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Aliases for ZG16B Gene

Aliases for ZG16B Gene

  • Zymogen Granule Protein 16B 2 3 5
  • Jacalin-Like Lectin Domain Containing 2 2 3
  • Pancreatic Adenocarcinoma Upregulated Factor 3
  • Zymogen Granule Protein 16 Homolog B (Rat) 2
  • Endocrine And Exocrine Protein 3
  • HRPE773 3
  • PRO1567 3
  • JCLN2 3
  • EECP 3
  • PAUF 3

External Ids for ZG16B Gene

Previous GeneCards Identifiers for ZG16B Gene

  • GC16P002821
  • GC16P002881

Summaries for ZG16B Gene

GeneCards Summary for ZG16B Gene

ZG16B (Zymogen Granule Protein 16B) is a Protein Coding gene. Diseases associated with ZG16B include ovarian mucinous neoplasm and branch retinal artery occlusion. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is ZG16.

Gene Wiki entry for ZG16B Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZG16B Gene

Genomics for ZG16B Gene

Regulatory Elements for ZG16B Gene

Genomic Location for ZG16B Gene

2,830,169 bp from pter
2,839,585 bp from pter
9,417 bases
Plus strand

Genomic View for ZG16B Gene

Genes around ZG16B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZG16B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZG16B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZG16B Gene

Proteins for ZG16B Gene

  • Protein details for ZG16B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zymogen granule protein 16 homolog B
    Protein Accession:
    Secondary Accessions:
    • A6NIY1
    • B2R4F6
    • Q6UW28

    Protein attributes for ZG16B Gene

    208 amino acids
    Molecular mass:
    22739 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAQ89380.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG34753.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZG16B Gene

neXtProt entry for ZG16B Gene

Proteomics data for ZG16B Gene at MOPED

Post-translational modifications for ZG16B Gene

  • Glycosylation at Asn 197
  • Modification sites at PhosphoSitePlus

Other Protein References for ZG16B Gene

Antibody Products

No data available for DME Specific Peptides for ZG16B Gene

Domains & Families for ZG16B Gene

Protein Domains for ZG16B Gene


Suggested Antigen Peptide Sequences for ZG16B Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 jacalin-type lectin domain.
  • Belongs to the jacalin lectin family.
  • Contains 1 jacalin-type lectin domain.
  • Belongs to the jacalin lectin family.
genes like me logo Genes that share domains with ZG16B: view

No data available for Gene Families for ZG16B Gene

Function for ZG16B Gene

Gene Ontology (GO) - Molecular Function for ZG16B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with ZG16B: view
genes like me logo Genes that share phenotypes with ZG16B: view

Animal Model Products

CRISPR Products

miRNA for ZG16B Gene

miRTarBase miRNAs that target ZG16B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZG16B Gene

Localization for ZG16B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZG16B Gene


Subcellular locations from

Jensen Localization Image for ZG16B Gene COMPARTMENTS Subcellular localization image for ZG16B gene
Compartment Confidence
extracellular 5
mitochondrion 2
nucleus 2
golgi apparatus 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for ZG16B Gene

Pathways & Interactions for ZG16B Gene

SuperPathways for ZG16B Gene

No Data Available

Interacting Proteins for ZG16B Gene

Gene Ontology (GO) - Biological Process for ZG16B Gene


No data available for Pathways by source and SIGNOR curated interactions for ZG16B Gene

Drugs & Compounds for ZG16B Gene

No Compound Related Data Available

Transcripts for ZG16B Gene

Unigene Clusters for ZG16B Gene

Zymogen granule protein 16B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZG16B Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c
SP1: - -
SP2: -
SP4: -

Relevant External Links for ZG16B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZG16B Gene

mRNA expression in normal human tissues for ZG16B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZG16B Gene

This gene is overexpressed in Minor Salivary Gland (x52.0).

