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ZHX1-C8orf76 Gene

protein-coding   GIFtS: 21
GCID: GC08M124239

ZHX1-C8orf76 Readthrough

  Search for ZHX1-C8orf76
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
ZHX1-C8orf76 Readthrough1 2
ZHX1-C8orf76 Readthrough Transcript Protein2 3
Zinc Fingers And Homeoboxes Protein 12
C8orf763

External Ids:    HGNC: 429751   Entrez Gene: 1005331062   Ensembl: ENSG000002593057   UniProtKB: Q96EF93   
ORGUL members:         

Export aliases for ZHX1-C8orf76 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZHX1-C8orf76 Gene:
This locus represents naturally occurring read-through transcription between the neighboring zinc fingers and
homeoboxes 1 (ZHX1) and chromosome 8 open reading frame 76 (C8orf76) genes. The read-through transcript encodes a
protein that shares sequence identity with the downstream gene, but it has a distinct N-terminus encoded by exon
structure from the upstream gene. (provided by RefSeq, Feb 2011)

GeneCards Summary for ZHX1-C8orf76 Gene:
ZHX1-C8orf76 (ZHX1-C8orf76 readthrough) is a protein-coding gene. An important paralog of this gene is C8orf76.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for ZHX1-C8orf76
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZHX1-C8orf76 promoter sequence
   Search Chromatin IP Primers for ZHX1-C8orf76

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZHX1-C8orf76


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q   Ensembl cytogenetic band:  8q24.13   HGNC cytogenetic band: 8q24.13

ZHX1-C8orf76 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZHX1-C8orf76 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M124239:  view genomic region     (about GC identifiers)

Start:
124,238,429 bp from pter      End:
124,286,727 bp from pter
Size:
48,299 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZHX1R_HUMAN, Q96EF9 (See protein sequence)
Recommended Name: Zinc fingers and homeoboxes protein 1, isoform 2  
Size: 292 amino acids; 33285 Da
Alternative splicing: 3 isoforms:  Q96EF9-1   Q9UKY1-1   Q96K31-1   (Based on a readthrough transcript which may produce a ZHX1-C8orf76 fusion protein. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZHX1-C8orf76: NX_Q96EF9

Post-translational modifications: 

  • Ubiquitination2 at Lys220
  • REFSEQ proteins: NP_001191109.1  
    ENSEMBL proteins: 
     ENSP00000349593  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR011990 TPR-like_helical

    Graphical View of Domain Structure for InterPro Entry Q96EF9

    ProtoNet protein and cluster: Q96EF9


    Find genes that share domains with ZHX1-C8orf76           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZHX1-C8orf76
    Interactions:

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZHX1-C8orf76 (ZHX1R)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
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    REFSEQ mRNAs for ZHX1-C8orf76 gene: 
    NM_001204180.1  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000357082(uc003yqd.3)
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --

    ZHX1-C8orf76 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZHX1-C8orf76 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    33(a)
    1 → many
    2(137542215-137550286)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    40(a)
    1 → many
    GL343581.1(454065-464654)
    zebrafish
    (Danio rerio)
    Actinopterygii C16H8orf766
    chromosome 8 open reading frame 76
    26(a)
    1 → many
    16(47513390-47523057) ENSDARG00000010738
            Species with no ortholog for ZHX1-C8orf76

    ENSEMBL Gene Tree for ZHX1-C8orf76 (if available)
    TreeFam Gene Tree for ZHX1-C8orf76 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZHX1-C8orf76 gene
    C8orf762  
    1 SIMAP similar gene for ZHX1-C8orf76 using alignment to 1 protein entry:     ZHX1R_HUMAN:
    C8orf76

    Find genes that share paralogs with ZHX1-C8orf76           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZHX1-C8orf76 (see all 71)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1902832111,2
    --124255778(+) AACTCC/TGCCTC 1 -- int10--------
    rs1824590301,2
    --124255844(+) ATGGAC/TAAAAG 1 -- int10--------
    rs1856908511,2
    --124255849(+) TAAAAA/GGTAGT 1 -- int10--------
    rs1441679371,2
    --124256035(+) AGCCAA/CTCCAA 1 -- int10--------
    rs1157501601,2
    F--124256071(+) GCATGG/TCCTCA 1 -- int11Minor allele frequency- T:0.02WA 118
    rs1478594371,2
    --124256077(+) CCTCAC/TTGTAC 1 -- int10--------
    rs1414160121,2
    --124256096(+) TCCACC/TTGAAA 1 -- int10--------
    rs778490221,2
    C--124256272(+) CGCTAC/GGGTAA 1 -- int10--------
    rs767561081,2
    C--124256273(+) GCTAGC/GGTAAT 1 -- int10--------
    rs101075231,2
    C,H--124256276(+) AGGGTA/CATGTC 1 -- int16Minor allele frequency- C:0.00NS EA NA 422

    HapMap Linkage Disequilibrium report for ZHX1-C8orf76 (124238429 - 124286727 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ZHX1-C8orf76: --
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    Search QIAGEN SeqTarget long-range PCR primers for resequencing ZHX1-C8orf76
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZHX1-C8orf76 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZHX1-C8orf76)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (PLoS ONE 2010)
    3. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (Nature 2006)
    4. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 100533106 HGNC: 42975 Ensembl:ENSG00000259305 euGenes: HUgn100533106 ECgene: ZHX1-C8orf76
    H-InvDB: ZHX1-C8orf76

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZHX1-C8orf76 gene:
    Search GeneIP for patents involving ZHX1-C8orf76

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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     SwitchGear Promoter luciferase reporter plasmids for ZHX1-C8orf76
     Search ThermoFisher Antibodies for ZHX1-C8orf76
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZHX1-C8orf76
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZHX1-C8orf76
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ZHX1-C8orf76
     Search LSBio for Antibodies for ZHX1-C8orf76
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     Search Addgene for plasmids for ZHX1-C8orf76
      Search eBioscience for proteins for ZHX1-C8orf76
      Search eBioscience for elisas for ZHX1-C8orf76
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