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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZHX2 Gene

protein-coding   GIFtS: 58
GCID: GC08P123793

Zinc Fingers And Homeoboxes 2

(Previous name: zinc-fingers and homeoboxes 2)
  See related diseases
at
MalaCards
 

Aliases
for ZHX2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Zinc Fingers And Homeoboxes 21 2     RAF2 3
Zinc-Fingers And Homeoboxes 21 2     AFP Regulator 12 3
Alpha-Fetoprotein Regulator 12 3     Transcription Factor ZHX22
Regulator Of AFP2 3     Zinc Fingers And Homeoboxes Protein 22
Zinc Finger And Homeodomain Protein 22 3     KIAA08543
AFR12 3     

External Ids:    HGNC: 185131   Entrez Gene: 228822   Ensembl: ENSG000001787647   OMIM: 6091855   UniProtKB: Q9Y6X83   

Export aliases for ZHX2 gene to outside databases

Previous GC identifers: GC08P123462 GC08P123750 GC08P123863 GC08P119119


Summaries
for ZHX2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ZHX2 Gene:
The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that
interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox
DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this
protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. (provided by RefSeq, Jul 2008)

GeneCards Summary for ZHX2 Gene: 
ZHX2 (zinc fingers and homeoboxes 2) is a protein-coding gene. Diseases associated with ZHX2 include usher syndrome, and thalassemia. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZHX3.

UniProtKB/Swiss-Prot: ZHX2_HUMAN, Q9Y6X8
Function: Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by
NFYA

Gene Wiki entry for ZHX2 Gene


Genomic Views
for ZHX2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008046.16  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZHX2 gene promoter:
         SRF   E2F-4   E2F-3a   E2F-5   SRF (504 AA)   MyoD   E2F-2   IRF-2   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZHX2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZHX2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZHX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.13   Ensembl cytogenetic band:  8q24.13   HGNC cytogenetic band: 8q24.13

ZHX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZHX2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P123793:  view genomic region     (about GC identifiers)

Start:
 123,793,633 bp from pter      End:
 123,986,755 bp from pter
Size:
 193,123 bases      Orientation:
 plus strand

Proteins
for ZHX2 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: ZHX2_HUMAN, Q9Y6X8 (See protein sequence)
Recommended Name: Zinc fingers and homeoboxes protein 2  
Size: 837 amino acids; 92307 Da
Subunit: Forms a homodimer (via homeobox domain). Forms a heterodimer with ZHX1 (via HD1 domain). Forms a
heterodimer with ZHX3. Heterodimerization with ZHX1 is not necessary for repressor activity. Interacts (via
homeobox domain) with NFYA (via N-terminus)
Subcellular location: Nucleus
Sequence caution: Sequence=BAA74877.2; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for ZHX2:
2DMP (3D)        3NAU (3D)    

Explore the universe of human proteins at neXtProt for ZHX2: NX_Q9Y6X8

Explore proteomics data for ZHX2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y6X8

    • ZHX2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZHX2 Protein Expression
    REFSEQ proteins: NP_055758.1  
    ENSEMBL proteins: 
     ENSP00000314709   ENSP00000452720  

    Human Recombinant Protein Products for ZHX2: 
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    Novus Biologicals ZHX2 Protein
    Novus Biologicals ZHX2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZHX2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--

    ZHX2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for ZHX2 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    ZFHX: Homeoboxes / ZF class
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9Y6X8

    ProtoNet protein and cluster: Q9Y6X8

    UniProtKB/Swiss-Prot: ZHX2_HUMAN, Q9Y6X8
    Similarity: Belongs to the ZHX family
    Similarity: Contains 2 C2H2-type zinc fingers
    Similarity: Contains 4 homeobox DNA-binding domains


    ZHX2 for domains           About GeneDecksing


    Function
    for ZHX2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZHX2_HUMAN, Q9Y6X8
    Function: Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by
    NFYA

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IDA12741956
    GO:0003714transcription corepressor activity IDA12741956
    GO:0005515protein binding IPI12741956
    GO:0008270zinc ion binding ----
         
    ZHX2 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Zhx2):
     homeostasis/metabolism 

