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Aliases for ZHX1 Gene

Aliases for ZHX1 Gene

  • Zinc Fingers And Homeoboxes 1 2 3
  • Zinc-Fingers And Homeoboxes 1 2

External Ids for ZHX1 Gene

Previous GeneCards Identifiers for ZHX1 Gene

  • GC08M123375
  • GC08M124291
  • GC08M123902
  • GC08M124189
  • GC08M124217
  • GC08M124329
  • GC08M124260
  • GC08M119587

Summaries for ZHX1 Gene

Entrez Gene Summary for ZHX1 Gene

  • The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 1 of this gene family. In addition to forming homodimers, this protein heterodimerizes with members 2 and 3 of the zinc fingers and homeoboxes family. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 8 open reading frame 76 (C8orf76) gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for ZHX1 Gene

ZHX1 (Zinc Fingers And Homeoboxes 1) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is HOMEZ.

UniProtKB/Swiss-Prot for ZHX1 Gene

  • Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins.

Gene Wiki entry for ZHX1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZHX1 Gene

Genomics for ZHX1 Gene

Regulatory Elements for ZHX1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZHX1 Gene

123,248,450 bp from pter
123,275,541 bp from pter
27,092 bases
Minus strand

Genomic View for ZHX1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZHX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZHX1 Gene

Proteins for ZHX1 Gene

  • Protein details for ZHX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc fingers and homeoboxes protein 1
    Protein Accession:
    Secondary Accessions:
    • Q8IWD8

    Protein attributes for ZHX1 Gene

    873 amino acids
    Molecular mass:
    98098 Da
    Quaternary structure:
    • Forms homodimers. Heterodimer (via HD1 domain) with ZHX2 (via HD1 domain). Also forms a heterodimer with ZHX3 which is a prerequisite for repressor activity. Interacts with ATF7IP and NFYA. Interacts (via homeobox domains) with DNMT3B (via PWWP domain).

    Three dimensional structures from OCA and Proteopedia for ZHX1 Gene

    Alternative splice isoforms for ZHX1 Gene


neXtProt entry for ZHX1 Gene

Proteomics data for ZHX1 Gene at MOPED

Post-translational modifications for ZHX1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZHX1 Gene

No data available for DME Specific Peptides for ZHX1 Gene

Domains for ZHX1 Gene

Gene Families for ZHX1 Gene

  • ZNF :Zinc fingers, C2H2-type
  • ZFHX :Homeoboxes / ZF class

Protein Domains for ZHX1 Gene

Suggested Antigen Peptide Sequences for ZHX1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9UKY1
  • Contains 5 homeobox DNA-binding domains.
  • Belongs to the ZHX family.
  • Contains 2 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZHX1: view

Function for ZHX1 Gene

Molecular function for ZHX1 Gene

GENATLAS Biochemistry: zing-fingers and homeo boxes 1,with two alternatived spliced isoforms,ubiquitously expressed,interacting with the nuclear transcription factor NF-Y
UniProtKB/Swiss-Prot Function: Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins.

Gene Ontology (GO) - Molecular Function for ZHX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IDA 12237128
GO:0003714 transcription corepressor activity IDA 17303076
GO:0005515 protein binding IPI 10571058
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZHX1: view

Phenotypes for ZHX1 Gene

genes like me logo Genes that share phenotypes with ZHX1: view

Animal Model Products

CRISPR Products

miRNA for ZHX1 Gene

miRTarBase miRNAs that target ZHX1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZHX1 Gene

Localization for ZHX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZHX1 Gene

Nucleus. Note=Colocalized in the nucleus with DNMT3B.

