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ZHX2 Gene

protein-coding   GIFtS: 57
GCID: GC08P123793

Zinc Fingers And Homeoboxes 2

(Previous name: zinc-fingers and homeoboxes 2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Fingers And Homeoboxes 21 2     RAF2 3
Zinc-Fingers And Homeoboxes 21 2     AFP Regulator 12 3
Alpha-Fetoprotein Regulator 12 3     Transcription Factor ZHX22
Regulator Of AFP2 3     Zinc Fingers And Homeoboxes Protein 22
Zinc Finger And Homeodomain Protein 22 3     KIAA08543
AFR12 3     

External Ids:    HGNC: 185131   Entrez Gene: 228822   Ensembl: ENSG000001787647   OMIM: 6091855   UniProtKB: Q9Y6X83   

Export aliases for ZHX2 gene to outside databases

Previous GC identifers: GC08P123462 GC08P123750 GC08P123863 GC08P119119


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZHX2 Gene:
The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that
interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox
DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this
protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. (provided by RefSeq, Jul 2008)

GeneCards Summary for ZHX2 Gene:
ZHX2 (zinc fingers and homeoboxes 2) is a protein-coding gene. Diseases associated with ZHX2 include drug addiction, and usher syndrome. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZHX3.

UniProtKB/Swiss-Prot: ZHX2_HUMAN, Q9Y6X8
Function: Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by
NFYA

Gene Wiki entry for ZHX2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NT_008046.17  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZHX2 gene promoter:
         SRF   E2F-4   E2F-3a   E2F-5   SRF (504 AA)   MyoD   E2F-2   IRF-2   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZHX2 promoter sequence
   Search Chromatin IP Primers for ZHX2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZHX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.13   Ensembl cytogenetic band:  8q24.13   HGNC cytogenetic band: 8q24.13

ZHX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZHX2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P123793:  view genomic region     (about GC identifiers)

Start:
123,793,633 bp from pter      End:
123,986,755 bp from pter
Size:
193,123 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZHX2_HUMAN, Q9Y6X8 (See protein sequence)
Recommended Name: Zinc fingers and homeoboxes protein 2  
Size: 837 amino acids; 92307 Da
Subunit: Forms a homodimer (via homeobox domain). Forms a heterodimer with ZHX1 (via HD1 domain). Forms a
heterodimer with ZHX3. Heterodimerization with ZHX1 is not necessary for repressor activity. Interacts (via
homeobox domain) with NFYA (via N-terminus)
Sequence caution: Sequence=BAA74877.2; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for ZHX2:
2DMP (3D)        3NAU (3D)    

Explore the universe of human proteins at neXtProt for ZHX2: NX_Q9Y6X8

Explore proteomics data for ZHX2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZHX2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055758.1  
    ENSEMBL proteins: 
     ENSP00000314709   ENSP00000452720  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZFHX: Homeoboxes / ZF class
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9Y6X8

    ProtoNet protein and cluster: Q9Y6X8

    UniProtKB/Swiss-Prot: ZHX2_HUMAN, Q9Y6X8
    Similarity: Belongs to the ZHX family
    Similarity: Contains 2 C2H2-type zinc fingers
    Similarity: Contains 4 homeobox DNA-binding domains


    ZHX2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZHX2_HUMAN, Q9Y6X8
    Function: Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by
    NFYA

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IDA12741956
    GO:0003714transcription corepressor activity IDA12741956
    GO:0005515protein binding IPI12741956
    GO:0042803protein homodimerization activity IDA12741956
         
    ZHX2 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Zhx2):
     homeostasis/metabolism 

    ZHX2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZHX2
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ZHX2 (see all 53):
    hsa-miR-106a hsa-miR-199a-3p hsa-miR-1258 hsa-miR-1260b hsa-let-7a-2* hsa-miR-624 hsa-miR-519a hsa-miR-548m
    SwitchGear 3'UTR luciferase reporter plasmidZHX2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZHX2_HUMAN, Q9Y6X8: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    plasma membrane4
    cytoskeleton2
    extracellular2
    mitochondrion2
    endoplasmic reticulum1
    golgi apparatus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--

    ZHX2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZHX2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Hypothetical Network for Drug Addiction
    Hypothetical Network for Drug Addiction


    1 BioSystems Pathway for ZHX2
        Hypothetical Network for Drug Addiction


        Pathway & Disease-focused RT2 Profiler PCR Array including ZHX2: 
              Oncogenes & Tumor Suppressor Genes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ZHX2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for ZHX2 (Q9Y6X82, 3 ENSP000003147094) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542532, 3, ENSP000002447694MINT-2869952 I2D: score=3 STRING: ENSP00000244769
    PARP2Q9UGN52, 3, ENSP000002504164MINT-8202110 I2D: score=1 STRING: ENSP00000250416
    ZHX3Q9H4I23, ENSP000003122224I2D: score=5 STRING: ENSP00000312222
    ZHX1Q9UKY13, ENSP000002978574I2D: score=2 STRING: ENSP00000297857
    HRASP011123, ENSP000003098454I2D: score=1 STRING: ENSP00000309845
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA12741956
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0006402mRNA catabolic process IEA--

    ZHX2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZHX2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZHX2 gene: 
    NM_014943.3  

    Unigene Clusters for ZHX2:

    Zinc fingers and homeoboxes 2
    Hs.377090  [show with all ESTs], Hs.658443
    Unigene Representative Sequences: NM_014943, AF075099
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000314393(uc003ypk.1) ENST00000534247
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ZHX2 (see all 53):
    hsa-miR-106a hsa-miR-199a-3p hsa-miR-1258 hsa-miR-1260b hsa-let-7a-2* hsa-miR-624 hsa-miR-519a hsa-miR-548m
    SwitchGear 3'UTR luciferase reporter plasmidZHX2 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ZHX2
      QuantiFast Probe-based Assays in human, mouse, rat ZHX2

