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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZHX1 Gene

protein-coding   GIFtS: 51
GCID: GC08M124260

zinc fingers and homeoboxes 1

(Previous name: zinc-fingers and homeoboxes 1 )
 Explore 3 diseases affiliated with
ZHX1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ZHX1    

Aliases
for ZHX1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Fingers And Homeoboxes 11 2
Zinc-Fingers And Homeoboxes 11
Zinc Finger And Homeodomain Protein 12
Zinc Fingers And Homeobox 12
Zinc Fingers And Homeoboxes Protein 12

External Ids:    HGNC: 128711   Entrez Gene: 112442   Ensembl: ENSG000001651567   OMIM: 6047645   UniProtKB: Q9UKY13   
ORGUL members:         
NONCODE:n410633 n410632    

Export aliases for ZHX1 gene to outside databases

Previous GC identifers: GC08M123375 GC08M124291 GC08M123902 GC08M124189 GC08M124217 GC08M124329 GC08M119587


Summaries
for ZHX1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ZHX1:
The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that
interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox
DNA-binding domains. This gene encodes member 1 of this gene family. In addition to forming homodimers, this protein
heterodimerizes with members 2 and 3 of the zinc fingers and homeoboxes family. Alternative splicing results in
multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 8
open reading frame 76 (C8orf76) gene. (provided by RefSeq, Feb 2011)

UniProtKB/Swiss-Prot: ZHX1_HUMAN, Q9UKY1
Function: Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when
DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins

Gene Wiki entry for ZHX1


Genomic Views
for ZHX1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZHX1 gene promoter:
         STAT1   STAT4   STAT1beta   STAT5A   IRF-1   STAT1alpha   AREB6   IRF-2   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZHX1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZHX1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZHX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.13   Ensembl cytogenetic band:  8q24.13   HGNC cytogenetic band: 8q24.13

ZHX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZHX1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M124260:  view genomic region     (about GC identifiers)

Start:
 124,260,696 bp from pter      End:
 124,287,781 bp from pter
Size:
 27,086 bases      Orientation:
 minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for ZHX1

Proteins
for ZHX1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ZHX1_HUMAN, Q9UKY1 (See protein sequence)
Recommended Name: Zinc fingers and homeoboxes protein 1  
Size: 873 amino acids; 98098 Da
Subunit: Forms homodimers. Heterodimer (via HD1 domain) with ZHX2 (via HD1 domain). Also forms a heterodimer with ZHX3
which is a prerequisite for repressor activity. Interacts with ATF7IP and NFYA. Interacts (via homeobox domains) with
DNMT3B (via PWWP domain)
Subcellular location: Nucleus. Note=Colocalized in the nucleus with DNMT3B
4 PDB 3D structures from and Proteopedia for ZHX1:
2ECB (3D)        2GHF (3D)        2LY9 (3D)        3NAR (3D)    
Secondary accessions: Q8IWD8
Alternative splicing: 2 isoforms:  Q9UKY1-1   Q96EF9-1   (Based on a readthrough transcript which may produce a ZHX1-C8orf76 fusion protein. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZHX1: NX_Q9UKY1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UKY1

    • ZHX1 Protein expression data from MOPED and PaxDb:    About this image 
    ZHX1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001017926.1  NP_009153.3  

    ENSEMBL proteins: 
     ENSP00000378938   ENSP00000428676   ENSP00000428761   ENSP00000428821   ENSP00000297857  

    Human Recombinant Protein Products for ZHX1: 
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    OriGene Protein Over-expression Lysate (see all 2): ZHX1
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    Novus Biologicals ZHX1 Proteins
    Novus Biologicals ZHX1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ZHX1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17056598

    ZHX1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ZHX1

    Protein Domains /
    Families
    for ZHX1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ZHX1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9UKY1

    ProtoNet protein and cluster: Q9UKY1

    UniProtKB/Swiss-Prot: ZHX1_HUMAN, Q9UKY1
    Similarity: Belongs to the ZHX family
    Similarity: Contains 2 C2H2-type zinc fingers
    Similarity: Contains 5 homeobox DNA-binding domains


    Function
    for ZHX1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZHX1_HUMAN, Q9UKY1
    Function: Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when
    DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins

         Genatlas biochemistry entry for ZHX1:
    zing-fingers and homeo boxes 1,with two alternatived spliced isoforms,ubiquitously expressed,interacting with the
    nuclear transcription factor NF-Y

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IDA12237128
    GO:0003714transcription corepressor activity IDA17303076
    GO:0005515protein binding IPI17303076
    GO:0008270zinc ion binding IEA--
         
    ZHX1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZHX1:
     Decreased number of cells in m 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ZHX1 

    miRNA
    Products:            		miRTarBase miRNAs that target ZHX1:
    hsa-mir-373 (MIRT002558)

