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Aliases for ZGPAT Gene

Aliases for ZGPAT Gene

  • Zinc Finger, CCCH-Type With G Patch Domain 2 3
  • KIAA1847 2 3 4
  • Zinc Finger And G Patch Domain-Containing Protein 3 4
  • Zinc Finger CCCH Domain-Containing Protein 9 3 4
  • G Patch Domain-Containing Protein 6 3 4
  • GPATCH6 3 4
  • ZC3HDC9 3 4
  • GPATC6 3 4
  • ZC3H9 3 4
  • ZIP 3 4
  • Zinc Finger CCCH-Type With G Patch Domain-Containing Protein 3

External Ids for ZGPAT Gene

Previous Symbols for ZGPAT Gene

  • KIAA1847

Summaries for ZGPAT Gene

GeneCards Summary for ZGPAT Gene

ZGPAT (Zinc Finger, CCCH-Type With G Patch Domain) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is ENSG00000273154.

UniProtKB/Swiss-Prot for ZGPAT Gene

  • Transcription repressor that specifically binds the 5-GGAG[GA]A[GA]A-3 consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis.

  • Isoform 4: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA.

Gene Wiki entry for ZGPAT Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZGPAT Gene

Genomics for ZGPAT Gene

Genomic Location for ZGPAT Gene

Start:
63,707,442 bp from pter
End:
63,736,142 bp from pter
Size:
28,701 bases
Orientation:
Plus strand

Genomic View for ZGPAT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZGPAT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZGPAT Gene

Regulatory Elements for ZGPAT Gene

Proteins for ZGPAT Gene

  • Protein details for ZGPAT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5A5-ZGPAT_HUMAN
    Recommended name:
    Zinc finger CCCH-type with G patch domain-containing protein
    Protein Accession:
    Q8N5A5
    Secondary Accessions:
    • E1P5K1
    • Q4VXN9
    • Q5JWI9
    • Q5JWJ0
    • Q8NC55
    • Q8WUV4
    • Q96JI0
    • Q96JU4
    • Q9H401

    Protein attributes for ZGPAT Gene

    Size:
    531 amino acids
    Molecular mass:
    57359 Da
    Quaternary structure:
    • Interacts with CHD4/Mi-2; the interaction is direct.
    SequenceCaution:
    • Sequence=BAB47476.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC11317.1; Type=Frameshift; Positions=290; Evidence={ECO:0000305}; Sequence=CAI95713.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZGPAT Gene

    Alternative splice isoforms for ZGPAT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZGPAT Gene

Proteomics data for ZGPAT Gene at MOPED

Post-translational modifications for ZGPAT Gene

  • Ubiquitinated in case of infection by HIV-1, leading to its degradation. Ubiquitination is mediated by the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex that is hijacked by HIV-1 via interaction between HIV-1 Vpr and DCAF1/VPRBP.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZGPAT Gene

Domains for ZGPAT Gene

Gene Families for ZGPAT Gene

HGNC:
  • GPATCH :G patch domain containing
  • ZC3H :Zinc fingers, CCCH-type domain containing

Protein Domains for ZGPAT Gene

UniProtKB/Swiss-Prot:

ZGPAT_HUMAN
Domain:
  • Contains 1 G-patch domain.:
    • Q8N5A5
Similarity:
  • Contains 1 C3H1-type zinc finger.:
    • Q8N5A5
genes like me logo Genes that share domains with ZGPAT: view

Function for ZGPAT Gene

Molecular function for ZGPAT Gene

UniProtKB/Swiss-Prot Function: Transcription repressor that specifically binds the 5-GGAG[GA]A[GA]A-3 consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis.
UniProtKB/Swiss-Prot Function: Isoform 4: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA.
UniProtKB/Swiss-Prot Induction: Down-regulated in breast carcinomas

Gene Ontology (GO) - Molecular Function for ZGPAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 19644445
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA 19644445
GO:0003676 nucleic acid binding --
GO:0003700 sequence-specific DNA binding transcription factor activity IDA 19644445
GO:0005515 protein binding IPI 19644445
genes like me logo Genes that share ontologies with ZGPAT: view

Phenotypes for ZGPAT Gene

GenomeRNAi human phenotypes for ZGPAT:
genes like me logo Genes that share phenotypes with ZGPAT: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZGPAT Gene

Localization for ZGPAT Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZGPAT Gene

Nucleus.
Isoform 4: Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZGPAT Gene COMPARTMENTS Subcellular localization image for ZGPAT gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZGPAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19644445
genes like me logo Genes that share ontologies with ZGPAT: view

Pathways for ZGPAT Gene

SuperPathways for ZGPAT Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZGPAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 19644445
GO:0006351 transcription, DNA-templated IEA --
GO:0007175 negative regulation of epidermal growth factor-activated receptor activity IDA 19644445
GO:0045892 negative regulation of transcription, DNA-templated IDA 19644445
genes like me logo Genes that share ontologies with ZGPAT: view

No data available for Pathways by source for ZGPAT Gene

Transcripts for ZGPAT Gene

Unigene Clusters for ZGPAT Gene

Zinc finger, CCCH-type with G patch domain:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZGPAT Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ·
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - -
SP4:
SP5: - -
SP6:
SP7:
SP8: - - - -
SP9: - - -
SP10:
SP11:
SP12:
SP13: - - - -
SP14: -
SP15: -
SP16: - -

