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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZHX1-C8ORF76 Gene

protein-coding   GIFtS: 23
GCID: GC08M124238

ZHX1-C8ORF76 readthrough
  Search for ZHX1-C8ORF76
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Biological research products
for ZHX1-C8ORF76    

Aliases
for ZHX1-C8ORF76 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ZHX1-C8ORF76 Readthrough1 2
ZHX1-C8orf76 Readthrough Transcript Protein2 3
Zinc Fingers And Homeoboxes Protein 12
C8orf763

External Ids:    HGNC: 429751   Entrez Gene: 1005331062   Ensembl: ENSG000002593057   UniProtKB: Q96EF93   

Export aliases for ZHX1-C8ORF76 gene to outside databases

Previous GC identifer: GC08U901526


Summaries
for ZHX1-C8ORF76 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ZHX1-C8ORF76:
This locus represents naturally occurring read-through transcription between the neighboring zinc fingers and
homeoboxes 1 (ZHX1) and chromosome 8 open reading frame 76 (C8orf76) genes. The read-through transcript encodes a
protein that shares sequence identity with the downstream gene, but it has a distinct N-terminus encoded by exon
structure from the upstream gene. (provided by RefSeq, Feb 2011)




Genomic Views
for ZHX1-C8ORF76 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ZHX1-C8ORF76
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZHX1-C8ORF76 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZHX1-C8ORF76

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZHX1-C8ORF76


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q   Ensembl cytogenetic band:  8q24.13   HGNC cytogenetic band: 8q24.13

ZHX1-C8ORF76 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZHX1-C8ORF76 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M124238:  view genomic region     (about GC identifiers)

Start:
 124,238,431 bp from pter      End:
 124,279,627 bp from pter
Size:
 41,197 bases      Orientation:
 minus strand

Proteins
for ZHX1-C8ORF76 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ZHX1R_HUMAN, Q96EF9 (See protein sequence)
Recommended Name: Zinc fingers and homeoboxes protein 1, isoform 2  
Size: 292 amino acids; 33285 Da
Alternative splicing: 3 isoforms:  Q96EF9-1   Q9UKY1-1   Q96K31-1   (Based on a readthrough transcript which may produce a ZHX1-C8orf76 fusion protein. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZHX1-C8ORF76: NX_Q96EF9

ZHX1-C8ORF76 Protein expression data from MOPED and PaxDb: --

REFSEQ proteins: NP_001191109.1  
ENSEMBL proteins: 
 ENSP00000349593  

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Protein Domains /
Families
for ZHX1-C8ORF76 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
ZHX1-C8ORF76 for domains           About GeneDecksing

1 InterPro domain/family:
 IPR011990 TPR-like_helical

Graphical View of Domain Structure for InterPro Entry Q96EF9

ProtoNet protein and cluster: Q96EF9


Function
for ZHX1-C8ORF76 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
miRNA
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Pathways & Interactions
for ZHX1-C8ORF76 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZHX1-C8ORF76

Drugs & Compounds
for ZHX1-C8ORF76 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for ZHX1-C8ORF76
Search CenterWatch for drugs/clinical trials and news about ZHX1-C8ORF76 / ZHX1R 

Transcripts
for ZHX1-C8ORF76 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
REFSEQ mRNAs for ZHX1-C8ORF76 gene: 
NM_001204180.1  

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000357082(uc003yqd.3)

miRNA
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Inhib. RNA
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GeneLoc Exon Structure


Expression
for ZHX1-C8ORF76 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZHX1-C8ORF76 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image
Genevestigator expression for ZHX1-C8ORF76
    SABiosciences Custom PCR Arrays for ZHX1-C8ORF76
Primer
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In Situ
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Orthologs
for ZHX1-C8ORF76 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of chordates.

Orthologs for ZHX1-C8ORF76 gene from 3/8 species (see all 8)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
chicken
(Gallus gallus)		 Aves C2H8ORF766
 Uncharacterized protein
 33(a)
 1 → many
 2(143590853-143598924)
lizard
(Anolis carolinensis)		 Reptilia --
 --
 40(a)
 1 → many
 GL343581.1(456171-464587)
zebrafish
(Danio rerio)		 Actinopterygii zgc:1017166
 zgc:101716
 26(a)
 1 → many
 16(47513390-47523057)
        Species with no ortholog for ZHX1-C8ORF76

ENSEMBL Gene Tree for ZHX1-C8ORF76 (if available)
TreeFam Gene Tree for ZHX1-C8ORF76 (if available) 

Paralogs
for ZHX1-C8ORF76 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for ZHX1-C8ORF76 gene
C8orf762  

ZHX1-C8ORF76 for paralogs           About GeneDecksing



Genomic Variants
for ZHX1-C8ORF76 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/62 NCBI SNPs in ZHX1-C8ORF76 are shown (see all 62)     About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance		Chr 8 posSequence#AA
Chg		TypeMore#Allele
freq		PopTotal
sample		More
----------
rs1902832111,2
--124255778(+) AACTCC/TGCCTC 1 -- int10--------
rs1824590301,2
--124255844(+) ATGGAC/TAAAAG 1 -- int10--------
rs1856908511,2
--124255849(+) TAAAAA/GGTAGT 1 -- int10--------
rs1441679371,2
--124256035(+) AGCCAA/CTCCAA 1 -- int10--------
rs1157501601,2
F,--124256071(+) GCATGG/TCCTCA 1 -- int11Minor allele frequency- T:0.02WA 118
rs1478594371,2
--124256077(+) CCTCAC/TTGTAC 1 -- int10--------
rs1414160121,2
--124256096(+) TCCACC/TTGAAA 1 -- int10--------
rs778490221,2
C--124256272(+) CGCTAC/GGGTAA 1 -- int10--------
rs767561081,2
C--124256273(+) GCTAGC/GGTAAT 1 -- int10--------
rs101075231,2
C,H--124256276(+) AGGGTA/CATGTC 1 -- int16Minor allele frequency- C:0.00NS EA NA 422

HapMap Linkage Disequilibrium report for ZHX1-C8ORF76 (124238431 - 124279627 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for ZHX1-C8ORF76: --

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Disorders / Diseases
for ZHX1-C8ORF76 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
   --

Publications
for ZHX1-C8ORF76 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for ZHX1-C8ORF76 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZHX1-C8ORF76)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (2010)
  2. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
  3. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

External Searches for ZHX1-C8ORF76 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing ZHX1-C8ORF76 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 100533106 HGNC: 42975 Ensembl:ENSG00000259305 euGenes: HUgn100533106 ECgene: ZHX1-C8ORF76
H-InvDB: ZHX1-C8ORF76

Other Databases showing ZHX1-C8ORF76 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing ZHX1-C8ORF76 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
   --

Intellectual Property
for ZHX1-C8ORF76 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for ZHX1-C8ORF76 gene:
Search GeneIP for patents involving ZHX1-C8ORF76

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
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 SwitchGear Promoter luciferase reporter plasmids for ZHX1-C8ORF76
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 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZHX1-C8ORF76
       
GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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VWF
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von Willebrand factor
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