ZG16B Gene
protein-coding GIFtS: 47
GCID: GC16P002881
|
|
zymogen granule protein 16B(Previous name: zymogen granule protein 16 homolog B (rat) )
| |
Aliases
for ZG16B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zymogen Granule Protein 16B1 2 | | PAUF2 | | HRPE7731 2 | | Endocrine And Exocrine Protein2 | | JCLN21 2 | | Jacalin-Like Lectin Domain Containing 22 | | PRO15671 2 | | Pancreatic Adenocarcinoma Upregulated Factor2 | | Zymogen Granule Protein 16 Homolog B (Rat)1 | | Zymogen Granule Protein 16 Homolog B2 | | EECP2 | | |
Export aliases for ZG16B gene to outside databasesPrevious GC identifer: GC16P002821 |
Summaries
for ZG16B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for ZG16B (LOC124220)
|
Genomic Views
for ZG16B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZG16B gene promoter:
RORalpha1 NF-1 AP-1 NRSF form 1 NRSF form 2 En-1 Arnt Roaz
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZG16B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZG16B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3ZG16B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P002881: view genomic region
(about GC identifiers)
Start:
|
2,880,170 bp from pter |
End:
|
2,888,967 bp from pter |
Size:
|
8,798 bases |
Orientation:
|
plus strand |
|
Proteins
for ZG16B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZG16B_HUMAN, Q96DA0 (See
protein sequence)Recommended Name: Zymogen granule protein 16 homolog B precursor Size: 208 amino acids; 22739 Da
Subcellular location: Secreted (Potential)
Caution: It is uncertain whether Met-1, Met-13 or Met-31 is the initiator
Sequence caution: Sequence=AAQ89380.1; Type=Erroneous initiation; Sequence=BAG34753.1; Type=Erroneous initiation;
1 PDB 3D structure from  and Proteopedia  for ZG16B:3AQG (3D)
Secondary accessions: A6NIY1 B2R4F6 Q6UW28Explore the universe of human proteins at neXtProt for ZG16B: NX_Q96DA0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96DA0
ZG16B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_660295.2
ENSEMBL proteins: ENSP00000371715 ENSP00000460793 ENSP00000458847 ENSP00000461740
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
ZG16B for ontologies About GeneDecksing
ZG16B Antibody Products:
Assay Products for ZG16B: |
Protein
Domains /
Families
for ZG16B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZG16B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96DA0ProtoNet protein and cluster: Q96DA0 UniProtKB/Swiss-Prot: ZG16B_HUMAN, Q96DA0Similarity: Belongs to the jacalin lectin family |
Function
for ZG16B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZG16B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZG16B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZG16B (NM_145252) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZG16B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZG16B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZG16B |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030246 | carbohydrate binding |
-- | -- |
ZG16B for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZG16B:
|
Pathways & Interactions
for ZG16B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZG16B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/10 Interacting proteins for ZG16B (Q96DA02, 3 ENSP000003717154) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
|
Drugs & Compounds
for ZG16B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZG16B
Search CenterWatch for drugs/clinical trials and news about ZG16B
|
Transcripts
for ZG16B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZG16B gene: NM_145252.2 Unigene Cluster for ZG16B: Zymogen granule protein 16B Hs.105887 [show with all ESTs]Unigene Representative Sequence: BU5582476 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000382280(uc002cru.3) ENST00000570670 ENST00000576423 ENST00000573019
ENST00000571723 ENST00000572863
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZG16B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZG16B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZG16B (NM_145252) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZG16B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZG16B |
Additional cDNA sequence: AK311810.1 AY359021.1 BC009722.1 EF067313.1 JN411265.1 3 DOTS entries: DT.100021339 DT.120656002 DT.97777676 24/72 AceView cDNA sequences (see all 72): BU858000 AA722847 BQ924772 BE787020 BM849630 BP334240 BM773499 BM769212 AA577045 CD675363 BP334345 BE621031 BP334806 CA946275 AI559190 BX486660 BP334244 BP334230 BU956799 BC009722 BG332049 BP334928 BM977697 AA716150
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for ZG16B About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c |
|---|
|
| SP1: | | | - | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | |
ECgene alternative splicing isoforms for ZG16B
|
Expression
for ZG16B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZG16B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACACCAGCA
About this image
See ZG16B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZG16B
SOURCE GeneReport for Unigene cluster: Hs.105887
SABiosciences Custom PCR Arrays for ZG16B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZG16B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZG16B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZG16B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZG16B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZG16B |
Orthologs
for ZG16B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZG16B (if available)
TreeFam Gene Tree for ZG16B (if available) |
Paralogs
for ZG16B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZG16B gene
- ZG162
3 SIMAP similar genes for ZG16B using alignment to 3 protein entries: ZG16B_HUMAN (see all proteins):EECP PAUF ZG16
ZG16B for paralogs About GeneDecksing
|
Genomic Variants
for ZG16B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZG16B (2880170 - 2888967 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZG16B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZG16B |
|
Disorders
/ Diseases
for ZG16B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZG16B for disorders About GeneDecksing
5  diseases for ZG16B: About MalaCardsadenocarcinoma pancreatitis pancreatic ductal adenocarcinoma pancreatic cancer
ataxia
Export disorders for ZG16B gene to outside databases
|
Publications
for ZG16B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZG16B gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with ZG16B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Crystal structures of human secretory proteins ZG16p and ZG16b reveal a Jacalin-related beta-prism fold. (PubMed id 21110947)1, 2 Kanagawa M.... Yamaguchi Y. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Mass spectrometry allows direct identification of proteins in large genomes. (PubMed id 11678034)1, 2 Kuster B.... Mann M. (2001)
- SIRT1 inhibits proliferation of pancreatic cancer cell s expressing pancreatic adenocarcinoma up-regulated factor (PAUF), a novel oncog ene, by suppression of b-catenin. (PubMed id 22640743)1 Cho I.R....Chung Y.H. (2012)
- Pancreatic adenocarcinoma up-regulated factor (PAUF) enhances the expression of I^-catenin, leading to a rapid proliferation of pancr eatic cells. (PubMed id 21196815)1 Cho I.R....Chung Y.H. (2011)
- Pancreatic adenocarcinoma upregulated factor promotes metastasis by regulating TLR/CXCR4 activation. (PubMed id 20802527)1 Park H.D....Lim D.S. (2011)
- PAUF promotes adhesiveness of pancreatic cancer cells by modulating focal adhesion kinase. (PubMed id 21464589)1 Lee Y.S....Koh S.S. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
|
External Searches for ZG16B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZG16B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZG16B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZG16B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZG16B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZG16B gene:
Search GeneIP for patents involving ZG16B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZG16B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZG16B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZG16B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZG16B | | | OriGene Protein Over-expression Lysate for ZG16B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZG16B | | OriGene 3'-UTR Clone for ZG16B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZG16B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZG16B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ZG16B | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZG16B | | OriGene Custom Protein Services for ZG16B | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZG16B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZG16B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZG16B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZG16B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZG16B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZG16B |
| |
 |  |  |  | |
| | | | Search Tocris compounds for ZG16B |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | ZG16B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZG16B |
|  |  |  | | | | ThermoFisher Antibodies for ZG16B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZG16B |
|
|
|
|