    ZHX2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZHX2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZHX2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZHX2 
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    miRNA
    Products:            		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZHX2
    8/53 QIAGEN miScript miRNA Assays for microRNAs that regulate ZHX2 (see all 53):
    hsa-miR-106a hsa-miR-199a-3p hsa-miR-1258 hsa-miR-1260b hsa-let-7a-2* hsa-miR-624 hsa-miR-519a hsa-miR-548m
    SwitchGear 3'UTR luciferase reporter plasmid: ZHX2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of ZHX2 

    Cell Line
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    Search LifeMap BioReagents cell lines for ZHX2
    In Situ Assay
    Products:       
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    Pathways & Interactions
    for ZHX2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZHX2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Hypothetical Network for Drug Addiction
    		Hypothetical Network for Drug Addiction


    1 BioSystems Pathway for ZHX2
        Hypothetical Network for Drug Addiction


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZHX2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/17 Interacting proteins for ZHX2 (Q9Y6X82, 3 ENSP000003147094) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542532, 3, ENSP000002447694MINT-2869952 I2D: score=3 STRING: ENSP00000244769
    PARP2Q9UGN52, 3, ENSP000002504164MINT-8202110 I2D: score=1 STRING: ENSP00000250416
    ZHX3Q9H4I23, ENSP000003122224I2D: score=5 STRING: ENSP00000312222
    ZHX1Q9UKY13, ENSP000002978574I2D: score=2 STRING: ENSP00000297857
    HRASP011123, ENSP000003098454I2D: score=1 STRING: ENSP00000309845
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA12741956
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0006402mRNA catabolic process IEA--

    ZHX2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ZHX2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZHX2

    Search CenterWatch for drugs/clinical trials and news about ZHX2

    Transcripts
    for ZHX2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ZHX2 gene: 
    NM_014943.3  

    Unigene Clusters for ZHX2:

    Zinc fingers and homeoboxes 2
    Hs.377090  [show with all ESTs], Hs.658443
    Unigene Representative Sequences: NM_014943, AF075099
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000314393(uc003ypk.1) ENST00000534247
    miRNA
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    8/53 QIAGEN miScript miRNA Assays for microRNAs that regulate ZHX2 (see all 53):
    hsa-miR-106a hsa-miR-199a-3p hsa-miR-1258 hsa-miR-1260b hsa-let-7a-2* hsa-miR-624 hsa-miR-519a hsa-miR-548m
    SwitchGear 3'UTR luciferase reporter plasmid: ZHX2 3' UTR sequence
    Inhib. RNA
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    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZHX2
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZHX2
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    Additional mRNA sequence: AF075099.1 

    5 DOTS entries:

    DT.215814  DT.40190209  DT.121471822  DT.121471869  DT.75122475 

    24/121 AceView cDNA sequences (see all 121):

    N47512 CA392286 BM477083 AA688093 AA909221 BC042145 BE349554 BQ879545 
    BE855934 AB083653 BM141990 NM_014943 BM710651 T06258 AA282525 CA487642 
    BM721473 AW575095 BQ025777 BF343272 BQ183226 AA086374 H83695 CA432946 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZHX2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9
    SP1:                                                                  
    SP2:        -     -     -     -     -     -                           
    SP3:                                                                  


    ECgene alternative splicing isoforms for ZHX2

    Expression
    for ZHX2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZHX2 expression in normal human tissues (normalized intensities)      ZHX2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTGATTTT
    ZHX2 Expression
    About this image


    ZHX2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Liver (Hepatobiliary System)    fully expand to see all 3 entries
             Fetal Hepatocytes Liver Lobule
     
     Lymph (Hematopoietic System)    fully expand to see all 2 entries
             lymph node   
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Human Lens Epithelial Cells (HLEpiC)   
     
     Epithelium (Uncategorized)    fully expand to see all 2 entries
             Human Lens Epithelial Cells (HLEpiC)   
     
     Blood (Hematopoietic System)
             b cells   

    See ZHX2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZHX2

    SOURCE GeneReport for Unigene clusters: Hs.377090 Hs.658443

    UniProtKB/Swiss-Prot: ZHX2_HUMAN, Q9Y6X8
    Tissue specificity: Ubiquitously expressed. Expressed in podocytes