Protein differential expression in normal tissues from HIPED for ZG16B Gene

This gene is overexpressed in Skin (26.6), Salivary gland (23.0), and Saliva (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZG16B Gene

SOURCE GeneReport for Unigene cluster for ZG16B Gene Hs.105887

genes like me logo Genes that share expression patterns with ZG16B: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZG16B Gene

Orthologs for ZG16B Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZG16B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZG16B 35
  • 68.1 (n)
  • 53.99 (a)
-- 36
  • 41 (a)
-- 36
  • 45 (a)
-- 36
  • 52 (a)
(Canis familiaris)
Mammalia ZG16B 35
  • 64.52 (n)
  • 52.86 (a)
ZG16B 36
  • 48 (a)
(Pan troglodytes)
Mammalia ZG16B 35
  • 99.2 (n)
  • 98.08 (a)
ZG16B 36
  • 98 (a)
(Mus musculus)
Mammalia Sbp 36
  • 24 (a)
Sbpl 36
  • 20 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 29 (a)
-- 36
  • 29 (a)
Species with no ortholog for ZG16B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZG16B Gene

Gene Tree for ZG16B (if available)
Gene Tree for ZG16B (if available)

Paralogs for ZG16B Gene

Paralogs for ZG16B Gene

(3) SIMAP similar genes for ZG16B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZG16B: view

Variants for ZG16B Gene

Sequence variations from dbSNP and Humsavar for ZG16B Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs35533993 - 2,831,929(-) GACCA(C/T)ACCCC reference, missense
rs12373 -- 2,832,196(-) ACCAC(A/C)CAGAT utr-variant-3-prime
rs929435 -- 2,829,560(-) CCTCA(C/T)CTGGG upstream-variant-2KB
rs758189 -- 2,831,674(-) GGGTC(C/T)CTGAC intron-variant
rs886953 -- 2,832,266(-) CAGAA(C/G)CTTTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZG16B Gene

Variant ID Type Subtype PubMed ID
nsv905152 CNV Loss 21882294
nsv905162 CNV Gain 21882294
nsv905165 CNV Loss 21882294
nsv905169 CNV Loss 21882294
nsv905170 CNV Loss 21882294
dgv2574n71 CNV Loss 21882294
esv2663371 CNV Deletion 23128226

Variation tolerance for ZG16B Gene

Residual Variation Intolerance Score: 66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.46; 43.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZG16B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZG16B Gene

Disorders for ZG16B Gene

MalaCards: The human disease database

(3) MalaCards diseases for ZG16B Gene - From: DISEASES

Disorder Aliases PubMed IDs
ovarian mucinous neoplasm
  • malignant ovarian mucinous neoplasm
branch retinal artery occlusion
  • arterial retinal branch occlusion
vertebrobasilar insufficiency
  • vertebro-basilar insufficiency
- elite association - COSMIC cancer census association via MalaCards
Search ZG16B in MalaCards View complete list of genes associated with diseases

Relevant External Links for ZG16B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ZG16B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZG16B Gene

Publications for ZG16B Gene

  1. Crystal structures of human secretory proteins ZG16p and ZG16b reveal a Jacalin-related beta-prism fold. (PMID: 21110947) Kanagawa M. … Yamaguchi Y. (Biochem. Biophys. Res. Commun. 2011) 2 3 4 67
  2. Genetic variation in microRNA-binding site and prognosis of patients with colorectal cancer. (PMID: 25079514) Kim J.G. … Choi G.S. (J. Cancer Res. Clin. Oncol. 2015) 3
  3. Pancreatic adenocarcinoma upregulated factor (PAUF) confers resistance to pancreatic cancer cells against oncolytic parvovirus H-1 infection through IFNA receptor-mediated signaling. (PMID: 25727013) Kaowinn S. … Chung Y.H. (Biochem. Biophys. Res. Commun. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks. (PMID: 24550385) Abu-Odeh M. … Aqeilan R.I. (J. Biol. Chem. 2014) 3

Products for ZG16B Gene

Sources for ZG16B Gene

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