    Additional mRNA sequence: AF075099.1 

    5 DOTS entries:

    DT.215814  DT.40190209  DT.121471822  DT.121471869  DT.75122475 

    Selected AceView cDNA sequences (see all 121):

    BM141990 NM_014943 BM710651 T06258 AA282525 CA487642 BM721473 N47512 
    CA392286 BM477083 AA688093 AA909221 BC042145 BE349554 BQ879545 BE855934 
    AB083653 BQ649483 BI769972 BX485477 BM994283 AA744757 CD251688 AW574755 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZHX2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9
    SP1:                                                                  
    SP2:        -     -     -     -     -     -                           
    SP3:                                                                  


    ECgene alternative splicing isoforms for ZHX2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZHX2 expression in normal human tissues (normalized intensities)      ZHX2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTGATTTT
    ZHX2 Expression
    About this image


    ZHX2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Liver (Hepatobiliary System)    fully expand to see all 3 entries
             Fetal Hepatocytes Liver Lobule
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    ZHX2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZHX2 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.377090 Hs.658443

    UniProtKB/Swiss-Prot: ZHX2_HUMAN, Q9Y6X8
    Tissue specificity: Ubiquitously expressed. Expressed in podocytes

        Pathway & Disease-focused RT2 Profiler PCR Array including ZHX2: 
              Oncogenes & Tumor Suppressor Genes in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZHX2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zhx21 , 5 zinc fingers and homeoboxes 21, 5 84.93(n)1
    87.2(a)1
      15 (24.01 cM)5
    3876091  NM_199449.21  NP_955520.11 
     576946655 
    chicken
    (Gallus gallus)
    Aves ZHX21 zinc fingers and homeoboxes 2 69.85(n)
    70.01(a)
      420351  XM_418458.4  XP_418458.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZHX26
    zinc fingers and homeoboxes 2
    60(a)
    1 ↔ 1
    GL343581.1(375189-377588)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.139322 Xenopus laevis transcribed sequence with weak similarity more 79.89(n)    BU901985.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zhx22 zinc-fingers and homeoboxes 2 74.54(n)   386660  AY311507.1 


    ENSEMBL Gene Tree for ZHX2 (if available)
    TreeFam Gene Tree for ZHX2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZHX2 gene
    ZHX32  HOMEZ2  ZHX12  
    2 SIMAP similar genes for ZHX2 using alignment to 2 protein entries:     ZHX2_HUMAN (see all proteins):
    ZHX1    ZHX3

    ZHX2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZHX2 (see all 3989)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs715736571,2
    C--119224961(+) CCACC-/GT/   
      GTGTGT
    GTGTG
    1 -- int11NA 2
    rs1854651651,2
    C--123792113(+) AGACTA/C/TCTTCC 1 -- us2k10--------
    rs1386621551,2
    --123792145(+) GGGCGC/GTTAAA 1 -- us2k10--------
    rs1125018501,2
    C,F--123792156(+) ATGCAT/AACAAA 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs773551491,2
    F--123792258(+) TTCTGC/GGGAGT 1 -- us2k10--------
    rs733317331,2
    C,F--123792303(+) GAACTT/CACAAA 1 -- us2k13Minor allele frequency- C:0.11WA 122
    rs1393157921,2
    --123792440(+) GCCTCG/TCCGCT 1 -- us2k10--------
    rs1907180261,2
    --123792572(+) CTGCAA/GGGCGG 1 -- us2k10--------
    rs1814230361,2
    --123792671(+) CCCTCC/GTCCCC 1 -- us2k10--------
    rs733317341,2
    C,F--123792824(+) GCACTG/ATGGCA 1 -- us2k11Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for ZHX2 (123793633 - 123986755 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZHX2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2737525CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609185    OMIM disorders: --

    13 diseases for ZHX2:    About MalaCards
    drug addiction    usher syndrome    smallpox    neurofibromatosis
    thalassemia    nephrotic syndrome    pertussis    hodgkin's lymphoma
    ataxia    neuroblastoma    prostate cancer    prostatitis
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for ZHX2:
    Cancer

    ZHX2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZHX2
    Human Genome Epidemiology (HuGE) Navigator: ZHX2 (4 documents)

    Export disorders for ZHX2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZHX2 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with ZHX2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor. (PubMed id 12741956)1, 2, 3 Kawata H.... Miyamoto K. (Biochem. J. 2003)
    2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1998)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PubMed id 20080650)1, 4 Xu J....Isaacs W.B. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    6. ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome. (PubMed id 17056598)1, 2 Liu G.... Chugh S.S. (J. Biol. Chem. 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. ZHX2 is a repressor of alpha-fetoprotein expression in human hepatoma cell lines. (PubMed id 18194454)1, 9 Shen H....Ma C. (J. Cell. Mol. Med. 2008)
    9. The mouse zinc-fingers and homeoboxes (ZHX) family; ZHX2 forms a heterodimer with ZHX3. (PubMed id 14659886)1, 9 Kawata H....Miyamoto K. (Gene 2003)
    10. A genome-wide association study of behavioral disinhibition. (PubMed id 23942779)1 McGue M....Iacono W.G. (Behav. Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22882 HGNC: 18513 AceView: ZHX2 Ensembl:ENSG00000178764 euGenes: HUgn22882
    ECgene: ZHX2 H-InvDB: ZHX2

    (According to HUGE)
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    HUGE: KIAA0854

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZHX2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZHX2 gene:
    Search GeneIP for patents involving ZHX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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