2:

Zinc fingers and homeoboxes 2

Hs.377090 [show with all ESTs], Hs.658443

Unigene Representative Sequences: NM_014943, AF075099

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000314393(uc003ypk.1) ENST00000534247

miRNA Products:		Block miRNA regulation of human, mouse, rat ZHX2 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate ZHX2 (see all 53):
		hsa-miR-106a hsa-miR-199a-3p hsa-miR-1258 hsa-miR-1260b hsa-let-7a-2* hsa-miR-624 hsa-miR-519a hsa-miR-548m

		SwitchGear 3'UTR luciferase reporter plasmid: ZHX2 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for ZHX2
		Predesigned siRNA for gene silencing in human, mouse, rat ZHX2

Clone Products:		OriGene clones in human, mouse for ZHX2 (see all 7) OriGene ORF clones in mouse, rat for ZHX2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ZHX2 (NM_014943)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZHX2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZHX2

Primer Products:		OriGene qPCR primer pairs and template standards for ZHX2 OriGene qSTAR qPCR primer pairs in human, mouse for ZHX2
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat ZHX2
		QuantiTect SYBR Green Assays in human, mouse, rat ZHX2
		QuantiFast Probe-based Assays in human, mouse, rat ZHX2

Additional mRNA sequence: AF075099.1

5 DOTS entries:

DT.215814 DT.40190209 DT.121471822 DT.121471869 DT.75122475

Selected AceView cDNA sequences (see all 121):

BM141990 NM_014943 BM710651 T06258 AA282525 CA487642 BM721473 N47512

CA392286 BM477083 AA688093 AA909221 BC042145 BE349554 BQ879545 BE855934

AB083653 BQ649483 BI769972 BX485477 BM994283 AA744757 CD251688 AW574755

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for ZHX2 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8a	·	8b	^	9
SP1:
SP2:			-		-		-		-		-		-
SP3:

ECgene alternative splicing isoforms for ZHX2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

ZHX2 expression in normal human tissues (normalized intensities) ZHX2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AATTGATTTT

About this image

ZHX2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 4) fully expand


Brain (Nervous System) fully expand to see all 4 entries
Cerebral Cortex

Liver (Hepatobiliary System) fully expand to see all 3 entries
Fetal Hepatocytes Liver Lobule

Ovary (Reproductive System)
Oviduct

Testis (Reproductive System)
Leydig Cells Testis Interstitium

ZHX2 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

ZHX2 Protein Expression

SOURCE GeneReport for Unigene clusters: Hs.377090 Hs.658443

UniProtKB/Swiss-Prot: ZHX2_HUMAN, Q9Y6X8

Tissue specificity: Ubiquitously expressed. Expressed in podocytes

Pathway & Disease-focused RT² Profiler PCR Array including ZHX2:

Oncogenes & Tumor Suppressor Genes in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for ZHX2 OriGene qSTAR qPCR primer pairs in human, mouse for ZHX2
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat ZHX2
		QuantiTect SYBR Green Assays in human, mouse, rat ZHX2
		QuantiFast Probe-based Assays in human, mouse, rat ZHX2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZHX2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of chordates.

Orthologs for ZHX2 gene from Selected species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Zhx2^{1 , 5}	zinc fingers and homeoboxes 2^{1, 5}	84.93(n)¹ 87.2(a)¹		15 (24.01 cM)⁵ 387609¹ NM_199449.2¹ NP_955520.1¹ 57694665⁵
chicken (Gallus gallus)	Aves	ZHX2¹	zinc fingers and homeoboxes 2	69.85(n) 70.01(a)		420351 XM_418458.4 XP_418458.1
lizard (Anolis carolinensis)	Reptilia	ZHX2⁶	zinc fingers and homeoboxes 2	60(a)	1 ↔ 1	GL343581.1(375189-377588)
African clawed frog (Xenopus laevis)	Amphibia	Xl.13932²	Xenopus laevis transcribed sequence with weak similarity more	79.89(n)		BU901985.1
zebrafish (Danio rerio)	Actinopterygii	zhx2²	zinc-fingers and homeoboxes 2	74.54(n)		386660 AY311507.1

ENSEMBL Gene Tree for ZHX2 (if available)
TreeFam Gene Tree for ZHX2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

