ZHX2 Gene

Aliases
for ZHX2 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC08P123462 GC08P123750 GC08P123863 GC08P119119

Summaries
for ZHX2 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for ZHX2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000008.10  NT_008046.17  NC_018919.2  

SwitchGear Promoter luciferase reporter plasmid: ZHX2 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZHX2

ZHX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P123793:  view genomic region     (about GC identifiers)

Proteins
for ZHX2 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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2 PDB 3D structures from and Proteopedia for ZHX2:

2DMP (3D)        3NAU (3D)    

Explore the universe of human proteins at neXtProt for ZHX2: NX_Q9Y6X8

Explore proteomics data for ZHX2 at MOPED

Post-translational modifications: 

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	antibodies-online peptides for ZHX2

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	antibodies-online kits for ZHX2 (6 products)

Domains /
Families
for ZHX2 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q9Y6X8

Find genes that share domains with ZHX2           About GenesLikeMe

Function
for ZHX2 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

(inferred from 1 allele) (MGI details for Zhx2)

genOway: Develop your customized and physiologically relevant rodent model for ZHX2

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		Selected qRT-PCR Assays for microRNAs that regulate ZHX2 (see all 53):
		hsa-miR-106a hsa-miR-199a-3p hsa-miR-1258 hsa-miR-1260b hsa-let-7a-2* hsa-miR-624 hsa-miR-519a hsa-miR-548m
		SwitchGear 3'UTR luciferase reporter plasmid: ZHX2 3' UTR sequence

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Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for ZHX2

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZHX2

Localization
for ZHX2 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
nucleus	5
cytosol	4
plasma membrane	4
cytoskeleton	2
extracellular	2
mitochondrion	2
endoplasmic reticulum	1
golgi apparatus	1

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Gene Ontology (GO): 4 cellular component terms:    About this table

Pathways & Interactions
for ZHX2 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for ZHX2 About     See pathways by source

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	SuperPath	Contained pathways About
1	Hypothetical Network for Drug Addiction	Hypothetical Network for Drug Addiction

1 BioSystems Pathway for ZHX2

Hypothetical Network for Drug Addiction

Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

Drugs & Compounds
for ZHX2 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for ZHX2 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for ZHX2 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZHX2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AATTGATTTT

About this image

Brain (Nervous System)    fully expand to see all 4 entries
Cerebral Cortex
Liver (Hepatobiliary System)    fully expand to see all 3 entries
Fetal Hepatocytes Liver Lobule
Ovary (Reproductive System)
Oviduct
Testis (Reproductive System)
Leydig Cells Testis Interstitium

Primer Products:		OriGene qPCR primer pairs and template standards for ZHX2 OriGene qSTAR qPCR primer pairs in human, mouse for ZHX2
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZHX2

Orthologs
for ZHX2 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for ZHX2 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for ZHX2 gene

ZHX3²  HOMEZ²  ZHX1²  

2 SIMAP similar genes for ZHX2 using alignment to 2 protein entries:     ZHX2_HUMAN (see all proteins):

ZHX1    ZHX3

Find genes that share paralogs with ZHX2           About GenesLikeMe

Genomic Variants
for ZHX2 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ZHX2 (see all 3989)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs715736571,2	C	--	119224961(+)	CCACC-/GT/      GTGTGTGTGTG	1	--	int1		1		NA	2
rs1854651651,2	C	--	123792113(+)	AGACTA/C/TCTTCC	1	--	us2k1		0	--	--	--	--
rs1386621551,2		--	123792145(+)	GGGCGC/GTTAAA	1	--	us2k1		0	--	--	--	--
rs1125018501,2	C,F	--	123792156(+)	ATGCAT/AACAAA	1	--	us2k1		1		CSA	2
rs773551491,2	F	--	123792258(+)	TTCTGC/GGGAGT	1	--	us2k1		0	--	--	--	--
rs733317331,2	C,F	--	123792303(+)	GAACTT/CACAAA	1	--	us2k1		3		WA	122
rs1393157921,2		--	123792440(+)	GCCTCG/TCCGCT	1	--	us2k1		0	--	--	--	--
rs1907180261,2		--	123792572(+)	CTGCAA/GGGCGG	1	--	us2k1		0	--	--	--	--
rs1814230361,2		--	123792671(+)	CCCTCC/GTCCCC	1	--	us2k1		0	--	--	--	--
rs733317341,2	C,F	--	123792824(+)	GCACTG/ATGGCA	1	--	us2k1		1		WA	2

HapMap Linkage Disequilibrium report for ZHX2 (123793633 - 123986755 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for ZHX2:    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2737525	CNV	Deletion	23290073

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing ZHX2

DNA2.0 Custom Variant and Variant Library Synthesis for ZHX2

Disorders / Diseases
for ZHX2 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for ZHX2 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor. (PubMed id 12741956)^{1, 2, 3} Kawata H.... Miyamoto K. (Biochem. J. 2003)
2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)^{1, 2, 3} Nagase T.... Ohara O. (DNA Res. 1998)
3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
4. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PubMed id 20080650)^{1, 4} Xu J....Isaacs W.B. (Proc. Natl. Acad. Sci. U.S.A. 2010)
5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)^{1, 4} Trynka G....Wijmenga C. (Gut 2009)
6. ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome. (PubMed id 17056598)^{1, 2} Liu G.... Chugh S.S. (J. Biol. Chem. 2006)
7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
8. ZHX2 is a repressor of alpha-fetoprotein expression in human hepatoma cell lines. (PubMed id 18194454)^{1, 9} Shen H....Ma C. (J. Cell. Mol. Med. 2008)
9. The mouse zinc-fingers and homeoboxes (ZHX) family; ZHX2 forms a heterodimer with ZHX3. (PubMed id 14659886)^{1, 9} Kawata H....Miyamoto K. (Gene 2003)
10. A genome-wide association study of behavioral disinhibition. (PubMed id 23942779)¹ McGue M....Iacono W.G. (Behav. Genet. 2013)

External Searches for ZHX2 gene

Genome Databases showing ZHX2 gene

Other Databases showing ZHX2 gene

Specialized Databases showing ZHX2 gene

Products
for ZHX2 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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