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Aliases for ZHX1-C8orf76 Gene

Aliases for ZHX1-C8orf76 Gene

  • ZHX1-C8orf76 Readthrough 2 3 5
  • ZHX1-C8orf76 Readthrough Transcript Protein 4
  • C8orf76 4

External Ids for ZHX1-C8orf76 Gene

Previous GeneCards Identifiers for ZHX1-C8orf76 Gene

  • GC08M124239

Summaries for ZHX1-C8orf76 Gene

Entrez Gene Summary for ZHX1-C8orf76 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring zinc fingers and homeoboxes 1 (ZHX1) and chromosome 8 open reading frame 76 (C8orf76) genes. The read-through transcript encodes a protein that shares sequence identity with the downstream gene, but it has a distinct N-terminus encoded by exon structure from the upstream gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for ZHX1-C8orf76 Gene

ZHX1-C8orf76 (ZHX1-C8orf76 Readthrough) is a Protein Coding gene. An important paralog of this gene is C8orf76.

Additional gene information for ZHX1-C8orf76 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZHX1-C8orf76 Gene

Genomics for ZHX1-C8orf76 Gene

Regulatory Elements for ZHX1-C8orf76 Gene

Enhancers for ZHX1-C8orf76 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H123271 1.1 ENCODE 0.7 +0.6 615 4 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 RNU6-875P MIR548AA1 DUTP2 FAM83A ZHX1-C8orf76 RNU6-628P
GH08H123269 0.8 Ensembl ENCODE 0.4 +5.4 5387 0 PKNOX1 STAT1 POLR2A ETV1 STAT2 ZHX1-C8orf76 RNU6-628P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZHX1-C8orf76 on UCSC Golden Path with GeneCards custom track

Promoters for ZHX1-C8orf76 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000229977 387 3800 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1

Genomic Location for ZHX1-C8orf76 Gene

Chromosome:
8
Start:
123,226,189 bp from pter
End:
123,274,487 bp from pter
Size:
48,299 bases
Orientation:
Minus strand

Genomic View for ZHX1-C8orf76 Gene

Genes around ZHX1-C8orf76 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZHX1-C8orf76 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZHX1-C8orf76 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZHX1-C8orf76 Gene

Proteins for ZHX1-C8orf76 Gene

  • Protein details for ZHX1-C8orf76 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EF9-ZHX1R_HUMAN
    Recommended name:
    Zinc fingers and homeoboxes protein 1, isoform 2
    Protein Accession:
    Q96EF9

    Protein attributes for ZHX1-C8orf76 Gene

    Size:
    292 amino acids
    Molecular mass:
    33285 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZHX1-C8orf76 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZHX1-C8orf76 Gene

Post-translational modifications for ZHX1-C8orf76 Gene

No Post-translational modifications

Other Protein References for ZHX1-C8orf76 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZHX1-C8orf76 Gene

Domains & Families for ZHX1-C8orf76 Gene

Gene Families for ZHX1-C8orf76 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZHX1-C8orf76 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZHX1-C8orf76: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ZHX1-C8orf76 Gene

Function for ZHX1-C8orf76 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZHX1-C8orf76 Gene

Localization for ZHX1-C8orf76 Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleoplasm (1)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ZHX1-C8orf76 Gene

Pathways & Interactions for ZHX1-C8orf76 Gene

SuperPathways for ZHX1-C8orf76 Gene

No Data Available

Interacting Proteins for ZHX1-C8orf76 Gene

Gene Ontology (GO) - Biological Process for ZHX1-C8orf76 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZHX1-C8orf76 Gene

Drugs & Compounds for ZHX1-C8orf76 Gene

No Compound Related Data Available

Transcripts for ZHX1-C8orf76 Gene

mRNA/cDNA for ZHX1-C8orf76 Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ZHX1-C8orf76 Gene

No ASD Table

Relevant External Links for ZHX1-C8orf76 Gene

GeneLoc Exon Structure for
ZHX1-C8orf76
ECgene alternative splicing isoforms for
ZHX1-C8orf76

Expression for ZHX1-C8orf76 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZHX1-C8orf76 Gene

Orthologs for ZHX1-C8orf76 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZHX1-C8orf76 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 34
  • 81 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 63 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 50 (a)
OneToMany
mouse
(Mus musculus)
Mammalia 9130401M01Rik 34
  • 50 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 40 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 33 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 40 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii C16H8orf76 34
  • 26 (a)
OneToMany
Species where no ortholog for ZHX1-C8orf76 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZHX1-C8orf76 Gene

ENSEMBL:
Gene Tree for ZHX1-C8orf76 (if available)
TreeFam:
Gene Tree for ZHX1-C8orf76 (if available)

Paralogs for ZHX1-C8orf76 Gene

Paralogs for ZHX1-C8orf76 Gene

(1) SIMAP similar genes for ZHX1-C8orf76 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZHX1-C8orf76: view

Variants for ZHX1-C8orf76 Gene

Sequence variations from dbSNP and Humsavar for ZHX1-C8orf76 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000020950 -- 123,272,139(+) GAAGA(C/T)GTTAA intron-variant
rs1000074255 -- 123,258,737(+) AACTT(C/T)AAATA intron-variant
rs1000117185 -- 123,234,140(+) TACGC(A/G)GTGCC intron-variant
rs1000151804 -- 123,241,124(+) GCCTG(A/C)CAGGG intron-variant
rs1000187769 -- 123,232,800(+) TGTCC(C/T)TCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZHX1-C8orf76 Gene

Variant ID Type Subtype PubMed ID
nsv1032827 CNV gain 25217958
nsv1124373 CNV deletion 24896259
nsv831449 CNV loss 17160897
nsv981978 CNV duplication 23825009

Relevant External Links for ZHX1-C8orf76 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZHX1-C8orf76

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for ZHX1-C8orf76 Gene

Disorders for ZHX1-C8orf76 Gene

Relevant External Links for ZHX1-C8orf76

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZHX1-C8orf76

No disorders were found for ZHX1-C8orf76 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZHX1-C8orf76 Gene

Publications for ZHX1-C8orf76 Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 60
  2. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C … Lander ES (Nature 2006) 4 60
  3. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y … Sugano S (Genome research 2004) 3 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for ZHX1-C8orf76 Gene

Sources for ZHX1-C8orf76 Gene

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