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Aliases for ZHX2 Gene

Aliases for ZHX2 Gene

  • Zinc Fingers And Homeoboxes 2 2 3
  • Zinc Finger And Homeodomain Protein 2 3 4
  • Zinc-Fingers And Homeoboxes 2 2 3
  • Alpha-Fetoprotein Regulator 1 3 4
  • Regulator Of AFP 3 4
  • AFP Regulator 1 3 4
  • AFR1 3 4
  • RAF 3 4
  • Zinc Fingers And Homeoboxes Protein 2 3
  • Transcription Factor ZHX2 3
  • KIAA0854 4

External Ids for ZHX2 Gene

Summaries for ZHX2 Gene

Entrez Gene Summary for ZHX2 Gene

  • The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZHX2 Gene

ZHX2 (Zinc Fingers And Homeoboxes 2) is a Protein Coding gene. Among its related pathways are Hypothetical Network for Drug Addiction. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is ZHX1.

UniProtKB/Swiss-Prot for ZHX2 Gene

  • Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA.

Gene Wiki entry for ZHX2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZHX2 Gene

Genomics for ZHX2 Gene

Genomic Location for ZHX2 Gene

Start:
122,780,656 bp from pter
End:
122,974,515 bp from pter
Size:
193,860 bases
Orientation:
Plus strand

Genomic View for ZHX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZHX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZHX2 Gene

Regulatory Elements for ZHX2 Gene

Proteins for ZHX2 Gene

  • Protein details for ZHX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6X8-ZHX2_HUMAN
    Recommended name:
    Zinc fingers and homeoboxes protein 2
    Protein Accession:
    Q9Y6X8
    Secondary Accessions:

    Protein attributes for ZHX2 Gene

    Size:
    837 amino acids
    Molecular mass:
    92307 Da
    Quaternary structure:
    • Forms a homodimer (via homeobox domain). Forms a heterodimer with ZHX1 (via HD1 domain). Forms a heterodimer with ZHX3. Heterodimerization with ZHX1 is not necessary for repressor activity. Interacts (via homeobox domain) with NFYA (via N-terminus).
    SequenceCaution:
    • Sequence=BAA74877.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZHX2 Gene

neXtProt entry for ZHX2 Gene

Proteomics data for ZHX2 Gene at MOPED

Post-translational modifications for ZHX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZHX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZHX2 Gene

Domains for ZHX2 Gene

Gene Families for ZHX2 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type
  • ZFHX :Homeoboxes / ZF class

Protein Domains for ZHX2 Gene

UniProtKB/Swiss-Prot:

ZHX2_HUMAN
Domain:
  • Contains 4 homeobox DNA-binding domains.:
    • Q9Y6X8
Family:
  • Belongs to the ZHX family.:
    • Q9Y6X8
Similarity:
  • Contains 2 C2H2-type zinc fingers.:
    • Q9Y6X8
genes like me logo Genes that share domains with ZHX2: view

Function for ZHX2 Gene

Molecular function for ZHX2 Gene

UniProtKB/Swiss-Prot Function: Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA.

Gene Ontology (GO) - Molecular Function for ZHX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IDA 12741956
GO:0003714 transcription corepressor activity IDA 12741956
GO:0005515 protein binding IPI 12741956
GO:0042802 identical protein binding IPI 12741956
genes like me logo Genes that share ontologies with ZHX2: view

Phenotypes for ZHX2 Gene

genes like me logo Genes that share phenotypes with ZHX2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZHX2 Gene

Localization for ZHX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZHX2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZHX2 Gene COMPARTMENTS Subcellular localization image for ZHX2 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 4
cytoskeleton 2
extracellular 2
mitochondrion 2
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ZHX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12741956
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with ZHX2: view