TryGeneCards Plus

Paralogs for ZHX2 gene

ZHX3² HOMEZ² ZHX1²

2 SIMAP similar genes for ZHX2 using alignment to 2 protein entries: ZHX2_HUMAN (see all proteins):

ZHX1 ZHX3

ZHX2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs71573657^1,2	C	--	119224961(+)	`CCACC-/GT/ GTGTGTGTGTG`	1	--	int¹		1		NA	2
rs185465165^1,2	C	--	123792113(+)	`AGACTA/C/TCTTCC`	1	--	us2k¹		0	--	--	--	--
rs138662155^1,2		--	123792145(+)	`GGGCGC/GTTAAA`	1	--	us2k¹		0	--	--	--	--
rs112501850^1,2	C,F	--	123792156(+)	`ATGCAT/AACAAA`	1	--	us2k¹		1		CSA	2
rs77355149^1,2	F	--	123792258(+)	`TTCTGC/GGGAGT`	1	--	us2k¹		0	--	--	--	--
rs73331733^1,2	C,F	--	123792303(+)	`GAACTT/CACAAA`	1	--	us2k¹		3		WA	122
rs139315792^1,2		--	123792440(+)	`GCCTCG/TCCGCT`	1	--	us2k¹		0	--	--	--	--
rs190718026^1,2		--	123792572(+)	`CTGCAA/GGGCGG`	1	--	us2k¹		0	--	--	--	--
rs181423036^1,2		--	123792671(+)	`CCCTCC/GTCCCC`	1	--	us2k¹		0	--	--	--	--
rs73331734^1,2	C,F	--	123792824(+)	`GCACTG/ATGGCA`	1	--	us2k¹		1		WA	2

HapMap Linkage Disequilibrium report for ZHX2 (123793633 - 123986755 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for ZHX2: About this table

Variant ID	Type	Subtype	PubMed ID
esv2737525	CNV	Deletion	23290073

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing ZHX2

DNA2.0 Custom Variant and Variant Library Synthesis for ZHX2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus

OMIM gene information: 609185 OMIM disorders: --

13 diseases for ZHX2: About MalaCards

drug addiction usher syndrome smallpox neurofibromatosis

thalassemia nephrotic syndrome pertussis hodgkin's lymphoma

ataxia neuroblastoma prostate cancer prostatitis

neuronitis

1 disease from the University of Copenhagen DISEASES database for ZHX2:

Cancer

ZHX2 for disorders About GeneDecksing

Genetic Association Database (GAD): ZHX2
Human Genome Epidemiology (HuGE) Navigator: ZHX2 (4 documents)

Export disorders for ZHX2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for ZHX2 gene, integrated from 10 sources (see all 36):
(articles sorted by number of sources associating them with ZHX2)

Utopia: connect your pdf to the dynamic
world of online information

Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor. (PubMed id 12741956)^{1, 2, 3} Kawata H.... Miyamoto K. (Biochem. J. 2003)
Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)^{1, 2, 3} Nagase T.... Ohara O. (DNA Res. 1998)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PubMed id 20080650)^{1, 4} Xu J....Isaacs W.B. (Proc. Natl. Acad. Sci. U.S.A. 2010)
Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)^{1, 4} Trynka G....Wijmenga C. (Gut 2009)
ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome. (PubMed id 17056598)^{1, 2} Liu G.... Chugh S.S. (J. Biol. Chem. 2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
ZHX2 is a repressor of alpha-fetoprotein expression in human hepatoma cell lines. (PubMed id 18194454)^{1, 9} Shen H....Ma C. (J. Cell. Mol. Med. 2008)
The mouse zinc-fingers and homeoboxes (ZHX) family; ZHX2 forms a heterodimer with ZHX3. (PubMed id 14659886)^{1, 9} Kawata H....Miyamoto K. (Gene 2003)
A genome-wide association study of behavioral disinhibition. (PubMed id 23942779)¹ McGue M....Iacono W.G. (Behav. Genet. 2013)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus

Entrez Gene: 22882	HGNC: 18513	AceView: ZHX2	Ensembl:ENSG00000178764	euGenes: HUgn22882
ECgene: ZHX2	H-InvDB: ZHX2

(According to HUGE)
About This Section

TryGeneCards Plus

HUGE: KIAA0854

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus

Name	Description
PharmGKB entry for ZHX2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZHX2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

TryGeneCards Plus

Patent Information for ZHX2 gene:
Search GeneIP for patents involving ZHX2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus


	EMD Millipore genomic analysis products

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Enzyme Activity Assays/Reagents
	Browse ELISpot/FluoroSpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Luminex Assays
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Recombinant/Natural Proteins		Browse Stem Cell Products
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	OriGene Antibodies for ZHX2		OriGene RNAi products in human, mouse, rat for ZHX2
	OriGene qPCR primer pairs and template standards for ZHX2		OriGene Protein Over-expression Lysate for ZHX2
	OriGene MassSpec something-or-other for ZHX2		OriGene clones in human, mouse for ZHX2
	OriGene qSTAR qPCR primer pairs in human, mouse for ZHX2		OriGene Purified Protein for ZHX2
	OriGene ORF clones in mouse, rat for ZHX2		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for ZHX2		OriGene Custom Protein Services for ZHX2

