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Aliases for ZGRF1 Gene

Aliases for ZGRF1 Gene

  • Zinc Finger GRF-Type Containing 1 2 3
  • GRF-Type Zinc Finger Domain-Containing Protein 1 3 4
  • Zinc Finger, GRF-Type Containing 1 3 5
  • C4orf21 3 4
  • Chromosome 4 Open Reading Frame 21 2

External Ids for ZGRF1 Gene

Previous HGNC Symbols for ZGRF1 Gene

  • C4orf21

Previous GeneCards Identifiers for ZGRF1 Gene

  • GC04M113461

Summaries for ZGRF1 Gene

GeneCards Summary for ZGRF1 Gene

ZGRF1 (Zinc Finger GRF-Type Containing 1) is a Protein Coding gene. An important paralog of this gene is UPF1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZGRF1 Gene

Genomics for ZGRF1 Gene

Regulatory Elements for ZGRF1 Gene

Enhancers for ZGRF1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZGRF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZGRF1 Gene

Chromosome:
4
Start:
112,539,333 bp from pter
End:
112,636,995 bp from pter
Size:
97,663 bases
Orientation:
Minus strand

Genomic View for ZGRF1 Gene

Genes around ZGRF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZGRF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZGRF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZGRF1 Gene

Proteins for ZGRF1 Gene

  • Protein details for ZGRF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YA3-ZGRF1_HUMAN
    Recommended name:
    Protein ZGRF1
    Protein Accession:
    Q86YA3
    Secondary Accessions:
    • B3KQX2
    • B4DSN6
    • B4DYU8
    • E9PDE1
    • G5EA02
    • Q6ZU11
    • Q9NSW3
    • Q9NUJ4

    Protein attributes for ZGRF1 Gene

    Size:
    2104 amino acids
    Molecular mass:
    236602 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC86416.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZGRF1 Gene

neXtProt entry for ZGRF1 Gene

Proteomics data for ZGRF1 Gene at MOPED

Post-translational modifications for ZGRF1 Gene

  • Ubiquitination at Lys 183
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZGRF1 Gene

Domains & Families for ZGRF1 Gene

Gene Families for ZGRF1 Gene

Protein Domains for ZGRF1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZGRF1: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ZGRF1 Gene

Function for ZGRF1 Gene

genes like me logo Genes that share phenotypes with ZGRF1: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZGRF1 Gene

Localization for ZGRF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZGRF1 Gene

Membrane; Single-pass membrane protein.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ZGRF1 Gene

Pathways & Interactions for ZGRF1 Gene

SuperPathways for ZGRF1 Gene

No Data Available

Interacting Proteins for ZGRF1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000424737%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000424737 for ZGRF1 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for ZGRF1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZGRF1 Gene

Drugs & Compounds for ZGRF1 Gene

No Compound Related Data Available

Transcripts for ZGRF1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ZGRF1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13
SP1: - - -
SP2: - -
SP3: -
SP4: - -
SP5:

Relevant External Links for ZGRF1 Gene

GeneLoc Exon Structure for
ZGRF1
ECgene alternative splicing isoforms for
ZGRF1

Expression for ZGRF1 Gene

mRNA expression in normal human tissues for ZGRF1 Gene

Protein differential expression in normal tissues from HIPED for ZGRF1 Gene

This gene is overexpressed in Plasma (45.4), Pancreatic juice (13.4), and Skin (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZGRF1 Gene



genes like me logo Genes that share expression patterns with ZGRF1: view

Protein tissue co-expression partners for ZGRF1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZGRF1 Gene

Orthologs for ZGRF1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZGRF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZGRF1 35
  • 85.38 (n)
  • 77.38 (a)
C4orf21 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4930422G04Rik 35
  • 77.21 (n)
  • 67.28 (a)
Zgrf1 16
4930422G04Rik 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC461442 35
  • 99.37 (n)
  • 99 (a)
rat
(Rattus norvegicus)
Mammalia RGD1305834 35
  • 76.85 (n)
  • 66.58 (a)
dog
(Canis familiaris)
Mammalia C4orf21 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C4orf21 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
chicken
(Gallus gallus)
Aves C4H4ORF21 35
  • 64.41 (n)
  • 56.85 (a)
C4orf21 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C4orf21 36
  • 65 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6701 36
  • 13 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAM7 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToOne
Species with no ortholog for ZGRF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZGRF1 Gene

ENSEMBL:
Gene Tree for ZGRF1 (if available)
TreeFam:
Gene Tree for ZGRF1 (if available)

Paralogs for ZGRF1 Gene

Paralogs for ZGRF1 Gene

genes like me logo Genes that share paralogs with ZGRF1: view

Variants for ZGRF1 Gene

Sequence variations from dbSNP and Humsavar for ZGRF1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs7696816 - 112,618,813(+) TTTCA(C/T)TGAAT nc-transcript-variant, reference, missense
rs17854334 - 112,618,690(+) CTGAT(C/T)CTTTA nc-transcript-variant, reference, missense
rs17669218 - 112,603,567(+) CTGGT(A/G)TCTCT intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense
rs3828539 - 112,584,047(-) TGATA(C/T)TAAGA nc-transcript-variant, reference, missense
rs17605622 - 112,560,990(+) TTGGC(A/G)AAGAC nc-transcript-variant, downstream-variant-500B, reference, missense

Variation tolerance for ZGRF1 Gene

Residual Variation Intolerance Score: 74.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.57; 82.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZGRF1 Gene

HapMap Linkage Disequilibrium report
ZGRF1
Human Gene Mutation Database (HGMD)
ZGRF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZGRF1 Gene

Disorders for ZGRF1 Gene

Relevant External Links for ZGRF1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZGRF1

No disorders were found for ZGRF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZGRF1 Gene

Publications for ZGRF1 Gene

  1. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. A genome-wide association study on thyroid function and anti-thyroid peroxidase antibodies in Koreans. (PMID: 24722205) Kwak S.H. … Cho N.H. (Hum. Mol. Genet. 2014) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for ZGRF1 Gene

Sources for ZGRF1 Gene

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