    OriGene 3'-UTR Clone (see all 2): ZHX1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZHX1
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate ZHX1 (see all 21):
    hsa-miR-140-5p hsa-miR-3607-3p hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-1271 hsa-miR-128 hsa-miR-144
    SwitchGear 3'UTR luciferase reporter plasmid: ZHX1 3' UTR sequence
    Inhib. RNA
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    OriGene siRNA: ZHX1
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    Sirion Biotech Custom design and validation of potent shRNA sequences against ZHX1 

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of ZHX1 
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): ZHX1 (NM_001017926)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZHX1
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    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZHX1


    Pathways & Interactions
    for ZHX1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZHX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/73 Interacting proteins for ZHX1 (Q9UKY11, 2, 3 ENSP000002978574) via UniProtKB, MINT, STRING, and/or I2D (see all 73)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TALDO1P378372, 3, ENSP000003212594MINT-3980591 I2D: score=3 STRING: ENSP00000321259
    AKR1C3P423302, 3MINT-63743 I2D: score=5 
    BHLHE40O145032, 3MINT-63053 I2D: score=5 
    LYARQ9NX582, 3MINT-65658 I2D: score=5 
    MPHOSPH6Q995472, 3MINT-65279 I2D: score=5 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA17303076
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0030154cell differentiation IEA--
    GO:0045892negative regulation of transcription, DNA-dependent IDA12237128

    ZHX1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ZHX1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZHX1

    1 HMDB Compound for ZHX1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ZincZinc (see all 2)7440-66-6--
    Search CenterWatch for drugs/clinical trials and news about ZHX1 

    Transcripts
    for ZHX1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ZHX1 gene (2 alternative transcripts): 
    NM_001017926.2  NM_007222.4  

    Unigene Cluster for ZHX1:

    Zinc fingers and homeoboxes 1
    Hs.521800  [show with all ESTs]
    Unigene Representative Sequence: NM_001017926
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395571(uc003yqe.3) ENST00000520474 ENST00000517516 ENST00000522655
    ENST00000522595 ENST00000524267 ENST00000480132 ENST00000297857(uc003yqf.3 uc003yqg.3 uc010mdi.3)


    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): ZHX1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZHX1
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate ZHX1 (see all 21):
    hsa-miR-140-5p hsa-miR-3607-3p hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-1271 hsa-miR-128 hsa-miR-144
    SwitchGear 3'UTR luciferase reporter plasmid: ZHX1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZHX1 (see all 7)
    OriGene shRNA RFP: ZHX1
    OriGene siRNA: ZHX1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZHX1
    Sirion Biotech Custom design and validation of potent shRNA sequences against ZHX1 
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZHX1 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): ZHX1 (NM_001017926)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZHX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZHX1 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZHX1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZHX1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZHX1

    Additional cDNA sequence: 

    AF106862.1 AF195766.1 AK025236.1 AK094451.1 AK289532.1 BC040481.1 NR_037873.1 NR_037874.1 

    14 DOTS entries:

    DT.99946482  DT.214601  DT.97801774  DT.121491192  DT.95173427  DT.97802743  DT.121491259  DT.99947673 
    DT.100816230  DT.40248134  DT.121491219  DT.121491230  DT.121491253  DT.95173428 

    24/293 AceView cDNA sequences (see all 293):

    CB156214 AA680145 AI082599 CB160468 BM715992 BF435323 BQ230291 AI818072 
    BI912925 AA918304 BM990290 BP361476 BM461738 BQ007142 CD675937 AI005384 
    AW274674 BC067796 CB160472 AA626793 CR594463 AW249926 BF111907 BU680133 

    GeneLoc Exon Structure


    Expression
    for ZHX1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZHX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGCTTTCAT
    ZHX1 Expression
    About this image
    See ZHX1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZHX1

    SOURCE GeneReport for Unigene cluster: Hs.521800

    UniProtKB/Swiss-Prot: ZHX1_HUMAN, Q9UKY1
    Tissue specificity: Ubiquitously expressed. Expressed in podocytes

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    In Situ
    Assay Products:     
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    Orthologs
    for ZHX1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ZHX1 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Zhx11 , 5 zinc fingers and homeoboxes 11, 5 89.5(n)1
    91.29(a)1    		   15 (24.25 cM)5
    227701  NM_001042438.11  NP_001035903.11 
     580470175 
    chicken
    (Gallus gallus)    		 Aves ZHX11 zinc fingers and homeoboxes 1 78.38(n)
    82.26(a)    		   420347  XM_418454.3  XP_418454.2 
    lizard
    (Anolis carolinensis)    		 Reptilia ZHX16
    		 --
    		 73(a)
    		 1 ↔ 1
    		 4(6847434-6850022)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia AL897286.22   -- 76.69(n)    AL897286.2 
    rainbow trout
    (Oncorhynchus mykiss)    		 Actinopterygii BX302457.12   -- 75.24(n)    BX302457.1 


