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Aliases for ZGLP1 Gene

Aliases for ZGLP1 Gene

  • Zinc Finger, GATA-Like Protein 1 2 3
  • GATA Zinc Finger Domain Containing 3 2 3
  • GATA Like Protein 1 2 3
  • GATA-Like Protein 1 3 4
  • GLP-1 3 4
  • GLP1 3 4
  • GATA Like Protein-1 3
  • GATAD3 3

External Ids for ZGLP1 Gene

Previous GeneCards Identifiers for ZGLP1 Gene

  • GC19M010279
  • GC19M010415
  • GC19M009995

Summaries for ZGLP1 Gene

GeneCards Summary for ZGLP1 Gene

ZGLP1 (Zinc Finger, GATA-Like Protein 1) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding.

UniProtKB/Swiss-Prot for ZGLP1 Gene

  • Transcriptional repressor that plays a central role in somatic cells of the gonad and is required for germ cell development. Able to repress GATA transcription factor function (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZGLP1 Gene

Genomics for ZGLP1 Gene

Genomic Location for ZGLP1 Gene

Chromosome:
19
Start:
10,304,803 bp from pter
End:
10,309,880 bp from pter
Size:
5,078 bases
Orientation:
Minus strand

Genomic View for ZGLP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZGLP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZGLP1 Gene

No data available for Regulatory Elements for ZGLP1 Gene

Proteins for ZGLP1 Gene

  • Protein details for ZGLP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C6A0-ZGLP1_HUMAN
    Recommended name:
    GATA-type zinc finger protein 1
    Protein Accession:
    P0C6A0

    Protein attributes for ZGLP1 Gene

    Size:
    271 amino acids
    Molecular mass:
    29628 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZGLP1 Gene

Proteomics data for ZGLP1 Gene at MOPED

Post-translational modifications for ZGLP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZGLP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ZGLP1 Gene

Domains & Families for ZGLP1 Gene

Gene Families for ZGLP1 Gene

Protein Domains for ZGLP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZGLP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0C6A0

UniProtKB/Swiss-Prot:

ZGLP1_HUMAN :
  • Contains 1 GATA-type zinc finger.
Similarity:
  • Contains 1 GATA-type zinc finger.
genes like me logo Genes that share domains with ZGLP1: view

Function for ZGLP1 Gene

Molecular function for ZGLP1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor that plays a central role in somatic cells of the gonad and is required for germ cell development. Able to repress GATA transcription factor function (By similarity).

Gene Ontology (GO) - Molecular Function for ZGLP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0001085 RNA polymerase II transcription factor binding IBA --
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IBA --
GO:0003682 chromatin binding IBA --
GO:0003700 transcription factor activity, sequence-specific DNA binding --
genes like me logo Genes that share ontologies with ZGLP1: view
genes like me logo Genes that share phenotypes with ZGLP1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZGLP1 Gene

Localization for ZGLP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZGLP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZGLP1 Gene COMPARTMENTS Subcellular localization image for ZGLP1 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZGLP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005667 transcription factor complex IBA --
genes like me logo Genes that share ontologies with ZGLP1: view

Pathways & Interactions for ZGLP1 Gene

SuperPathways for ZGLP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZGLP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with ZGLP1: view

No data available for Pathways by source and SIGNOR curated interactions for ZGLP1 Gene

Drugs & Compounds for ZGLP1 Gene

No Compound Related Data Available

Transcripts for ZGLP1 Gene

mRNA/cDNA for ZGLP1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZGLP1 Gene

Zinc finger, GATA-like protein 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZGLP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZGLP1 Gene

No ASD Table

Relevant External Links for ZGLP1 Gene

GeneLoc Exon Structure for
ZGLP1
ECgene alternative splicing isoforms for
ZGLP1

Expression for ZGLP1 Gene

mRNA expression in normal human tissues for ZGLP1 Gene

Protein differential expression in normal tissues from HIPED for ZGLP1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (29.8), Testis (24.3), and Fetal ovary (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZGLP1 Gene



SOURCE GeneReport for Unigene cluster for ZGLP1 Gene Hs.709296

genes like me logo Genes that share expression patterns with ZGLP1: view

Protein tissue co-expression partners for ZGLP1 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZGLP1 Gene

Orthologs for ZGLP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZGLP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZGLP1 35
  • 78.53 (n)
  • 73.87 (a)
ZGLP1 36
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZGLP1 35
  • 80.37 (n)
  • 70.32 (a)
ZGLP1 36
  • 59 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zglp1 35
  • 73.56 (n)
  • 68.75 (a)
Zglp1 16
Zglp1 36
  • 55 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZGLP1 35
  • 99.38 (n)
  • 99.26 (a)
ZGLP1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zglp1 35
  • 72.6 (n)
  • 67.79 (a)
zebrafish
(Danio rerio)
Actinopterygii zglp1 36
  • 24 (a)
OneToOne
Species with no ortholog for ZGLP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZGLP1 Gene

ENSEMBL:
Gene Tree for ZGLP1 (if available)
TreeFam:
Gene Tree for ZGLP1 (if available)

Paralogs for ZGLP1 Gene

No data available for Paralogs for ZGLP1 Gene

Variants for ZGLP1 Gene

Sequence variations from dbSNP and Humsavar for ZGLP1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs281416 -- 10,308,108(+) GCCAG(A/G)GAGCA intron-variant
rs281417 -- 10,308,454(+) AGGAC(C/T)GGGGT synonymous-codon, reference
rs281419 -- 10,306,166(+) ggagt(A/G)tagtg intron-variant
rs882589 -- 10,309,278(-) GGGGT(C/T)ATGAC utr-variant-5-prime
rs2291473 -- 10,305,105(+) CTGAA(C/T)GGGGT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZGLP1 Gene

Variant ID Type Subtype PubMed ID
nsv911029 CNV Loss 21882294
nsv911030 CNV Loss 21882294
dgv3725n71 CNV Loss 21882294
dgv3726n71 CNV Loss 21882294
nsv470124 CNV Gain 18288195

Variation tolerance for ZGLP1 Gene

Residual Variation Intolerance Score: 52.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZGLP1 Gene

HapMap Linkage Disequilibrium report
ZGLP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZGLP1 Gene

Disorders for ZGLP1 Gene

Relevant External Links for ZGLP1

Human Genome Epidemiology (HuGE) Navigator
ZGLP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZGLP1
genes like me logo Genes that share disorders with ZGLP1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZGLP1 Gene

Publications for ZGLP1 Gene

  1. GLP-1: a novel zinc finger protein required in somatic cells of the gonad for germ cell development. (PMID: 16982049) Li S. … Morrisey E.E. (Dev. Biol. 2007) 2 67
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 67
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for ZGLP1 Gene

Sources for ZGLP1 Gene

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