ExUns: 10c ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c · 14d ^ 15a · 15b · 15c
SP1:
SP2:
SP3:
SP4: -
SP5: - - -
SP6: - -
SP7: -
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for ZGPAT Gene

GeneLoc Exon Structure for
ZGPAT
ECgene alternative splicing isoforms for
ZGPAT

Expression for ZGPAT Gene

mRNA expression in normal human tissues for ZGPAT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZGPAT Gene

SOURCE GeneReport for Unigene cluster for ZGPAT Gene Hs.590868

mRNA Expression by UniProt/SwissProt for ZGPAT Gene

Q8N5A5-ZGPAT_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with ZGPAT: view

Orthologs for ZGPAT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZGPAT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZGPAT 36
  • 99.35 (n)
  • 99.41 (a)
ZGPAT 37
  • 99 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ZGPAT 36
  • 83.43 (n)
  • 80.75 (a)
ZGPAT 37
  • 79 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 75 (a)
OneToMany
ZGPAT 36
  • 81.22 (n)
  • 79.17 (a)
mouse
(Mus musculus)
Mammalia Zgpat 36
  • 80.88 (n)
  • 80.94 (a)
Zgpat 16
Zgpat 37
  • 80 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 60 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 66 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zgpat 36
  • 80.66 (n)
  • 80 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 62 (a)
OneToMany
ZGPAT 36
  • 68.78 (n)
  • 69.64 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 63 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2135 36
zebrafish
(Danio rerio)
Actinopterygii -- 36
CABZ01022575.1 37
  • 50 (a)
ManyToMany
zgpat 36
  • 58.32 (n)
  • 53.56 (a)
zgpat 37
  • 51 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta ZGPAT_ANOGA 36
  • 48.19 (n)
  • 35.69 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4709 36
  • 45.09 (n)
  • 33.81 (a)
CG4709 37
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C33H5.17 36
  • 38.14 (n)
  • 31.23 (a)
C33H5.17 37
  • 24 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G24830 36
  • 39.51 (n)
  • 27.47 (a)
rice
(Oryza sativa)
Liliopsida Os02g0793000 36
  • 42.45 (n)
  • 32.05 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 31 (a)
OneToMany
Species with no ortholog for ZGPAT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZGPAT Gene

ENSEMBL:
Gene Tree for ZGPAT (if available)
TreeFam:
Gene Tree for ZGPAT (if available)

Paralogs for ZGPAT Gene

Paralogs for ZGPAT Gene

genes like me logo Genes that share paralogs with ZGPAT: view

Variants for ZGPAT Gene

Sequence variations from dbSNP and Humsavar for ZGPAT Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs1151622 -- 63,734,204(+) TGTGT(A/G)TGCGT intron-variant
rs1291213 -- 63,721,274(+) ttcaa(C/T)ccagg intron-variant
rs1298721 -- 63,720,967(+) aaaga(C/T)tatat intron-variant
rs1741706 -- 63,715,835(+) ATATA(G/T)AGAGA intron-variant
rs1758199 -- 63,721,475(+) cttct(C/T)gctcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZGPAT Gene

Variant ID Type Subtype PubMed ID
dgv4618n71 CNV Loss 21882294
nsv913190 CNV Loss 21882294
dgv1344e1 CNV Complex 17122850
nsv913213 CNV Loss 21882294
nsv470563 CNV Loss 18288195
dgv4644n71 CNV Loss 21882294
dgv1345e1 CNV Complex 17122850
nsv428381 CNV Gain+Loss 18775914
nsv913241 CNV Loss 21882294
dgv4645n71 CNV Loss 21882294
dgv4646n71 CNV Loss 21882294
dgv4647n71 CNV Loss 21882294
nsv913249 CNV Loss 21882294
nsv913250 CNV Loss 21882294
nsv913253 CNV Loss 21882294
nsv913255 CNV Gain 21882294
nsv828801 CNV Loss 20364138
esv7227 CNV Loss 19470904
esv2722959 CNV Deletion 23290073
esv2722960 CNV Deletion 23290073
esv2722961 CNV Deletion 23290073
esv2722963 CNV Deletion 23290073
esv2722964 CNV Deletion 23290073
nsv913256 CNV Loss 21882294
dgv4648n71 CNV Loss 21882294
esv2722965 CNV Deletion 23290073
nsv913258 CNV Loss 21882294
dgv4649n71 CNV Loss 21882294
esv5348 CNV Deletion 18987735
esv2722966 CNV Deletion 23290073
esv2661713 CNV Deletion 23128226
dgv4650n71 CNV Loss 21882294
dgv4651n71 CNV Loss 21882294

Relevant External Links for ZGPAT Gene

HapMap Linkage Disequilibrium report
ZGPAT

Disorders for ZGPAT Gene

Relevant External Links for ZGPAT

Genetic Association Database (GAD)
ZGPAT
Human Genome Epidemiology (HuGE) Navigator
ZGPAT
genes like me logo Genes that share disorders with ZGPAT: view

No data available for UniProtKB/Swiss-Prot for ZGPAT Gene

Publications for ZGPAT Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 3 4
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Comprehensive DNA methylation profiling in a human cancer genome identifies novel epigenetic targets. (PMID: 16952911) Ordway J.M. … Jeddeloh J.A. (Carcinogenesis 2006) 2 3

Products for ZGPAT Gene

Sources for ZGPAT Gene

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