        SABiosciences Expression via Pathway-Focused PCR Array including ZHX2: 
              Oncogenes & Tumor Suppressor Genes in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for ZHX2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ZHX2 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Zhx21 , 5 zinc fingers and homeoboxes 21, 5 84.93(n)1
    87.2(a)1    		   15 (24.01 cM)5
    3876091  NM_199449.21  NP_955520.11 
     576946655 
    chicken
    (Gallus gallus)    		 Aves ZHX21 zinc fingers and homeoboxes 2 69.88(n)
    69.76(a)    		   420351  XM_418458.3  XP_418458.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ZHX26
    		 Uncharacterized protein
    		 60(a)
    		 1 ↔ 1
    		 GL343581.1(375189-377588)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.139322 Xenopus laevis transcribed sequence with weak similarity more 79.89(n)    BU901985.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zhx22 zinc-fingers and homeoboxes 2 74.54(n)   386660  AY311507.1 


    ENSEMBL Gene Tree for ZHX2 (if available)
    TreeFam Gene Tree for ZHX2 (if available)

    Paralogs
    for ZHX2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZHX2 gene
    ZHX32  HOMEZ2  ZHX12  
    2 SIMAP similar genes for ZHX2 using alignment to 2 protein entries:     ZHX2_HUMAN (see all proteins):
    ZHX1    ZHX3

    ZHX2 for paralogs           About GeneDecksing



    Genomic Variants
    for ZHX2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3989 SNPs in ZHX2 are shown (see all 3989)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs715736571,2
    		C--119224961(+) CCACC-/GT/   
      GTGTGT    GTGTG     		1 -- int11NA 2
    rs1854651651,2
    		C--123792113(+) AGACTA/C/TCTTCC 1 -- us2k10--------
    rs1386621551,2
    		--123792145(+) GGGCGC/GTTAAA 1 -- us2k10--------
    rs1125018501,2
    		C,F--123792156(+) ATGCAT/AACAAA 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs773551491,2
    		F--123792258(+) TTCTGC/GGGAGT 1 -- us2k10--------
    rs733317331,2
    		C,F--123792303(+) GAACTT/CACAAA 1 -- us2k13Minor allele frequency- C:0.11WA 122
    rs1393157921,2
    		--123792440(+) GCCTCG/TCCGCT 1 -- us2k10--------
    rs1907180261,2
    		--123792572(+) CTGCAA/GGGCGG 1 -- us2k10--------
    rs1814230361,2
    		--123792671(+) CCCTCC/GTCCCC 1 -- us2k10--------
    rs733317341,2
    		C,F--123792824(+) GCACTG/ATGGCA 1 -- us2k11Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for ZHX2 (123793633 - 123986755 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZHX2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2737525CNV Deletion23290073

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    Disorders / Diseases
    for ZHX2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 609185    OMIM disorders: --

    10 diseases for ZHX2:    About MalaCards
    usher syndrome    thalassemia    neurofibromatosis    nephrotic syndrome
    pertussis    hodgkin's lymphoma    neuroblastoma    prostate cancer
    prostatitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for ZHX2:
    Cancer

    ZHX2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZHX2
    Human Genome Epidemiology (HuGE) Navigator: ZHX2 (4 documents)

    Export disorders for ZHX2 gene to outside databases

    Publications
    for ZHX2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZHX2 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with ZHX2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor. (PubMed id 12741956)1, 2, 3 Kawata H.... Miyamoto K. (2003)
    2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T....Ohara O. (1998)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Inherited genetic variant predisposes to aggressive b ut not indolent prostate cancer. (PubMed id 20080650)1, 4 Xu J....Isaacs W.B. (2010)
    5. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (2009)
    6. ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome. (PubMed id 17056598)1, 2 Liu G....Chugh S.S. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. ZHX2 is a repressor of alpha-fetoprotein expression in human hepatoma cell lines. (PubMed id 18194454)1, 9 Shen H....Ma C. (2008)
    9. The mouse zinc-fingers and homeoboxes (ZHX) family; ZHX2 forms a heterodimer with ZHX3. (PubMed id 14659886)1, 9 Kawata H....Miyamoto K. (2003)
    10. The importance of the Erk pathway in the development o f linker for activation of T cells-mediated autoimmunity. (PubMed id 22984075)1 Fuller D.M....Zhang W. (2012)

    External Searches for ZHX2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ZHX2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22882 HGNC: 18513 AceView: ZHX2 Ensembl:ENSG00000178764 euGenes: HUgn22882
    ECgene: ZHX2 H-InvDB: ZHX2

    Other Databases showing ZHX2 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0854

    Specialized Databases showing ZHX2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZHX2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ZHX2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ZHX2 gene:
    Search GeneIP for patents involving ZHX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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