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Aliases for ZHX1-C8orf76 Gene

Aliases for ZHX1-C8orf76 Gene

  • ZHX1-C8orf76 Readthrough 2 3 5
  • ZHX1-C8orf76 Readthrough Transcript Protein 4
  • C8orf76 4

External Ids for ZHX1-C8orf76 Gene

Previous GeneCards Identifiers for ZHX1-C8orf76 Gene

  • GC08M124239

Summaries for ZHX1-C8orf76 Gene

Entrez Gene Summary for ZHX1-C8orf76 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring zinc fingers and homeoboxes 1 (ZHX1) and chromosome 8 open reading frame 76 (C8orf76) genes. The read-through transcript encodes a protein that shares sequence identity with the downstream gene, but it has a distinct N-terminus encoded by exon structure from the upstream gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for ZHX1-C8orf76 Gene

ZHX1-C8orf76 (ZHX1-C8orf76 Readthrough) is a Protein Coding gene. An important paralog of this gene is C8orf76.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZHX1-C8orf76 Gene

Genomics for ZHX1-C8orf76 Gene

Regulatory Elements for ZHX1-C8orf76 Gene

Enhancers for ZHX1-C8orf76 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F123268 1.4 Ensembl ENCODE 0.8 +5.0 4995 1.0 BCOR PKNOX1 STAT1 ZMYM3 ATF2 HDAC2 STAT2 PBX2 KDM1A IRF1 ZHX1-C8orf76 RNU6-628P
GH08F123270 0.5 Ensembl 0.8 +3.9 3887 0.4 BCOR ZNF121 SP7 ZHX1-C8orf76 RNU6-628P
GH08F123271 0.6 ENCODE 0.8 +0.6 615 4.3 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 RNU6-875P MIR548AA1 DUTP2 FAM83A ZHX1-C8orf76 RNU6-628P
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZHX1-C8orf76 on UCSC Golden Path with GeneCards custom track

Promoters for ZHX1-C8orf76 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ZHX1-C8orf76 Gene

123,226,189 bp from pter
123,274,487 bp from pter
48,299 bases
Minus strand

Genomic View for ZHX1-C8orf76 Gene

Genes around ZHX1-C8orf76 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZHX1-C8orf76 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZHX1-C8orf76 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZHX1-C8orf76 Gene

Proteins for ZHX1-C8orf76 Gene

  • Protein details for ZHX1-C8orf76 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc fingers and homeoboxes protein 1, isoform 2
    Protein Accession:

    Protein attributes for ZHX1-C8orf76 Gene

    292 amino acids
    Molecular mass:
    33285 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZHX1-C8orf76 Gene


neXtProt entry for ZHX1-C8orf76 Gene

Post-translational modifications for ZHX1-C8orf76 Gene

No Post-translational modifications

Other Protein References for ZHX1-C8orf76 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZHX1-C8orf76 Gene

Domains & Families for ZHX1-C8orf76 Gene

Protein Domains for ZHX1-C8orf76 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZHX1-C8orf76: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ZHX1-C8orf76 Gene

Function for ZHX1-C8orf76 Gene

Animal Model Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZHX1-C8orf76 Gene

Localization for ZHX1-C8orf76 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ZHX1-C8orf76 Gene

Pathways & Interactions for ZHX1-C8orf76 Gene

SuperPathways for ZHX1-C8orf76 Gene

No Data Available

Interacting Proteins for ZHX1-C8orf76 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000349593 for ZHX1-C8orf76 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for ZHX1-C8orf76 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZHX1-C8orf76 Gene

Transcripts for ZHX1-C8orf76 Gene

mRNA/cDNA for ZHX1-C8orf76 Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ZHX1-C8orf76 Gene

No ASD Table

Relevant External Links for ZHX1-C8orf76 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZHX1-C8orf76 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZHX1-C8orf76 Gene

Orthologs for ZHX1-C8orf76 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZHX1-C8orf76 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia -- 35
  • 81 (a)
(Bos Taurus)
Mammalia -- 35
  • 63 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 50 (a)
(Mus musculus)
Mammalia 9130401M01Rik 35
  • 50 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 40 (a)
(Gallus gallus)
Aves -- 35
  • 33 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 40 (a)
(Danio rerio)
Actinopterygii C16H8orf76 35
  • 26 (a)
Species where no ortholog for ZHX1-C8orf76 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZHX1-C8orf76 Gene

Gene Tree for ZHX1-C8orf76 (if available)
Gene Tree for ZHX1-C8orf76 (if available)

Paralogs for ZHX1-C8orf76 Gene

Paralogs for ZHX1-C8orf76 Gene

(1) SIMAP similar genes for ZHX1-C8orf76 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZHX1-C8orf76: view

Variants for ZHX1-C8orf76 Gene

Sequence variations from dbSNP and Humsavar for ZHX1-C8orf76 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10107523 -- 123,244,036(+) AGGGT(A/C)ATGTC intron-variant
rs10282889 -- 123,275,305(+) ACGTG(A/G)AGGAA intron-variant, upstream-variant-2KB
rs1044714 -- 123,252,687(-) CTGTT(A/G)AAAGT intron-variant
rs10505432 -- 123,249,472(+) CACGA(C/T)TGTAA intron-variant, nc-transcript-variant, utr-variant-3-prime
rs111248288 -- 123,237,802(+) CCAAG(C/T)TTGCA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZHX1-C8orf76 Gene

Variant ID Type Subtype PubMed ID
nsv1032827 CNV gain 25217958
nsv1124373 CNV deletion 24896259
nsv831449 CNV loss 17160897
nsv981978 CNV duplication 23825009

Relevant External Links for ZHX1-C8orf76 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for ZHX1-C8orf76 Gene

Disorders for ZHX1-C8orf76 Gene

Relevant External Links for ZHX1-C8orf76

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZHX1-C8orf76 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZHX1-C8orf76 Gene

Publications for ZHX1-C8orf76 Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3 64
  2. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 4 64
  3. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for ZHX1-C8orf76 Gene

Sources for ZHX1-C8orf76 Gene

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