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ZGLP1 Gene

protein-coding   GIFtS: 34
GCID: GC19M010415

Zinc Finger, GATA-Like Protein 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger, GATA-Like Protein 11 2     GATA-Like Protein 12 3
GLP12 3 5     GATAD32
GATA Like Protein 11 2     GATA Like Protein-12
GATA Zinc Finger Domain Containing 31 2     GATA-Type Zinc Finger Protein 12
GLP-12 3     

External Ids:    HGNC: 372451   Entrez Gene: 1001252882   Ensembl: ENSG000002202017   OMIM: 6116395   UniProtKB: P0C6A03   

Export aliases for ZGLP1 gene to outside databases

Previous GC identifers: GC19M010279 GC19M009995


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZGLP1 Gene:
ZGLP1 (zinc finger, GATA-like protein 1) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: ZGLP1_HUMAN, P0C6A0
Function: Transcriptional repressor that plays a central role in somatic cells of the gonad and is required for
germ cell development. Able to repress GATA transcription factor function (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for ZGLP1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ZGLP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZGLP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

ZGLP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZGLP1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M010415:  view genomic region     (about GC identifiers)

Start:
10,415,479 bp from pter      End:
10,420,556 bp from pter
Size:
5,078 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZGLP1_HUMAN, P0C6A0 (See protein sequence)
Recommended Name: GATA-type zinc finger protein 1  
Size: 271 amino acids; 29628 Da

Explore the universe of human proteins at neXtProt for ZGLP1: NX_P0C6A0

Explore proteomics data for ZGLP1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZGLP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001096637.1  
    ENSEMBL proteins: 
     ENSP00000384434   ENSP00000385403  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GATAD: GATA zinc finger domain containing

    2 InterPro protein domains:
     IPR000679 Znf_GATA
     IPR013088 Znf_NHR/GATA

    Graphical View of Domain Structure for InterPro Entry P0C6A0

    ProtoNet protein and cluster: P0C6A0

    UniProtKB/Swiss-Prot: ZGLP1_HUMAN, P0C6A0
    Similarity: Contains 1 GATA-type zinc finger


    Find genes that share domains with ZGLP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZGLP1_HUMAN, P0C6A0
    Function: Transcriptional repressor that plays a central role in somatic cells of the gonad and is required for
    germ cell development. Able to repress GATA transcription factor function (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0008270zinc ion binding IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with ZGLP1           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Zglp1):
     cellular  endocrine/exocrine gland  reproductive system 

    Find genes that share phenotypes with ZGLP1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZGLP1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZGLP1_HUMAN, P0C6A0: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    extracellular1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZGLP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZGLP1
    Interactions:

        Search GeneGlobe Interaction Network for ZGLP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for ZGLP1 (ENSP000003844344) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EHMT1ENSP000004179804STRING: ENSP00000417980
    RELAENSP000003842734STRING: ENSP00000384273
    BCL6ENSP000002320144STRING: ENSP00000232014
    BPTFENSP000003072084STRING: ENSP00000307208
    PBRM1ENSP000003492134STRING: ENSP00000349213
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis IEA--

    Find genes that share ontologies with ZGLP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for ZGLP1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZGLP1 gene: 
    NM_001103167.1  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000480726 ENST00000403903(uc002mnw.4) ENST00000403352
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZGLP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAGGAGTCG
    ZGLP1 Expression
    About this image

    ZGLP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZGLP1 Protein Expression
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZGLP1 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zglp11 , 5 zinc finger, GATA-like protein 11, 5 73.56(n)1
    68.75(a)1
      9 (7.70 cM)5
    1000096001  NM_001103168.11  NP_001096638.11 
     210623935 
    zebrafish
    (Danio rerio)
    Actinopterygii zglp16
    zinc finger, GATA-like protein 1
    24(a)
    1 ↔ 1
    6(88036-92278) ENSDARG00000067669


    ENSEMBL Gene Tree for ZGLP1 (if available)
    TreeFam Gene Tree for ZGLP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZGLP1 (see all 110)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1510774331,2
    --10414990(+) TCATCA/GTGTTG 1 -- ds50010--------
    rs1872697181,2
    C--10415121(+) TGTATA/GTAACA 1 -- ds50010--------
    rs1920245141,2
    --10415154(+) CTGGTC/TTCAAA 1 -- ds50010--------
    rs1827772211,2
    --10415201(+) CAAAGC/TGTTGG 1 -- ds50010--------
    rs1502560361,2
    --10415233(+) CACCCA/GGCTTG 1 -- ds50010--------
    rs1869104961,2
    --10415298(+) CATGGA/GACATT 1 -- ds50010--------
    rs591745941,2
    C,F--10415326(+) TTCCCT/CGTGTG 1 -- ds50012Minor allele frequency- C:0.07WA 120
    rs1917745801,2
    --10415372(+) GCATGC/TGCACG 1 -- ds50010--------
    rs1475850141,2
    --10415483(+) CTCTCA/GGCATA 1 -- ut310--------
    rs1420964841,2
    C--10415578(+) GAGAAC/GGGGCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZGLP1 (10415479 - 10420556 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ZGLP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911030CNV Loss21882294
    nsv911029CNV Loss21882294
    dgv3726n71CNV Loss21882294
    dgv3725n71CNV Loss21882294
    nsv470124CNV Gain18288195

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611639    OMIM disorders: --


    Find genes that share disorders with ZGLP1           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: ZGLP1 (1 document)

    Export disorders for ZGLP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZGLP1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZGLP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. GLP-1: a novel zinc finger protein required in somatic cells of the gonad for germ cell development. (PubMed id 16982049)1, 3 Li S....Morrisey E.E. (Dev. Biol. 2007)
    2. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 100125288 HGNC: 37245 Ensembl:ENSG00000220201 euGenes: HUgn100125288 ECgene: ZGLP1
    H-InvDB: ZGLP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZGLP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZGLP1 gene:
    Search GeneIP for patents involving ZGLP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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