Subcellular locations from

Jensen Localization Image for ZHX1 Gene COMPARTMENTS Subcellular localization image for ZHX1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZHX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12237128
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZHX1: view

Pathways for ZHX1 Gene

SuperPathways for ZHX1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZHX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 17303076
GO:0006351 transcription, DNA-templated IEA --
GO:0030154 cell differentiation IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 12237128
genes like me logo Genes that share ontologies with ZHX1: view

No data available for Pathways by source for ZHX1 Gene

Compounds for ZHX1 Gene

(1) HMDB Compounds for ZHX1 Gene

Compound Synonyms Cas Number PubMed IDs
  • Zinc
genes like me logo Genes that share compounds with ZHX1: view

Transcripts for ZHX1 Gene

Unigene Clusters for ZHX1 Gene

Zinc fingers and homeoboxes 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZHX1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZHX1 Gene

No ASD Table

Relevant External Links for ZHX1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZHX1 Gene

mRNA expression in normal human tissues for ZHX1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZHX1 Gene

SOURCE GeneReport for Unigene cluster for ZHX1 Gene Hs.521800

mRNA Expression by UniProt/SwissProt for ZHX1 Gene

Tissue specificity: Ubiquitously expressed. Expressed in podocytes.
genes like me logo Genes that share expressions with ZHX1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZHX1 Gene

Orthologs for ZHX1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZHX1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZHX1 35
  • 99.85 (n)
  • 99.77 (a)
ZHX1 36
  • 100 (a)
(Bos Taurus)
Mammalia ZHX1 35
  • 91.83 (n)
  • 94.27 (a)
ZHX1 36
  • 94 (a)
(Canis familiaris)
Mammalia ZHX1 35
  • 93.55 (n)
  • 96.22 (a)
ZHX1 36
  • 96 (a)
(Mus musculus)
Mammalia Zhx1 35
  • 89.5 (n)
  • 91.29 (a)
Zhx1 16
Zhx1 36
  • 91 (a)
(Monodelphis domestica)
Mammalia ZHX1 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia ZHX1 36
  • 51 (a)
(Rattus norvegicus)
Mammalia Zhx1 35
  • 89.73 (n)
  • 92.44 (a)
(Gallus gallus)
Aves ZHX1 35
  • 77.61 (n)
  • 81.22 (a)
ZHX1 36
  • 82 (a)
(Anolis carolinensis)
Reptilia ZHX1 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zhx1 35
  • 67.28 (n)
  • 67.94 (a)
Species with no ortholog for ZHX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZHX1 Gene

Gene Tree for ZHX1 (if available)
Gene Tree for ZHX1 (if available)

Paralogs for ZHX1 Gene

Paralogs for ZHX1 Gene

Selected SIMAP similar genes for ZHX1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZHX1: view

Variants for ZHX1 Gene

Sequence variations from dbSNP and Humsavar for ZHX1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs4445209 -- 123,276,778(+) ATAAA(A/G)ATGTG upstream-variant-2KB
rs7003464 -- 123,276,952(+) TTCAC(G/T)GCCCA upstream-variant-2KB
rs35532257 -- 123,277,333(+) CTAGA(-/T)TTTTT upstream-variant-2KB
rs57891828 -- 123,276,563(+) TGGTC(A/G)GGCTG upstream-variant-2KB
rs112557448 -- 123,277,387(+) CAAAA(C/T)TTCAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZHX1 Gene

Variant ID Type Subtype PubMed ID
nsv831449 CNV Loss 17160897

Relevant External Links for ZHX1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZHX1 Gene

Disorders for ZHX1 Gene

No disorders were found for ZHX1 Gene.

No data available for UniProtKB/Swiss-Prot for ZHX1 Gene

Publications for ZHX1 Gene

  1. Human ZHX1: cloning, chromosomal location, and interaction with transcription factor NF-Y. (PMID: 10441475) Yamada K. … Granner D.K. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 23
  2. BS69, a corepressor interacting with ZHX1, is a bifunctional transcription factor. (PMID: 17127430) Ogata-Kawata H. … Miyamoto K. (Front. Biosci. 2007) 3 23
  3. Identification of proteins that interact with NF-YA. (PMID: 10571058) Yamada K. … Granner D.K. (FEBS Lett. 1999) 3 4
  4. Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3. (PMID: 12659632) Yamada K. … Miyamoto K. (Biochem. J. 2003) 3 4
  5. Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor. (PMID: 12741956) Kawata H. … Miyamoto K. (Biochem. J. 2003) 3 4

Products for ZHX1 Gene

Sources for ZHX1 Gene

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