Pathways for ZHX2 Gene

genes like me logo Genes that share pathways with ZHX2: view

Pathways by source for ZHX2 Gene

1 BioSystems pathway for ZHX2 Gene

Gene Ontology (GO) - Biological Process for ZHX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 12741956
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter --
GO:0006402 mRNA catabolic process IEA --
GO:0035019 somatic stem cell maintenance IEA --
genes like me logo Genes that share ontologies with ZHX2: view

Transcripts for ZHX2 Gene

Unigene Clusters for ZHX2 Gene

Zinc fingers and homeoboxes 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZHX2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9
SP1:
SP2: - - - - - -
SP3:

Relevant External Links for ZHX2 Gene

GeneLoc Exon Structure for
ZHX2
ECgene alternative splicing isoforms for
ZHX2

Expression for ZHX2 Gene

mRNA expression in normal human tissues for ZHX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZHX2 Gene

SOURCE GeneReport for Unigene cluster for ZHX2 Gene Hs.377090

mRNA Expression by UniProt/SwissProt for ZHX2 Gene

Q9Y6X8-ZHX2_HUMAN
Tissue specificity: Ubiquitously expressed. Expressed in podocytes.
genes like me logo Genes that share expressions with ZHX2: view

Orthologs for ZHX2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZHX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZHX2 36
  • 99.24 (n)
  • 99.64 (a)
ZHX2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZHX2 36
  • 86.94 (n)
  • 91.28 (a)
ZHX2 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZHX2 36
  • 88.77 (n)
  • 91.52 (a)
ZHX2 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zhx2 36
  • 84.93 (n)
  • 87.2 (a)
Zhx2 16
Zhx2 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZHX2 37
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zhx2 36
  • 84.45 (n)
  • 86.36 (a)
chicken
(Gallus gallus)
Aves ZHX2 36
  • 69.85 (n)
  • 70.01 (a)
ZHX2 37
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZHX2 37
  • 60 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13932 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1051 36
zhx2 36
  • 62.87 (n)
  • 61.2 (a)
zebrafish
(Danio rerio)
Actinopterygii zhx2 36
  • 56.85 (n)
  • 51.34 (a)
zhx2 37
  • 45 (a)
OneToOne
Species with no ortholog for ZHX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZHX2 Gene

ENSEMBL:
Gene Tree for ZHX2 (if available)
TreeFam:
Gene Tree for ZHX2 (if available)

Paralogs for ZHX2 Gene

Paralogs for ZHX2 Gene

Selected SIMAP similar genes for ZHX2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZHX2: view

Variants for ZHX2 Gene

Sequence variations from dbSNP and Humsavar for ZHX2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs2833 -- 122,974,409(-) TGCGG(C/T)GTACT utr-variant-3-prime
rs7758 -- 122,974,382(-) TGGGA(C/G)GGGGA utr-variant-3-prime
rs727221 -- 122,808,181(+) TAGAT(A/G)TGAGC intron-variant
rs748856 -- 122,802,586(+) AAGCC(C/T)GCATG intron-variant
rs750709 -- 122,803,525(-) GATGC(C/T)GCCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZHX2 Gene

Variant ID Type Subtype PubMed ID
esv2737525 CNV Deletion 23290073

Relevant External Links for ZHX2 Gene

HapMap Linkage Disequilibrium report
ZHX2

Disorders for ZHX2 Gene

(1) University of Copenhagen DISEASES for ZHX2 Gene

Relevant External Links for ZHX2

Genetic Association Database (GAD)
ZHX2
Human Genome Epidemiology (HuGE) Navigator
ZHX2
genes like me logo Genes that share disorders with ZHX2: view

No data available for UniProtKB/Swiss-Prot for ZHX2 Gene

Publications for ZHX2 Gene

  1. Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor. (PMID: 12741956) Kawata H. … Miyamoto K. (Biochem. J. 2003) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 49
  4. ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome. (PMID: 17056598) Liu G. … Chugh S.S. (J. Biol. Chem. 2006) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ZHX2 Gene

Sources for ZHX2 Gene

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