    ENSEMBL Gene Tree for ZHX1 (if available)
    TreeFam Gene Tree for ZHX1 (if available) 

    Paralogs
    for ZHX1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZHX1 gene
    ENSG000002601752  ZHX22  ZHX32  HOMEZ2  
    2 SIMAP similar genes for ZHX1 using alignment to 3 protein entries:     ZHX1_HUMAN (see all proteins):
    ZHX2    ZHX3

    ZHX1 for paralogs           About GeneDecksing



    Genomic Variants
    for ZHX1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/386 NCBI SNPs in ZHX1 are shown (see all 386)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1180013711,2
    		--124260218(+) ATACAT/CGGATA 5 -- int1 ds50011Minor allele frequency- C:0.01NA 120
    rs1427827541,2
    		C--124260264(+) GACAA-/ACACACA 5 -- int1 ds50010--------
    rs784894681,2
    		C,F--124260294(+) CATAAA/TTCAGC 5 -- int1 ds50014Minor allele frequency- T:0.26WA CSA 123
    rs1473513551,2
    		--124260355(+) AAACAC/TTATAA 5 -- ds5001 int10--------
    rs1398096111,2
    		--124260357(+) ACATTA/GTAAGT 5 -- int1 ds50010--------
    rs1924349431,2
    		--124260387(+) AAGGGA/CAAATA 5 -- ds5001 int10--------
    rs1856805811,2
    		--124260390(+) GGCAAA/TTATTT 5 -- ds5001 int10--------
    rs1894900031,2
    		--124260714(+) ACTACC/TTTTAT 5 -- nc-transcript-variantut31 int10--------
    rs58946561,2
    		C--124260839(+) GGGAA-/ATTT  
                ATTAA     		5 -- int1 ut31 nc-transcript-variant0--------
    rs30784321,2
    		F--124260842(+) AAATT-/TATT  
                AATAG     		5 -- int1 nc-transcript-variantut315Minor allele frequency- TATT:0.05EU EA NA MN 430

    HapMap Linkage Disequilibrium report for ZHX1 (124260696 - 124287781 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ZHX1: --

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    Disorders / Diseases
    for ZHX1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ZHX1 for disorders           About GeneDecksing

    OMIM gene information: 604764    OMIM disorders: --

    3 diseases for ZHX1:    About MalaCards
    nephrotic syndrome    huntington's disease    ataxia


    Export disorders for ZHX1 gene to outside databases

    Publications
    for ZHX1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZHX1 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with ZHX1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human ZHX1: cloning, chromosomal location, and interaction with transcription factor NF-Y. (PubMed id 10441475)1, 2, 3, 9 Yamada K.... Granner D.K. (1999)
    2. Novel structural features in two ZHX homeodomains der ived from a systematic study of single and multiple domains. (PubMed id 20509910)1, 2 Bird L.E....Stammers D.K. (2010)
    3. The tandem zinc-finger region of human ZHX adopts a n ovel C2H2 zinc finger structure with a C-terminal extension. (PubMed id 19348505)1, 2 Wienk H....Folkers G.E. (2009)
    4. Zinc-fingers and homeoboxes 1 (ZHX1) binds DNA methyltransferase (DNMT) 3B to enhance DNMT3B-mediated transcriptional repression. (PubMed id 17303076)1, 2 Kim S.H....Kim T.Y. (2007)
    5. ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome. (PubMed id 17056598)1, 2 Liu G....Chugh S.S. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3. (PubMed id 12659632)1, 2 Yamada K.... Miyamoto K. (2003)
    8. Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor. (PubMed id 12741956)1, 2 Kawata H.... Miyamoto K. (2003)
    9. Functional analysis and the molecular dissection of zinc-fingers and homeoboxes 1 (ZHX1). (PubMed id 12237128)1, 2 Yamada K.... Miyamoto K. (2002)
    10. Identification of proteins that interact with NF-YA. (PubMed id 10571058)1, 2 Yamada K.... Granner D.K. (1999)

    External Searches for ZHX1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    		PubMed
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    Genome Databases showing ZHX1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11244 HGNC: 12871 AceView: ZHX1andFLJ14825 Ensembl:ENSG00000165156 euGenes: HUgn11244
    ECgene: ZHX1 H-InvDB: ZHX1

    Other Databases showing ZHX1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ZHX1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZHX1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ZHX1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ZHX1 gene:
    Search GeneIP for patents involving ZHX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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