	Block miRNA regulation of human, mouse, rat ZHX2 using miScript Target Protectors		SeqTarget long-range PCR primers for resequencing ZHX2
	DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZHX2		Predesigned siRNA for gene silencing in human, mouse, rat ZHX2
	QuantiFast Probe-based Assays in human, mouse, rat ZHX2		QuantiTect SYBR Green Assays in human, mouse, rat ZHX2
	PCR Arrays including human, mouse, rat ZHX2		Search Chromatin IP Primers for ZHX2
	Pre-validated RT² qPCR Primer Assay in human, mouse, rat ZHX2		GeneGlobe Interaction Network for ZHX2
	Regulatory tfbs in ZHX2 promoter

	GenScript Custom Purified and Recombinant Proteins Services for ZHX2		GenScript cDNA clones with any tag delivered in your preferred vector for ZHX2
	GenScript Custom Assay Services for ZHX2		GenScript Custom overexpressing Cell Line Services for ZHX2
	CloneReady with Over 120,000 Genes		Gene Synthesis: Any Gene in Any Vector
	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

Search for Antibodies & Assays

Search Tocris compounds for ZHX2

	Browse Sino Biological Proteins
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	ZHX2 antibodies
	ZHX2 proteins
	ZHX2 lysates

	Antibodies for ZHX2
	See all of Abcam's Antibodies, Kits and Proteins for ZHX2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for ZHX2
	Antibodies for ZHX2
	ELISAs for ZHX2
	CLIAs for ZHX2

Browse ESI BIO Cell Lines and PureStem Progenitors for ZHX2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZHX2

	SwitchGear 3'UTR luciferase reporter plasmids for ZHX2
	SwitchGear Promoter luciferase reporter plasmids for ZHX2

ThermoFisher Antibody for ZHX2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZHX2

	inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZHX2
	inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ZHX2

LSBio Antibodies in human, mouse, rat for ZHX2

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

Browse compounds at ApexBio

GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category			(GIFtS: )
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZHX2 gene at Home site.

Version: 3.12.136 22 July 2014
hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4

GeneCards Plus

Advanced Search

Export list of displayed genes

ZHX2 Gene

Zinc Fingers And Homeoboxes 2

Aliases
for ZHX2 gene

Summaries
for ZHX2 gene

Genomic Views
for ZHX2 gene

Proteins
for ZHX2 gene

ZHX2 Human Recombinant Protein Products:

ZHX2 Antibody Products:

ZHX2 Assay Products:

Domains /
Families
for ZHX2 gene

Function
for ZHX2 gene

Localization
for ZHX2 gene

Pathways & Interactions
for ZHX2 gene

Drugs & Compounds
for ZHX2 gene

Transcripts
for ZHX2 gene

Expression
for ZHX2 gene

Orthologs
for ZHX2 gene

Paralogs
for ZHX2 gene

Genomic Variants
for ZHX2 gene

Disorders / Diseases
for ZHX2 gene

Publications
for ZHX2 gene

External Searches for ZHX2 gene

Genome Databases showing ZHX2 gene

Other Databases showing ZHX2 gene

Specialized Databases showing ZHX2 gene

Intellectual Property
for ZHX2 gene

Products
for ZHX2 gene

View Random Gene

GeneCards Plus

Advanced Search

Export list of displayed genes

ZHX2 Gene

Zinc Fingers And Homeoboxes 2

Aliasesfor ZHX2 gene

Summariesfor ZHX2 gene

Genomic Viewsfor ZHX2 gene

Proteinsfor ZHX2 gene

ZHX2 Human Recombinant Protein Products:

ZHX2 Antibody Products:

ZHX2 Assay Products:

Domains /Familiesfor ZHX2 gene

Functionfor ZHX2 gene

Localizationfor ZHX2 gene

Pathways & Interactionsfor ZHX2 gene

Drugs & Compoundsfor ZHX2 gene

Transcriptsfor ZHX2 gene

Expression for ZHX2 gene

Orthologsfor ZHX2 gene

Paralogsfor ZHX2 gene

Genomic Variantsfor ZHX2 gene

Disorders / Diseasesfor ZHX2 gene

Publicationsfor ZHX2 gene

External Searches for ZHX2 gene

Genome Databases showing ZHX2 gene

Other Databases showing ZHX2 gene

Specialized Databases showing ZHX2 gene

Intellectual Propertyfor ZHX2 gene

Productsfor ZHX2 gene

View Random Gene

Aliases
for ZHX2 gene

Summaries
for ZHX2 gene

Genomic Views
for ZHX2 gene

Proteins
for ZHX2 gene

Domains /
Families
for ZHX2 gene

Function
for ZHX2 gene

Localization
for ZHX2 gene

Pathways & Interactions
for ZHX2 gene

Drugs & Compounds
for ZHX2 gene

Transcripts
for ZHX2 gene

Expression
for ZHX2 gene

Orthologs
for ZHX2 gene

Paralogs
for ZHX2 gene

Genomic Variants
for ZHX2 gene

Disorders / Diseases
for ZHX2 gene

Publications
for ZHX2 gene

Intellectual Property
for ZHX2 gene

Products
for ZHX2 gene