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Aliases for ZGRF1 Gene

Aliases for ZGRF1 Gene

  • Zinc Finger, GRF-Type Containing 1 2 3
  • GRF-Type Zinc Finger Domain-Containing Protein 1 3 4
  • C4orf21 3 4
  • Chromosome 4 Open Reading Frame 21 2
  • Protein ZGRF1 3

External Ids for ZGRF1 Gene

Previous HGNC Symbols for ZGRF1 Gene

  • C4orf21

Previous GeneCards Identifiers for ZGRF1 Gene

  • GC04M113461

Summaries for ZGRF1 Gene

GeneCards Summary for ZGRF1 Gene

ZGRF1 (Zinc Finger, GRF-Type Containing 1) is a Protein Coding gene. An important paralog of this gene is UPF1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZGRF1 Gene

Genomics for ZGRF1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZGRF1 Gene

112,539,333 bp from pter
112,636,995 bp from pter
97,663 bases
Minus strand

Genomic View for ZGRF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZGRF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZGRF1 Gene

No data available for Regulatory Elements for ZGRF1 Gene

Proteins for ZGRF1 Gene

  • Protein details for ZGRF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein ZGRF1
    Protein Accession:
    Secondary Accessions:
    • B3KQX2
    • B4DSN6
    • B4DYU8
    • E9PDE1
    • G5EA02
    • Q6ZU11
    • Q9NSW3
    • Q9NUJ4

    Protein attributes for ZGRF1 Gene

    2104 amino acids
    Molecular mass:
    236602 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC86416.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZGRF1 Gene

neXtProt entry for ZGRF1 Gene

Proteomics data for ZGRF1 Gene at MOPED

Post-translational modifications for ZGRF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZGRF1 Gene

Domains for ZGRF1 Gene

Protein Domains for ZGRF1 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZGRF1: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ZGRF1 Gene

Function for ZGRF1 Gene

Gene Ontology (GO) - Molecular Function for ZGRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ZGRF1: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZGRF1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZGRF1 Gene

Localization for ZGRF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZGRF1 Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for ZGRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZGRF1: view

No data available for Subcellular locations from COMPARTMENTS for ZGRF1 Gene

Pathways for ZGRF1 Gene

SuperPathways for ZGRF1 Gene

No Data Available

Interacting Proteins for ZGRF1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000424737 for ZGRF1 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for ZGRF1 Gene


No data available for Pathways by source for ZGRF1 Gene

Transcripts for ZGRF1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZGRF1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZGRF1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13
SP1: - - -
SP2: - -
SP3: -
SP4: - -

Relevant External Links for ZGRF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZGRF1 Gene

mRNA expression in normal human tissues for ZGRF1 Gene

Protein differential expression in normal tissues for ZGRF1 Gene

This gene is overexpressed in Plasma (45.4), Pancreatic juice (13.4), and Skin (8.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZGRF1 Gene

genes like me logo Genes that share expressions with ZGRF1: view

Expression partners for ZGRF1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZGRF1 Gene

Orthologs for ZGRF1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZGRF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZGRF1 35
  • 85.38 (n)
  • 77.38 (a)
C4orf21 36
  • 87 (a)
(Mus musculus)
Mammalia 4930422G04Rik 35
  • 77.21 (n)
  • 67.28 (a)
4930422G04Rik 16
4930422G04Rik 36
  • 67 (a)
(Pan troglodytes)
Mammalia LOC461442 35
  • 99.37 (n)
  • 99 (a)
(Rattus norvegicus)
Mammalia RGD1305834 35
  • 76.85 (n)
  • 66.58 (a)
(Canis familiaris)
Mammalia C4orf21 36
  • 86 (a)
(Monodelphis domestica)
Mammalia C4orf21 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
-- 36
  • 60 (a)
(Gallus gallus)
Aves C4H4ORF21 35
  • 64.41 (n)
  • 56.85 (a)
C4orf21 36
  • 68 (a)
(Anolis carolinensis)
Reptilia C4orf21 36
  • 65 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6701 36
  • 13 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAM7 36
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
Species with no ortholog for ZGRF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZGRF1 Gene

Gene Tree for ZGRF1 (if available)
Gene Tree for ZGRF1 (if available)

Paralogs for ZGRF1 Gene

Paralogs for ZGRF1 Gene

genes like me logo Genes that share paralogs with ZGRF1: view

Variants for ZGRF1 Gene

Sequence variations from dbSNP and Humsavar for ZGRF1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1471879 -- 112,625,267(-) CTGTC(A/G)CCCAG intron-variant
rs1471880 -- 112,624,951(-) TATAC(A/C)TTTGG intron-variant
rs1486863 -- 112,569,870(-) CTAGT(A/G)TTAGT intron-variant
rs1486864 -- 112,544,610(-) TTCTC(A/C/T)GTACC intron-variant
rs1486865 -- 112,544,495(-) AACTG(C/T)CAAGT intron-variant

Relevant External Links for ZGRF1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZGRF1 Gene

Disorders for ZGRF1 Gene

No disorders were found for ZGRF1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ZGRF1 Gene

Publications for ZGRF1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 3 4
  4. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G. … Riley B.P. (Hum. Mol. Genet. 2010) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for ZGRF1 Gene

Sources for ZGRF1 Gene

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